diff --git a/.librarian/generator-input/client-post-processing/add-dependency-google-cloud-common.yaml b/.librarian/generator-input/client-post-processing/add-dependency-google-cloud-common.yaml
index 289ca7c7712d..c01f2e3ec861 100644
--- a/.librarian/generator-input/client-post-processing/add-dependency-google-cloud-common.yaml
+++ b/.librarian/generator-input/client-post-processing/add-dependency-google-cloud-common.yaml
@@ -19,14 +19,14 @@ replacements:
     ]
     before: |
       dependencies = \[
-          "google-api-core\[grpc\] >= 2.17.1, <3.0.0",
+          "google-api-core\[grpc\] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
           "grpcio >= 1.59.0, < 2.0.0",
     after: |
       dependencies = [
-          "google-api-core[grpc] >= 2.17.1, <3.0.0",
+          "google-api-core[grpc] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
diff --git a/.librarian/generator-input/client-post-processing/add-missing-dependencies-to-setup-py-constraints.yaml b/.librarian/generator-input/client-post-processing/add-missing-dependencies-to-setup-py-constraints.yaml
index 1f8c7353df3a..21516829d772 100644
--- a/.librarian/generator-input/client-post-processing/add-missing-dependencies-to-setup-py-constraints.yaml
+++ b/.librarian/generator-input/client-post-processing/add-missing-dependencies-to-setup-py-constraints.yaml
@@ -19,14 +19,14 @@ replacements:
     ]
     before: |
       dependencies = \[
-          "google-api-core\[grpc\] >= 2.17.1, <3.0.0",
+          "google-api-core\[grpc\] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
           "grpcio >= 1.59.0, < 2.0.0",
     after:  |
       dependencies = [
-          "google-api-core[grpc] >= 2.17.1, <3.0.0",
+          "google-api-core[grpc] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
@@ -38,14 +38,14 @@ replacements:
     ]
     before: |
       dependencies = \[
-          "google-api-core\[grpc\] >= 2.17.1, <3.0.0",
+          "google-api-core\[grpc\] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
           "grpcio >= 1.59.0, < 2.0.0",
     after:  |
       dependencies = [
-          "google-api-core[grpc] >= 2.17.1, <3.0.0",
+          "google-api-core[grpc] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
@@ -57,14 +57,14 @@ replacements:
     ]
     before: |
       dependencies = \[
-          "google-api-core\[grpc\] >= 2.17.1, <3.0.0",
+          "google-api-core\[grpc\] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
           "grpcio >= 1.59.0, < 2.0.0",
     after:  |
       dependencies = [
-          "google-api-core[grpc] >= 2.17.1, <3.0.0",
+          "google-api-core[grpc] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
@@ -76,14 +76,14 @@ replacements:
     ]
     before: |
       dependencies = \[
-          "google-api-core\[grpc\] >= 2.17.1, <3.0.0",
+          "google-api-core\[grpc\] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
           "grpcio >= 1.59.0, < 2.0.0",
     after:  |
       dependencies = [
-          "google-api-core[grpc] >= 2.17.1, <3.0.0",
+          "google-api-core[grpc] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
@@ -95,14 +95,14 @@ replacements:
     ]
     before: |
       dependencies = \[
-          "google-api-core\[grpc\] >= 2.17.1, <3.0.0",
+          "google-api-core\[grpc\] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
           "grpcio >= 1.59.0, < 2.0.0",
     after:  |
       dependencies = [
-          "google-api-core[grpc] >= 2.17.1, <3.0.0",
+          "google-api-core[grpc] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
@@ -114,14 +114,14 @@ replacements:
     ]
     before: |
       dependencies = \[
-          "google-api-core\[grpc\] >= 2.17.1, <3.0.0",
+          "google-api-core\[grpc\] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
           "grpcio >= 1.59.0, < 2.0.0",
     after:  |
       dependencies = [
-          "google-api-core[grpc] >= 2.17.1, <3.0.0",
+          "google-api-core[grpc] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
diff --git a/.librarian/generator-input/client-post-processing/asset-integration.yaml b/.librarian/generator-input/client-post-processing/asset-integration.yaml
index 8246cb16f7a8..7b208999fc37 100644
--- a/.librarian/generator-input/client-post-processing/asset-integration.yaml
+++ b/.librarian/generator-input/client-post-processing/asset-integration.yaml
@@ -19,14 +19,14 @@ replacements:
     ]
     before: |
       dependencies = \[
-          "google-api-core\[grpc\] >= 2.17.1, <3.0.0",
+          "google-api-core\[grpc\] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
           "grpcio >= 1.59.0, < 2.0.0",
     after:  |
       dependencies = [
-          "google-api-core[grpc] >= 2.17.1, <3.0.0",
+          "google-api-core[grpc] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
@@ -38,10 +38,10 @@ replacements:
       packages/google-cloud-asset/testing/constraints-3.10.txt
     ]
     before: |
-      google-api-core==2.17.1
+      google-api-core==2.24.2
       google-auth==2.14.1
     after: |
-      google-api-core==2.17.1
+      google-api-core==2.24.2
       google-cloud-org-policy==1.11.1
       google-auth==2.14.1
     count: 1
diff --git a/.librarian/generator-input/client-post-processing/bigtable-integration.yaml b/.librarian/generator-input/client-post-processing/bigtable-integration.yaml
index b2edca54a00c..539a3469f7c7 100644
--- a/.librarian/generator-input/client-post-processing/bigtable-integration.yaml
+++ b/.librarian/generator-input/client-post-processing/bigtable-integration.yaml
@@ -194,10 +194,10 @@ replacements:
       packages/google-cloud-bigtable/setup.py,
     ]
     before: |
-      "protobuf >= 4.25.8, < 8.0.0",
-      \]
+      "protobuf >= 6.33.5, < 8.0.0",
+      ]
     after: |
-      "protobuf >= 4.25.8, < 8.0.0",
+      "protobuf >= 6.33.5, < 8.0.0",
           "google-cloud-core >= 2.0.0, <3.0.0",
           "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
           "google-crc32c>=1.6.0, <2.0.0dev",
@@ -207,10 +207,10 @@ replacements:
       packages/google-cloud-bigtable/testing/constraints-3.10.txt,
     ]
     before: |
-        google-api-core==2.17.1
+        google-api-core==2.24.2
         google-auth==2.14.1
     after: |
-        google-api-core==2.17.1
+        google-api-core==2.24.2
         google-cloud-core==2.0.0
         grpc-google-iam-v1==0.14.0
         google-crc32c==1.6.0
diff --git a/.librarian/generator-input/client-post-processing/containeranalysis-grafeas-integration.yaml b/.librarian/generator-input/client-post-processing/containeranalysis-grafeas-integration.yaml
index 65602c6d2286..6f8fe28e7966 100644
--- a/.librarian/generator-input/client-post-processing/containeranalysis-grafeas-integration.yaml
+++ b/.librarian/generator-input/client-post-processing/containeranalysis-grafeas-integration.yaml
@@ -19,14 +19,14 @@ replacements:
     ]
     before: |
       dependencies = \[
-          "google-api-core\[grpc\] >= 2.17.1, <3.0.0",
+          "google-api-core\[grpc\] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
           "grpcio >= 1.59.0, < 2.0.0",
     after: |
       dependencies = [
-          "google-api-core[grpc] >= 2.17.1, <3.0.0",
+          "google-api-core[grpc] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
diff --git a/.librarian/generator-input/client-post-processing/integrate-isolated-handwritten-code.yaml b/.librarian/generator-input/client-post-processing/integrate-isolated-handwritten-code.yaml
index d7a85d8e40a8..a2239b2072d2 100644
--- a/.librarian/generator-input/client-post-processing/integrate-isolated-handwritten-code.yaml
+++ b/.librarian/generator-input/client-post-processing/integrate-isolated-handwritten-code.yaml
@@ -60,14 +60,14 @@ replacements:
     ]
     before: |
       dependencies = \[
-          "google-api-core\[grpc\] >= 2.17.1, <3.0.0",
+          "google-api-core\[grpc\] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
           "grpcio >= 1.59.0, < 2.0.0",
     after: |
       dependencies = [
-          "google-api-core[grpc] >= 2.17.1, <3.0.0",
+          "google-api-core[grpc] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
@@ -210,10 +210,10 @@ replacements:
       packages/google-cloud-automl/testing/constraints-3.10.txt,
     ]
     before: |
-      google-api-core==2.17.1
+      google-api-core==2.24.2
       google-auth==2.14.1
     after: |
-      google-api-core==2.17.1
+      google-api-core==2.24.2
       google-cloud-storage==2.14.0
       libcst==0.2.5
       pandas==1.3.4
@@ -424,10 +424,10 @@ replacements:
       "packages/google-cloud-monitoring/testing/constraints-3.10.txt",
     ]
     before: |
-      google-api-core==2.17.1
+      google-api-core==2.24.2
       google-auth==2.14.1
     after: |
-      google-api-core==2.17.1
+      google-api-core==2.24.2
       pandas==1.3.4
       numpy==1.21.3
       google-auth==2.14.1
diff --git a/.librarian/generator-input/client-post-processing/pubsub-integration.yaml b/.librarian/generator-input/client-post-processing/pubsub-integration.yaml
index 97e87b026ae5..d90529897d1c 100644
--- a/.librarian/generator-input/client-post-processing/pubsub-integration.yaml
+++ b/.librarian/generator-input/client-post-processing/pubsub-integration.yaml
@@ -506,9 +506,9 @@ replacements:
 
   - paths:
       - "packages/google-cloud-pubsub/testing/constraints-3.10.txt"
-    before: 'grpc-google-iam-v1==0\.14\.0\n(?!grpcio-status)'
+    before: 'grpc-google-iam-v1==0\.14\.2\n(?!grpcio-status)'
     after: |-
-      grpc-google-iam-v1==0.14.0
+      grpc-google-iam-v1==0.14.2
       grpcio-status==1.51.3
       opentelemetry-api==1.27.0
       opentelemetry-sdk==1.27.0
diff --git a/.librarian/generator-input/client-post-processing/spanner-integration.yaml b/.librarian/generator-input/client-post-processing/spanner-integration.yaml
index 42b8909c01d4..d4ed02b968f5 100644
--- a/.librarian/generator-input/client-post-processing/spanner-integration.yaml
+++ b/.librarian/generator-input/client-post-processing/spanner-integration.yaml
@@ -125,7 +125,7 @@ replacements:
     before: '(?s)dependencies = \[.*?\]\nextras = \{\s*\}'
     after: |
       dependencies = [
-          "google-api-core[grpc] >= 2.17.1, <3.0.0",
+          "google-api-core[grpc] >= 2.24.2, <3.0.0",
           # Exclude incompatible versions of `google-auth`
           # See https://github.com/googleapis/google-cloud-python/issues/12364
           "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
@@ -1397,9 +1397,9 @@ replacements:
           """Run all tests with core dependencies installed from source,
     count: 1
   - paths: [packages/google-cloud-spanner/testing/constraints-3.10.txt]
-    before: '(?s)protobuf==4.25.8\n(?!google-cloud-core)'
+    before: '(?s)protobuf==6.33.5\n(?!google-cloud-core)'
     after: |
-      protobuf==4.25.8
+      protobuf==6.33.5
       google-cloud-core==2.0.0
       grpc-google-iam-v1==0.12.4
       sqlparse==0.4.4
diff --git a/.librarian/generator-input/client-post-processing/storage-integration.yaml b/.librarian/generator-input/client-post-processing/storage-integration.yaml
index 55a062f43071..eb1fc8547227 100644
--- a/.librarian/generator-input/client-post-processing/storage-integration.yaml
+++ b/.librarian/generator-input/client-post-processing/storage-integration.yaml
@@ -640,12 +640,12 @@ replacements:
       packages/google-cloud-storage/testing/constraints-3.10.txt
     ]
     before: |
-      google-api-core==2.17.1
+      google-api-core==2.24.2
       google-auth==2.14.1
       grpcio==1.59.0
-      proto-plus==1.22.3
-      protobuf==4.25.8
-      grpc-google-iam-v1==0.14.0
+      proto-plus==1.26.1
+      protobuf==6.33.5
+      grpc-google-iam-v1==0.14.2
     after: |
       google-auth==2.26.1
       # cryptography is a direct dependency of google-auth
diff --git a/librarian.yaml b/librarian.yaml
index 34509c96c53d..ee94a36843cf 100644
--- a/librarian.yaml
+++ b/librarian.yaml
@@ -12,7 +12,7 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 language: python
-version: v0.19.0
+version: v0.21.0
 repo: googleapis/google-cloud-python
 sources:
   googleapis:
diff --git a/packages/google-ads-admanager/google/ads/admanager_v1/__init__.py b/packages/google-ads-admanager/google/ads/admanager_v1/__init__.py
index 8b39194d132b..c0b4c9857aa5 100644
--- a/packages/google-ads-admanager/google/ads/admanager_v1/__init__.py
+++ b/packages/google-ads-admanager/google/ads/admanager_v1/__init__.py
@@ -582,7 +582,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -611,9 +611,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-ads-admanager/setup.py b/packages/google-ads-admanager/setup.py
index 58ac519a48ab..cf1356d9e3d7 100644
--- a/packages/google-ads-admanager/setup.py
+++ b/packages/google-ads-admanager/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/ads/admanager/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-ads-admanager"
diff --git a/packages/google-ads-admanager/testing/constraints-3.10.txt b/packages/google-ads-admanager/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-ads-admanager/testing/constraints-3.10.txt
+++ b/packages/google-ads-admanager/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-ads-admanager/testing/constraints-3.13.txt b/packages/google-ads-admanager/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-ads-admanager/testing/constraints-3.13.txt
+++ b/packages/google-ads-admanager/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-ads-admanager/testing/constraints-3.14.txt b/packages/google-ads-admanager/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-ads-admanager/testing/constraints-3.14.txt
+++ b/packages/google-ads-admanager/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-ads-datamanager/google/ads/datamanager_v1/__init__.py b/packages/google-ads-datamanager/google/ads/datamanager_v1/__init__.py
index ada6908ff2af..090ecb7224b2 100644
--- a/packages/google-ads-datamanager/google/ads/datamanager_v1/__init__.py
+++ b/packages/google-ads-datamanager/google/ads/datamanager_v1/__init__.py
@@ -191,7 +191,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -220,9 +220,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-ads-datamanager/setup.py b/packages/google-ads-datamanager/setup.py
index 46fabd9b7fcf..4ac14d2a8cf3 100644
--- a/packages/google-ads-datamanager/setup.py
+++ b/packages/google-ads-datamanager/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/ads/datamanager/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-ads-datamanager"
diff --git a/packages/google-ads-datamanager/testing/constraints-3.10.txt b/packages/google-ads-datamanager/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-ads-datamanager/testing/constraints-3.10.txt
+++ b/packages/google-ads-datamanager/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-ads-datamanager/testing/constraints-3.13.txt b/packages/google-ads-datamanager/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-ads-datamanager/testing/constraints-3.13.txt
+++ b/packages/google-ads-datamanager/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-ads-datamanager/testing/constraints-3.14.txt b/packages/google-ads-datamanager/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-ads-datamanager/testing/constraints-3.14.txt
+++ b/packages/google-ads-datamanager/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-ads-marketingplatform-admin/google/ads/marketingplatform_admin_v1alpha/__init__.py b/packages/google-ads-marketingplatform-admin/google/ads/marketingplatform_admin_v1alpha/__init__.py
index 04eadd2381ff..fce2c804bf34 100644
--- a/packages/google-ads-marketingplatform-admin/google/ads/marketingplatform_admin_v1alpha/__init__.py
+++ b/packages/google-ads-marketingplatform-admin/google/ads/marketingplatform_admin_v1alpha/__init__.py
@@ -75,7 +75,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -104,9 +104,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-ads-marketingplatform-admin/setup.py b/packages/google-ads-marketingplatform-admin/setup.py
index b4e9ddafeb60..f965e024ed18 100644
--- a/packages/google-ads-marketingplatform-admin/setup.py
+++ b/packages/google-ads-marketingplatform-admin/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/ads/marketingplatform_admin/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-ads-marketingplatform-admin"
diff --git a/packages/google-ads-marketingplatform-admin/testing/constraints-3.10.txt b/packages/google-ads-marketingplatform-admin/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-ads-marketingplatform-admin/testing/constraints-3.10.txt
+++ b/packages/google-ads-marketingplatform-admin/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-ads-marketingplatform-admin/testing/constraints-3.13.txt b/packages/google-ads-marketingplatform-admin/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-ads-marketingplatform-admin/testing/constraints-3.13.txt
+++ b/packages/google-ads-marketingplatform-admin/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-ads-marketingplatform-admin/testing/constraints-3.14.txt b/packages/google-ads-marketingplatform-admin/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-ads-marketingplatform-admin/testing/constraints-3.14.txt
+++ b/packages/google-ads-marketingplatform-admin/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1/__init__.py b/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1/__init__.py
index 4457758668f1..294e4da544c1 100644
--- a/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1/__init__.py
+++ b/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1/__init__.py
@@ -89,7 +89,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -118,9 +118,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1alpha/__init__.py b/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1alpha/__init__.py
index 891df6525c05..a6e7f1e556c1 100644
--- a/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1alpha/__init__.py
+++ b/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1alpha/__init__.py
@@ -256,7 +256,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -285,9 +285,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1beta/__init__.py b/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1beta/__init__.py
index 93eea1a9c84a..58c0e656ac41 100644
--- a/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1beta/__init__.py
+++ b/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1beta/__init__.py
@@ -287,7 +287,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -316,9 +316,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1beta2/__init__.py b/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1beta2/__init__.py
index c1dd2005fc76..c1713865fa8d 100644
--- a/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1beta2/__init__.py
+++ b/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1beta2/__init__.py
@@ -80,7 +80,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -109,9 +109,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1beta3/__init__.py b/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1beta3/__init__.py
index 8eaeca833014..f87f1d11c52a 100644
--- a/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1beta3/__init__.py
+++ b/packages/google-ai-generativelanguage/google/ai/generativelanguage_v1beta3/__init__.py
@@ -120,7 +120,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -149,9 +149,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-ai-generativelanguage/setup.py b/packages/google-ai-generativelanguage/setup.py
index 26599479f3c7..e42402798b73 100644
--- a/packages/google-ai-generativelanguage/setup.py
+++ b/packages/google-ai-generativelanguage/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/ai/generativelanguage/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-ai-generativelanguage"
diff --git a/packages/google-ai-generativelanguage/testing/constraints-3.10.txt b/packages/google-ai-generativelanguage/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-ai-generativelanguage/testing/constraints-3.10.txt
+++ b/packages/google-ai-generativelanguage/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-ai-generativelanguage/testing/constraints-3.13.txt b/packages/google-ai-generativelanguage/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-ai-generativelanguage/testing/constraints-3.13.txt
+++ b/packages/google-ai-generativelanguage/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-ai-generativelanguage/testing/constraints-3.14.txt b/packages/google-ai-generativelanguage/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-ai-generativelanguage/testing/constraints-3.14.txt
+++ b/packages/google-ai-generativelanguage/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-analytics-admin/google/analytics/admin_v1alpha/__init__.py b/packages/google-analytics-admin/google/analytics/admin_v1alpha/__init__.py
index d41121620ee6..d5044effcba8 100644
--- a/packages/google-analytics-admin/google/analytics/admin_v1alpha/__init__.py
+++ b/packages/google-analytics-admin/google/analytics/admin_v1alpha/__init__.py
@@ -359,7 +359,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -388,9 +388,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-analytics-admin/google/analytics/admin_v1beta/__init__.py b/packages/google-analytics-admin/google/analytics/admin_v1beta/__init__.py
index 3b9b525df797..4c5e04368ced 100644
--- a/packages/google-analytics-admin/google/analytics/admin_v1beta/__init__.py
+++ b/packages/google-analytics-admin/google/analytics/admin_v1beta/__init__.py
@@ -169,7 +169,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -198,9 +198,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-analytics-admin/setup.py b/packages/google-analytics-admin/setup.py
index 5bf56c657b44..2566dfedcc5e 100644
--- a/packages/google-analytics-admin/setup.py
+++ b/packages/google-analytics-admin/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/analytics/admin/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-analytics-admin"
diff --git a/packages/google-analytics-admin/testing/constraints-3.10.txt b/packages/google-analytics-admin/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-analytics-admin/testing/constraints-3.10.txt
+++ b/packages/google-analytics-admin/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-analytics-admin/testing/constraints-3.13.txt b/packages/google-analytics-admin/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-analytics-admin/testing/constraints-3.13.txt
+++ b/packages/google-analytics-admin/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-analytics-admin/testing/constraints-3.14.txt b/packages/google-analytics-admin/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-analytics-admin/testing/constraints-3.14.txt
+++ b/packages/google-analytics-admin/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-analytics-data/google/analytics/data_v1alpha/__init__.py b/packages/google-analytics-data/google/analytics/data_v1alpha/__init__.py
index 03764340690c..75bf16a771fe 100644
--- a/packages/google-analytics-data/google/analytics/data_v1alpha/__init__.py
+++ b/packages/google-analytics-data/google/analytics/data_v1alpha/__init__.py
@@ -171,7 +171,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -200,9 +200,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-analytics-data/google/analytics/data_v1beta/__init__.py b/packages/google-analytics-data/google/analytics/data_v1beta/__init__.py
index 41d22479e94f..2a7dcb2cb486 100644
--- a/packages/google-analytics-data/google/analytics/data_v1beta/__init__.py
+++ b/packages/google-analytics-data/google/analytics/data_v1beta/__init__.py
@@ -118,7 +118,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -147,9 +147,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-analytics-data/setup.py b/packages/google-analytics-data/setup.py
index 2587aad63f16..f65b9a764f3c 100644
--- a/packages/google-analytics-data/setup.py
+++ b/packages/google-analytics-data/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/analytics/data/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-analytics-data"
diff --git a/packages/google-analytics-data/testing/constraints-3.10.txt b/packages/google-analytics-data/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-analytics-data/testing/constraints-3.10.txt
+++ b/packages/google-analytics-data/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-analytics-data/testing/constraints-3.13.txt b/packages/google-analytics-data/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-analytics-data/testing/constraints-3.13.txt
+++ b/packages/google-analytics-data/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-analytics-data/testing/constraints-3.14.txt b/packages/google-analytics-data/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-analytics-data/testing/constraints-3.14.txt
+++ b/packages/google-analytics-data/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-apps-card/google/apps/card_v1/__init__.py b/packages/google-apps-card/google/apps/card_v1/__init__.py
index c096c576359d..313419bb4c4b 100644
--- a/packages/google-apps-card/google/apps/card_v1/__init__.py
+++ b/packages/google-apps-card/google/apps/card_v1/__init__.py
@@ -79,7 +79,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -108,9 +108,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-apps-card/setup.py b/packages/google-apps-card/setup.py
index 318cd93ce4d4..161175be73be 100644
--- a/packages/google-apps-card/setup.py
+++ b/packages/google-apps-card/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/apps/card/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-apps-card"
diff --git a/packages/google-apps-card/testing/constraints-3.10.txt b/packages/google-apps-card/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-apps-card/testing/constraints-3.10.txt
+++ b/packages/google-apps-card/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-apps-card/testing/constraints-3.13.txt b/packages/google-apps-card/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-apps-card/testing/constraints-3.13.txt
+++ b/packages/google-apps-card/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-apps-card/testing/constraints-3.14.txt b/packages/google-apps-card/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-apps-card/testing/constraints-3.14.txt
+++ b/packages/google-apps-card/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-apps-chat/google/apps/chat_v1/__init__.py b/packages/google-apps-chat/google/apps/chat_v1/__init__.py
index 52f15f6f26c2..630ee3de1917 100644
--- a/packages/google-apps-chat/google/apps/chat_v1/__init__.py
+++ b/packages/google-apps-chat/google/apps/chat_v1/__init__.py
@@ -193,7 +193,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -222,9 +222,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-apps-chat/setup.py b/packages/google-apps-chat/setup.py
index 2c5c14bd9670..4b1e23dc5449 100644
--- a/packages/google-apps-chat/setup.py
+++ b/packages/google-apps-chat/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/apps/chat/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
     "google-apps-card >= 0.3.0, <1.0.0",
 ]
 extras = {}
diff --git a/packages/google-apps-chat/testing/constraints-3.10.txt b/packages/google-apps-chat/testing/constraints-3.10.txt
index 3af90f8e61b8..1e4d176ff35e 100644
--- a/packages/google-apps-chat/testing/constraints-3.10.txt
+++ b/packages/google-apps-chat/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
 google-apps-card==0.3.0
diff --git a/packages/google-apps-chat/testing/constraints-3.13.txt b/packages/google-apps-chat/testing/constraints-3.13.txt
index 6cffc701cac5..dfbecf969055 100644
--- a/packages/google-apps-chat/testing/constraints-3.13.txt
+++ b/packages/google-apps-chat/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-apps-card>=0
diff --git a/packages/google-apps-chat/testing/constraints-3.14.txt b/packages/google-apps-chat/testing/constraints-3.14.txt
index 6cffc701cac5..dfbecf969055 100644
--- a/packages/google-apps-chat/testing/constraints-3.14.txt
+++ b/packages/google-apps-chat/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-apps-card>=0
diff --git a/packages/google-apps-events-subscriptions/google/apps/events_subscriptions_v1/__init__.py b/packages/google-apps-events-subscriptions/google/apps/events_subscriptions_v1/__init__.py
index 14e026c429e0..cb688f7b8572 100644
--- a/packages/google-apps-events-subscriptions/google/apps/events_subscriptions_v1/__init__.py
+++ b/packages/google-apps-events-subscriptions/google/apps/events_subscriptions_v1/__init__.py
@@ -71,7 +71,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -100,9 +100,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-apps-events-subscriptions/google/apps/events_subscriptions_v1beta/__init__.py b/packages/google-apps-events-subscriptions/google/apps/events_subscriptions_v1beta/__init__.py
index 3663cdeae9ad..ffc141d511d5 100644
--- a/packages/google-apps-events-subscriptions/google/apps/events_subscriptions_v1beta/__init__.py
+++ b/packages/google-apps-events-subscriptions/google/apps/events_subscriptions_v1beta/__init__.py
@@ -71,7 +71,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -100,9 +100,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-apps-events-subscriptions/setup.py b/packages/google-apps-events-subscriptions/setup.py
index 639938a7908d..b5b08e9309ca 100644
--- a/packages/google-apps-events-subscriptions/setup.py
+++ b/packages/google-apps-events-subscriptions/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/apps/events_subscriptions/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-apps-events-subscriptions"
diff --git a/packages/google-apps-events-subscriptions/testing/constraints-3.10.txt b/packages/google-apps-events-subscriptions/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-apps-events-subscriptions/testing/constraints-3.10.txt
+++ b/packages/google-apps-events-subscriptions/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-apps-events-subscriptions/testing/constraints-3.13.txt b/packages/google-apps-events-subscriptions/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-apps-events-subscriptions/testing/constraints-3.13.txt
+++ b/packages/google-apps-events-subscriptions/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-apps-events-subscriptions/testing/constraints-3.14.txt b/packages/google-apps-events-subscriptions/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-apps-events-subscriptions/testing/constraints-3.14.txt
+++ b/packages/google-apps-events-subscriptions/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-apps-meet/google/apps/meet_v2/__init__.py b/packages/google-apps-meet/google/apps/meet_v2/__init__.py
index 11df27e80829..0c41eb5e68c8 100644
--- a/packages/google-apps-meet/google/apps/meet_v2/__init__.py
+++ b/packages/google-apps-meet/google/apps/meet_v2/__init__.py
@@ -94,7 +94,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -123,9 +123,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-apps-meet/google/apps/meet_v2beta/__init__.py b/packages/google-apps-meet/google/apps/meet_v2beta/__init__.py
index e0b7b696428d..cbb111edec93 100644
--- a/packages/google-apps-meet/google/apps/meet_v2beta/__init__.py
+++ b/packages/google-apps-meet/google/apps/meet_v2beta/__init__.py
@@ -102,7 +102,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -131,9 +131,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-apps-meet/setup.py b/packages/google-apps-meet/setup.py
index e6790d3df309..76e2a406cb6c 100644
