diff --git a/Lib/uuid.py b/Lib/uuid.py
index 4bdcb67775a2ea1..be77d8c98984398 100644
--- a/Lib/uuid.py
+++ b/Lib/uuid.py
@@ -213,8 +213,12 @@ def __init__(self, hex=None, bytes=None, bytes_le=None, fields=None,
         if int is not None:
             pass
         elif hex is not None:
-            hex = hex.replace('urn:', '').replace('uuid:', '')
+            original_hex = hex
+            hex = hex.removeprefix('urn:uuid:')
             hex = hex.strip('{}').replace('-', '')
+            if len(hex) != 32:
+                hex = original_hex.replace('urn:', '').replace('uuid:', '')
+                hex = hex.strip('{}').replace('-', '')
             if len(hex) != 32:
                 raise ValueError('badly formed hexadecimal UUID string')
             int = int_(hex, 16)
diff --git a/Misc/NEWS.d/next/Library/2026-05-22-12-10-00.gh-issue-150226.uuid-perf.rst b/Misc/NEWS.d/next/Library/2026-05-22-12-10-00.gh-issue-150226.uuid-perf.rst
new file mode 100644
index 000000000000000..35995e8827797f2
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2026-05-22-12-10-00.gh-issue-150226.uuid-perf.rst
@@ -0,0 +1 @@
+Speed up construction of :class:`uuid.UUID` from documented string formats.