--- a/packages/google-apps-meet/setup.py
+++ b/packages/google-apps-meet/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/apps/meet/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-apps-meet"
diff --git a/packages/google-apps-meet/testing/constraints-3.10.txt b/packages/google-apps-meet/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-apps-meet/testing/constraints-3.10.txt
+++ b/packages/google-apps-meet/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-apps-meet/testing/constraints-3.13.txt b/packages/google-apps-meet/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-apps-meet/testing/constraints-3.13.txt
+++ b/packages/google-apps-meet/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-apps-meet/testing/constraints-3.14.txt b/packages/google-apps-meet/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-apps-meet/testing/constraints-3.14.txt
+++ b/packages/google-apps-meet/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-apps-script-type/google/apps/script/type/__init__.py b/packages/google-apps-script-type/google/apps/script/type/__init__.py
index 3092b9f884ba..07fa33487f10 100644
--- a/packages/google-apps-script-type/google/apps/script/type/__init__.py
+++ b/packages/google-apps-script-type/google/apps/script/type/__init__.py
@@ -61,7 +61,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -90,9 +90,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-apps-script-type/google/apps/script/type/calendar/__init__.py b/packages/google-apps-script-type/google/apps/script/type/calendar/__init__.py
index 5ce17f903e0d..751d9070fcac 100644
--- a/packages/google-apps-script-type/google/apps/script/type/calendar/__init__.py
+++ b/packages/google-apps-script-type/google/apps/script/type/calendar/__init__.py
@@ -54,7 +54,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -83,9 +83,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-apps-script-type/google/apps/script/type/docs/__init__.py b/packages/google-apps-script-type/google/apps/script/type/docs/__init__.py
index fc22178650d9..c61b1a0a687d 100644
--- a/packages/google-apps-script-type/google/apps/script/type/docs/__init__.py
+++ b/packages/google-apps-script-type/google/apps/script/type/docs/__init__.py
@@ -50,7 +50,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -79,9 +79,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-apps-script-type/google/apps/script/type/drive/__init__.py b/packages/google-apps-script-type/google/apps/script/type/drive/__init__.py
index 1a88a001d639..2c4e0113d725 100644
--- a/packages/google-apps-script-type/google/apps/script/type/drive/__init__.py
+++ b/packages/google-apps-script-type/google/apps/script/type/drive/__init__.py
@@ -50,7 +50,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -79,9 +79,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-apps-script-type/google/apps/script/type/gmail/__init__.py b/packages/google-apps-script-type/google/apps/script/type/gmail/__init__.py
index ee1f432bb819..15b7ab7cfee6 100644
--- a/packages/google-apps-script-type/google/apps/script/type/gmail/__init__.py
+++ b/packages/google-apps-script-type/google/apps/script/type/gmail/__init__.py
@@ -56,7 +56,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -85,9 +85,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-apps-script-type/google/apps/script/type/sheets/__init__.py b/packages/google-apps-script-type/google/apps/script/type/sheets/__init__.py
index aeedd177542d..6eb865763637 100644
--- a/packages/google-apps-script-type/google/apps/script/type/sheets/__init__.py
+++ b/packages/google-apps-script-type/google/apps/script/type/sheets/__init__.py
@@ -50,7 +50,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -79,9 +79,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-apps-script-type/google/apps/script/type/slides/__init__.py b/packages/google-apps-script-type/google/apps/script/type/slides/__init__.py
index 8c9e5517ee6a..2cb67b5f5a8b 100644
--- a/packages/google-apps-script-type/google/apps/script/type/slides/__init__.py
+++ b/packages/google-apps-script-type/google/apps/script/type/slides/__init__.py
@@ -50,7 +50,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -79,9 +79,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-apps-script-type/setup.py b/packages/google-apps-script-type/setup.py
index 7a4b08ab118e..6b6ef8d5f37e 100644
--- a/packages/google-apps-script-type/setup.py
+++ b/packages/google-apps-script-type/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/apps/script/type/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-apps-script-type"
diff --git a/packages/google-apps-script-type/testing/constraints-3.10.txt b/packages/google-apps-script-type/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-apps-script-type/testing/constraints-3.10.txt
+++ b/packages/google-apps-script-type/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-apps-script-type/testing/constraints-3.13.txt b/packages/google-apps-script-type/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-apps-script-type/testing/constraints-3.13.txt
+++ b/packages/google-apps-script-type/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-apps-script-type/testing/constraints-3.14.txt b/packages/google-apps-script-type/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-apps-script-type/testing/constraints-3.14.txt
+++ b/packages/google-apps-script-type/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-area120-tables/google/area120/tables_v1alpha1/__init__.py b/packages/google-area120-tables/google/area120/tables_v1alpha1/__init__.py
index 616b3ca2f849..fb36c8448d4b 100644
--- a/packages/google-area120-tables/google/area120/tables_v1alpha1/__init__.py
+++ b/packages/google-area120-tables/google/area120/tables_v1alpha1/__init__.py
@@ -77,7 +77,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -106,9 +106,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-area120-tables/setup.py b/packages/google-area120-tables/setup.py
index 033db87198aa..0bd6b1303c90 100644
--- a/packages/google-area120-tables/setup.py
+++ b/packages/google-area120-tables/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/area120/tables/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-area120-tables"
diff --git a/packages/google-area120-tables/testing/constraints-3.10.txt b/packages/google-area120-tables/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-area120-tables/testing/constraints-3.10.txt
+++ b/packages/google-area120-tables/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-area120-tables/testing/constraints-3.13.txt b/packages/google-area120-tables/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-area120-tables/testing/constraints-3.13.txt
+++ b/packages/google-area120-tables/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-area120-tables/testing/constraints-3.14.txt b/packages/google-area120-tables/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-area120-tables/testing/constraints-3.14.txt
+++ b/packages/google-area120-tables/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-backstory/google/backstory/__init__.py b/packages/google-backstory/google/backstory/__init__.py
index bdb09ee6600d..95cf541e8151 100644
--- a/packages/google-backstory/google/backstory/__init__.py
+++ b/packages/google-backstory/google/backstory/__init__.py
@@ -162,7 +162,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -191,9 +191,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-backstory/setup.py b/packages/google-backstory/setup.py
index 0bc1a58702fc..91d7cdddecd6 100644
--- a/packages/google-backstory/setup.py
+++ b/packages/google-backstory/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/backstory/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-backstory"
diff --git a/packages/google-backstory/testing/constraints-3.10.txt b/packages/google-backstory/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-backstory/testing/constraints-3.10.txt
+++ b/packages/google-backstory/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-backstory/testing/constraints-3.13.txt b/packages/google-backstory/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-backstory/testing/constraints-3.13.txt
+++ b/packages/google-backstory/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-backstory/testing/constraints-3.14.txt b/packages/google-backstory/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-backstory/testing/constraints-3.14.txt
+++ b/packages/google-backstory/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-access-approval/google/cloud/accessapproval_v1/__init__.py b/packages/google-cloud-access-approval/google/cloud/accessapproval_v1/__init__.py
index abffedbe7fe8..c6a648dccb13 100644
--- a/packages/google-cloud-access-approval/google/cloud/accessapproval_v1/__init__.py
+++ b/packages/google-cloud-access-approval/google/cloud/accessapproval_v1/__init__.py
@@ -73,7 +73,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -102,9 +102,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-access-approval/setup.py b/packages/google-cloud-access-approval/setup.py
index 7da5c9780181..dcc6f6cfbf13 100644
--- a/packages/google-cloud-access-approval/setup.py
+++ b/packages/google-cloud-access-approval/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/accessapproval/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-access-approval"
diff --git a/packages/google-cloud-access-approval/testing/constraints-3.10.txt b/packages/google-cloud-access-approval/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-access-approval/testing/constraints-3.10.txt
+++ b/packages/google-cloud-access-approval/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-access-approval/testing/constraints-3.13.txt b/packages/google-cloud-access-approval/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-access-approval/testing/constraints-3.13.txt
+++ b/packages/google-cloud-access-approval/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-access-approval/testing/constraints-3.14.txt b/packages/google-cloud-access-approval/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-access-approval/testing/constraints-3.14.txt
+++ b/packages/google-cloud-access-approval/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-advisorynotifications/google/cloud/advisorynotifications_v1/__init__.py b/packages/google-cloud-advisorynotifications/google/cloud/advisorynotifications_v1/__init__.py
index 0c721afc0fc0..a1970d649ca3 100644
--- a/packages/google-cloud-advisorynotifications/google/cloud/advisorynotifications_v1/__init__.py
+++ b/packages/google-cloud-advisorynotifications/google/cloud/advisorynotifications_v1/__init__.py
@@ -71,7 +71,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -100,9 +100,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-advisorynotifications/setup.py b/packages/google-cloud-advisorynotifications/setup.py
index 8d0ca3914c4b..c52060f36d3e 100644
--- a/packages/google-cloud-advisorynotifications/setup.py
+++ b/packages/google-cloud-advisorynotifications/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/advisorynotifications/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-advisorynotifications"
diff --git a/packages/google-cloud-advisorynotifications/testing/constraints-3.10.txt b/packages/google-cloud-advisorynotifications/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-advisorynotifications/testing/constraints-3.10.txt
+++ b/packages/google-cloud-advisorynotifications/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-advisorynotifications/testing/constraints-3.13.txt b/packages/google-cloud-advisorynotifications/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-advisorynotifications/testing/constraints-3.13.txt
+++ b/packages/google-cloud-advisorynotifications/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-advisorynotifications/testing/constraints-3.14.txt b/packages/google-cloud-advisorynotifications/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-advisorynotifications/testing/constraints-3.14.txt
+++ b/packages/google-cloud-advisorynotifications/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-agentidentitycredentials/google/cloud/agentidentitycredentials_v1/__init__.py b/packages/google-cloud-agentidentitycredentials/google/cloud/agentidentitycredentials_v1/__init__.py
index aa5fecf0e405..bf30d3d6f734 100644
--- a/packages/google-cloud-agentidentitycredentials/google/cloud/agentidentitycredentials_v1/__init__.py
+++ b/packages/google-cloud-agentidentitycredentials/google/cloud/agentidentitycredentials_v1/__init__.py
@@ -59,7 +59,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -88,9 +88,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-agentidentitycredentials/setup.py b/packages/google-cloud-agentidentitycredentials/setup.py
index d664811f1e93..8f0e6f4c9798 100644
--- a/packages/google-cloud-agentidentitycredentials/setup.py
+++ b/packages/google-cloud-agentidentitycredentials/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/agentidentitycredentials/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-agentidentitycredentials"
diff --git a/packages/google-cloud-agentidentitycredentials/testing/constraints-3.10.txt b/packages/google-cloud-agentidentitycredentials/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-agentidentitycredentials/testing/constraints-3.10.txt
+++ b/packages/google-cloud-agentidentitycredentials/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-agentidentitycredentials/testing/constraints-3.13.txt b/packages/google-cloud-agentidentitycredentials/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-agentidentitycredentials/testing/constraints-3.13.txt
+++ b/packages/google-cloud-agentidentitycredentials/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-agentidentitycredentials/testing/constraints-3.14.txt b/packages/google-cloud-agentidentitycredentials/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-agentidentitycredentials/testing/constraints-3.14.txt
+++ b/packages/google-cloud-agentidentitycredentials/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-alloydb-connectors/google/cloud/alloydb/connectors_v1/__init__.py b/packages/google-cloud-alloydb-connectors/google/cloud/alloydb/connectors_v1/__init__.py
index 31debc4106be..34f50e5adfcf 100644
--- a/packages/google-cloud-alloydb-connectors/google/cloud/alloydb/connectors_v1/__init__.py
+++ b/packages/google-cloud-alloydb-connectors/google/cloud/alloydb/connectors_v1/__init__.py
@@ -50,7 +50,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -79,9 +79,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-alloydb-connectors/google/cloud/alloydb/connectors_v1alpha/__init__.py b/packages/google-cloud-alloydb-connectors/google/cloud/alloydb/connectors_v1alpha/__init__.py
index a98244871cda..656daf15acd2 100644
--- a/packages/google-cloud-alloydb-connectors/google/cloud/alloydb/connectors_v1alpha/__init__.py
+++ b/packages/google-cloud-alloydb-connectors/google/cloud/alloydb/connectors_v1alpha/__init__.py
@@ -50,7 +50,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -79,9 +79,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-alloydb-connectors/google/cloud/alloydb/connectors_v1beta/__init__.py b/packages/google-cloud-alloydb-connectors/google/cloud/alloydb/connectors_v1beta/__init__.py
index 66c5491aeda7..ab60f0ecc6e2 100644
--- a/packages/google-cloud-alloydb-connectors/google/cloud/alloydb/connectors_v1beta/__init__.py
+++ b/packages/google-cloud-alloydb-connectors/google/cloud/alloydb/connectors_v1beta/__init__.py
@@ -50,7 +50,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -79,9 +79,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-alloydb-connectors/setup.py b/packages/google-cloud-alloydb-connectors/setup.py
index 47dc6f396d48..5270893f7303 100644
--- a/packages/google-cloud-alloydb-connectors/setup.py
+++ b/packages/google-cloud-alloydb-connectors/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/alloydb/connectors/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-alloydb-connectors"
diff --git a/packages/google-cloud-alloydb-connectors/testing/constraints-3.10.txt b/packages/google-cloud-alloydb-connectors/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-alloydb-connectors/testing/constraints-3.10.txt
+++ b/packages/google-cloud-alloydb-connectors/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-alloydb-connectors/testing/constraints-3.13.txt b/packages/google-cloud-alloydb-connectors/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-alloydb-connectors/testing/constraints-3.13.txt
+++ b/packages/google-cloud-alloydb-connectors/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-alloydb-connectors/testing/constraints-3.14.txt b/packages/google-cloud-alloydb-connectors/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-alloydb-connectors/testing/constraints-3.14.txt
+++ b/packages/google-cloud-alloydb-connectors/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-alloydb/google/cloud/alloydb_v1/__init__.py b/packages/google-cloud-alloydb/google/cloud/alloydb_v1/__init__.py
index 5b2a718d48ac..d420ba1bc373 100644
--- a/packages/google-cloud-alloydb/google/cloud/alloydb_v1/__init__.py
+++ b/packages/google-cloud-alloydb/google/cloud/alloydb_v1/__init__.py
@@ -140,7 +140,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -169,9 +169,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-alloydb/google/cloud/alloydb_v1alpha/__init__.py b/packages/google-cloud-alloydb/google/cloud/alloydb_v1alpha/__init__.py
index 2745dc6bc514..ff2b3915e356 100644
--- a/packages/google-cloud-alloydb/google/cloud/alloydb_v1alpha/__init__.py
+++ b/packages/google-cloud-alloydb/google/cloud/alloydb_v1alpha/__init__.py
@@ -148,7 +148,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -177,9 +177,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-alloydb/google/cloud/alloydb_v1beta/__init__.py b/packages/google-cloud-alloydb/google/cloud/alloydb_v1beta/__init__.py
index 5fe84055a0e0..aa18b69d95d6 100644
--- a/packages/google-cloud-alloydb/google/cloud/alloydb_v1beta/__init__.py
+++ b/packages/google-cloud-alloydb/google/cloud/alloydb_v1beta/__init__.py
@@ -148,7 +148,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -177,9 +177,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-alloydb/setup.py b/packages/google-cloud-alloydb/setup.py
index 87face2890a5..f9c7c1bdd5ca 100644
--- a/packages/google-cloud-alloydb/setup.py
+++ b/packages/google-cloud-alloydb/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/alloydb/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-alloydb"
diff --git a/packages/google-cloud-alloydb/testing/constraints-3.10.txt b/packages/google-cloud-alloydb/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-alloydb/testing/constraints-3.10.txt
+++ b/packages/google-cloud-alloydb/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-alloydb/testing/constraints-3.13.txt b/packages/google-cloud-alloydb/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-alloydb/testing/constraints-3.13.txt
+++ b/packages/google-cloud-alloydb/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-alloydb/testing/constraints-3.14.txt b/packages/google-cloud-alloydb/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-alloydb/testing/constraints-3.14.txt
+++ b/packages/google-cloud-alloydb/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-api-gateway/google/cloud/apigateway_v1/__init__.py b/packages/google-cloud-api-gateway/google/cloud/apigateway_v1/__init__.py
index a7a79f57bb81..b74a9fa26c8c 100644
--- a/packages/google-cloud-api-gateway/google/cloud/apigateway_v1/__init__.py
+++ b/packages/google-cloud-api-gateway/google/cloud/apigateway_v1/__init__.py
@@ -77,7 +77,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -106,9 +106,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-api-gateway/setup.py b/packages/google-cloud-api-gateway/setup.py
index 9c62ef5a32e9..af69e4d1519a 100644
--- a/packages/google-cloud-api-gateway/setup.py
+++ b/packages/google-cloud-api-gateway/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/apigateway/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-api-gateway"
diff --git a/packages/google-cloud-api-gateway/testing/constraints-3.10.txt b/packages/google-cloud-api-gateway/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-api-gateway/testing/constraints-3.10.txt
+++ b/packages/google-cloud-api-gateway/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-api-gateway/testing/constraints-3.13.txt b/packages/google-cloud-api-gateway/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-api-gateway/testing/constraints-3.13.txt
+++ b/packages/google-cloud-api-gateway/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-api-gateway/testing/constraints-3.14.txt b/packages/google-cloud-api-gateway/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-api-gateway/testing/constraints-3.14.txt
+++ b/packages/google-cloud-api-gateway/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-api-keys/google/cloud/api_keys_v2/__init__.py b/packages/google-cloud-api-keys/google/cloud/api_keys_v2/__init__.py
index 13b0a41f7116..f738f1cddb71 100644
--- a/packages/google-cloud-api-keys/google/cloud/api_keys_v2/__init__.py
+++ b/packages/google-cloud-api-keys/google/cloud/api_keys_v2/__init__.py
@@ -73,7 +73,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -102,9 +102,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-api-keys/setup.py b/packages/google-cloud-api-keys/setup.py
index 1a6adc159e8e..d207a495b289 100644
--- a/packages/google-cloud-api-keys/setup.py
+++ b/packages/google-cloud-api-keys/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/api_keys/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-api-keys"
diff --git a/packages/google-cloud-api-keys/testing/constraints-3.10.txt b/packages/google-cloud-api-keys/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-api-keys/testing/constraints-3.10.txt
+++ b/packages/google-cloud-api-keys/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-api-keys/testing/constraints-3.13.txt b/packages/google-cloud-api-keys/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-api-keys/testing/constraints-3.13.txt
+++ b/packages/google-cloud-api-keys/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-api-keys/testing/constraints-3.14.txt b/packages/google-cloud-api-keys/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-api-keys/testing/constraints-3.14.txt
+++ b/packages/google-cloud-api-keys/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-apigee-connect/google/cloud/apigeeconnect_v1/__init__.py b/packages/google-cloud-apigee-connect/google/cloud/apigeeconnect_v1/__init__.py
index 7dd770701659..c8d0eda85b7f 100644
--- a/packages/google-cloud-apigee-connect/google/cloud/apigeeconnect_v1/__init__.py
+++ b/packages/google-cloud-apigee-connect/google/cloud/apigeeconnect_v1/__init__.py
@@ -73,7 +73,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -102,9 +102,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-apigee-connect/setup.py b/packages/google-cloud-apigee-connect/setup.py
index 99b0c60e3202..112f0ccbe8a6 100644
--- a/packages/google-cloud-apigee-connect/setup.py
+++ b/packages/google-cloud-apigee-connect/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/apigeeconnect/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-apigee-connect"
diff --git a/packages/google-cloud-apigee-connect/testing/constraints-3.10.txt b/packages/google-cloud-apigee-connect/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-apigee-connect/testing/constraints-3.10.txt
+++ b/packages/google-cloud-apigee-connect/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-apigee-connect/testing/constraints-3.13.txt b/packages/google-cloud-apigee-connect/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-apigee-connect/testing/constraints-3.13.txt
+++ b/packages/google-cloud-apigee-connect/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-apigee-connect/testing/constraints-3.14.txt b/packages/google-cloud-apigee-connect/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-apigee-connect/testing/constraints-3.14.txt
+++ b/packages/google-cloud-apigee-connect/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-apigee-registry/google/cloud/apigee_registry_v1/__init__.py b/packages/google-cloud-apigee-registry/google/cloud/apigee_registry_v1/__init__.py
index 6ccbe4508678..3695d603ebf6 100644
--- a/packages/google-cloud-apigee-registry/google/cloud/apigee_registry_v1/__init__.py
+++ b/packages/google-cloud-apigee-registry/google/cloud/apigee_registry_v1/__init__.py
@@ -103,7 +103,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -132,9 +132,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-apigee-registry/setup.py b/packages/google-cloud-apigee-registry/setup.py
index fc332bd518ed..a29d8f16ed7a 100644
--- a/packages/google-cloud-apigee-registry/setup.py
+++ b/packages/google-cloud-apigee-registry/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/apigee_registry/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-apigee-registry"
diff --git a/packages/google-cloud-apigee-registry/testing/constraints-3.10.txt b/packages/google-cloud-apigee-registry/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-apigee-registry/testing/constraints-3.10.txt
+++ b/packages/google-cloud-apigee-registry/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-apigee-registry/testing/constraints-3.13.txt b/packages/google-cloud-apigee-registry/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-apigee-registry/testing/constraints-3.13.txt
+++ b/packages/google-cloud-apigee-registry/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-apigee-registry/testing/constraints-3.14.txt b/packages/google-cloud-apigee-registry/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-apigee-registry/testing/constraints-3.14.txt
+++ b/packages/google-cloud-apigee-registry/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-apihub/google/cloud/apihub_v1/__init__.py b/packages/google-cloud-apihub/google/cloud/apihub_v1/__init__.py
index 46f8f03fa5c0..f04e150bc40e 100644
--- a/packages/google-cloud-apihub/google/cloud/apihub_v1/__init__.py
+++ b/packages/google-cloud-apihub/google/cloud/apihub_v1/__init__.py
@@ -264,7 +264,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -293,9 +293,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-apihub/setup.py b/packages/google-cloud-apihub/setup.py
index ac4c98f6d437..1a2517509dda 100644
--- a/packages/google-cloud-apihub/setup.py
+++ b/packages/google-cloud-apihub/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/apihub/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-apihub"
diff --git a/packages/google-cloud-apihub/testing/constraints-3.10.txt b/packages/google-cloud-apihub/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-apihub/testing/constraints-3.10.txt
+++ b/packages/google-cloud-apihub/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-apihub/testing/constraints-3.13.txt b/packages/google-cloud-apihub/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-apihub/testing/constraints-3.13.txt
+++ b/packages/google-cloud-apihub/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-apihub/testing/constraints-3.14.txt b/packages/google-cloud-apihub/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-apihub/testing/constraints-3.14.txt
+++ b/packages/google-cloud-apihub/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-apiregistry/google/cloud/apiregistry_v1beta/__init__.py b/packages/google-cloud-apiregistry/google/cloud/apiregistry_v1beta/__init__.py
index 3501061a0239..d71fce5b3e1a 100644
--- a/packages/google-cloud-apiregistry/google/cloud/apiregistry_v1beta/__init__.py
+++ b/packages/google-cloud-apiregistry/google/cloud/apiregistry_v1beta/__init__.py
@@ -63,7 +63,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -92,9 +92,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-apiregistry/setup.py b/packages/google-cloud-apiregistry/setup.py
index 5c9a2841ab1c..c5864e119c12 100644
--- a/packages/google-cloud-apiregistry/setup.py
+++ b/packages/google-cloud-apiregistry/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/apiregistry/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-apiregistry"
diff --git a/packages/google-cloud-apiregistry/testing/constraints-3.10.txt b/packages/google-cloud-apiregistry/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-apiregistry/testing/constraints-3.10.txt
+++ b/packages/google-cloud-apiregistry/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-apiregistry/testing/constraints-3.13.txt b/packages/google-cloud-apiregistry/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-apiregistry/testing/constraints-3.13.txt
+++ b/packages/google-cloud-apiregistry/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-apiregistry/testing/constraints-3.14.txt b/packages/google-cloud-apiregistry/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-apiregistry/testing/constraints-3.14.txt
+++ b/packages/google-cloud-apiregistry/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-appengine-admin/google/cloud/appengine_admin_v1/__init__.py b/packages/google-cloud-appengine-admin/google/cloud/appengine_admin_v1/__init__.py
index 9e31c27ba93c..058686a141fa 100644
--- a/packages/google-cloud-appengine-admin/google/cloud/appengine_admin_v1/__init__.py
+++ b/packages/google-cloud-appengine-admin/google/cloud/appengine_admin_v1/__init__.py
@@ -167,7 +167,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -196,9 +196,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-appengine-admin/setup.py b/packages/google-cloud-appengine-admin/setup.py
index 14d844e106b8..a8a3e2904a77 100644
--- a/packages/google-cloud-appengine-admin/setup.py
+++ b/packages/google-cloud-appengine-admin/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/appengine_admin/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-appengine-admin"
diff --git a/packages/google-cloud-appengine-admin/testing/constraints-3.10.txt b/packages/google-cloud-appengine-admin/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-appengine-admin/testing/constraints-3.10.txt
+++ b/packages/google-cloud-appengine-admin/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-appengine-admin/testing/constraints-3.13.txt b/packages/google-cloud-appengine-admin/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-appengine-admin/testing/constraints-3.13.txt
+++ b/packages/google-cloud-appengine-admin/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-appengine-admin/testing/constraints-3.14.txt b/packages/google-cloud-appengine-admin/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-appengine-admin/testing/constraints-3.14.txt
+++ b/packages/google-cloud-appengine-admin/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-appengine-logging/google/cloud/appengine_logging_v1/__init__.py b/packages/google-cloud-appengine-logging/google/cloud/appengine_logging_v1/__init__.py
index c46ad467ef94..3c3a3310b970 100644
--- a/packages/google-cloud-appengine-logging/google/cloud/appengine_logging_v1/__init__.py
+++ b/packages/google-cloud-appengine-logging/google/cloud/appengine_logging_v1/__init__.py
@@ -50,7 +50,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -79,9 +79,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-appengine-logging/setup.py b/packages/google-cloud-appengine-logging/setup.py
index 422fb283d3e9..33e6e627889d 100644
--- a/packages/google-cloud-appengine-logging/setup.py
+++ b/packages/google-cloud-appengine-logging/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/appengine_logging/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-appengine-logging"
diff --git a/packages/google-cloud-appengine-logging/testing/constraints-3.10.txt b/packages/google-cloud-appengine-logging/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-appengine-logging/testing/constraints-3.10.txt
+++ b/packages/google-cloud-appengine-logging/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-appengine-logging/testing/constraints-3.13.txt b/packages/google-cloud-appengine-logging/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-appengine-logging/testing/constraints-3.13.txt
+++ b/packages/google-cloud-appengine-logging/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-appengine-logging/testing/constraints-3.14.txt b/packages/google-cloud-appengine-logging/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-appengine-logging/testing/constraints-3.14.txt
+++ b/packages/google-cloud-appengine-logging/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-apphub/google/cloud/apphub_v1/__init__.py b/packages/google-cloud-apphub/google/cloud/apphub_v1/__init__.py
index 08aa2bba560d..63922ed6fc67 100644
--- a/packages/google-cloud-apphub/google/cloud/apphub_v1/__init__.py
+++ b/packages/google-cloud-apphub/google/cloud/apphub_v1/__init__.py
@@ -105,7 +105,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -134,9 +134,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-apphub/setup.py b/packages/google-cloud-apphub/setup.py
index 64006dd5326b..ebd87f8a63c8 100644
--- a/packages/google-cloud-apphub/setup.py
+++ b/packages/google-cloud-apphub/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/apphub/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-apphub"
diff --git a/packages/google-cloud-apphub/testing/constraints-3.10.txt b/packages/google-cloud-apphub/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-apphub/testing/constraints-3.10.txt
+++ b/packages/google-cloud-apphub/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-apphub/testing/constraints-3.13.txt b/packages/google-cloud-apphub/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-apphub/testing/constraints-3.13.txt
+++ b/packages/google-cloud-apphub/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-apphub/testing/constraints-3.14.txt b/packages/google-cloud-apphub/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-apphub/testing/constraints-3.14.txt
+++ b/packages/google-cloud-apphub/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-appoptimize/google/cloud/appoptimize_v1beta/__init__.py b/packages/google-cloud-appoptimize/google/cloud/appoptimize_v1beta/__init__.py
index 19657159864e..d6ac1a0cf62a 100644
--- a/packages/google-cloud-appoptimize/google/cloud/appoptimize_v1beta/__init__.py
+++ b/packages/google-cloud-appoptimize/google/cloud/appoptimize_v1beta/__init__.py
@@ -63,7 +63,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -92,9 +92,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-appoptimize/setup.py b/packages/google-cloud-appoptimize/setup.py
index be384ed6d500..76f2f022a3ff 100644
--- a/packages/google-cloud-appoptimize/setup.py
+++ b/packages/google-cloud-appoptimize/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/appoptimize/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-appoptimize"
diff --git a/packages/google-cloud-appoptimize/testing/constraints-3.10.txt b/packages/google-cloud-appoptimize/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-appoptimize/testing/constraints-3.10.txt
+++ b/packages/google-cloud-appoptimize/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-appoptimize/testing/constraints-3.13.txt b/packages/google-cloud-appoptimize/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-appoptimize/testing/constraints-3.13.txt
+++ b/packages/google-cloud-appoptimize/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-appoptimize/testing/constraints-3.14.txt b/packages/google-cloud-appoptimize/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-appoptimize/testing/constraints-3.14.txt
+++ b/packages/google-cloud-appoptimize/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-artifact-registry/google/cloud/artifactregistry_v1/__init__.py b/packages/google-cloud-artifact-registry/google/cloud/artifactregistry_v1/__init__.py
index 016b58fb7874..a96e1e87ccbc 100644
--- a/packages/google-cloud-artifact-registry/google/cloud/artifactregistry_v1/__init__.py
+++ b/packages/google-cloud-artifact-registry/google/cloud/artifactregistry_v1/__init__.py
@@ -176,7 +176,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -205,9 +205,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-artifact-registry/google/cloud/artifactregistry_v1beta2/__init__.py b/packages/google-cloud-artifact-registry/google/cloud/artifactregistry_v1beta2/__init__.py
index 1c908cb04de7..dde84b7d9368 100644
--- a/packages/google-cloud-artifact-registry/google/cloud/artifactregistry_v1beta2/__init__.py
+++ b/packages/google-cloud-artifact-registry/google/cloud/artifactregistry_v1beta2/__init__.py
@@ -109,7 +109,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -138,9 +138,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-artifact-registry/setup.py b/packages/google-cloud-artifact-registry/setup.py
index ed26efd33d9f..192863a30dce 100644
--- a/packages/google-cloud-artifact-registry/setup.py
+++ b/packages/google-cloud-artifact-registry/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/artifactregistry/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-artifact-registry"
diff --git a/packages/google-cloud-artifact-registry/testing/constraints-3.10.txt b/packages/google-cloud-artifact-registry/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-artifact-registry/testing/constraints-3.10.txt
+++ b/packages/google-cloud-artifact-registry/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-artifact-registry/testing/constraints-3.13.txt b/packages/google-cloud-artifact-registry/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-artifact-registry/testing/constraints-3.13.txt
+++ b/packages/google-cloud-artifact-registry/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-artifact-registry/testing/constraints-3.14.txt b/packages/google-cloud-artifact-registry/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-artifact-registry/testing/constraints-3.14.txt
+++ b/packages/google-cloud-artifact-registry/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-asset/google/cloud/asset_v1/__init__.py b/packages/google-cloud-asset/google/cloud/asset_v1/__init__.py
index 9d80550b47d0..bb9de558b7ed 100644
--- a/packages/google-cloud-asset/google/cloud/asset_v1/__init__.py
+++ b/packages/google-cloud-asset/google/cloud/asset_v1/__init__.py
@@ -135,7 +135,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -164,9 +164,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-asset/google/cloud/asset_v1p1beta1/__init__.py b/packages/google-cloud-asset/google/cloud/asset_v1p1beta1/__init__.py
index d3091091d399..2e8f02021f6c 100644
--- a/packages/google-cloud-asset/google/cloud/asset_v1p1beta1/__init__.py
+++ b/packages/google-cloud-asset/google/cloud/asset_v1p1beta1/__init__.py
@@ -57,7 +57,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -86,9 +86,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-asset/google/cloud/asset_v1p2beta1/__init__.py b/packages/google-cloud-asset/google/cloud/asset_v1p2beta1/__init__.py
index d1ce85f9cf46..0810de2ae7dc 100644
--- a/packages/google-cloud-asset/google/cloud/asset_v1p2beta1/__init__.py
+++ b/packages/google-cloud-asset/google/cloud/asset_v1p2beta1/__init__.py
@@ -67,7 +67,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -96,9 +96,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-asset/google/cloud/asset_v1p5beta1/__init__.py b/packages/google-cloud-asset/google/cloud/asset_v1p5beta1/__init__.py
index 1769e4ec28d0..59e25df37eb5 100644
--- a/packages/google-cloud-asset/google/cloud/asset_v1p5beta1/__init__.py
+++ b/packages/google-cloud-asset/google/cloud/asset_v1p5beta1/__init__.py
@@ -52,7 +52,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -81,9 +81,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-asset/setup.py b/packages/google-cloud-asset/setup.py
index cec358ae0145..164495382d79 100644
--- a/packages/google-cloud-asset/setup.py
+++ b/packages/google-cloud-asset/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/asset/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,19 +42,18 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "google-cloud-org-policy >= 1.11.1, <2.0.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "google-cloud-access-context-manager >= 0.2.0, <1.0.0",
-    "google-cloud-os-config >= 1.13.0, <2.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "google-cloud-access-context-manager >= 0.2.2, <1.0.0",
+    "google-cloud-os-config >= 1.20.1, <2.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-asset"
diff --git a/packages/google-cloud-asset/testing/constraints-3.10.txt b/packages/google-cloud-asset/testing/constraints-3.10.txt
index 7d034c762509..620e00eb73a6 100644
--- a/packages/google-cloud-asset/testing/constraints-3.10.txt
+++ b/packages/google-cloud-asset/testing/constraints-3.10.txt
@@ -4,12 +4,12 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-cloud-org-policy==1.11.1
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-google-cloud-access-context-manager==0.2.0
-google-cloud-os-config==1.13.0
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+google-cloud-access-context-manager==0.2.2
+google-cloud-os-config==1.20.1
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-asset/testing/constraints-3.13.txt b/packages/google-cloud-asset/testing/constraints-3.13.txt
index c3db09a0c746..f63842dab6f9 100644
--- a/packages/google-cloud-asset/testing/constraints-3.13.txt
+++ b/packages/google-cloud-asset/testing/constraints-3.13.txt
@@ -9,7 +9,7 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-cloud-access-context-manager>=0
 google-cloud-os-config>=1
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-asset/testing/constraints-3.14.txt b/packages/google-cloud-asset/testing/constraints-3.14.txt
index c3db09a0c746..f63842dab6f9 100644
--- a/packages/google-cloud-asset/testing/constraints-3.14.txt
+++ b/packages/google-cloud-asset/testing/constraints-3.14.txt
@@ -9,7 +9,7 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-cloud-access-context-manager>=0
 google-cloud-os-config>=1
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-assured-workloads/google/cloud/assuredworkloads_v1/__init__.py b/packages/google-cloud-assured-workloads/google/cloud/assuredworkloads_v1/__init__.py
index e64f9d9e2750..4adbfd534c49 100644
--- a/packages/google-cloud-assured-workloads/google/cloud/assuredworkloads_v1/__init__.py
+++ b/packages/google-cloud-assured-workloads/google/cloud/assuredworkloads_v1/__init__.py
@@ -72,7 +72,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -101,9 +101,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-assured-workloads/google/cloud/assuredworkloads_v1beta1/__init__.py b/packages/google-cloud-assured-workloads/google/cloud/assuredworkloads_v1beta1/__init__.py
index 8d348ad3bc8b..8e903cbe1d56 100644
--- a/packages/google-cloud-assured-workloads/google/cloud/assuredworkloads_v1beta1/__init__.py
+++ b/packages/google-cloud-assured-workloads/google/cloud/assuredworkloads_v1beta1/__init__.py
@@ -67,7 +67,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -96,9 +96,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-assured-workloads/setup.py b/packages/google-cloud-assured-workloads/setup.py
index f5ee5362e2de..72e54799d8ad 100644
--- a/packages/google-cloud-assured-workloads/setup.py
+++ b/packages/google-cloud-assured-workloads/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/assuredworkloads/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-assured-workloads"
diff --git a/packages/google-cloud-assured-workloads/testing/constraints-3.10.txt b/packages/google-cloud-assured-workloads/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-assured-workloads/testing/constraints-3.10.txt
+++ b/packages/google-cloud-assured-workloads/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-assured-workloads/testing/constraints-3.13.txt b/packages/google-cloud-assured-workloads/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-assured-workloads/testing/constraints-3.13.txt
+++ b/packages/google-cloud-assured-workloads/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-assured-workloads/testing/constraints-3.14.txt b/packages/google-cloud-assured-workloads/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-assured-workloads/testing/constraints-3.14.txt
+++ b/packages/google-cloud-assured-workloads/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-auditmanager/google/cloud/auditmanager_v1/__init__.py b/packages/google-cloud-auditmanager/google/cloud/auditmanager_v1/__init__.py
index 666540e33d2d..0f2b2f3c7eff 100644
--- a/packages/google-cloud-auditmanager/google/cloud/auditmanager_v1/__init__.py
+++ b/packages/google-cloud-auditmanager/google/cloud/auditmanager_v1/__init__.py
@@ -76,7 +76,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -105,9 +105,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-auditmanager/setup.py b/packages/google-cloud-auditmanager/setup.py
index ce758e6b51b6..6a1b623e55ed 100644
--- a/packages/google-cloud-auditmanager/setup.py
+++ b/packages/google-cloud-auditmanager/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/auditmanager/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-auditmanager"
diff --git a/packages/google-cloud-auditmanager/testing/constraints-3.10.txt b/packages/google-cloud-auditmanager/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-auditmanager/testing/constraints-3.10.txt
+++ b/packages/google-cloud-auditmanager/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-auditmanager/testing/constraints-3.13.txt b/packages/google-cloud-auditmanager/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-auditmanager/testing/constraints-3.13.txt
+++ b/packages/google-cloud-auditmanager/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-auditmanager/testing/constraints-3.14.txt b/packages/google-cloud-auditmanager/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-auditmanager/testing/constraints-3.14.txt
+++ b/packages/google-cloud-auditmanager/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-automl/google/cloud/automl_v1/__init__.py b/packages/google-cloud-automl/google/cloud/automl_v1/__init__.py
index 60d64076048b..9bd10ba234fd 100644
--- a/packages/google-cloud-automl/google/cloud/automl_v1/__init__.py
+++ b/packages/google-cloud-automl/google/cloud/automl_v1/__init__.py
@@ -159,7 +159,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -188,9 +188,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-automl/google/cloud/automl_v1beta1/__init__.py b/packages/google-cloud-automl/google/cloud/automl_v1beta1/__init__.py
index 07baf5afcb7c..0d0a6e9a7000 100644
--- a/packages/google-cloud-automl/google/cloud/automl_v1beta1/__init__.py
+++ b/packages/google-cloud-automl/google/cloud/automl_v1beta1/__init__.py
@@ -205,7 +205,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -234,9 +234,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-automl/setup.py b/packages/google-cloud-automl/setup.py
index fc5d8bfa6429..787260e821b9 100644
--- a/packages/google-cloud-automl/setup.py
+++ b/packages/google-cloud-automl/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/automl/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {
     "libcst": "libcst >= 0.2.5",
diff --git a/packages/google-cloud-automl/testing/constraints-3.10.txt b/packages/google-cloud-automl/testing/constraints-3.10.txt
index 81484ad92a64..ffcaae697c9b 100644
--- a/packages/google-cloud-automl/testing/constraints-3.10.txt
+++ b/packages/google-cloud-automl/testing/constraints-3.10.txt
@@ -4,7 +4,7 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-cloud-storage==2.14.0
 libcst==0.2.5
 pandas==1.3.4
@@ -12,5 +12,5 @@ pandas==1.3.4
 numpy==1.21.3
 google-auth==2.23.3
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-automl/testing/constraints-3.13.txt b/packages/google-cloud-automl/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-automl/testing/constraints-3.13.txt
+++ b/packages/google-cloud-automl/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-automl/testing/constraints-3.14.txt b/packages/google-cloud-automl/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-automl/testing/constraints-3.14.txt
+++ b/packages/google-cloud-automl/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-backupdr/google/cloud/backupdr_v1/__init__.py b/packages/google-cloud-backupdr/google/cloud/backupdr_v1/__init__.py
index f8ffecfa2df7..5631aec5a891 100644
--- a/packages/google-cloud-backupdr/google/cloud/backupdr_v1/__init__.py
+++ b/packages/google-cloud-backupdr/google/cloud/backupdr_v1/__init__.py
@@ -206,7 +206,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -235,9 +235,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-backupdr/setup.py b/packages/google-cloud-backupdr/setup.py
index bba6f7d0675e..73280f359103 100644
--- a/packages/google-cloud-backupdr/setup.py
+++ b/packages/google-cloud-backupdr/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/backupdr/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-backupdr"
diff --git a/packages/google-cloud-backupdr/testing/constraints-3.10.txt b/packages/google-cloud-backupdr/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-backupdr/testing/constraints-3.10.txt
+++ b/packages/google-cloud-backupdr/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-backupdr/testing/constraints-3.13.txt b/packages/google-cloud-backupdr/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-backupdr/testing/constraints-3.13.txt
+++ b/packages/google-cloud-backupdr/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-backupdr/testing/constraints-3.14.txt b/packages/google-cloud-backupdr/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-backupdr/testing/constraints-3.14.txt
+++ b/packages/google-cloud-backupdr/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-bare-metal-solution/google/cloud/bare_metal_solution_v2/__init__.py b/packages/google-cloud-bare-metal-solution/google/cloud/bare_metal_solution_v2/__init__.py
index 49106f94510b..cf3ff8755a58 100644
--- a/packages/google-cloud-bare-metal-solution/google/cloud/bare_metal_solution_v2/__init__.py
+++ b/packages/google-cloud-bare-metal-solution/google/cloud/bare_metal_solution_v2/__init__.py
@@ -148,7 +148,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -177,9 +177,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bare-metal-solution/setup.py b/packages/google-cloud-bare-metal-solution/setup.py
index 06ba1790302e..983d14e9488b 100644
--- a/packages/google-cloud-bare-metal-solution/setup.py
+++ b/packages/google-cloud-bare-metal-solution/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/bare_metal_solution/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-bare-metal-solution"
diff --git a/packages/google-cloud-bare-metal-solution/testing/constraints-3.10.txt b/packages/google-cloud-bare-metal-solution/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-bare-metal-solution/testing/constraints-3.10.txt
+++ b/packages/google-cloud-bare-metal-solution/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-bare-metal-solution/testing/constraints-3.13.txt b/packages/google-cloud-bare-metal-solution/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-bare-metal-solution/testing/constraints-3.13.txt
+++ b/packages/google-cloud-bare-metal-solution/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-bare-metal-solution/testing/constraints-3.14.txt b/packages/google-cloud-bare-metal-solution/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-bare-metal-solution/testing/constraints-3.14.txt
+++ b/packages/google-cloud-bare-metal-solution/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-batch/google/cloud/batch_v1/__init__.py b/packages/google-cloud-batch/google/cloud/batch_v1/__init__.py
index 223bc938260d..80afe12bf729 100644
--- a/packages/google-cloud-batch/google/cloud/batch_v1/__init__.py
+++ b/packages/google-cloud-batch/google/cloud/batch_v1/__init__.py
@@ -84,7 +84,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -113,9 +113,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-batch/google/cloud/batch_v1alpha/__init__.py b/packages/google-cloud-batch/google/cloud/batch_v1alpha/__init__.py
index f0f5ad9b9cdf..cc7c32de6060 100644
--- a/packages/google-cloud-batch/google/cloud/batch_v1alpha/__init__.py
+++ b/packages/google-cloud-batch/google/cloud/batch_v1alpha/__init__.py
@@ -103,7 +103,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -132,9 +132,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-batch/setup.py b/packages/google-cloud-batch/setup.py
index e87950027e82..79cb501263f1 100644
--- a/packages/google-cloud-batch/setup.py
+++ b/packages/google-cloud-batch/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/batch/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-batch"
diff --git a/packages/google-cloud-batch/testing/constraints-3.10.txt b/packages/google-cloud-batch/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-batch/testing/constraints-3.10.txt
+++ b/packages/google-cloud-batch/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-batch/testing/constraints-3.13.txt b/packages/google-cloud-batch/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-batch/testing/constraints-3.13.txt
+++ b/packages/google-cloud-batch/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-batch/testing/constraints-3.14.txt b/packages/google-cloud-batch/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-batch/testing/constraints-3.14.txt
+++ b/packages/google-cloud-batch/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-beyondcorp-appconnections/google/cloud/beyondcorp_appconnections_v1/__init__.py b/packages/google-cloud-beyondcorp-appconnections/google/cloud/beyondcorp_appconnections_v1/__init__.py
index 629262b6deba..2dd0b1f2e9ec 100644
--- a/packages/google-cloud-beyondcorp-appconnections/google/cloud/beyondcorp_appconnections_v1/__init__.py
+++ b/packages/google-cloud-beyondcorp-appconnections/google/cloud/beyondcorp_appconnections_v1/__init__.py
@@ -65,7 +65,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -94,9 +94,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-beyondcorp-appconnections/setup.py b/packages/google-cloud-beyondcorp-appconnections/setup.py
index 9689016c75a5..9b5cfbb2d49e 100644
--- a/packages/google-cloud-beyondcorp-appconnections/setup.py
+++ b/packages/google-cloud-beyondcorp-appconnections/setup.py
@@ -33,7 +33,10 @@
         package_root, "google/cloud/beyondcorp_appconnections/gapic_version.py"
     )
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -43,16 +46,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-beyondcorp-appconnections"
diff --git a/packages/google-cloud-beyondcorp-appconnections/testing/constraints-3.10.txt b/packages/google-cloud-beyondcorp-appconnections/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-beyondcorp-appconnections/testing/constraints-3.10.txt
+++ b/packages/google-cloud-beyondcorp-appconnections/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-beyondcorp-appconnections/testing/constraints-3.13.txt b/packages/google-cloud-beyondcorp-appconnections/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-beyondcorp-appconnections/testing/constraints-3.13.txt
+++ b/packages/google-cloud-beyondcorp-appconnections/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-beyondcorp-appconnections/testing/constraints-3.14.txt b/packages/google-cloud-beyondcorp-appconnections/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-beyondcorp-appconnections/testing/constraints-3.14.txt
+++ b/packages/google-cloud-beyondcorp-appconnections/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-beyondcorp-appconnectors/google/cloud/beyondcorp_appconnectors_v1/__init__.py b/packages/google-cloud-beyondcorp-appconnectors/google/cloud/beyondcorp_appconnectors_v1/__init__.py
index 96cbf5fca0e4..c199a7dbc8a9 100644
--- a/packages/google-cloud-beyondcorp-appconnectors/google/cloud/beyondcorp_appconnectors_v1/__init__.py
+++ b/packages/google-cloud-beyondcorp-appconnectors/google/cloud/beyondcorp_appconnectors_v1/__init__.py
@@ -70,7 +70,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -99,9 +99,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-beyondcorp-appconnectors/setup.py b/packages/google-cloud-beyondcorp-appconnectors/setup.py
index aa8f8581926a..b5bf867d74f5 100644
--- a/packages/google-cloud-beyondcorp-appconnectors/setup.py
+++ b/packages/google-cloud-beyondcorp-appconnectors/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/beyondcorp_appconnectors/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-beyondcorp-appconnectors"
diff --git a/packages/google-cloud-beyondcorp-appconnectors/testing/constraints-3.10.txt b/packages/google-cloud-beyondcorp-appconnectors/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-beyondcorp-appconnectors/testing/constraints-3.10.txt
+++ b/packages/google-cloud-beyondcorp-appconnectors/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-beyondcorp-appconnectors/testing/constraints-3.13.txt b/packages/google-cloud-beyondcorp-appconnectors/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-beyondcorp-appconnectors/testing/constraints-3.13.txt
+++ b/packages/google-cloud-beyondcorp-appconnectors/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-beyondcorp-appconnectors/testing/constraints-3.14.txt b/packages/google-cloud-beyondcorp-appconnectors/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-beyondcorp-appconnectors/testing/constraints-3.14.txt
+++ b/packages/google-cloud-beyondcorp-appconnectors/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-beyondcorp-appgateways/google/cloud/beyondcorp_appgateways_v1/__init__.py b/packages/google-cloud-beyondcorp-appgateways/google/cloud/beyondcorp_appgateways_v1/__init__.py
index 86d0be0285ab..6d3f2b8b5c29 100644
--- a/packages/google-cloud-beyondcorp-appgateways/google/cloud/beyondcorp_appgateways_v1/__init__.py
+++ b/packages/google-cloud-beyondcorp-appgateways/google/cloud/beyondcorp_appgateways_v1/__init__.py
@@ -62,7 +62,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -91,9 +91,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-beyondcorp-appgateways/setup.py b/packages/google-cloud-beyondcorp-appgateways/setup.py
index 3c11fb6f7788..990893ae46e3 100644
--- a/packages/google-cloud-beyondcorp-appgateways/setup.py
+++ b/packages/google-cloud-beyondcorp-appgateways/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/beyondcorp_appgateways/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-beyondcorp-appgateways"
diff --git a/packages/google-cloud-beyondcorp-appgateways/testing/constraints-3.10.txt b/packages/google-cloud-beyondcorp-appgateways/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-beyondcorp-appgateways/testing/constraints-3.10.txt
+++ b/packages/google-cloud-beyondcorp-appgateways/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-beyondcorp-appgateways/testing/constraints-3.13.txt b/packages/google-cloud-beyondcorp-appgateways/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-beyondcorp-appgateways/testing/constraints-3.13.txt
+++ b/packages/google-cloud-beyondcorp-appgateways/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-beyondcorp-appgateways/testing/constraints-3.14.txt b/packages/google-cloud-beyondcorp-appgateways/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-beyondcorp-appgateways/testing/constraints-3.14.txt
+++ b/packages/google-cloud-beyondcorp-appgateways/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-beyondcorp-clientconnectorservices/google/cloud/beyondcorp_clientconnectorservices_v1/__init__.py b/packages/google-cloud-beyondcorp-clientconnectorservices/google/cloud/beyondcorp_clientconnectorservices_v1/__init__.py
index 0662358cd914..3230fcd5aa83 100644
--- a/packages/google-cloud-beyondcorp-clientconnectorservices/google/cloud/beyondcorp_clientconnectorservices_v1/__init__.py
+++ b/packages/google-cloud-beyondcorp-clientconnectorservices/google/cloud/beyondcorp_clientconnectorservices_v1/__init__.py
@@ -67,7 +67,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -96,9 +96,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-beyondcorp-clientconnectorservices/setup.py b/packages/google-cloud-beyondcorp-clientconnectorservices/setup.py
index 8a24bca5f233..343e0184ce38 100644
--- a/packages/google-cloud-beyondcorp-clientconnectorservices/setup.py
+++ b/packages/google-cloud-beyondcorp-clientconnectorservices/setup.py
@@ -33,7 +33,10 @@
         package_root, "google/cloud/beyondcorp_clientconnectorservices/gapic_version.py"
     )
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -43,16 +46,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-beyondcorp-clientconnectorservices"
diff --git a/packages/google-cloud-beyondcorp-clientconnectorservices/testing/constraints-3.10.txt b/packages/google-cloud-beyondcorp-clientconnectorservices/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-beyondcorp-clientconnectorservices/testing/constraints-3.10.txt
+++ b/packages/google-cloud-beyondcorp-clientconnectorservices/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-beyondcorp-clientconnectorservices/testing/constraints-3.13.txt b/packages/google-cloud-beyondcorp-clientconnectorservices/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-beyondcorp-clientconnectorservices/testing/constraints-3.13.txt
+++ b/packages/google-cloud-beyondcorp-clientconnectorservices/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-beyondcorp-clientconnectorservices/testing/constraints-3.14.txt b/packages/google-cloud-beyondcorp-clientconnectorservices/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-beyondcorp-clientconnectorservices/testing/constraints-3.14.txt
+++ b/packages/google-cloud-beyondcorp-clientconnectorservices/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-beyondcorp-clientgateways/google/cloud/beyondcorp_clientgateways_v1/__init__.py b/packages/google-cloud-beyondcorp-clientgateways/google/cloud/beyondcorp_clientgateways_v1/__init__.py
index 43b74bf2a747..2faf507370e0 100644
--- a/packages/google-cloud-beyondcorp-clientgateways/google/cloud/beyondcorp_clientgateways_v1/__init__.py
+++ b/packages/google-cloud-beyondcorp-clientgateways/google/cloud/beyondcorp_clientgateways_v1/__init__.py
@@ -62,7 +62,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -91,9 +91,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-beyondcorp-clientgateways/setup.py b/packages/google-cloud-beyondcorp-clientgateways/setup.py
index 29b091e58ee1..d04f040e7cc4 100644
--- a/packages/google-cloud-beyondcorp-clientgateways/setup.py
+++ b/packages/google-cloud-beyondcorp-clientgateways/setup.py
@@ -33,7 +33,10 @@
         package_root, "google/cloud/beyondcorp_clientgateways/gapic_version.py"
     )
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -43,16 +46,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-beyondcorp-clientgateways"
diff --git a/packages/google-cloud-beyondcorp-clientgateways/testing/constraints-3.10.txt b/packages/google-cloud-beyondcorp-clientgateways/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-beyondcorp-clientgateways/testing/constraints-3.10.txt
+++ b/packages/google-cloud-beyondcorp-clientgateways/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-beyondcorp-clientgateways/testing/constraints-3.13.txt b/packages/google-cloud-beyondcorp-clientgateways/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-beyondcorp-clientgateways/testing/constraints-3.13.txt
+++ b/packages/google-cloud-beyondcorp-clientgateways/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-beyondcorp-clientgateways/testing/constraints-3.14.txt b/packages/google-cloud-beyondcorp-clientgateways/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-beyondcorp-clientgateways/testing/constraints-3.14.txt
+++ b/packages/google-cloud-beyondcorp-clientgateways/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-biglake-hive/google/cloud/biglake_hive_v1beta/__init__.py b/packages/google-cloud-biglake-hive/google/cloud/biglake_hive_v1beta/__init__.py
index 2174fa25184e..1f59c805e65c 100644
--- a/packages/google-cloud-biglake-hive/google/cloud/biglake_hive_v1beta/__init__.py
+++ b/packages/google-cloud-biglake-hive/google/cloud/biglake_hive_v1beta/__init__.py
@@ -90,7 +90,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -119,9 +119,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-biglake-hive/setup.py b/packages/google-cloud-biglake-hive/setup.py
index 552430cb475c..2e3676303c3e 100644
--- a/packages/google-cloud-biglake-hive/setup.py
+++ b/packages/google-cloud-biglake-hive/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/biglake_hive/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-biglake-hive"
diff --git a/packages/google-cloud-biglake-hive/testing/constraints-3.10.txt b/packages/google-cloud-biglake-hive/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-biglake-hive/testing/constraints-3.10.txt
+++ b/packages/google-cloud-biglake-hive/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-biglake-hive/testing/constraints-3.13.txt b/packages/google-cloud-biglake-hive/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-biglake-hive/testing/constraints-3.13.txt
+++ b/packages/google-cloud-biglake-hive/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-biglake-hive/testing/constraints-3.14.txt b/packages/google-cloud-biglake-hive/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-biglake-hive/testing/constraints-3.14.txt
+++ b/packages/google-cloud-biglake-hive/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-biglake/google/cloud/biglake_v1/__init__.py b/packages/google-cloud-biglake/google/cloud/biglake_v1/__init__.py
index fcda198246b7..68d8d4bd3cb7 100644
--- a/packages/google-cloud-biglake/google/cloud/biglake_v1/__init__.py
+++ b/packages/google-cloud-biglake/google/cloud/biglake_v1/__init__.py
@@ -66,7 +66,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -95,9 +95,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-biglake/setup.py b/packages/google-cloud-biglake/setup.py
index c1b3bb4bb6ba..07531e23c47f 100644
--- a/packages/google-cloud-biglake/setup.py
+++ b/packages/google-cloud-biglake/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/biglake/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-biglake"
diff --git a/packages/google-cloud-biglake/testing/constraints-3.10.txt b/packages/google-cloud-biglake/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-biglake/testing/constraints-3.10.txt
+++ b/packages/google-cloud-biglake/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-biglake/testing/constraints-3.13.txt b/packages/google-cloud-biglake/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-biglake/testing/constraints-3.13.txt
+++ b/packages/google-cloud-biglake/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-biglake/testing/constraints-3.14.txt b/packages/google-cloud-biglake/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-biglake/testing/constraints-3.14.txt
+++ b/packages/google-cloud-biglake/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-bigquery-analyticshub/google/cloud/bigquery_analyticshub_v1/__init__.py b/packages/google-cloud-bigquery-analyticshub/google/cloud/bigquery_analyticshub_v1/__init__.py
index 22d699f00625..104a4c928263 100644
--- a/packages/google-cloud-bigquery-analyticshub/google/cloud/bigquery_analyticshub_v1/__init__.py
+++ b/packages/google-cloud-bigquery-analyticshub/google/cloud/bigquery_analyticshub_v1/__init__.py
@@ -117,7 +117,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -146,9 +146,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-analyticshub/setup.py b/packages/google-cloud-bigquery-analyticshub/setup.py
index c97c4f9bb548..2c2506ab9dbc 100644
--- a/packages/google-cloud-bigquery-analyticshub/setup.py
+++ b/packages/google-cloud-bigquery-analyticshub/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/bigquery_analyticshub/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-bigquery-analyticshub"
diff --git a/packages/google-cloud-bigquery-analyticshub/testing/constraints-3.10.txt b/packages/google-cloud-bigquery-analyticshub/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-bigquery-analyticshub/testing/constraints-3.10.txt
+++ b/packages/google-cloud-bigquery-analyticshub/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-bigquery-analyticshub/testing/constraints-3.13.txt b/packages/google-cloud-bigquery-analyticshub/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-bigquery-analyticshub/testing/constraints-3.13.txt
+++ b/packages/google-cloud-bigquery-analyticshub/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-bigquery-analyticshub/testing/constraints-3.14.txt b/packages/google-cloud-bigquery-analyticshub/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-bigquery-analyticshub/testing/constraints-3.14.txt
+++ b/packages/google-cloud-bigquery-analyticshub/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-bigquery-biglake/google/cloud/bigquery_biglake_v1/__init__.py b/packages/google-cloud-bigquery-biglake/google/cloud/bigquery_biglake_v1/__init__.py
index 868e17a3ddbc..06279a89a7a8 100644
--- a/packages/google-cloud-bigquery-biglake/google/cloud/bigquery_biglake_v1/__init__.py
+++ b/packages/google-cloud-bigquery-biglake/google/cloud/bigquery_biglake_v1/__init__.py
@@ -79,7 +79,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -108,9 +108,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-biglake/google/cloud/bigquery_biglake_v1alpha1/__init__.py b/packages/google-cloud-bigquery-biglake/google/cloud/bigquery_biglake_v1alpha1/__init__.py
index fe7277897a92..e290bcabc1d7 100644
--- a/packages/google-cloud-bigquery-biglake/google/cloud/bigquery_biglake_v1alpha1/__init__.py
+++ b/packages/google-cloud-bigquery-biglake/google/cloud/bigquery_biglake_v1alpha1/__init__.py
@@ -85,7 +85,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -114,9 +114,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-biglake/setup.py b/packages/google-cloud-bigquery-biglake/setup.py
index 7d62c606c564..533cf287e093 100644
--- a/packages/google-cloud-bigquery-biglake/setup.py
+++ b/packages/google-cloud-bigquery-biglake/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/bigquery_biglake/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-bigquery-biglake"
diff --git a/packages/google-cloud-bigquery-biglake/testing/constraints-3.10.txt b/packages/google-cloud-bigquery-biglake/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-bigquery-biglake/testing/constraints-3.10.txt
+++ b/packages/google-cloud-bigquery-biglake/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-bigquery-biglake/testing/constraints-3.13.txt b/packages/google-cloud-bigquery-biglake/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-bigquery-biglake/testing/constraints-3.13.txt
+++ b/packages/google-cloud-bigquery-biglake/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-bigquery-biglake/testing/constraints-3.14.txt b/packages/google-cloud-bigquery-biglake/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-bigquery-biglake/testing/constraints-3.14.txt
+++ b/packages/google-cloud-bigquery-biglake/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-bigquery-connection/google/cloud/bigquery_connection_v1/__init__.py b/packages/google-cloud-bigquery-connection/google/cloud/bigquery_connection_v1/__init__.py
index 76600994b646..73bcafc38912 100644
--- a/packages/google-cloud-bigquery-connection/google/cloud/bigquery_connection_v1/__init__.py
+++ b/packages/google-cloud-bigquery-connection/google/cloud/bigquery_connection_v1/__init__.py
@@ -74,7 +74,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -103,9 +103,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-connection/setup.py b/packages/google-cloud-bigquery-connection/setup.py
index 9515d7a90b2e..fb0b40ee9d77 100644
--- a/packages/google-cloud-bigquery-connection/setup.py
+++ b/packages/google-cloud-bigquery-connection/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/bigquery_connection/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-bigquery-connection"
diff --git a/packages/google-cloud-bigquery-connection/testing/constraints-3.10.txt b/packages/google-cloud-bigquery-connection/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-bigquery-connection/testing/constraints-3.10.txt
+++ b/packages/google-cloud-bigquery-connection/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-bigquery-connection/testing/constraints-3.13.txt b/packages/google-cloud-bigquery-connection/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-bigquery-connection/testing/constraints-3.13.txt
+++ b/packages/google-cloud-bigquery-connection/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-bigquery-connection/testing/constraints-3.14.txt b/packages/google-cloud-bigquery-connection/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-bigquery-connection/testing/constraints-3.14.txt
+++ b/packages/google-cloud-bigquery-connection/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-bigquery-data-exchange/google/cloud/bigquery_data_exchange_v1beta1/__init__.py b/packages/google-cloud-bigquery-data-exchange/google/cloud/bigquery_data_exchange_v1beta1/__init__.py
index 319a13eba22b..194e49cf0eae 100644
--- a/packages/google-cloud-bigquery-data-exchange/google/cloud/bigquery_data_exchange_v1beta1/__init__.py
+++ b/packages/google-cloud-bigquery-data-exchange/google/cloud/bigquery_data_exchange_v1beta1/__init__.py
@@ -77,7 +77,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -106,9 +106,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-data-exchange/setup.py b/packages/google-cloud-bigquery-data-exchange/setup.py
index 709a469cfe64..3b7259d55234 100644
--- a/packages/google-cloud-bigquery-data-exchange/setup.py
+++ b/packages/google-cloud-bigquery-data-exchange/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/bigquery_data_exchange/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-bigquery-data-exchange"
diff --git a/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.10.txt b/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.10.txt
+++ b/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.13.txt b/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.13.txt
+++ b/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.14.txt b/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.14.txt
+++ b/packages/google-cloud-bigquery-data-exchange/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v1/__init__.py b/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v1/__init__.py
index 0e075f23a66c..1d64d26cd017 100644
--- a/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v1/__init__.py
+++ b/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v1/__init__.py
@@ -64,7 +64,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -93,9 +93,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v1beta1/__init__.py b/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v1beta1/__init__.py
index 82c1e6a21a95..ebbef5466a5d 100644
--- a/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v1beta1/__init__.py
+++ b/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v1beta1/__init__.py
@@ -63,7 +63,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -92,9 +92,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v2/__init__.py b/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v2/__init__.py
index 91f8a486274b..c3c1ffc649de 100644
--- a/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v2/__init__.py
+++ b/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v2/__init__.py
@@ -65,7 +65,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -94,9 +94,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v2beta1/__init__.py b/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v2beta1/__init__.py
index 76a08102cb7d..c1bf00714422 100644
--- a/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v2beta1/__init__.py
+++ b/packages/google-cloud-bigquery-datapolicies/google/cloud/bigquery_datapolicies_v2beta1/__init__.py
@@ -65,7 +65,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -94,9 +94,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-datapolicies/setup.py b/packages/google-cloud-bigquery-datapolicies/setup.py
index 6e5251e5523c..aafbb6248fcb 100644
--- a/packages/google-cloud-bigquery-datapolicies/setup.py
+++ b/packages/google-cloud-bigquery-datapolicies/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/bigquery_datapolicies/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-bigquery-datapolicies"
diff --git a/packages/google-cloud-bigquery-datapolicies/testing/constraints-3.10.txt b/packages/google-cloud-bigquery-datapolicies/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-bigquery-datapolicies/testing/constraints-3.10.txt
+++ b/packages/google-cloud-bigquery-datapolicies/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-bigquery-datapolicies/testing/constraints-3.13.txt b/packages/google-cloud-bigquery-datapolicies/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-bigquery-datapolicies/testing/constraints-3.13.txt
+++ b/packages/google-cloud-bigquery-datapolicies/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-bigquery-datapolicies/testing/constraints-3.14.txt b/packages/google-cloud-bigquery-datapolicies/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-bigquery-datapolicies/testing/constraints-3.14.txt
+++ b/packages/google-cloud-bigquery-datapolicies/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-bigquery-datatransfer/google/cloud/bigquery_datatransfer_v1/__init__.py b/packages/google-cloud-bigquery-datatransfer/google/cloud/bigquery_datatransfer_v1/__init__.py
index 028ec25eba72..b95aed28cf35 100644
--- a/packages/google-cloud-bigquery-datatransfer/google/cloud/bigquery_datatransfer_v1/__init__.py
+++ b/packages/google-cloud-bigquery-datatransfer/google/cloud/bigquery_datatransfer_v1/__init__.py
@@ -95,7 +95,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -124,9 +124,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-datatransfer/setup.py b/packages/google-cloud-bigquery-datatransfer/setup.py
index afeab9dee42b..55f1c624bd1f 100644
--- a/packages/google-cloud-bigquery-datatransfer/setup.py
+++ b/packages/google-cloud-bigquery-datatransfer/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/bigquery_datatransfer/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-bigquery-datatransfer"
diff --git a/packages/google-cloud-bigquery-datatransfer/testing/constraints-3.10.txt b/packages/google-cloud-bigquery-datatransfer/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-bigquery-datatransfer/testing/constraints-3.10.txt
+++ b/packages/google-cloud-bigquery-datatransfer/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-bigquery-datatransfer/testing/constraints-3.13.txt b/packages/google-cloud-bigquery-datatransfer/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-bigquery-datatransfer/testing/constraints-3.13.txt
+++ b/packages/google-cloud-bigquery-datatransfer/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-bigquery-datatransfer/testing/constraints-3.14.txt b/packages/google-cloud-bigquery-datatransfer/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-bigquery-datatransfer/testing/constraints-3.14.txt
+++ b/packages/google-cloud-bigquery-datatransfer/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-bigquery-logging/google/cloud/bigquery_logging_v1/__init__.py b/packages/google-cloud-bigquery-logging/google/cloud/bigquery_logging_v1/__init__.py
index adc721a8f93f..99908d1b8e90 100644
--- a/packages/google-cloud-bigquery-logging/google/cloud/bigquery_logging_v1/__init__.py
+++ b/packages/google-cloud-bigquery-logging/google/cloud/bigquery_logging_v1/__init__.py
@@ -86,7 +86,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -115,9 +115,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-logging/setup.py b/packages/google-cloud-bigquery-logging/setup.py
index ff79919fb839..7f3894065115 100644
--- a/packages/google-cloud-bigquery-logging/setup.py
+++ b/packages/google-cloud-bigquery-logging/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/bigquery_logging/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-bigquery-logging"
diff --git a/packages/google-cloud-bigquery-logging/testing/constraints-3.10.txt b/packages/google-cloud-bigquery-logging/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-bigquery-logging/testing/constraints-3.10.txt
+++ b/packages/google-cloud-bigquery-logging/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-bigquery-logging/testing/constraints-3.13.txt b/packages/google-cloud-bigquery-logging/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-bigquery-logging/testing/constraints-3.13.txt
+++ b/packages/google-cloud-bigquery-logging/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-bigquery-logging/testing/constraints-3.14.txt b/packages/google-cloud-bigquery-logging/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-bigquery-logging/testing/constraints-3.14.txt
+++ b/packages/google-cloud-bigquery-logging/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-bigquery-migration/google/cloud/bigquery_migration_v2/__init__.py b/packages/google-cloud-bigquery-migration/google/cloud/bigquery_migration_v2/__init__.py
index e634458e23ef..bb2ead57e0c9 100644
--- a/packages/google-cloud-bigquery-migration/google/cloud/bigquery_migration_v2/__init__.py
+++ b/packages/google-cloud-bigquery-migration/google/cloud/bigquery_migration_v2/__init__.py
@@ -116,7 +116,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -145,9 +145,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-migration/google/cloud/bigquery_migration_v2alpha/__init__.py b/packages/google-cloud-bigquery-migration/google/cloud/bigquery_migration_v2alpha/__init__.py
index 916f7fc5cb34..c2625d45a95a 100644
--- a/packages/google-cloud-bigquery-migration/google/cloud/bigquery_migration_v2alpha/__init__.py
+++ b/packages/google-cloud-bigquery-migration/google/cloud/bigquery_migration_v2alpha/__init__.py
@@ -100,7 +100,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -129,9 +129,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-migration/setup.py b/packages/google-cloud-bigquery-migration/setup.py
index 0ff1ca1557b4..ae821f3100c2 100644
--- a/packages/google-cloud-bigquery-migration/setup.py
+++ b/packages/google-cloud-bigquery-migration/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/bigquery_migration/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-bigquery-migration"
diff --git a/packages/google-cloud-bigquery-migration/testing/constraints-3.10.txt b/packages/google-cloud-bigquery-migration/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-bigquery-migration/testing/constraints-3.10.txt
+++ b/packages/google-cloud-bigquery-migration/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-bigquery-migration/testing/constraints-3.13.txt b/packages/google-cloud-bigquery-migration/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-bigquery-migration/testing/constraints-3.13.txt
+++ b/packages/google-cloud-bigquery-migration/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-bigquery-migration/testing/constraints-3.14.txt b/packages/google-cloud-bigquery-migration/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-bigquery-migration/testing/constraints-3.14.txt
+++ b/packages/google-cloud-bigquery-migration/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-bigquery-reservation/google/cloud/bigquery_reservation_v1/__init__.py b/packages/google-cloud-bigquery-reservation/google/cloud/bigquery_reservation_v1/__init__.py
index b10ed1d34990..da3978b93cb8 100644
--- a/packages/google-cloud-bigquery-reservation/google/cloud/bigquery_reservation_v1/__init__.py
+++ b/packages/google-cloud-bigquery-reservation/google/cloud/bigquery_reservation_v1/__init__.py
@@ -97,7 +97,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -126,9 +126,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-reservation/setup.py b/packages/google-cloud-bigquery-reservation/setup.py
index 07e6eba134b7..aca1403c128b 100644
--- a/packages/google-cloud-bigquery-reservation/setup.py
+++ b/packages/google-cloud-bigquery-reservation/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/bigquery_reservation/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-bigquery-reservation"
diff --git a/packages/google-cloud-bigquery-reservation/testing/constraints-3.10.txt b/packages/google-cloud-bigquery-reservation/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-bigquery-reservation/testing/constraints-3.10.txt
+++ b/packages/google-cloud-bigquery-reservation/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-bigquery-reservation/testing/constraints-3.13.txt b/packages/google-cloud-bigquery-reservation/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-bigquery-reservation/testing/constraints-3.13.txt
+++ b/packages/google-cloud-bigquery-reservation/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-bigquery-reservation/testing/constraints-3.14.txt b/packages/google-cloud-bigquery-reservation/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-bigquery-reservation/testing/constraints-3.14.txt
+++ b/packages/google-cloud-bigquery-reservation/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1/__init__.py b/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1/__init__.py
index fd0d8451304d..2ab62f3a4b43 100644
--- a/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1/__init__.py
+++ b/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1/__init__.py
@@ -59,7 +59,7 @@ class BigQueryWriteClient(client.BigQueryWriteClient):
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -88,9 +88,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1alpha/__init__.py b/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1alpha/__init__.py
index 5177548b5b5d..cf2821bc5802 100644
--- a/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1alpha/__init__.py
+++ b/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1alpha/__init__.py
@@ -48,7 +48,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -77,9 +77,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1beta/__init__.py b/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1beta/__init__.py
index 091cf62a94b8..4e21546e3ef0 100644
--- a/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1beta/__init__.py
+++ b/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1beta/__init__.py
@@ -48,7 +48,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -77,9 +77,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1beta2/__init__.py b/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1beta2/__init__.py
index 3494348486a5..3c664286d38e 100644
--- a/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1beta2/__init__.py
+++ b/packages/google-cloud-bigquery-storage/google/cloud/bigquery_storage_v1beta2/__init__.py
@@ -59,7 +59,7 @@ class BigQueryWriteClient(client.BigQueryWriteClient):
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -88,9 +88,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigquery-storage/setup.py b/packages/google-cloud-bigquery-storage/setup.py
index d3a6bc437845..3d2404674227 100644
--- a/packages/google-cloud-bigquery-storage/setup.py
+++ b/packages/google-cloud-bigquery-storage/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/bigquery_storage/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {
     "pandas": ["pandas>=1.1.3"],
diff --git a/packages/google-cloud-bigquery-storage/testing/constraints-3.10.txt b/packages/google-cloud-bigquery-storage/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-bigquery-storage/testing/constraints-3.10.txt
+++ b/packages/google-cloud-bigquery-storage/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-bigquery-storage/testing/constraints-3.13.txt b/packages/google-cloud-bigquery-storage/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-bigquery-storage/testing/constraints-3.13.txt
+++ b/packages/google-cloud-bigquery-storage/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-bigquery-storage/testing/constraints-3.14.txt b/packages/google-cloud-bigquery-storage/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-bigquery-storage/testing/constraints-3.14.txt
+++ b/packages/google-cloud-bigquery-storage/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-bigtable/google/cloud/bigtable_admin_v2/__init__.py b/packages/google-cloud-bigtable/google/cloud/bigtable_admin_v2/__init__.py
index ba8a489befb4..cce3f00aa270 100644
--- a/packages/google-cloud-bigtable/google/cloud/bigtable_admin_v2/__init__.py
+++ b/packages/google-cloud-bigtable/google/cloud/bigtable_admin_v2/__init__.py
@@ -185,7 +185,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -214,9 +214,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigtable/google/cloud/bigtable_v2/__init__.py b/packages/google-cloud-bigtable/google/cloud/bigtable_v2/__init__.py
index 2912b389aced..29d6dfdc1c76 100644
--- a/packages/google-cloud-bigtable/google/cloud/bigtable_v2/__init__.py
+++ b/packages/google-cloud-bigtable/google/cloud/bigtable_v2/__init__.py
@@ -148,7 +148,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -177,9 +177,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-bigtable/setup.py b/packages/google-cloud-bigtable/setup.py
index af210c742f7c..4e242c695aa5 100644
--- a/packages/google-cloud-bigtable/setup.py
+++ b/packages/google-cloud-bigtable/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/bigtable/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
     "google-cloud-core >= 2.0.0, <3.0.0",
     "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
     "google-crc32c>=1.6.0, <2.0.0dev",
diff --git a/packages/google-cloud-bigtable/testing/constraints-3.10.txt b/packages/google-cloud-bigtable/testing/constraints-3.10.txt
index 3c682654e6fa..0b9a5dab518c 100644
--- a/packages/google-cloud-bigtable/testing/constraints-3.10.txt
+++ b/packages/google-cloud-bigtable/testing/constraints-3.10.txt
@@ -4,11 +4,11 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-cloud-core==2.0.0
 grpc-google-iam-v1==0.14.0
 google-crc32c==1.6.0
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-bigtable/testing/constraints-3.13.txt b/packages/google-cloud-bigtable/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-bigtable/testing/constraints-3.13.txt
+++ b/packages/google-cloud-bigtable/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-bigtable/testing/constraints-3.14.txt b/packages/google-cloud-bigtable/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-bigtable/testing/constraints-3.14.txt
+++ b/packages/google-cloud-bigtable/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-billing-budgets/google/cloud/billing/budgets_v1/__init__.py b/packages/google-cloud-billing-budgets/google/cloud/billing/budgets_v1/__init__.py
index f9ab3b68b711..471698a911a6 100644
--- a/packages/google-cloud-billing-budgets/google/cloud/billing/budgets_v1/__init__.py
+++ b/packages/google-cloud-billing-budgets/google/cloud/billing/budgets_v1/__init__.py
@@ -68,7 +68,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -97,9 +97,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-billing-budgets/google/cloud/billing/budgets_v1beta1/__init__.py b/packages/google-cloud-billing-budgets/google/cloud/billing/budgets_v1beta1/__init__.py
index 21ded9065bf7..ac885e34439d 100644
--- a/packages/google-cloud-billing-budgets/google/cloud/billing/budgets_v1beta1/__init__.py
+++ b/packages/google-cloud-billing-budgets/google/cloud/billing/budgets_v1beta1/__init__.py
@@ -68,7 +68,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -97,9 +97,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-billing-budgets/setup.py b/packages/google-cloud-billing-budgets/setup.py
index eda177d690aa..0ecb58ba1c54 100644
--- a/packages/google-cloud-billing-budgets/setup.py
+++ b/packages/google-cloud-billing-budgets/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/billing/budgets/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-billing-budgets"
diff --git a/packages/google-cloud-billing-budgets/testing/constraints-3.10.txt b/packages/google-cloud-billing-budgets/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-billing-budgets/testing/constraints-3.10.txt
+++ b/packages/google-cloud-billing-budgets/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-billing-budgets/testing/constraints-3.13.txt b/packages/google-cloud-billing-budgets/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-billing-budgets/testing/constraints-3.13.txt
+++ b/packages/google-cloud-billing-budgets/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-billing-budgets/testing/constraints-3.14.txt b/packages/google-cloud-billing-budgets/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-billing-budgets/testing/constraints-3.14.txt
+++ b/packages/google-cloud-billing-budgets/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-billing/google/cloud/billing_v1/__init__.py b/packages/google-cloud-billing/google/cloud/billing_v1/__init__.py
index c3d2c0430d10..17e1f4a99e55 100644
--- a/packages/google-cloud-billing/google/cloud/billing_v1/__init__.py
+++ b/packages/google-cloud-billing/google/cloud/billing_v1/__init__.py
@@ -78,7 +78,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -107,9 +107,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-billing/setup.py b/packages/google-cloud-billing/setup.py
index d09922705fe2..f0e2f3767a48 100644
--- a/packages/google-cloud-billing/setup.py
+++ b/packages/google-cloud-billing/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/billing/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-billing"
diff --git a/packages/google-cloud-billing/testing/constraints-3.10.txt b/packages/google-cloud-billing/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-billing/testing/constraints-3.10.txt
+++ b/packages/google-cloud-billing/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-billing/testing/constraints-3.13.txt b/packages/google-cloud-billing/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-billing/testing/constraints-3.13.txt
+++ b/packages/google-cloud-billing/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-billing/testing/constraints-3.14.txt b/packages/google-cloud-billing/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-billing/testing/constraints-3.14.txt
+++ b/packages/google-cloud-billing/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-binary-authorization/google/cloud/binaryauthorization_v1/__init__.py b/packages/google-cloud-binary-authorization/google/cloud/binaryauthorization_v1/__init__.py
index 6b920a1440de..0ac101a280a7 100644
--- a/packages/google-cloud-binary-authorization/google/cloud/binaryauthorization_v1/__init__.py
+++ b/packages/google-cloud-binary-authorization/google/cloud/binaryauthorization_v1/__init__.py
@@ -80,7 +80,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -109,9 +109,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-binary-authorization/google/cloud/binaryauthorization_v1beta1/__init__.py b/packages/google-cloud-binary-authorization/google/cloud/binaryauthorization_v1beta1/__init__.py
index 9bcc90d114ab..d3218378af6a 100644
--- a/packages/google-cloud-binary-authorization/google/cloud/binaryauthorization_v1beta1/__init__.py
+++ b/packages/google-cloud-binary-authorization/google/cloud/binaryauthorization_v1beta1/__init__.py
@@ -78,7 +78,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -107,9 +107,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-binary-authorization/setup.py b/packages/google-cloud-binary-authorization/setup.py
index 801bbc527e32..32fab06a13ff 100644
--- a/packages/google-cloud-binary-authorization/setup.py
+++ b/packages/google-cloud-binary-authorization/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/binaryauthorization/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grafeas >= 1.7.0, <2.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-binary-authorization"
diff --git a/packages/google-cloud-binary-authorization/testing/constraints-3.10.txt b/packages/google-cloud-binary-authorization/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-binary-authorization/testing/constraints-3.10.txt
+++ b/packages/google-cloud-binary-authorization/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-binary-authorization/testing/constraints-3.13.txt b/packages/google-cloud-binary-authorization/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-binary-authorization/testing/constraints-3.13.txt
+++ b/packages/google-cloud-binary-authorization/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-binary-authorization/testing/constraints-3.14.txt b/packages/google-cloud-binary-authorization/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-binary-authorization/testing/constraints-3.14.txt
+++ b/packages/google-cloud-binary-authorization/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-build/google/cloud/devtools/cloudbuild_v1/__init__.py b/packages/google-cloud-build/google/cloud/devtools/cloudbuild_v1/__init__.py
index 901fe97b93bd..93671c66be5a 100644
--- a/packages/google-cloud-build/google/cloud/devtools/cloudbuild_v1/__init__.py
+++ b/packages/google-cloud-build/google/cloud/devtools/cloudbuild_v1/__init__.py
@@ -124,7 +124,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -153,9 +153,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-build/google/cloud/devtools/cloudbuild_v2/__init__.py b/packages/google-cloud-build/google/cloud/devtools/cloudbuild_v2/__init__.py
index 3433054f6bb0..44784edba1b8 100644
--- a/packages/google-cloud-build/google/cloud/devtools/cloudbuild_v2/__init__.py
+++ b/packages/google-cloud-build/google/cloud/devtools/cloudbuild_v2/__init__.py
@@ -89,7 +89,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -118,9 +118,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-build/setup.py b/packages/google-cloud-build/setup.py
index 103e6bbcc6f5..2bffbea45a43 100644
--- a/packages/google-cloud-build/setup.py
+++ b/packages/google-cloud-build/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/devtools/cloudbuild/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpc-google-iam-v1 >=0.12.4, <1.0.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-build"
diff --git a/packages/google-cloud-build/testing/constraints-3.10.txt b/packages/google-cloud-build/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-build/testing/constraints-3.10.txt
+++ b/packages/google-cloud-build/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-build/testing/constraints-3.13.txt b/packages/google-cloud-build/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-build/testing/constraints-3.13.txt
+++ b/packages/google-cloud-build/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-build/testing/constraints-3.14.txt b/packages/google-cloud-build/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-build/testing/constraints-3.14.txt
+++ b/packages/google-cloud-build/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-capacityplanner/google/cloud/capacityplanner_v1beta/__init__.py b/packages/google-cloud-capacityplanner/google/cloud/capacityplanner_v1beta/__init__.py
index d3efe8335f9f..c11e99fb4a28 100644
--- a/packages/google-cloud-capacityplanner/google/cloud/capacityplanner_v1beta/__init__.py
+++ b/packages/google-cloud-capacityplanner/google/cloud/capacityplanner_v1beta/__init__.py
@@ -86,7 +86,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -115,9 +115,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-capacityplanner/setup.py b/packages/google-cloud-capacityplanner/setup.py
index cf377b7839a8..0ff374547dd4 100644
--- a/packages/google-cloud-capacityplanner/setup.py
+++ b/packages/google-cloud-capacityplanner/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/capacityplanner/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-capacityplanner"
diff --git a/packages/google-cloud-capacityplanner/testing/constraints-3.10.txt b/packages/google-cloud-capacityplanner/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-capacityplanner/testing/constraints-3.10.txt
+++ b/packages/google-cloud-capacityplanner/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-capacityplanner/testing/constraints-3.13.txt b/packages/google-cloud-capacityplanner/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-capacityplanner/testing/constraints-3.13.txt
+++ b/packages/google-cloud-capacityplanner/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-capacityplanner/testing/constraints-3.14.txt b/packages/google-cloud-capacityplanner/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-capacityplanner/testing/constraints-3.14.txt
+++ b/packages/google-cloud-capacityplanner/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-certificate-manager/google/cloud/certificate_manager_v1/__init__.py b/packages/google-cloud-certificate-manager/google/cloud/certificate_manager_v1/__init__.py
index a278a76c1c7e..70491d02d234 100644
--- a/packages/google-cloud-certificate-manager/google/cloud/certificate_manager_v1/__init__.py
+++ b/packages/google-cloud-certificate-manager/google/cloud/certificate_manager_v1/__init__.py
@@ -102,7 +102,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -131,9 +131,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-certificate-manager/setup.py b/packages/google-cloud-certificate-manager/setup.py
index e3e6d2d628db..17f20bf48168 100644
--- a/packages/google-cloud-certificate-manager/setup.py
+++ b/packages/google-cloud-certificate-manager/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/certificate_manager/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-certificate-manager"
diff --git a/packages/google-cloud-certificate-manager/testing/constraints-3.10.txt b/packages/google-cloud-certificate-manager/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-certificate-manager/testing/constraints-3.10.txt
+++ b/packages/google-cloud-certificate-manager/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-certificate-manager/testing/constraints-3.13.txt b/packages/google-cloud-certificate-manager/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-certificate-manager/testing/constraints-3.13.txt
+++ b/packages/google-cloud-certificate-manager/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-certificate-manager/testing/constraints-3.14.txt b/packages/google-cloud-certificate-manager/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-certificate-manager/testing/constraints-3.14.txt
+++ b/packages/google-cloud-certificate-manager/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-ces/google/cloud/ces_v1/__init__.py b/packages/google-cloud-ces/google/cloud/ces_v1/__init__.py
index eaf1b8b99f6b..0cf94f276d46 100644
--- a/packages/google-cloud-ces/google/cloud/ces_v1/__init__.py
+++ b/packages/google-cloud-ces/google/cloud/ces_v1/__init__.py
@@ -231,7 +231,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -260,9 +260,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-ces/google/cloud/ces_v1beta/__init__.py b/packages/google-cloud-ces/google/cloud/ces_v1beta/__init__.py
index 481866dfbb65..a1e1f7c5b676 100644
--- a/packages/google-cloud-ces/google/cloud/ces_v1beta/__init__.py
+++ b/packages/google-cloud-ces/google/cloud/ces_v1beta/__init__.py
@@ -323,7 +323,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -352,9 +352,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-ces/setup.py b/packages/google-cloud-ces/setup.py
index c0021061dc76..ae05fd05f157 100644
--- a/packages/google-cloud-ces/setup.py
+++ b/packages/google-cloud-ces/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/ces/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-ces"
diff --git a/packages/google-cloud-ces/testing/constraints-3.10.txt b/packages/google-cloud-ces/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-ces/testing/constraints-3.10.txt
+++ b/packages/google-cloud-ces/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-ces/testing/constraints-3.13.txt b/packages/google-cloud-ces/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-ces/testing/constraints-3.13.txt
+++ b/packages/google-cloud-ces/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-ces/testing/constraints-3.14.txt b/packages/google-cloud-ces/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-ces/testing/constraints-3.14.txt
+++ b/packages/google-cloud-ces/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-channel/google/cloud/channel_v1/__init__.py b/packages/google-cloud-channel/google/cloud/channel_v1/__init__.py
index ce16ca721c7b..2e4febbe9be0 100644
--- a/packages/google-cloud-channel/google/cloud/channel_v1/__init__.py
+++ b/packages/google-cloud-channel/google/cloud/channel_v1/__init__.py
@@ -206,7 +206,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -235,9 +235,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-channel/setup.py b/packages/google-cloud-channel/setup.py
index 9e84aea01f00..1afbcbfe20c7 100644
--- a/packages/google-cloud-channel/setup.py
+++ b/packages/google-cloud-channel/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/channel/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-channel"
diff --git a/packages/google-cloud-channel/testing/constraints-3.10.txt b/packages/google-cloud-channel/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-channel/testing/constraints-3.10.txt
+++ b/packages/google-cloud-channel/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-channel/testing/constraints-3.13.txt b/packages/google-cloud-channel/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-channel/testing/constraints-3.13.txt
+++ b/packages/google-cloud-channel/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-channel/testing/constraints-3.14.txt b/packages/google-cloud-channel/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-channel/testing/constraints-3.14.txt
+++ b/packages/google-cloud-channel/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-chronicle/google/cloud/chronicle_v1/__init__.py b/packages/google-cloud-chronicle/google/cloud/chronicle_v1/__init__.py
index 8071d407990a..8f93142f2184 100644
--- a/packages/google-cloud-chronicle/google/cloud/chronicle_v1/__init__.py
+++ b/packages/google-cloud-chronicle/google/cloud/chronicle_v1/__init__.py
@@ -272,7 +272,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -301,9 +301,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-chronicle/setup.py b/packages/google-cloud-chronicle/setup.py
index 238ccb8ccf34..3f2b220e1ab8 100644
--- a/packages/google-cloud-chronicle/setup.py
+++ b/packages/google-cloud-chronicle/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/chronicle/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-chronicle"
diff --git a/packages/google-cloud-chronicle/testing/constraints-3.10.txt b/packages/google-cloud-chronicle/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-chronicle/testing/constraints-3.10.txt
+++ b/packages/google-cloud-chronicle/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-chronicle/testing/constraints-3.13.txt b/packages/google-cloud-chronicle/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-chronicle/testing/constraints-3.13.txt
+++ b/packages/google-cloud-chronicle/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-chronicle/testing/constraints-3.14.txt b/packages/google-cloud-chronicle/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-chronicle/testing/constraints-3.14.txt
+++ b/packages/google-cloud-chronicle/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-cloudcontrolspartner/google/cloud/cloudcontrolspartner_v1/__init__.py b/packages/google-cloud-cloudcontrolspartner/google/cloud/cloudcontrolspartner_v1/__init__.py
index 4e6790a72b2b..c74ef86bb85b 100644
--- a/packages/google-cloud-cloudcontrolspartner/google/cloud/cloudcontrolspartner_v1/__init__.py
+++ b/packages/google-cloud-cloudcontrolspartner/google/cloud/cloudcontrolspartner_v1/__init__.py
@@ -97,7 +97,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -126,9 +126,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-cloudcontrolspartner/google/cloud/cloudcontrolspartner_v1beta/__init__.py b/packages/google-cloud-cloudcontrolspartner/google/cloud/cloudcontrolspartner_v1beta/__init__.py
index 8590404f6d30..d6d3909103ab 100644
--- a/packages/google-cloud-cloudcontrolspartner/google/cloud/cloudcontrolspartner_v1beta/__init__.py
+++ b/packages/google-cloud-cloudcontrolspartner/google/cloud/cloudcontrolspartner_v1beta/__init__.py
@@ -97,7 +97,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -126,9 +126,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-cloudcontrolspartner/setup.py b/packages/google-cloud-cloudcontrolspartner/setup.py
index 72d0d864e14f..9392a65c36b8 100644
--- a/packages/google-cloud-cloudcontrolspartner/setup.py
+++ b/packages/google-cloud-cloudcontrolspartner/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/cloudcontrolspartner/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-cloudcontrolspartner"
diff --git a/packages/google-cloud-cloudcontrolspartner/testing/constraints-3.10.txt b/packages/google-cloud-cloudcontrolspartner/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-cloudcontrolspartner/testing/constraints-3.10.txt
+++ b/packages/google-cloud-cloudcontrolspartner/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-cloudcontrolspartner/testing/constraints-3.13.txt b/packages/google-cloud-cloudcontrolspartner/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-cloudcontrolspartner/testing/constraints-3.13.txt
+++ b/packages/google-cloud-cloudcontrolspartner/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-cloudcontrolspartner/testing/constraints-3.14.txt b/packages/google-cloud-cloudcontrolspartner/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-cloudcontrolspartner/testing/constraints-3.14.txt
+++ b/packages/google-cloud-cloudcontrolspartner/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-cloudsecuritycompliance/google/cloud/cloudsecuritycompliance_v1/__init__.py b/packages/google-cloud-cloudsecuritycompliance/google/cloud/cloudsecuritycompliance_v1/__init__.py
index c465e2600544..22965128f440 100644
--- a/packages/google-cloud-cloudsecuritycompliance/google/cloud/cloudsecuritycompliance_v1/__init__.py
+++ b/packages/google-cloud-cloudsecuritycompliance/google/cloud/cloudsecuritycompliance_v1/__init__.py
@@ -172,7 +172,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -201,9 +201,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-cloudsecuritycompliance/setup.py b/packages/google-cloud-cloudsecuritycompliance/setup.py
index 4ed3b0065cf7..89a604ff4594 100644
--- a/packages/google-cloud-cloudsecuritycompliance/setup.py
+++ b/packages/google-cloud-cloudsecuritycompliance/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/cloudsecuritycompliance/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-cloudsecuritycompliance"
diff --git a/packages/google-cloud-cloudsecuritycompliance/testing/constraints-3.10.txt b/packages/google-cloud-cloudsecuritycompliance/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-cloudsecuritycompliance/testing/constraints-3.10.txt
+++ b/packages/google-cloud-cloudsecuritycompliance/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-cloudsecuritycompliance/testing/constraints-3.13.txt b/packages/google-cloud-cloudsecuritycompliance/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-cloudsecuritycompliance/testing/constraints-3.13.txt
+++ b/packages/google-cloud-cloudsecuritycompliance/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-cloudsecuritycompliance/testing/constraints-3.14.txt b/packages/google-cloud-cloudsecuritycompliance/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-cloudsecuritycompliance/testing/constraints-3.14.txt
+++ b/packages/google-cloud-cloudsecuritycompliance/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-commerce-consumer-procurement/google/cloud/commerce_consumer_procurement_v1/__init__.py b/packages/google-cloud-commerce-consumer-procurement/google/cloud/commerce_consumer_procurement_v1/__init__.py
index 8c4c417007ba..d2481ac5e736 100644
--- a/packages/google-cloud-commerce-consumer-procurement/google/cloud/commerce_consumer_procurement_v1/__init__.py
+++ b/packages/google-cloud-commerce-consumer-procurement/google/cloud/commerce_consumer_procurement_v1/__init__.py
@@ -95,7 +95,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -124,9 +124,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-commerce-consumer-procurement/google/cloud/commerce_consumer_procurement_v1alpha1/__init__.py b/packages/google-cloud-commerce-consumer-procurement/google/cloud/commerce_consumer_procurement_v1alpha1/__init__.py
index 6b270a80f0cb..6803c631478d 100644
--- a/packages/google-cloud-commerce-consumer-procurement/google/cloud/commerce_consumer_procurement_v1alpha1/__init__.py
+++ b/packages/google-cloud-commerce-consumer-procurement/google/cloud/commerce_consumer_procurement_v1alpha1/__init__.py
@@ -75,7 +75,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -104,9 +104,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-commerce-consumer-procurement/setup.py b/packages/google-cloud-commerce-consumer-procurement/setup.py
index c4dca6e9f508..56051acd776b 100644
--- a/packages/google-cloud-commerce-consumer-procurement/setup.py
+++ b/packages/google-cloud-commerce-consumer-procurement/setup.py
@@ -33,7 +33,10 @@
         package_root, "google/cloud/commerce_consumer_procurement/gapic_version.py"
     )
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -43,15 +46,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-commerce-consumer-procurement"
diff --git a/packages/google-cloud-commerce-consumer-procurement/testing/constraints-3.10.txt b/packages/google-cloud-commerce-consumer-procurement/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-commerce-consumer-procurement/testing/constraints-3.10.txt
+++ b/packages/google-cloud-commerce-consumer-procurement/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-commerce-consumer-procurement/testing/constraints-3.13.txt b/packages/google-cloud-commerce-consumer-procurement/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-commerce-consumer-procurement/testing/constraints-3.13.txt
+++ b/packages/google-cloud-commerce-consumer-procurement/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-commerce-consumer-procurement/testing/constraints-3.14.txt b/packages/google-cloud-commerce-consumer-procurement/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-commerce-consumer-procurement/testing/constraints-3.14.txt
+++ b/packages/google-cloud-commerce-consumer-procurement/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-common/google/cloud/common/__init__.py b/packages/google-cloud-common/google/cloud/common/__init__.py
index 8d1f2e3a214b..fa4cf61f8479 100644
--- a/packages/google-cloud-common/google/cloud/common/__init__.py
+++ b/packages/google-cloud-common/google/cloud/common/__init__.py
@@ -50,7 +50,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -79,9 +79,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-common/setup.py b/packages/google-cloud-common/setup.py
index 1e5cbf370808..9572242780c0 100644
--- a/packages/google-cloud-common/setup.py
+++ b/packages/google-cloud-common/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/common/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-common"
diff --git a/packages/google-cloud-common/testing/constraints-3.10.txt b/packages/google-cloud-common/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-common/testing/constraints-3.10.txt
+++ b/packages/google-cloud-common/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-common/testing/constraints-3.13.txt b/packages/google-cloud-common/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-common/testing/constraints-3.13.txt
+++ b/packages/google-cloud-common/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-common/testing/constraints-3.14.txt b/packages/google-cloud-common/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-common/testing/constraints-3.14.txt
+++ b/packages/google-cloud-common/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-compute-v1beta/google/cloud/compute_v1beta/__init__.py b/packages/google-cloud-compute-v1beta/google/cloud/compute_v1beta/__init__.py
index 0ed7374600c0..6d9e0eafb450 100644
--- a/packages/google-cloud-compute-v1beta/google/cloud/compute_v1beta/__init__.py
+++ b/packages/google-cloud-compute-v1beta/google/cloud/compute_v1beta/__init__.py
@@ -2369,7 +2369,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -2398,9 +2398,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-compute-v1beta/setup.py b/packages/google-cloud-compute-v1beta/setup.py
index 36f6a285726e..9aa231a17583 100644
--- a/packages/google-cloud-compute-v1beta/setup.py
+++ b/packages/google-cloud-compute-v1beta/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/compute_v1beta/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-compute-v1beta"
diff --git a/packages/google-cloud-compute-v1beta/testing/constraints-3.10.txt b/packages/google-cloud-compute-v1beta/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-compute-v1beta/testing/constraints-3.10.txt
+++ b/packages/google-cloud-compute-v1beta/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-compute-v1beta/testing/constraints-3.13.txt b/packages/google-cloud-compute-v1beta/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-compute-v1beta/testing/constraints-3.13.txt
+++ b/packages/google-cloud-compute-v1beta/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-compute-v1beta/testing/constraints-3.14.txt b/packages/google-cloud-compute-v1beta/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-compute-v1beta/testing/constraints-3.14.txt
+++ b/packages/google-cloud-compute-v1beta/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-compute/google/cloud/compute_v1/__init__.py b/packages/google-cloud-compute/google/cloud/compute_v1/__init__.py
index 79e76a65d034..f66c8a775ee4 100644
--- a/packages/google-cloud-compute/google/cloud/compute_v1/__init__.py
+++ b/packages/google-cloud-compute/google/cloud/compute_v1/__init__.py
@@ -2183,7 +2183,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -2212,9 +2212,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-compute/setup.py b/packages/google-cloud-compute/setup.py
index 3cf505112844..7726d6d12e62 100644
--- a/packages/google-cloud-compute/setup.py
+++ b/packages/google-cloud-compute/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/compute/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-compute"
diff --git a/packages/google-cloud-compute/testing/constraints-3.10.txt b/packages/google-cloud-compute/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-compute/testing/constraints-3.10.txt
+++ b/packages/google-cloud-compute/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-compute/testing/constraints-3.13.txt b/packages/google-cloud-compute/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-compute/testing/constraints-3.13.txt
+++ b/packages/google-cloud-compute/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-compute/testing/constraints-3.14.txt b/packages/google-cloud-compute/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-compute/testing/constraints-3.14.txt
+++ b/packages/google-cloud-compute/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-confidentialcomputing/google/cloud/confidentialcomputing_v1/__init__.py b/packages/google-cloud-confidentialcomputing/google/cloud/confidentialcomputing_v1/__init__.py
index f4e46fd93655..82c322de5274 100644
--- a/packages/google-cloud-confidentialcomputing/google/cloud/confidentialcomputing_v1/__init__.py
+++ b/packages/google-cloud-confidentialcomputing/google/cloud/confidentialcomputing_v1/__init__.py
@@ -78,7 +78,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -107,9 +107,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-confidentialcomputing/setup.py b/packages/google-cloud-confidentialcomputing/setup.py
index f91a86958f03..d1ce807c115e 100644
--- a/packages/google-cloud-confidentialcomputing/setup.py
+++ b/packages/google-cloud-confidentialcomputing/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/confidentialcomputing/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-confidentialcomputing"
diff --git a/packages/google-cloud-confidentialcomputing/testing/constraints-3.10.txt b/packages/google-cloud-confidentialcomputing/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-confidentialcomputing/testing/constraints-3.10.txt
+++ b/packages/google-cloud-confidentialcomputing/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-confidentialcomputing/testing/constraints-3.13.txt b/packages/google-cloud-confidentialcomputing/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-confidentialcomputing/testing/constraints-3.13.txt
+++ b/packages/google-cloud-confidentialcomputing/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-confidentialcomputing/testing/constraints-3.14.txt b/packages/google-cloud-confidentialcomputing/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-confidentialcomputing/testing/constraints-3.14.txt
+++ b/packages/google-cloud-confidentialcomputing/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-config/google/cloud/config_v1/__init__.py b/packages/google-cloud-config/google/cloud/config_v1/__init__.py
index c95023ad8a58..7632712ba10d 100644
--- a/packages/google-cloud-config/google/cloud/config_v1/__init__.py
+++ b/packages/google-cloud-config/google/cloud/config_v1/__init__.py
@@ -138,7 +138,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -167,9 +167,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-config/setup.py b/packages/google-cloud-config/setup.py
index 0fe433100501..9ee4a6723db2 100644
--- a/packages/google-cloud-config/setup.py
+++ b/packages/google-cloud-config/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/config/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-config"
diff --git a/packages/google-cloud-config/testing/constraints-3.10.txt b/packages/google-cloud-config/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-config/testing/constraints-3.10.txt
+++ b/packages/google-cloud-config/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-config/testing/constraints-3.13.txt b/packages/google-cloud-config/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-config/testing/constraints-3.13.txt
+++ b/packages/google-cloud-config/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-config/testing/constraints-3.14.txt b/packages/google-cloud-config/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-config/testing/constraints-3.14.txt
+++ b/packages/google-cloud-config/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-configdelivery/google/cloud/configdelivery_v1/__init__.py b/packages/google-cloud-configdelivery/google/cloud/configdelivery_v1/__init__.py
index 61603789d0e2..7200700d54f5 100644
--- a/packages/google-cloud-configdelivery/google/cloud/configdelivery_v1/__init__.py
+++ b/packages/google-cloud-configdelivery/google/cloud/configdelivery_v1/__init__.py
@@ -102,7 +102,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -131,9 +131,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-configdelivery/google/cloud/configdelivery_v1alpha/__init__.py b/packages/google-cloud-configdelivery/google/cloud/configdelivery_v1alpha/__init__.py
index f83b190b41e7..4b367f4b7ea1 100644
--- a/packages/google-cloud-configdelivery/google/cloud/configdelivery_v1alpha/__init__.py
+++ b/packages/google-cloud-configdelivery/google/cloud/configdelivery_v1alpha/__init__.py
@@ -102,7 +102,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -131,9 +131,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-configdelivery/google/cloud/configdelivery_v1beta/__init__.py b/packages/google-cloud-configdelivery/google/cloud/configdelivery_v1beta/__init__.py
index 7571ad9598a6..909ff28b09be 100644
--- a/packages/google-cloud-configdelivery/google/cloud/configdelivery_v1beta/__init__.py
+++ b/packages/google-cloud-configdelivery/google/cloud/configdelivery_v1beta/__init__.py
@@ -102,7 +102,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -131,9 +131,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-configdelivery/setup.py b/packages/google-cloud-configdelivery/setup.py
index 61419b531d46..626e8eec7d17 100644
--- a/packages/google-cloud-configdelivery/setup.py
+++ b/packages/google-cloud-configdelivery/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/configdelivery/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-configdelivery"
diff --git a/packages/google-cloud-configdelivery/testing/constraints-3.10.txt b/packages/google-cloud-configdelivery/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-configdelivery/testing/constraints-3.10.txt
+++ b/packages/google-cloud-configdelivery/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-configdelivery/testing/constraints-3.13.txt b/packages/google-cloud-configdelivery/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-configdelivery/testing/constraints-3.13.txt
+++ b/packages/google-cloud-configdelivery/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-configdelivery/testing/constraints-3.14.txt b/packages/google-cloud-configdelivery/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-configdelivery/testing/constraints-3.14.txt
+++ b/packages/google-cloud-configdelivery/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-contact-center-insights/google/cloud/contact_center_insights_v1/__init__.py b/packages/google-cloud-contact-center-insights/google/cloud/contact_center_insights_v1/__init__.py
index 98fc38e51452..d9ce6c12e7c1 100644
--- a/packages/google-cloud-contact-center-insights/google/cloud/contact_center_insights_v1/__init__.py
+++ b/packages/google-cloud-contact-center-insights/google/cloud/contact_center_insights_v1/__init__.py
@@ -231,7 +231,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -260,9 +260,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-contact-center-insights/setup.py b/packages/google-cloud-contact-center-insights/setup.py
index f9d7d118c5e5..fae0aaf7f5a3 100644
--- a/packages/google-cloud-contact-center-insights/setup.py
+++ b/packages/google-cloud-contact-center-insights/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/contact_center_insights/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-contact-center-insights"
diff --git a/packages/google-cloud-contact-center-insights/testing/constraints-3.10.txt b/packages/google-cloud-contact-center-insights/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-contact-center-insights/testing/constraints-3.10.txt
+++ b/packages/google-cloud-contact-center-insights/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-contact-center-insights/testing/constraints-3.13.txt b/packages/google-cloud-contact-center-insights/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-contact-center-insights/testing/constraints-3.13.txt
+++ b/packages/google-cloud-contact-center-insights/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-contact-center-insights/testing/constraints-3.14.txt b/packages/google-cloud-contact-center-insights/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-contact-center-insights/testing/constraints-3.14.txt
+++ b/packages/google-cloud-contact-center-insights/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-container/google/cloud/container_v1/__init__.py b/packages/google-cloud-container/google/cloud/container_v1/__init__.py
index b5f5f5dc023c..462aa79c68e6 100644
--- a/packages/google-cloud-container/google/cloud/container_v1/__init__.py
+++ b/packages/google-cloud-container/google/cloud/container_v1/__init__.py
@@ -274,7 +274,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -303,9 +303,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-container/google/cloud/container_v1beta1/__init__.py b/packages/google-cloud-container/google/cloud/container_v1beta1/__init__.py
index 8f909159b0b6..6ff7ecec793f 100644
--- a/packages/google-cloud-container/google/cloud/container_v1beta1/__init__.py
+++ b/packages/google-cloud-container/google/cloud/container_v1beta1/__init__.py
@@ -295,7 +295,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -324,9 +324,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-container/setup.py b/packages/google-cloud-container/setup.py
index afad62d98b9c..507acea00403 100644
--- a/packages/google-cloud-container/setup.py
+++ b/packages/google-cloud-container/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/container/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-container"
diff --git a/packages/google-cloud-container/testing/constraints-3.10.txt b/packages/google-cloud-container/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-container/testing/constraints-3.10.txt
+++ b/packages/google-cloud-container/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-container/testing/constraints-3.13.txt b/packages/google-cloud-container/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-container/testing/constraints-3.13.txt
+++ b/packages/google-cloud-container/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-container/testing/constraints-3.14.txt b/packages/google-cloud-container/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-container/testing/constraints-3.14.txt
+++ b/packages/google-cloud-container/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-containeranalysis/google/cloud/devtools/containeranalysis_v1/__init__.py b/packages/google-cloud-containeranalysis/google/cloud/devtools/containeranalysis_v1/__init__.py
index ef77b86ef531..145d9c9b86d3 100644
--- a/packages/google-cloud-containeranalysis/google/cloud/devtools/containeranalysis_v1/__init__.py
+++ b/packages/google-cloud-containeranalysis/google/cloud/devtools/containeranalysis_v1/__init__.py
@@ -59,7 +59,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -88,9 +88,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-containeranalysis/setup.py b/packages/google-cloud-containeranalysis/setup.py
index 7c49cf1731a0..2402207f279b 100644
--- a/packages/google-cloud-containeranalysis/setup.py
+++ b/packages/google-cloud-containeranalysis/setup.py
@@ -33,7 +33,10 @@
         package_root, "google/cloud/devtools/containeranalysis/gapic_version.py"
     )
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -43,17 +46,16 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grafeas >=1.7.0, <2.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-containeranalysis"
diff --git a/packages/google-cloud-containeranalysis/testing/constraints-3.10.txt b/packages/google-cloud-containeranalysis/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-containeranalysis/testing/constraints-3.10.txt
+++ b/packages/google-cloud-containeranalysis/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-containeranalysis/testing/constraints-3.13.txt b/packages/google-cloud-containeranalysis/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-containeranalysis/testing/constraints-3.13.txt
+++ b/packages/google-cloud-containeranalysis/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-containeranalysis/testing/constraints-3.14.txt b/packages/google-cloud-containeranalysis/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-containeranalysis/testing/constraints-3.14.txt
+++ b/packages/google-cloud-containeranalysis/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-contentwarehouse/google/cloud/contentwarehouse_v1/__init__.py b/packages/google-cloud-contentwarehouse/google/cloud/contentwarehouse_v1/__init__.py
index 33a650da1a10..7297cb7b399c 100644
--- a/packages/google-cloud-contentwarehouse/google/cloud/contentwarehouse_v1/__init__.py
+++ b/packages/google-cloud-contentwarehouse/google/cloud/contentwarehouse_v1/__init__.py
@@ -204,7 +204,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -233,9 +233,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-contentwarehouse/setup.py b/packages/google-cloud-contentwarehouse/setup.py
index 2dfccc30ac23..a3fc187795e1 100644
--- a/packages/google-cloud-contentwarehouse/setup.py
+++ b/packages/google-cloud-contentwarehouse/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/contentwarehouse/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,17 +44,16 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "google-cloud-documentai >= 2.4.1, <4.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "google-cloud-documentai >= 3.2.1, <4.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-contentwarehouse"
diff --git a/packages/google-cloud-contentwarehouse/testing/constraints-3.10.txt b/packages/google-cloud-contentwarehouse/testing/constraints-3.10.txt
index 8b0bfae23e7f..ea87757c3942 100644
--- a/packages/google-cloud-contentwarehouse/testing/constraints-3.10.txt
+++ b/packages/google-cloud-contentwarehouse/testing/constraints-3.10.txt
@@ -4,10 +4,10 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-google-cloud-documentai==2.4.1
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+google-cloud-documentai==3.2.1
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-contentwarehouse/testing/constraints-3.13.txt b/packages/google-cloud-contentwarehouse/testing/constraints-3.13.txt
index fc148ee44beb..daf20eb644e0 100644
--- a/packages/google-cloud-contentwarehouse/testing/constraints-3.13.txt
+++ b/packages/google-cloud-contentwarehouse/testing/constraints-3.13.txt
@@ -9,6 +9,6 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-cloud-documentai>=3
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-contentwarehouse/testing/constraints-3.14.txt b/packages/google-cloud-contentwarehouse/testing/constraints-3.14.txt
index fc148ee44beb..daf20eb644e0 100644
--- a/packages/google-cloud-contentwarehouse/testing/constraints-3.14.txt
+++ b/packages/google-cloud-contentwarehouse/testing/constraints-3.14.txt
@@ -9,6 +9,6 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-cloud-documentai>=3
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-data-fusion/google/cloud/data_fusion_v1/__init__.py b/packages/google-cloud-data-fusion/google/cloud/data_fusion_v1/__init__.py
index 78328c8d509b..c78083bfbc09 100644
--- a/packages/google-cloud-data-fusion/google/cloud/data_fusion_v1/__init__.py
+++ b/packages/google-cloud-data-fusion/google/cloud/data_fusion_v1/__init__.py
@@ -67,7 +67,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -96,9 +96,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-data-fusion/setup.py b/packages/google-cloud-data-fusion/setup.py
index e885b43b28a4..9a4d5c6a0ec8 100644
--- a/packages/google-cloud-data-fusion/setup.py
+++ b/packages/google-cloud-data-fusion/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/data_fusion/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-data-fusion"
diff --git a/packages/google-cloud-data-fusion/testing/constraints-3.10.txt b/packages/google-cloud-data-fusion/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-data-fusion/testing/constraints-3.10.txt
+++ b/packages/google-cloud-data-fusion/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-data-fusion/testing/constraints-3.13.txt b/packages/google-cloud-data-fusion/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-data-fusion/testing/constraints-3.13.txt
+++ b/packages/google-cloud-data-fusion/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-data-fusion/testing/constraints-3.14.txt b/packages/google-cloud-data-fusion/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-data-fusion/testing/constraints-3.14.txt
+++ b/packages/google-cloud-data-fusion/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-data-qna/google/cloud/dataqna_v1alpha/__init__.py b/packages/google-cloud-data-qna/google/cloud/dataqna_v1alpha/__init__.py
index bfb33f772ea1..a9900d44e191 100644
--- a/packages/google-cloud-data-qna/google/cloud/dataqna_v1alpha/__init__.py
+++ b/packages/google-cloud-data-qna/google/cloud/dataqna_v1alpha/__init__.py
@@ -82,7 +82,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -111,9 +111,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-data-qna/setup.py b/packages/google-cloud-data-qna/setup.py
index 680a0e811f7e..61963741f6c3 100644
--- a/packages/google-cloud-data-qna/setup.py
+++ b/packages/google-cloud-data-qna/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/dataqna/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-data-qna"
diff --git a/packages/google-cloud-data-qna/testing/constraints-3.10.txt b/packages/google-cloud-data-qna/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-data-qna/testing/constraints-3.10.txt
+++ b/packages/google-cloud-data-qna/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-data-qna/testing/constraints-3.13.txt b/packages/google-cloud-data-qna/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-data-qna/testing/constraints-3.13.txt
+++ b/packages/google-cloud-data-qna/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-data-qna/testing/constraints-3.14.txt b/packages/google-cloud-data-qna/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-data-qna/testing/constraints-3.14.txt
+++ b/packages/google-cloud-data-qna/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-databasecenter/google/cloud/databasecenter_v1beta/__init__.py b/packages/google-cloud-databasecenter/google/cloud/databasecenter_v1beta/__init__.py
index 85d7aa68fe13..3cb441b01ec6 100644
--- a/packages/google-cloud-databasecenter/google/cloud/databasecenter_v1beta/__init__.py
+++ b/packages/google-cloud-databasecenter/google/cloud/databasecenter_v1beta/__init__.py
@@ -124,7 +124,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -153,9 +153,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-databasecenter/setup.py b/packages/google-cloud-databasecenter/setup.py
index 1dd5154980d1..935696dce31e 100644
--- a/packages/google-cloud-databasecenter/setup.py
+++ b/packages/google-cloud-databasecenter/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/databasecenter/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-databasecenter"
diff --git a/packages/google-cloud-databasecenter/testing/constraints-3.10.txt b/packages/google-cloud-databasecenter/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-databasecenter/testing/constraints-3.10.txt
+++ b/packages/google-cloud-databasecenter/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-databasecenter/testing/constraints-3.13.txt b/packages/google-cloud-databasecenter/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-databasecenter/testing/constraints-3.13.txt
+++ b/packages/google-cloud-databasecenter/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-databasecenter/testing/constraints-3.14.txt b/packages/google-cloud-databasecenter/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-databasecenter/testing/constraints-3.14.txt
+++ b/packages/google-cloud-databasecenter/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-datacatalog-lineage-configmanagement/google/cloud/datacatalog_lineage_configmanagement_v1/__init__.py b/packages/google-cloud-datacatalog-lineage-configmanagement/google/cloud/datacatalog_lineage_configmanagement_v1/__init__.py
index 45e0f1ba4a1d..548a0083e0ef 100644
--- a/packages/google-cloud-datacatalog-lineage-configmanagement/google/cloud/datacatalog_lineage_configmanagement_v1/__init__.py
+++ b/packages/google-cloud-datacatalog-lineage-configmanagement/google/cloud/datacatalog_lineage_configmanagement_v1/__init__.py
@@ -60,7 +60,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -89,9 +89,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-datacatalog-lineage-configmanagement/setup.py b/packages/google-cloud-datacatalog-lineage-configmanagement/setup.py
index 383994524bfc..f0c08ce28e78 100644
--- a/packages/google-cloud-datacatalog-lineage-configmanagement/setup.py
+++ b/packages/google-cloud-datacatalog-lineage-configmanagement/setup.py
@@ -34,7 +34,10 @@
         "google/cloud/datacatalog_lineage_configmanagement/gapic_version.py",
     )
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -44,15 +47,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-datacatalog-lineage-configmanagement"
diff --git a/packages/google-cloud-datacatalog-lineage-configmanagement/testing/constraints-3.10.txt b/packages/google-cloud-datacatalog-lineage-configmanagement/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-datacatalog-lineage-configmanagement/testing/constraints-3.10.txt
+++ b/packages/google-cloud-datacatalog-lineage-configmanagement/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-datacatalog-lineage-configmanagement/testing/constraints-3.13.txt b/packages/google-cloud-datacatalog-lineage-configmanagement/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-datacatalog-lineage-configmanagement/testing/constraints-3.13.txt
+++ b/packages/google-cloud-datacatalog-lineage-configmanagement/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-datacatalog-lineage-configmanagement/testing/constraints-3.14.txt b/packages/google-cloud-datacatalog-lineage-configmanagement/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-datacatalog-lineage-configmanagement/testing/constraints-3.14.txt
+++ b/packages/google-cloud-datacatalog-lineage-configmanagement/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-datacatalog-lineage/google/cloud/datacatalog_lineage_v1/__init__.py b/packages/google-cloud-datacatalog-lineage/google/cloud/datacatalog_lineage_v1/__init__.py
index a3c913d09c18..8d46559e3ecb 100644
--- a/packages/google-cloud-datacatalog-lineage/google/cloud/datacatalog_lineage_v1/__init__.py
+++ b/packages/google-cloud-datacatalog-lineage/google/cloud/datacatalog_lineage_v1/__init__.py
@@ -91,7 +91,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -120,9 +120,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-datacatalog-lineage/setup.py b/packages/google-cloud-datacatalog-lineage/setup.py
index d2326fe061e9..02c5bd3d9593 100644
--- a/packages/google-cloud-datacatalog-lineage/setup.py
+++ b/packages/google-cloud-datacatalog-lineage/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/datacatalog_lineage/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-datacatalog-lineage"
diff --git a/packages/google-cloud-datacatalog-lineage/testing/constraints-3.10.txt b/packages/google-cloud-datacatalog-lineage/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-datacatalog-lineage/testing/constraints-3.10.txt
+++ b/packages/google-cloud-datacatalog-lineage/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-datacatalog-lineage/testing/constraints-3.13.txt b/packages/google-cloud-datacatalog-lineage/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-datacatalog-lineage/testing/constraints-3.13.txt
+++ b/packages/google-cloud-datacatalog-lineage/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-datacatalog-lineage/testing/constraints-3.14.txt b/packages/google-cloud-datacatalog-lineage/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-datacatalog-lineage/testing/constraints-3.14.txt
+++ b/packages/google-cloud-datacatalog-lineage/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-datacatalog/google/cloud/datacatalog_v1/__init__.py b/packages/google-cloud-datacatalog/google/cloud/datacatalog_v1/__init__.py
index b43453e73c88..750234275869 100644
--- a/packages/google-cloud-datacatalog/google/cloud/datacatalog_v1/__init__.py
+++ b/packages/google-cloud-datacatalog/google/cloud/datacatalog_v1/__init__.py
@@ -184,7 +184,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -213,9 +213,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-datacatalog/google/cloud/datacatalog_v1beta1/__init__.py b/packages/google-cloud-datacatalog/google/cloud/datacatalog_v1beta1/__init__.py
index 30a0de4cabb0..5636d837da3e 100644
--- a/packages/google-cloud-datacatalog/google/cloud/datacatalog_v1beta1/__init__.py
+++ b/packages/google-cloud-datacatalog/google/cloud/datacatalog_v1beta1/__init__.py
@@ -131,7 +131,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -160,9 +160,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-datacatalog/setup.py b/packages/google-cloud-datacatalog/setup.py
index 199f4daffb54..1550b4895931 100644
--- a/packages/google-cloud-datacatalog/setup.py
+++ b/packages/google-cloud-datacatalog/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/datacatalog/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-datacatalog"
diff --git a/packages/google-cloud-datacatalog/testing/constraints-3.10.txt b/packages/google-cloud-datacatalog/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-datacatalog/testing/constraints-3.10.txt
+++ b/packages/google-cloud-datacatalog/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-datacatalog/testing/constraints-3.13.txt b/packages/google-cloud-datacatalog/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-datacatalog/testing/constraints-3.13.txt
+++ b/packages/google-cloud-datacatalog/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-datacatalog/testing/constraints-3.14.txt b/packages/google-cloud-datacatalog/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-datacatalog/testing/constraints-3.14.txt
+++ b/packages/google-cloud-datacatalog/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-dataflow-client/google/cloud/dataflow_v1beta3/__init__.py b/packages/google-cloud-dataflow-client/google/cloud/dataflow_v1beta3/__init__.py
index 58baf9846f36..8942e1d18466 100644
--- a/packages/google-cloud-dataflow-client/google/cloud/dataflow_v1beta3/__init__.py
+++ b/packages/google-cloud-dataflow-client/google/cloud/dataflow_v1beta3/__init__.py
@@ -197,7 +197,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -226,9 +226,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-dataflow-client/setup.py b/packages/google-cloud-dataflow-client/setup.py
index f64881ee3409..e2e70a586f98 100644
--- a/packages/google-cloud-dataflow-client/setup.py
+++ b/packages/google-cloud-dataflow-client/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/dataflow/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-dataflow-client"
diff --git a/packages/google-cloud-dataflow-client/testing/constraints-3.10.txt b/packages/google-cloud-dataflow-client/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-dataflow-client/testing/constraints-3.10.txt
+++ b/packages/google-cloud-dataflow-client/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-dataflow-client/testing/constraints-3.13.txt b/packages/google-cloud-dataflow-client/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-dataflow-client/testing/constraints-3.13.txt
+++ b/packages/google-cloud-dataflow-client/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-dataflow-client/testing/constraints-3.14.txt b/packages/google-cloud-dataflow-client/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-dataflow-client/testing/constraints-3.14.txt
+++ b/packages/google-cloud-dataflow-client/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-dataform/google/cloud/dataform_v1/__init__.py b/packages/google-cloud-dataform/google/cloud/dataform_v1/__init__.py
index 268b5c5ba09d..c8e83474dacb 100644
--- a/packages/google-cloud-dataform/google/cloud/dataform_v1/__init__.py
+++ b/packages/google-cloud-dataform/google/cloud/dataform_v1/__init__.py
@@ -188,7 +188,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -217,9 +217,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-dataform/google/cloud/dataform_v1beta1/__init__.py b/packages/google-cloud-dataform/google/cloud/dataform_v1beta1/__init__.py
index d83bf644c121..097c288f8006 100644
--- a/packages/google-cloud-dataform/google/cloud/dataform_v1beta1/__init__.py
+++ b/packages/google-cloud-dataform/google/cloud/dataform_v1beta1/__init__.py
@@ -183,7 +183,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -212,9 +212,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-dataform/setup.py b/packages/google-cloud-dataform/setup.py
index 3b2562f571fd..3f18e5c500f6 100644
--- a/packages/google-cloud-dataform/setup.py
+++ b/packages/google-cloud-dataform/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/dataform/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-dataform"
diff --git a/packages/google-cloud-dataform/testing/constraints-3.10.txt b/packages/google-cloud-dataform/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-dataform/testing/constraints-3.10.txt
+++ b/packages/google-cloud-dataform/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-dataform/testing/constraints-3.13.txt b/packages/google-cloud-dataform/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-dataform/testing/constraints-3.13.txt
+++ b/packages/google-cloud-dataform/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-dataform/testing/constraints-3.14.txt b/packages/google-cloud-dataform/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-dataform/testing/constraints-3.14.txt
+++ b/packages/google-cloud-dataform/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-datalabeling/google/cloud/datalabeling_v1beta1/__init__.py b/packages/google-cloud-datalabeling/google/cloud/datalabeling_v1beta1/__init__.py
index 4983f7dc0c2a..15b203a438af 100644
--- a/packages/google-cloud-datalabeling/google/cloud/datalabeling_v1beta1/__init__.py
+++ b/packages/google-cloud-datalabeling/google/cloud/datalabeling_v1beta1/__init__.py
@@ -196,7 +196,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -225,9 +225,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-datalabeling/setup.py b/packages/google-cloud-datalabeling/setup.py
index e32ddc444741..c9b782264427 100644
--- a/packages/google-cloud-datalabeling/setup.py
+++ b/packages/google-cloud-datalabeling/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/datalabeling/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-datalabeling"
diff --git a/packages/google-cloud-datalabeling/testing/constraints-3.10.txt b/packages/google-cloud-datalabeling/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-datalabeling/testing/constraints-3.10.txt
+++ b/packages/google-cloud-datalabeling/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-datalabeling/testing/constraints-3.13.txt b/packages/google-cloud-datalabeling/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-datalabeling/testing/constraints-3.13.txt
+++ b/packages/google-cloud-datalabeling/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-datalabeling/testing/constraints-3.14.txt b/packages/google-cloud-datalabeling/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-datalabeling/testing/constraints-3.14.txt
+++ b/packages/google-cloud-datalabeling/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-dataplex/google/cloud/dataplex_v1/__init__.py b/packages/google-cloud-dataplex/google/cloud/dataplex_v1/__init__.py
index f57d85ad0fe3..bade5997771d 100644
--- a/packages/google-cloud-dataplex/google/cloud/dataplex_v1/__init__.py
+++ b/packages/google-cloud-dataplex/google/cloud/dataplex_v1/__init__.py
@@ -313,7 +313,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -342,9 +342,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-dataplex/setup.py b/packages/google-cloud-dataplex/setup.py
index db1491be3ac3..71aaae470977 100644
--- a/packages/google-cloud-dataplex/setup.py
+++ b/packages/google-cloud-dataplex/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/dataplex/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-dataplex"
diff --git a/packages/google-cloud-dataplex/testing/constraints-3.10.txt b/packages/google-cloud-dataplex/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-dataplex/testing/constraints-3.10.txt
+++ b/packages/google-cloud-dataplex/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-dataplex/testing/constraints-3.13.txt b/packages/google-cloud-dataplex/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-dataplex/testing/constraints-3.13.txt
+++ b/packages/google-cloud-dataplex/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-dataplex/testing/constraints-3.14.txt b/packages/google-cloud-dataplex/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-dataplex/testing/constraints-3.14.txt
+++ b/packages/google-cloud-dataplex/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-dataproc-metastore/google/cloud/metastore_v1/__init__.py b/packages/google-cloud-dataproc-metastore/google/cloud/metastore_v1/__init__.py
index 17d0509ed010..80b613cf788b 100644
--- a/packages/google-cloud-dataproc-metastore/google/cloud/metastore_v1/__init__.py
+++ b/packages/google-cloud-dataproc-metastore/google/cloud/metastore_v1/__init__.py
@@ -112,7 +112,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -141,9 +141,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-dataproc-metastore/google/cloud/metastore_v1alpha/__init__.py b/packages/google-cloud-dataproc-metastore/google/cloud/metastore_v1alpha/__init__.py
index 72bbff3c4dff..b33d86e0f9d7 100644
--- a/packages/google-cloud-dataproc-metastore/google/cloud/metastore_v1alpha/__init__.py
+++ b/packages/google-cloud-dataproc-metastore/google/cloud/metastore_v1alpha/__init__.py
@@ -118,7 +118,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -147,9 +147,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-dataproc-metastore/google/cloud/metastore_v1beta/__init__.py b/packages/google-cloud-dataproc-metastore/google/cloud/metastore_v1beta/__init__.py
index f031c60faa7c..9e6521efc5b7 100644
--- a/packages/google-cloud-dataproc-metastore/google/cloud/metastore_v1beta/__init__.py
+++ b/packages/google-cloud-dataproc-metastore/google/cloud/metastore_v1beta/__init__.py
@@ -118,7 +118,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -147,9 +147,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-dataproc-metastore/setup.py b/packages/google-cloud-dataproc-metastore/setup.py
index b773b5a98b0d..9d60d24667eb 100644
--- a/packages/google-cloud-dataproc-metastore/setup.py
+++ b/packages/google-cloud-dataproc-metastore/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/metastore/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-dataproc-metastore"
diff --git a/packages/google-cloud-dataproc-metastore/testing/constraints-3.10.txt b/packages/google-cloud-dataproc-metastore/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-dataproc-metastore/testing/constraints-3.10.txt
+++ b/packages/google-cloud-dataproc-metastore/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-dataproc-metastore/testing/constraints-3.13.txt b/packages/google-cloud-dataproc-metastore/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-dataproc-metastore/testing/constraints-3.13.txt
+++ b/packages/google-cloud-dataproc-metastore/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-dataproc-metastore/testing/constraints-3.14.txt b/packages/google-cloud-dataproc-metastore/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-dataproc-metastore/testing/constraints-3.14.txt
+++ b/packages/google-cloud-dataproc-metastore/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-dataproc/google/cloud/dataproc_v1/__init__.py b/packages/google-cloud-dataproc/google/cloud/dataproc_v1/__init__.py
index 6b88a77379fa..0743d394c587 100644
--- a/packages/google-cloud-dataproc/google/cloud/dataproc_v1/__init__.py
+++ b/packages/google-cloud-dataproc/google/cloud/dataproc_v1/__init__.py
@@ -248,7 +248,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -277,9 +277,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-dataproc/setup.py b/packages/google-cloud-dataproc/setup.py
index 24eddbb83a43..76dd34fc8b49 100644
--- a/packages/google-cloud-dataproc/setup.py
+++ b/packages/google-cloud-dataproc/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/dataproc/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-dataproc"
diff --git a/packages/google-cloud-dataproc/testing/constraints-3.10.txt b/packages/google-cloud-dataproc/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-dataproc/testing/constraints-3.10.txt
+++ b/packages/google-cloud-dataproc/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-dataproc/testing/constraints-3.13.txt b/packages/google-cloud-dataproc/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-dataproc/testing/constraints-3.13.txt
+++ b/packages/google-cloud-dataproc/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-dataproc/testing/constraints-3.14.txt b/packages/google-cloud-dataproc/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-dataproc/testing/constraints-3.14.txt
+++ b/packages/google-cloud-dataproc/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-datastore/mypy.ini b/packages/google-cloud-datastore/mypy.ini
new file mode 100644
index 000000000000..e0e0da2e9e40
--- /dev/null
+++ b/packages/google-cloud-datastore/mypy.ini
@@ -0,0 +1,15 @@
+[mypy]
+python_version = 3.14
+namespace_packages = True
+ignore_missing_imports = False
+
+# TODO(https://github.com/googleapis/gapic-generator-python/issues/2563):
+# Dependencies that historically lacks py.typed markers
+[mypy-google.iam.*]
+ignore_missing_imports = True
+
+# Helps mypy navigate the 'google' namespace more reliably in 3.10+
+explicit_package_bases = True
+
+# Performance: reuse results from previous runs to speed up 'nox'
+incremental = True
diff --git a/packages/google-cloud-datastore/noxfile.py b/packages/google-cloud-datastore/noxfile.py
index 9e9c06b33b12..af42d740478e 100644
--- a/packages/google-cloud-datastore/noxfile.py
+++ b/packages/google-cloud-datastore/noxfile.py
@@ -46,8 +46,6 @@
 PREVIEW_PYTHON_VERSION = "3.14"
 
 CURRENT_DIRECTORY = pathlib.Path(__file__).parent.absolute()
-# Path to the centralized mypy configuration file at the repository root.
-MYPY_CONFIG_FILE = str(CURRENT_DIRECTORY.parent.parent / "mypy.ini")
 
 if (CURRENT_DIRECTORY / "testing").exists():
     LOWER_BOUND_CONSTRAINTS_FILE = (
@@ -109,7 +107,6 @@ def mypy(session):
     session.install(".")
     session.run(
         "mypy",
-        f"--config-file={MYPY_CONFIG_FILE}",
         "-p",
         "google",
         # TODO(https://github.com/googleapis/google-cloud-python/issues/16083)
diff --git a/packages/google-cloud-datastream/google/cloud/datastream_v1/__init__.py b/packages/google-cloud-datastream/google/cloud/datastream_v1/__init__.py
index 999476c4a595..1afa6550835e 100644
--- a/packages/google-cloud-datastream/google/cloud/datastream_v1/__init__.py
+++ b/packages/google-cloud-datastream/google/cloud/datastream_v1/__init__.py
@@ -164,7 +164,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -193,9 +193,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-datastream/google/cloud/datastream_v1alpha1/__init__.py b/packages/google-cloud-datastream/google/cloud/datastream_v1alpha1/__init__.py
index 7f645fd02506..ed581a7caeb2 100644
--- a/packages/google-cloud-datastream/google/cloud/datastream_v1alpha1/__init__.py
+++ b/packages/google-cloud-datastream/google/cloud/datastream_v1alpha1/__init__.py
@@ -117,7 +117,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -146,9 +146,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-datastream/setup.py b/packages/google-cloud-datastream/setup.py
index 215e519dc6c5..141a08c88cee 100644
--- a/packages/google-cloud-datastream/setup.py
+++ b/packages/google-cloud-datastream/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/datastream/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-datastream"
diff --git a/packages/google-cloud-datastream/testing/constraints-3.10.txt b/packages/google-cloud-datastream/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-datastream/testing/constraints-3.10.txt
+++ b/packages/google-cloud-datastream/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-datastream/testing/constraints-3.13.txt b/packages/google-cloud-datastream/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-datastream/testing/constraints-3.13.txt
+++ b/packages/google-cloud-datastream/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-datastream/testing/constraints-3.14.txt b/packages/google-cloud-datastream/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-datastream/testing/constraints-3.14.txt
+++ b/packages/google-cloud-datastream/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-deploy/google/cloud/deploy_v1/__init__.py b/packages/google-cloud-deploy/google/cloud/deploy_v1/__init__.py
index ecf53db6404a..ae086dd3f447 100644
--- a/packages/google-cloud-deploy/google/cloud/deploy_v1/__init__.py
+++ b/packages/google-cloud-deploy/google/cloud/deploy_v1/__init__.py
@@ -232,7 +232,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -261,9 +261,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-deploy/setup.py b/packages/google-cloud-deploy/setup.py
index 7637cd7081bf..e1a1fa50536c 100644
--- a/packages/google-cloud-deploy/setup.py
+++ b/packages/google-cloud-deploy/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/deploy/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-deploy"
diff --git a/packages/google-cloud-deploy/testing/constraints-3.10.txt b/packages/google-cloud-deploy/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-deploy/testing/constraints-3.10.txt
+++ b/packages/google-cloud-deploy/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-deploy/testing/constraints-3.13.txt b/packages/google-cloud-deploy/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-deploy/testing/constraints-3.13.txt
+++ b/packages/google-cloud-deploy/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-deploy/testing/constraints-3.14.txt b/packages/google-cloud-deploy/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-deploy/testing/constraints-3.14.txt
+++ b/packages/google-cloud-deploy/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-developerconnect/google/cloud/developerconnect_v1/__init__.py b/packages/google-cloud-developerconnect/google/cloud/developerconnect_v1/__init__.py
index 8e4b1016b04e..a5e7b35a4347 100644
--- a/packages/google-cloud-developerconnect/google/cloud/developerconnect_v1/__init__.py
+++ b/packages/google-cloud-developerconnect/google/cloud/developerconnect_v1/__init__.py
@@ -143,7 +143,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -172,9 +172,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-developerconnect/setup.py b/packages/google-cloud-developerconnect/setup.py
index aa6aca1f649f..2c50b79d2675 100644
--- a/packages/google-cloud-developerconnect/setup.py
+++ b/packages/google-cloud-developerconnect/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/developerconnect/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-developerconnect"
diff --git a/packages/google-cloud-developerconnect/testing/constraints-3.10.txt b/packages/google-cloud-developerconnect/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-developerconnect/testing/constraints-3.10.txt
+++ b/packages/google-cloud-developerconnect/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-developerconnect/testing/constraints-3.13.txt b/packages/google-cloud-developerconnect/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-developerconnect/testing/constraints-3.13.txt
+++ b/packages/google-cloud-developerconnect/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-developerconnect/testing/constraints-3.14.txt b/packages/google-cloud-developerconnect/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-developerconnect/testing/constraints-3.14.txt
+++ b/packages/google-cloud-developerconnect/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-devicestreaming/google/cloud/devicestreaming_v1/__init__.py b/packages/google-cloud-devicestreaming/google/cloud/devicestreaming_v1/__init__.py
index 14f3494e0ae1..fafed132819d 100644
--- a/packages/google-cloud-devicestreaming/google/cloud/devicestreaming_v1/__init__.py
+++ b/packages/google-cloud-devicestreaming/google/cloud/devicestreaming_v1/__init__.py
@@ -74,7 +74,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -103,9 +103,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-devicestreaming/setup.py b/packages/google-cloud-devicestreaming/setup.py
index ab00aacd2212..24f407ca6a62 100644
--- a/packages/google-cloud-devicestreaming/setup.py
+++ b/packages/google-cloud-devicestreaming/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/devicestreaming/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-devicestreaming"
diff --git a/packages/google-cloud-devicestreaming/testing/constraints-3.10.txt b/packages/google-cloud-devicestreaming/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-devicestreaming/testing/constraints-3.10.txt
+++ b/packages/google-cloud-devicestreaming/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-devicestreaming/testing/constraints-3.13.txt b/packages/google-cloud-devicestreaming/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-devicestreaming/testing/constraints-3.13.txt
+++ b/packages/google-cloud-devicestreaming/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-devicestreaming/testing/constraints-3.14.txt b/packages/google-cloud-devicestreaming/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-devicestreaming/testing/constraints-3.14.txt
+++ b/packages/google-cloud-devicestreaming/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-dialogflow-cx/google/cloud/dialogflowcx_v3/__init__.py b/packages/google-cloud-dialogflow-cx/google/cloud/dialogflowcx_v3/__init__.py
index 076e0643ba58..812b93f2d657 100644
--- a/packages/google-cloud-dialogflow-cx/google/cloud/dialogflowcx_v3/__init__.py
+++ b/packages/google-cloud-dialogflow-cx/google/cloud/dialogflowcx_v3/__init__.py
@@ -437,7 +437,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -466,9 +466,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-dialogflow-cx/google/cloud/dialogflowcx_v3beta1/__init__.py b/packages/google-cloud-dialogflow-cx/google/cloud/dialogflowcx_v3beta1/__init__.py
index cfac0ff2ec78..6f05a16ae2fe 100644
--- a/packages/google-cloud-dialogflow-cx/google/cloud/dialogflowcx_v3beta1/__init__.py
+++ b/packages/google-cloud-dialogflow-cx/google/cloud/dialogflowcx_v3beta1/__init__.py
@@ -460,7 +460,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -489,9 +489,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-dialogflow-cx/setup.py b/packages/google-cloud-dialogflow-cx/setup.py
index 5e7bec4a5b56..eb20ac067d53 100644
--- a/packages/google-cloud-dialogflow-cx/setup.py
+++ b/packages/google-cloud-dialogflow-cx/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/dialogflowcx/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-dialogflow-cx"
diff --git a/packages/google-cloud-dialogflow-cx/testing/constraints-3.10.txt b/packages/google-cloud-dialogflow-cx/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-dialogflow-cx/testing/constraints-3.10.txt
+++ b/packages/google-cloud-dialogflow-cx/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-dialogflow-cx/testing/constraints-3.13.txt b/packages/google-cloud-dialogflow-cx/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-dialogflow-cx/testing/constraints-3.13.txt
+++ b/packages/google-cloud-dialogflow-cx/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-dialogflow-cx/testing/constraints-3.14.txt b/packages/google-cloud-dialogflow-cx/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-dialogflow-cx/testing/constraints-3.14.txt
+++ b/packages/google-cloud-dialogflow-cx/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-dialogflow/google/cloud/dialogflow_v2/__init__.py b/packages/google-cloud-dialogflow/google/cloud/dialogflow_v2/__init__.py
index f980335cf78f..87ed765ed6cc 100644
--- a/packages/google-cloud-dialogflow/google/cloud/dialogflow_v2/__init__.py
+++ b/packages/google-cloud-dialogflow/google/cloud/dialogflow_v2/__init__.py
@@ -442,7 +442,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -471,9 +471,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-dialogflow/google/cloud/dialogflow_v2beta1/__init__.py b/packages/google-cloud-dialogflow/google/cloud/dialogflow_v2beta1/__init__.py
index cb2fcfce4c59..348927177b65 100644
--- a/packages/google-cloud-dialogflow/google/cloud/dialogflow_v2beta1/__init__.py
+++ b/packages/google-cloud-dialogflow/google/cloud/dialogflow_v2beta1/__init__.py
@@ -419,7 +419,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -448,9 +448,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-dialogflow/setup.py b/packages/google-cloud-dialogflow/setup.py
index 2dc803c41467..e531168dd1f2 100644
--- a/packages/google-cloud-dialogflow/setup.py
+++ b/packages/google-cloud-dialogflow/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/dialogflow/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-dialogflow"
diff --git a/packages/google-cloud-dialogflow/testing/constraints-3.10.txt b/packages/google-cloud-dialogflow/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-dialogflow/testing/constraints-3.10.txt
+++ b/packages/google-cloud-dialogflow/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-dialogflow/testing/constraints-3.13.txt b/packages/google-cloud-dialogflow/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-dialogflow/testing/constraints-3.13.txt
+++ b/packages/google-cloud-dialogflow/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-dialogflow/testing/constraints-3.14.txt b/packages/google-cloud-dialogflow/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-dialogflow/testing/constraints-3.14.txt
+++ b/packages/google-cloud-dialogflow/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-discoveryengine/google/cloud/discoveryengine_v1/__init__.py b/packages/google-cloud-discoveryengine/google/cloud/discoveryengine_v1/__init__.py
index c295e14246ed..08805283ccff 100644
--- a/packages/google-cloud-discoveryengine/google/cloud/discoveryengine_v1/__init__.py
+++ b/packages/google-cloud-discoveryengine/google/cloud/discoveryengine_v1/__init__.py
@@ -375,7 +375,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -404,9 +404,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-discoveryengine/google/cloud/discoveryengine_v1alpha/__init__.py b/packages/google-cloud-discoveryengine/google/cloud/discoveryengine_v1alpha/__init__.py
index 206ae0c2aa16..1b27234603fa 100644
--- a/packages/google-cloud-discoveryengine/google/cloud/discoveryengine_v1alpha/__init__.py
+++ b/packages/google-cloud-discoveryengine/google/cloud/discoveryengine_v1alpha/__init__.py
@@ -390,7 +390,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -419,9 +419,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-discoveryengine/google/cloud/discoveryengine_v1beta/__init__.py b/packages/google-cloud-discoveryengine/google/cloud/discoveryengine_v1beta/__init__.py
index f27dbbca2178..33ec2f3deebb 100644
--- a/packages/google-cloud-discoveryengine/google/cloud/discoveryengine_v1beta/__init__.py
+++ b/packages/google-cloud-discoveryengine/google/cloud/discoveryengine_v1beta/__init__.py
@@ -369,7 +369,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -398,9 +398,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-discoveryengine/setup.py b/packages/google-cloud-discoveryengine/setup.py
index d63cebc67086..7e75b11cd6fb 100644
--- a/packages/google-cloud-discoveryengine/setup.py
+++ b/packages/google-cloud-discoveryengine/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/discoveryengine/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-discoveryengine"
diff --git a/packages/google-cloud-discoveryengine/testing/constraints-3.10.txt b/packages/google-cloud-discoveryengine/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-discoveryengine/testing/constraints-3.10.txt
+++ b/packages/google-cloud-discoveryengine/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-discoveryengine/testing/constraints-3.13.txt b/packages/google-cloud-discoveryengine/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-discoveryengine/testing/constraints-3.13.txt
+++ b/packages/google-cloud-discoveryengine/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-discoveryengine/testing/constraints-3.14.txt b/packages/google-cloud-discoveryengine/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-discoveryengine/testing/constraints-3.14.txt
+++ b/packages/google-cloud-discoveryengine/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-dlp/google/cloud/dlp_v2/__init__.py b/packages/google-cloud-dlp/google/cloud/dlp_v2/__init__.py
index 350174be60ef..6b080ecb958d 100644
--- a/packages/google-cloud-dlp/google/cloud/dlp_v2/__init__.py
+++ b/packages/google-cloud-dlp/google/cloud/dlp_v2/__init__.py
@@ -378,7 +378,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -407,9 +407,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-dlp/setup.py b/packages/google-cloud-dlp/setup.py
index 7f7d1bd82cad..1fb2a2bb04f0 100644
--- a/packages/google-cloud-dlp/setup.py
+++ b/packages/google-cloud-dlp/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/dlp/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-dlp"
diff --git a/packages/google-cloud-dlp/testing/constraints-3.10.txt b/packages/google-cloud-dlp/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-dlp/testing/constraints-3.10.txt
+++ b/packages/google-cloud-dlp/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-dlp/testing/constraints-3.13.txt b/packages/google-cloud-dlp/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-dlp/testing/constraints-3.13.txt
+++ b/packages/google-cloud-dlp/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-dlp/testing/constraints-3.14.txt b/packages/google-cloud-dlp/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-dlp/testing/constraints-3.14.txt
+++ b/packages/google-cloud-dlp/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-dms/google/cloud/clouddms_v1/__init__.py b/packages/google-cloud-dms/google/cloud/clouddms_v1/__init__.py
index 9a4605d42457..d964d849f547 100644
--- a/packages/google-cloud-dms/google/cloud/clouddms_v1/__init__.py
+++ b/packages/google-cloud-dms/google/cloud/clouddms_v1/__init__.py
@@ -194,7 +194,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -223,9 +223,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-dms/setup.py b/packages/google-cloud-dms/setup.py
index a6792bcd5ca5..2f7c0c6c32fa 100644
--- a/packages/google-cloud-dms/setup.py
+++ b/packages/google-cloud-dms/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/clouddms/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-dms"
diff --git a/packages/google-cloud-dms/testing/constraints-3.10.txt b/packages/google-cloud-dms/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-dms/testing/constraints-3.10.txt
+++ b/packages/google-cloud-dms/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-dms/testing/constraints-3.13.txt b/packages/google-cloud-dms/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-dms/testing/constraints-3.13.txt
+++ b/packages/google-cloud-dms/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-dms/testing/constraints-3.14.txt b/packages/google-cloud-dms/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-dms/testing/constraints-3.14.txt
+++ b/packages/google-cloud-dms/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-documentai/google/cloud/documentai_v1/__init__.py b/packages/google-cloud-documentai/google/cloud/documentai_v1/__init__.py
index 2fab63e832c3..bfd3283f728a 100644
--- a/packages/google-cloud-documentai/google/cloud/documentai_v1/__init__.py
+++ b/packages/google-cloud-documentai/google/cloud/documentai_v1/__init__.py
@@ -122,7 +122,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -151,9 +151,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-documentai/google/cloud/documentai_v1beta3/__init__.py b/packages/google-cloud-documentai/google/cloud/documentai_v1beta3/__init__.py
index 8f5bb7f97b2b..fc13acd350f7 100644
--- a/packages/google-cloud-documentai/google/cloud/documentai_v1beta3/__init__.py
+++ b/packages/google-cloud-documentai/google/cloud/documentai_v1beta3/__init__.py
@@ -156,7 +156,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -185,9 +185,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-documentai/setup.py b/packages/google-cloud-documentai/setup.py
index acb38ef0ea31..1386c7beb099 100644
--- a/packages/google-cloud-documentai/setup.py
+++ b/packages/google-cloud-documentai/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/documentai/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-documentai"
diff --git a/packages/google-cloud-documentai/testing/constraints-3.10.txt b/packages/google-cloud-documentai/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-documentai/testing/constraints-3.10.txt
+++ b/packages/google-cloud-documentai/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-documentai/testing/constraints-3.13.txt b/packages/google-cloud-documentai/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-documentai/testing/constraints-3.13.txt
+++ b/packages/google-cloud-documentai/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-documentai/testing/constraints-3.14.txt b/packages/google-cloud-documentai/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-documentai/testing/constraints-3.14.txt
+++ b/packages/google-cloud-documentai/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-domains/google/cloud/domains_v1/__init__.py b/packages/google-cloud-domains/google/cloud/domains_v1/__init__.py
index 586b59820078..4435eacb6994 100644
--- a/packages/google-cloud-domains/google/cloud/domains_v1/__init__.py
+++ b/packages/google-cloud-domains/google/cloud/domains_v1/__init__.py
@@ -83,7 +83,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -112,9 +112,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-domains/google/cloud/domains_v1beta1/__init__.py b/packages/google-cloud-domains/google/cloud/domains_v1beta1/__init__.py
index 9606c3ebb01f..1864df637864 100644
--- a/packages/google-cloud-domains/google/cloud/domains_v1beta1/__init__.py
+++ b/packages/google-cloud-domains/google/cloud/domains_v1beta1/__init__.py
@@ -83,7 +83,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -112,9 +112,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-domains/setup.py b/packages/google-cloud-domains/setup.py
index 897e10ebaedb..9b88f3c3879b 100644
--- a/packages/google-cloud-domains/setup.py
+++ b/packages/google-cloud-domains/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/domains/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-domains"
diff --git a/packages/google-cloud-domains/testing/constraints-3.10.txt b/packages/google-cloud-domains/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-domains/testing/constraints-3.10.txt
+++ b/packages/google-cloud-domains/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-domains/testing/constraints-3.13.txt b/packages/google-cloud-domains/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-domains/testing/constraints-3.13.txt
+++ b/packages/google-cloud-domains/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-domains/testing/constraints-3.14.txt b/packages/google-cloud-domains/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-domains/testing/constraints-3.14.txt
+++ b/packages/google-cloud-domains/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-edgecontainer/google/cloud/edgecontainer_v1/__init__.py b/packages/google-cloud-edgecontainer/google/cloud/edgecontainer_v1/__init__.py
index 49ba75ed766e..da72e2163411 100644
--- a/packages/google-cloud-edgecontainer/google/cloud/edgecontainer_v1/__init__.py
+++ b/packages/google-cloud-edgecontainer/google/cloud/edgecontainer_v1/__init__.py
@@ -103,7 +103,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -132,9 +132,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-edgecontainer/setup.py b/packages/google-cloud-edgecontainer/setup.py
index cb72ce7e68de..d628c5485443 100644
--- a/packages/google-cloud-edgecontainer/setup.py
+++ b/packages/google-cloud-edgecontainer/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/edgecontainer/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-edgecontainer"
diff --git a/packages/google-cloud-edgecontainer/testing/constraints-3.10.txt b/packages/google-cloud-edgecontainer/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-edgecontainer/testing/constraints-3.10.txt
+++ b/packages/google-cloud-edgecontainer/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-edgecontainer/testing/constraints-3.13.txt b/packages/google-cloud-edgecontainer/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-edgecontainer/testing/constraints-3.13.txt
+++ b/packages/google-cloud-edgecontainer/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-edgecontainer/testing/constraints-3.14.txt b/packages/google-cloud-edgecontainer/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-edgecontainer/testing/constraints-3.14.txt
+++ b/packages/google-cloud-edgecontainer/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-edgenetwork/google/cloud/edgenetwork_v1/__init__.py b/packages/google-cloud-edgenetwork/google/cloud/edgenetwork_v1/__init__.py
index 315857c34d38..e5c511eeb3b6 100644
--- a/packages/google-cloud-edgenetwork/google/cloud/edgenetwork_v1/__init__.py
+++ b/packages/google-cloud-edgenetwork/google/cloud/edgenetwork_v1/__init__.py
@@ -103,7 +103,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -132,9 +132,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-edgenetwork/setup.py b/packages/google-cloud-edgenetwork/setup.py
index 85e448469a8c..6f58d945b83a 100644
--- a/packages/google-cloud-edgenetwork/setup.py
+++ b/packages/google-cloud-edgenetwork/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/edgenetwork/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-edgenetwork"
diff --git a/packages/google-cloud-edgenetwork/testing/constraints-3.10.txt b/packages/google-cloud-edgenetwork/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-edgenetwork/testing/constraints-3.10.txt
+++ b/packages/google-cloud-edgenetwork/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-edgenetwork/testing/constraints-3.13.txt b/packages/google-cloud-edgenetwork/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-edgenetwork/testing/constraints-3.13.txt
+++ b/packages/google-cloud-edgenetwork/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-edgenetwork/testing/constraints-3.14.txt b/packages/google-cloud-edgenetwork/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-edgenetwork/testing/constraints-3.14.txt
+++ b/packages/google-cloud-edgenetwork/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-enterpriseknowledgegraph/google/cloud/enterpriseknowledgegraph_v1/__init__.py b/packages/google-cloud-enterpriseknowledgegraph/google/cloud/enterpriseknowledgegraph_v1/__init__.py
index 3c70c813e8a3..2deabc420657 100644
--- a/packages/google-cloud-enterpriseknowledgegraph/google/cloud/enterpriseknowledgegraph_v1/__init__.py
+++ b/packages/google-cloud-enterpriseknowledgegraph/google/cloud/enterpriseknowledgegraph_v1/__init__.py
@@ -79,7 +79,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -108,9 +108,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-enterpriseknowledgegraph/setup.py b/packages/google-cloud-enterpriseknowledgegraph/setup.py
index fff6bc032467..efa8f398627e 100644
--- a/packages/google-cloud-enterpriseknowledgegraph/setup.py
+++ b/packages/google-cloud-enterpriseknowledgegraph/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/enterpriseknowledgegraph/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-enterpriseknowledgegraph"
diff --git a/packages/google-cloud-enterpriseknowledgegraph/testing/constraints-3.10.txt b/packages/google-cloud-enterpriseknowledgegraph/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-enterpriseknowledgegraph/testing/constraints-3.10.txt
+++ b/packages/google-cloud-enterpriseknowledgegraph/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-enterpriseknowledgegraph/testing/constraints-3.13.txt b/packages/google-cloud-enterpriseknowledgegraph/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-enterpriseknowledgegraph/testing/constraints-3.13.txt
+++ b/packages/google-cloud-enterpriseknowledgegraph/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-enterpriseknowledgegraph/testing/constraints-3.14.txt b/packages/google-cloud-enterpriseknowledgegraph/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-enterpriseknowledgegraph/testing/constraints-3.14.txt
+++ b/packages/google-cloud-enterpriseknowledgegraph/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-error-reporting/google/cloud/errorreporting_v1beta1/__init__.py b/packages/google-cloud-error-reporting/google/cloud/errorreporting_v1beta1/__init__.py
index 5f955693de7c..3d3ae8d23715 100644
--- a/packages/google-cloud-error-reporting/google/cloud/errorreporting_v1beta1/__init__.py
+++ b/packages/google-cloud-error-reporting/google/cloud/errorreporting_v1beta1/__init__.py
@@ -91,7 +91,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -120,9 +120,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-error-reporting/setup.py b/packages/google-cloud-error-reporting/setup.py
index 58594b2a336c..0dcc7ed07cfd 100644
--- a/packages/google-cloud-error-reporting/setup.py
+++ b/packages/google-cloud-error-reporting/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/errorreporting/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "google-cloud-logging>=3.9.0, <4.0.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-error-reporting"
diff --git a/packages/google-cloud-error-reporting/testing/constraints-3.10.txt b/packages/google-cloud-error-reporting/testing/constraints-3.10.txt
index 76cd237011f5..23d2e45f8cd4 100644
--- a/packages/google-cloud-error-reporting/testing/constraints-3.10.txt
+++ b/packages/google-cloud-error-reporting/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 google-cloud-logging==3.9.0
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-error-reporting/testing/constraints-3.13.txt b/packages/google-cloud-error-reporting/testing/constraints-3.13.txt
index a16f760afe46..ccb38bfd45df 100644
--- a/packages/google-cloud-error-reporting/testing/constraints-3.13.txt
+++ b/packages/google-cloud-error-reporting/testing/constraints-3.13.txt
@@ -10,4 +10,4 @@ google-auth>=2
 google-cloud-logging>=3
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-error-reporting/testing/constraints-3.14.txt b/packages/google-cloud-error-reporting/testing/constraints-3.14.txt
index a16f760afe46..ccb38bfd45df 100644
--- a/packages/google-cloud-error-reporting/testing/constraints-3.14.txt
+++ b/packages/google-cloud-error-reporting/testing/constraints-3.14.txt
@@ -10,4 +10,4 @@ google-auth>=2
 google-cloud-logging>=3
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-essential-contacts/google/cloud/essential_contacts_v1/__init__.py b/packages/google-cloud-essential-contacts/google/cloud/essential_contacts_v1/__init__.py
index 1478133cb01c..a01991f83306 100644
--- a/packages/google-cloud-essential-contacts/google/cloud/essential_contacts_v1/__init__.py
+++ b/packages/google-cloud-essential-contacts/google/cloud/essential_contacts_v1/__init__.py
@@ -66,7 +66,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -95,9 +95,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-essential-contacts/setup.py b/packages/google-cloud-essential-contacts/setup.py
index 731fc7517951..8d37a95bd0c3 100644
--- a/packages/google-cloud-essential-contacts/setup.py
+++ b/packages/google-cloud-essential-contacts/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/essential_contacts/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-essential-contacts"
diff --git a/packages/google-cloud-essential-contacts/testing/constraints-3.10.txt b/packages/google-cloud-essential-contacts/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-essential-contacts/testing/constraints-3.10.txt
+++ b/packages/google-cloud-essential-contacts/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-essential-contacts/testing/constraints-3.13.txt b/packages/google-cloud-essential-contacts/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-essential-contacts/testing/constraints-3.13.txt
+++ b/packages/google-cloud-essential-contacts/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-essential-contacts/testing/constraints-3.14.txt b/packages/google-cloud-essential-contacts/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-essential-contacts/testing/constraints-3.14.txt
+++ b/packages/google-cloud-essential-contacts/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-eventarc-publishing/google/cloud/eventarc_publishing_v1/__init__.py b/packages/google-cloud-eventarc-publishing/google/cloud/eventarc_publishing_v1/__init__.py
index c294d86fde47..b8c9b2e30dbd 100644
--- a/packages/google-cloud-eventarc-publishing/google/cloud/eventarc_publishing_v1/__init__.py
+++ b/packages/google-cloud-eventarc-publishing/google/cloud/eventarc_publishing_v1/__init__.py
@@ -59,7 +59,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -88,9 +88,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-eventarc-publishing/setup.py b/packages/google-cloud-eventarc-publishing/setup.py
index c99abf91b14d..e09c5416c1bf 100644
--- a/packages/google-cloud-eventarc-publishing/setup.py
+++ b/packages/google-cloud-eventarc-publishing/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/eventarc_publishing/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-eventarc-publishing"
diff --git a/packages/google-cloud-eventarc-publishing/testing/constraints-3.10.txt b/packages/google-cloud-eventarc-publishing/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-eventarc-publishing/testing/constraints-3.10.txt
+++ b/packages/google-cloud-eventarc-publishing/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-eventarc-publishing/testing/constraints-3.13.txt b/packages/google-cloud-eventarc-publishing/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-eventarc-publishing/testing/constraints-3.13.txt
+++ b/packages/google-cloud-eventarc-publishing/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-eventarc-publishing/testing/constraints-3.14.txt b/packages/google-cloud-eventarc-publishing/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-eventarc-publishing/testing/constraints-3.14.txt
+++ b/packages/google-cloud-eventarc-publishing/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-eventarc/google/cloud/eventarc_v1/__init__.py b/packages/google-cloud-eventarc/google/cloud/eventarc_v1/__init__.py
index d201f36ee0e7..0cd8d61edca5 100644
--- a/packages/google-cloud-eventarc/google/cloud/eventarc_v1/__init__.py
+++ b/packages/google-cloud-eventarc/google/cloud/eventarc_v1/__init__.py
@@ -122,7 +122,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -151,9 +151,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-eventarc/setup.py b/packages/google-cloud-eventarc/setup.py
index 9c47a7ec37ff..ee3a7ae26e20 100644
--- a/packages/google-cloud-eventarc/setup.py
+++ b/packages/google-cloud-eventarc/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/eventarc/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-eventarc"
diff --git a/packages/google-cloud-eventarc/testing/constraints-3.10.txt b/packages/google-cloud-eventarc/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-eventarc/testing/constraints-3.10.txt
+++ b/packages/google-cloud-eventarc/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-eventarc/testing/constraints-3.13.txt b/packages/google-cloud-eventarc/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-eventarc/testing/constraints-3.13.txt
+++ b/packages/google-cloud-eventarc/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-eventarc/testing/constraints-3.14.txt b/packages/google-cloud-eventarc/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-eventarc/testing/constraints-3.14.txt
+++ b/packages/google-cloud-eventarc/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-filestore/google/cloud/filestore_v1/__init__.py b/packages/google-cloud-filestore/google/cloud/filestore_v1/__init__.py
index a6c56bc8612a..0a4d44d65ed4 100644
--- a/packages/google-cloud-filestore/google/cloud/filestore_v1/__init__.py
+++ b/packages/google-cloud-filestore/google/cloud/filestore_v1/__init__.py
@@ -84,7 +84,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -113,9 +113,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-filestore/setup.py b/packages/google-cloud-filestore/setup.py
index 37dc387b12a4..55b1b9fa1d89 100644
--- a/packages/google-cloud-filestore/setup.py
+++ b/packages/google-cloud-filestore/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/filestore/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "google-cloud-common >= 1.0.0, <2.0.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-filestore"
diff --git a/packages/google-cloud-filestore/testing/constraints-3.10.txt b/packages/google-cloud-filestore/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-filestore/testing/constraints-3.10.txt
+++ b/packages/google-cloud-filestore/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-filestore/testing/constraints-3.13.txt b/packages/google-cloud-filestore/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-filestore/testing/constraints-3.13.txt
+++ b/packages/google-cloud-filestore/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-filestore/testing/constraints-3.14.txt b/packages/google-cloud-filestore/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-filestore/testing/constraints-3.14.txt
+++ b/packages/google-cloud-filestore/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-financialservices/google/cloud/financialservices_v1/__init__.py b/packages/google-cloud-financialservices/google/cloud/financialservices_v1/__init__.py
index 986dfd5f4f49..be0caee9ca28 100644
--- a/packages/google-cloud-financialservices/google/cloud/financialservices_v1/__init__.py
+++ b/packages/google-cloud-financialservices/google/cloud/financialservices_v1/__init__.py
@@ -125,7 +125,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -154,9 +154,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-financialservices/setup.py b/packages/google-cloud-financialservices/setup.py
index a487f81da4e8..008e7a178a2a 100644
--- a/packages/google-cloud-financialservices/setup.py
+++ b/packages/google-cloud-financialservices/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/financialservices/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-financialservices"
diff --git a/packages/google-cloud-financialservices/testing/constraints-3.10.txt b/packages/google-cloud-financialservices/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-financialservices/testing/constraints-3.10.txt
+++ b/packages/google-cloud-financialservices/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-financialservices/testing/constraints-3.13.txt b/packages/google-cloud-financialservices/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-financialservices/testing/constraints-3.13.txt
+++ b/packages/google-cloud-financialservices/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-financialservices/testing/constraints-3.14.txt b/packages/google-cloud-financialservices/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-financialservices/testing/constraints-3.14.txt
+++ b/packages/google-cloud-financialservices/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-functions/google/cloud/functions_v1/__init__.py b/packages/google-cloud-functions/google/cloud/functions_v1/__init__.py
index 893977f8f305..1d830eecceab 100644
--- a/packages/google-cloud-functions/google/cloud/functions_v1/__init__.py
+++ b/packages/google-cloud-functions/google/cloud/functions_v1/__init__.py
@@ -76,7 +76,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -105,9 +105,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-functions/google/cloud/functions_v2/__init__.py b/packages/google-cloud-functions/google/cloud/functions_v2/__init__.py
index 716df5469dd7..aff47bb1edcc 100644
--- a/packages/google-cloud-functions/google/cloud/functions_v2/__init__.py
+++ b/packages/google-cloud-functions/google/cloud/functions_v2/__init__.py
@@ -83,7 +83,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -112,9 +112,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-functions/setup.py b/packages/google-cloud-functions/setup.py
index 10c335da2fca..4f9b20f341b5 100644
--- a/packages/google-cloud-functions/setup.py
+++ b/packages/google-cloud-functions/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/functions/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-functions"
diff --git a/packages/google-cloud-functions/testing/constraints-3.10.txt b/packages/google-cloud-functions/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-functions/testing/constraints-3.10.txt
+++ b/packages/google-cloud-functions/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-functions/testing/constraints-3.13.txt b/packages/google-cloud-functions/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-functions/testing/constraints-3.13.txt
+++ b/packages/google-cloud-functions/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-functions/testing/constraints-3.14.txt b/packages/google-cloud-functions/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-functions/testing/constraints-3.14.txt
+++ b/packages/google-cloud-functions/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-gdchardwaremanagement/google/cloud/gdchardwaremanagement_v1alpha/__init__.py b/packages/google-cloud-gdchardwaremanagement/google/cloud/gdchardwaremanagement_v1alpha/__init__.py
index ea810cfbb178..2ca2bc0ac2ae 100644
--- a/packages/google-cloud-gdchardwaremanagement/google/cloud/gdchardwaremanagement_v1alpha/__init__.py
+++ b/packages/google-cloud-gdchardwaremanagement/google/cloud/gdchardwaremanagement_v1alpha/__init__.py
@@ -127,7 +127,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -156,9 +156,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-gdchardwaremanagement/setup.py b/packages/google-cloud-gdchardwaremanagement/setup.py
index 22c537fdf4cc..ce8aa43cbe25 100644
--- a/packages/google-cloud-gdchardwaremanagement/setup.py
+++ b/packages/google-cloud-gdchardwaremanagement/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/gdchardwaremanagement/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-gdchardwaremanagement"
diff --git a/packages/google-cloud-gdchardwaremanagement/testing/constraints-3.10.txt b/packages/google-cloud-gdchardwaremanagement/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-gdchardwaremanagement/testing/constraints-3.10.txt
+++ b/packages/google-cloud-gdchardwaremanagement/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-gdchardwaremanagement/testing/constraints-3.13.txt b/packages/google-cloud-gdchardwaremanagement/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-gdchardwaremanagement/testing/constraints-3.13.txt
+++ b/packages/google-cloud-gdchardwaremanagement/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-gdchardwaremanagement/testing/constraints-3.14.txt b/packages/google-cloud-gdchardwaremanagement/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-gdchardwaremanagement/testing/constraints-3.14.txt
+++ b/packages/google-cloud-gdchardwaremanagement/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-geminidataanalytics/google/cloud/geminidataanalytics_v1/__init__.py b/packages/google-cloud-geminidataanalytics/google/cloud/geminidataanalytics_v1/__init__.py
index 0f4040145eb1..a2c89951668a 100644
--- a/packages/google-cloud-geminidataanalytics/google/cloud/geminidataanalytics_v1/__init__.py
+++ b/packages/google-cloud-geminidataanalytics/google/cloud/geminidataanalytics_v1/__init__.py
@@ -144,7 +144,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -173,9 +173,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-geminidataanalytics/google/cloud/geminidataanalytics_v1alpha/__init__.py b/packages/google-cloud-geminidataanalytics/google/cloud/geminidataanalytics_v1alpha/__init__.py
index f8d496d36869..fae0dc1ca676 100644
--- a/packages/google-cloud-geminidataanalytics/google/cloud/geminidataanalytics_v1alpha/__init__.py
+++ b/packages/google-cloud-geminidataanalytics/google/cloud/geminidataanalytics_v1alpha/__init__.py
@@ -149,7 +149,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -178,9 +178,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-geminidataanalytics/google/cloud/geminidataanalytics_v1beta/__init__.py b/packages/google-cloud-geminidataanalytics/google/cloud/geminidataanalytics_v1beta/__init__.py
index db78fe9542c2..5c98a2e1694d 100644
--- a/packages/google-cloud-geminidataanalytics/google/cloud/geminidataanalytics_v1beta/__init__.py
+++ b/packages/google-cloud-geminidataanalytics/google/cloud/geminidataanalytics_v1beta/__init__.py
@@ -161,7 +161,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -190,9 +190,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-geminidataanalytics/setup.py b/packages/google-cloud-geminidataanalytics/setup.py
index cb8dfd005a02..1face59793e2 100644
--- a/packages/google-cloud-geminidataanalytics/setup.py
+++ b/packages/google-cloud-geminidataanalytics/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/geminidataanalytics/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-geminidataanalytics"
diff --git a/packages/google-cloud-geminidataanalytics/testing/constraints-3.10.txt b/packages/google-cloud-geminidataanalytics/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-geminidataanalytics/testing/constraints-3.10.txt
+++ b/packages/google-cloud-geminidataanalytics/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-geminidataanalytics/testing/constraints-3.13.txt b/packages/google-cloud-geminidataanalytics/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-geminidataanalytics/testing/constraints-3.13.txt
+++ b/packages/google-cloud-geminidataanalytics/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-geminidataanalytics/testing/constraints-3.14.txt b/packages/google-cloud-geminidataanalytics/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-geminidataanalytics/testing/constraints-3.14.txt
+++ b/packages/google-cloud-geminidataanalytics/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-gke-backup/google/cloud/gke_backup_v1/__init__.py b/packages/google-cloud-gke-backup/google/cloud/gke_backup_v1/__init__.py
index 0cab7fc74563..4c800a10e5ea 100644
--- a/packages/google-cloud-gke-backup/google/cloud/gke_backup_v1/__init__.py
+++ b/packages/google-cloud-gke-backup/google/cloud/gke_backup_v1/__init__.py
@@ -124,7 +124,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -153,9 +153,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-gke-backup/setup.py b/packages/google-cloud-gke-backup/setup.py
index 7257d38c1fc7..0956ed99ec2e 100644
--- a/packages/google-cloud-gke-backup/setup.py
+++ b/packages/google-cloud-gke-backup/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/gke_backup/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-gke-backup"
diff --git a/packages/google-cloud-gke-backup/testing/constraints-3.10.txt b/packages/google-cloud-gke-backup/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-gke-backup/testing/constraints-3.10.txt
+++ b/packages/google-cloud-gke-backup/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-gke-backup/testing/constraints-3.13.txt b/packages/google-cloud-gke-backup/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-gke-backup/testing/constraints-3.13.txt
+++ b/packages/google-cloud-gke-backup/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-gke-backup/testing/constraints-3.14.txt b/packages/google-cloud-gke-backup/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-gke-backup/testing/constraints-3.14.txt
+++ b/packages/google-cloud-gke-backup/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-gke-connect-gateway/google/cloud/gkeconnect/gateway_v1/__init__.py b/packages/google-cloud-gke-connect-gateway/google/cloud/gkeconnect/gateway_v1/__init__.py
index a2c882215730..a95668837fc8 100644
--- a/packages/google-cloud-gke-connect-gateway/google/cloud/gkeconnect/gateway_v1/__init__.py
+++ b/packages/google-cloud-gke-connect-gateway/google/cloud/gkeconnect/gateway_v1/__init__.py
@@ -51,7 +51,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -80,9 +80,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-gke-connect-gateway/google/cloud/gkeconnect/gateway_v1beta1/__init__.py b/packages/google-cloud-gke-connect-gateway/google/cloud/gkeconnect/gateway_v1beta1/__init__.py
index 376eb83aeb6b..a691f751aaae 100644
--- a/packages/google-cloud-gke-connect-gateway/google/cloud/gkeconnect/gateway_v1beta1/__init__.py
+++ b/packages/google-cloud-gke-connect-gateway/google/cloud/gkeconnect/gateway_v1beta1/__init__.py
@@ -51,7 +51,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -80,9 +80,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-gke-connect-gateway/setup.py b/packages/google-cloud-gke-connect-gateway/setup.py
index 95296f191dc0..2cfe3b1ab8b0 100644
--- a/packages/google-cloud-gke-connect-gateway/setup.py
+++ b/packages/google-cloud-gke-connect-gateway/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/gkeconnect/gateway/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-gke-connect-gateway"
diff --git a/packages/google-cloud-gke-connect-gateway/testing/constraints-3.10.txt b/packages/google-cloud-gke-connect-gateway/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-gke-connect-gateway/testing/constraints-3.10.txt
+++ b/packages/google-cloud-gke-connect-gateway/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-gke-connect-gateway/testing/constraints-3.13.txt b/packages/google-cloud-gke-connect-gateway/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-gke-connect-gateway/testing/constraints-3.13.txt
+++ b/packages/google-cloud-gke-connect-gateway/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-gke-connect-gateway/testing/constraints-3.14.txt b/packages/google-cloud-gke-connect-gateway/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-gke-connect-gateway/testing/constraints-3.14.txt
+++ b/packages/google-cloud-gke-connect-gateway/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-gke-hub/google/cloud/gkehub_v1/__init__.py b/packages/google-cloud-gke-hub/google/cloud/gkehub_v1/__init__.py
index 74e2a7e10d9f..c30bdf8ef380 100644
--- a/packages/google-cloud-gke-hub/google/cloud/gkehub_v1/__init__.py
+++ b/packages/google-cloud-gke-hub/google/cloud/gkehub_v1/__init__.py
@@ -150,7 +150,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -179,9 +179,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-gke-hub/google/cloud/gkehub_v1beta1/__init__.py b/packages/google-cloud-gke-hub/google/cloud/gkehub_v1beta1/__init__.py
index 1089fbd9be79..eaa69c0a8b3b 100644
--- a/packages/google-cloud-gke-hub/google/cloud/gkehub_v1beta1/__init__.py
+++ b/packages/google-cloud-gke-hub/google/cloud/gkehub_v1beta1/__init__.py
@@ -85,7 +85,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -114,9 +114,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-gke-hub/setup.py b/packages/google-cloud-gke-hub/setup.py
index e5a9ecc0bec0..c65cb02dd063 100644
--- a/packages/google-cloud-gke-hub/setup.py
+++ b/packages/google-cloud-gke-hub/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/gkehub/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpc-google-iam-v1 >=0.12.4, <1.0.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-gke-hub"
diff --git a/packages/google-cloud-gke-hub/testing/constraints-3.10.txt b/packages/google-cloud-gke-hub/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-gke-hub/testing/constraints-3.10.txt
+++ b/packages/google-cloud-gke-hub/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-gke-hub/testing/constraints-3.13.txt b/packages/google-cloud-gke-hub/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-gke-hub/testing/constraints-3.13.txt
+++ b/packages/google-cloud-gke-hub/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-gke-hub/testing/constraints-3.14.txt b/packages/google-cloud-gke-hub/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-gke-hub/testing/constraints-3.14.txt
+++ b/packages/google-cloud-gke-hub/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-gke-multicloud/google/cloud/gke_multicloud_v1/__init__.py b/packages/google-cloud-gke-multicloud/google/cloud/gke_multicloud_v1/__init__.py
index 4e08b4266842..8b894a676a8d 100644
--- a/packages/google-cloud-gke-multicloud/google/cloud/gke_multicloud_v1/__init__.py
+++ b/packages/google-cloud-gke-multicloud/google/cloud/gke_multicloud_v1/__init__.py
@@ -204,7 +204,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -233,9 +233,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-gke-multicloud/setup.py b/packages/google-cloud-gke-multicloud/setup.py
index 248c51dc4af8..01e4337de097 100644
--- a/packages/google-cloud-gke-multicloud/setup.py
+++ b/packages/google-cloud-gke-multicloud/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/gke_multicloud/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-gke-multicloud"
diff --git a/packages/google-cloud-gke-multicloud/testing/constraints-3.10.txt b/packages/google-cloud-gke-multicloud/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-gke-multicloud/testing/constraints-3.10.txt
+++ b/packages/google-cloud-gke-multicloud/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-gke-multicloud/testing/constraints-3.13.txt b/packages/google-cloud-gke-multicloud/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-gke-multicloud/testing/constraints-3.13.txt
+++ b/packages/google-cloud-gke-multicloud/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-gke-multicloud/testing/constraints-3.14.txt b/packages/google-cloud-gke-multicloud/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-gke-multicloud/testing/constraints-3.14.txt
+++ b/packages/google-cloud-gke-multicloud/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-gkerecommender/google/cloud/gkerecommender_v1/__init__.py b/packages/google-cloud-gkerecommender/google/cloud/gkerecommender_v1/__init__.py
index f65b5153e1ba..76070ed5a4c4 100644
--- a/packages/google-cloud-gkerecommender/google/cloud/gkerecommender_v1/__init__.py
+++ b/packages/google-cloud-gkerecommender/google/cloud/gkerecommender_v1/__init__.py
@@ -79,7 +79,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -108,9 +108,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-gkerecommender/setup.py b/packages/google-cloud-gkerecommender/setup.py
index cac4e5c4b9c5..106af27bef79 100644
--- a/packages/google-cloud-gkerecommender/setup.py
+++ b/packages/google-cloud-gkerecommender/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/gkerecommender/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-gkerecommender"
diff --git a/packages/google-cloud-gkerecommender/testing/constraints-3.10.txt b/packages/google-cloud-gkerecommender/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-gkerecommender/testing/constraints-3.10.txt
+++ b/packages/google-cloud-gkerecommender/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-gkerecommender/testing/constraints-3.13.txt b/packages/google-cloud-gkerecommender/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-gkerecommender/testing/constraints-3.13.txt
+++ b/packages/google-cloud-gkerecommender/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-gkerecommender/testing/constraints-3.14.txt b/packages/google-cloud-gkerecommender/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-gkerecommender/testing/constraints-3.14.txt
+++ b/packages/google-cloud-gkerecommender/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-gsuiteaddons/google/cloud/gsuiteaddons_v1/__init__.py b/packages/google-cloud-gsuiteaddons/google/cloud/gsuiteaddons_v1/__init__.py
index 423ed12593a9..d9e146ab0e75 100644
--- a/packages/google-cloud-gsuiteaddons/google/cloud/gsuiteaddons_v1/__init__.py
+++ b/packages/google-cloud-gsuiteaddons/google/cloud/gsuiteaddons_v1/__init__.py
@@ -66,7 +66,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -95,9 +95,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-gsuiteaddons/setup.py b/packages/google-cloud-gsuiteaddons/setup.py
index a2d572a5e832..b1a86f9ee763 100644
--- a/packages/google-cloud-gsuiteaddons/setup.py
+++ b/packages/google-cloud-gsuiteaddons/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/gsuiteaddons/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "google-apps-script-type >= 0.2.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "google-apps-script-type >= 0.3.14, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-gsuiteaddons"
diff --git a/packages/google-cloud-gsuiteaddons/testing/constraints-3.10.txt b/packages/google-cloud-gsuiteaddons/testing/constraints-3.10.txt
index 287fc3345b5d..c066e0be98f6 100644
--- a/packages/google-cloud-gsuiteaddons/testing/constraints-3.10.txt
+++ b/packages/google-cloud-gsuiteaddons/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-google-apps-script-type==0.2.0
+proto-plus==1.26.1
+protobuf==6.33.5
+google-apps-script-type==0.3.14
diff --git a/packages/google-cloud-gsuiteaddons/testing/constraints-3.13.txt b/packages/google-cloud-gsuiteaddons/testing/constraints-3.13.txt
index 0d0de33f3329..04f0ffb57ea2 100644
--- a/packages/google-cloud-gsuiteaddons/testing/constraints-3.13.txt
+++ b/packages/google-cloud-gsuiteaddons/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-apps-script-type>=0
diff --git a/packages/google-cloud-gsuiteaddons/testing/constraints-3.14.txt b/packages/google-cloud-gsuiteaddons/testing/constraints-3.14.txt
index 0d0de33f3329..04f0ffb57ea2 100644
--- a/packages/google-cloud-gsuiteaddons/testing/constraints-3.14.txt
+++ b/packages/google-cloud-gsuiteaddons/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-apps-script-type>=0
diff --git a/packages/google-cloud-hypercomputecluster/google/cloud/hypercomputecluster_v1/__init__.py b/packages/google-cloud-hypercomputecluster/google/cloud/hypercomputecluster_v1/__init__.py
index 74df1d167008..55c9949707bc 100644
--- a/packages/google-cloud-hypercomputecluster/google/cloud/hypercomputecluster_v1/__init__.py
+++ b/packages/google-cloud-hypercomputecluster/google/cloud/hypercomputecluster_v1/__init__.py
@@ -124,7 +124,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -153,9 +153,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-hypercomputecluster/google/cloud/hypercomputecluster_v1beta/__init__.py b/packages/google-cloud-hypercomputecluster/google/cloud/hypercomputecluster_v1beta/__init__.py
index 8c063839fb57..c5d5c86e2005 100644
--- a/packages/google-cloud-hypercomputecluster/google/cloud/hypercomputecluster_v1beta/__init__.py
+++ b/packages/google-cloud-hypercomputecluster/google/cloud/hypercomputecluster_v1beta/__init__.py
@@ -97,7 +97,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -126,9 +126,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-hypercomputecluster/setup.py b/packages/google-cloud-hypercomputecluster/setup.py
index 30775e33ba78..509bc3c7c319 100644
--- a/packages/google-cloud-hypercomputecluster/setup.py
+++ b/packages/google-cloud-hypercomputecluster/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/hypercomputecluster/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-hypercomputecluster"
diff --git a/packages/google-cloud-hypercomputecluster/testing/constraints-3.10.txt b/packages/google-cloud-hypercomputecluster/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-hypercomputecluster/testing/constraints-3.10.txt
+++ b/packages/google-cloud-hypercomputecluster/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-hypercomputecluster/testing/constraints-3.13.txt b/packages/google-cloud-hypercomputecluster/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-hypercomputecluster/testing/constraints-3.13.txt
+++ b/packages/google-cloud-hypercomputecluster/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-hypercomputecluster/testing/constraints-3.14.txt b/packages/google-cloud-hypercomputecluster/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-hypercomputecluster/testing/constraints-3.14.txt
+++ b/packages/google-cloud-hypercomputecluster/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-iam-logging/google/cloud/iam_logging_v1/__init__.py b/packages/google-cloud-iam-logging/google/cloud/iam_logging_v1/__init__.py
index a80d18dda2d8..e6147d2f88a8 100644
--- a/packages/google-cloud-iam-logging/google/cloud/iam_logging_v1/__init__.py
+++ b/packages/google-cloud-iam-logging/google/cloud/iam_logging_v1/__init__.py
@@ -50,7 +50,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -79,9 +79,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-iam-logging/setup.py b/packages/google-cloud-iam-logging/setup.py
index 910ca3483003..88b3288d40c2 100644
--- a/packages/google-cloud-iam-logging/setup.py
+++ b/packages/google-cloud-iam-logging/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/iam_logging/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-iam-logging"
diff --git a/packages/google-cloud-iam-logging/testing/constraints-3.10.txt b/packages/google-cloud-iam-logging/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-iam-logging/testing/constraints-3.10.txt
+++ b/packages/google-cloud-iam-logging/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-iam-logging/testing/constraints-3.13.txt b/packages/google-cloud-iam-logging/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-iam-logging/testing/constraints-3.13.txt
+++ b/packages/google-cloud-iam-logging/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-iam-logging/testing/constraints-3.14.txt b/packages/google-cloud-iam-logging/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-iam-logging/testing/constraints-3.14.txt
+++ b/packages/google-cloud-iam-logging/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-iam/google/cloud/iam_admin_v1/__init__.py b/packages/google-cloud-iam/google/cloud/iam_admin_v1/__init__.py
index 9673af81a7dc..cdf1b55d313f 100644
--- a/packages/google-cloud-iam/google/cloud/iam_admin_v1/__init__.py
+++ b/packages/google-cloud-iam/google/cloud/iam_admin_v1/__init__.py
@@ -100,7 +100,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -129,9 +129,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-iam/google/cloud/iam_credentials_v1/__init__.py b/packages/google-cloud-iam/google/cloud/iam_credentials_v1/__init__.py
index 5e89b36bdeeb..d2db0912b63e 100644
--- a/packages/google-cloud-iam/google/cloud/iam_credentials_v1/__init__.py
+++ b/packages/google-cloud-iam/google/cloud/iam_credentials_v1/__init__.py
@@ -60,7 +60,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -89,9 +89,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-iam/google/cloud/iam_v2/__init__.py b/packages/google-cloud-iam/google/cloud/iam_v2/__init__.py
index 5ca508743313..1d138b8b035d 100644
--- a/packages/google-cloud-iam/google/cloud/iam_v2/__init__.py
+++ b/packages/google-cloud-iam/google/cloud/iam_v2/__init__.py
@@ -62,7 +62,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -91,9 +91,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-iam/google/cloud/iam_v2beta/__init__.py b/packages/google-cloud-iam/google/cloud/iam_v2beta/__init__.py
index 58dad9e825e2..56b7def8936d 100644
--- a/packages/google-cloud-iam/google/cloud/iam_v2beta/__init__.py
+++ b/packages/google-cloud-iam/google/cloud/iam_v2beta/__init__.py
@@ -62,7 +62,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -91,9 +91,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-iam/google/cloud/iam_v3/__init__.py b/packages/google-cloud-iam/google/cloud/iam_v3/__init__.py
index ded72677d01f..6fe5d43a5f6a 100644
--- a/packages/google-cloud-iam/google/cloud/iam_v3/__init__.py
+++ b/packages/google-cloud-iam/google/cloud/iam_v3/__init__.py
@@ -81,7 +81,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -110,9 +110,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-iam/google/cloud/iam_v3beta/__init__.py b/packages/google-cloud-iam/google/cloud/iam_v3beta/__init__.py
index af90e3210d00..f4ef2ec89dc3 100644
--- a/packages/google-cloud-iam/google/cloud/iam_v3beta/__init__.py
+++ b/packages/google-cloud-iam/google/cloud/iam_v3beta/__init__.py
@@ -97,7 +97,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -126,9 +126,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-iam/setup.py b/packages/google-cloud-iam/setup.py
index daf8695c129d..a4f98034677d 100644
--- a/packages/google-cloud-iam/setup.py
+++ b/packages/google-cloud-iam/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/iam/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpc-google-iam-v1 >=0.12.4, <1.0.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-iam"
diff --git a/packages/google-cloud-iam/testing/constraints-3.10.txt b/packages/google-cloud-iam/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-iam/testing/constraints-3.10.txt
+++ b/packages/google-cloud-iam/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-iam/testing/constraints-3.13.txt b/packages/google-cloud-iam/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-iam/testing/constraints-3.13.txt
+++ b/packages/google-cloud-iam/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-iam/testing/constraints-3.14.txt b/packages/google-cloud-iam/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-iam/testing/constraints-3.14.txt
+++ b/packages/google-cloud-iam/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-iamconnectorcredentials/google/cloud/iamconnectorcredentials_v1alpha/__init__.py b/packages/google-cloud-iamconnectorcredentials/google/cloud/iamconnectorcredentials_v1alpha/__init__.py
index 9b4a28bc115d..8eb2f7402346 100644
--- a/packages/google-cloud-iamconnectorcredentials/google/cloud/iamconnectorcredentials_v1alpha/__init__.py
+++ b/packages/google-cloud-iamconnectorcredentials/google/cloud/iamconnectorcredentials_v1alpha/__init__.py
@@ -62,7 +62,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -91,9 +91,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-iamconnectorcredentials/setup.py b/packages/google-cloud-iamconnectorcredentials/setup.py
index db191dee7c5b..5d435da7c318 100644
--- a/packages/google-cloud-iamconnectorcredentials/setup.py
+++ b/packages/google-cloud-iamconnectorcredentials/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/iamconnectorcredentials/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-iamconnectorcredentials"
diff --git a/packages/google-cloud-iamconnectorcredentials/testing/constraints-3.10.txt b/packages/google-cloud-iamconnectorcredentials/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-iamconnectorcredentials/testing/constraints-3.10.txt
+++ b/packages/google-cloud-iamconnectorcredentials/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-iamconnectorcredentials/testing/constraints-3.13.txt b/packages/google-cloud-iamconnectorcredentials/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-iamconnectorcredentials/testing/constraints-3.13.txt
+++ b/packages/google-cloud-iamconnectorcredentials/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-iamconnectorcredentials/testing/constraints-3.14.txt b/packages/google-cloud-iamconnectorcredentials/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-iamconnectorcredentials/testing/constraints-3.14.txt
+++ b/packages/google-cloud-iamconnectorcredentials/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-iap/google/cloud/iap_v1/__init__.py b/packages/google-cloud-iap/google/cloud/iap_v1/__init__.py
index 86b512280851..4ce251b0b98f 100644
--- a/packages/google-cloud-iap/google/cloud/iap_v1/__init__.py
+++ b/packages/google-cloud-iap/google/cloud/iap_v1/__init__.py
@@ -95,7 +95,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -124,9 +124,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-iap/setup.py b/packages/google-cloud-iap/setup.py
index 4bf15966b7bd..5212cc518e8f 100644
--- a/packages/google-cloud-iap/setup.py
+++ b/packages/google-cloud-iap/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/iap/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-iap"
diff --git a/packages/google-cloud-iap/testing/constraints-3.10.txt b/packages/google-cloud-iap/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-iap/testing/constraints-3.10.txt
+++ b/packages/google-cloud-iap/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-iap/testing/constraints-3.13.txt b/packages/google-cloud-iap/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-iap/testing/constraints-3.13.txt
+++ b/packages/google-cloud-iap/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-iap/testing/constraints-3.14.txt b/packages/google-cloud-iap/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-iap/testing/constraints-3.14.txt
+++ b/packages/google-cloud-iap/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-ids/google/cloud/ids_v1/__init__.py b/packages/google-cloud-ids/google/cloud/ids_v1/__init__.py
index 318d9606e30b..598e4ca18f93 100644
--- a/packages/google-cloud-ids/google/cloud/ids_v1/__init__.py
+++ b/packages/google-cloud-ids/google/cloud/ids_v1/__init__.py
@@ -59,7 +59,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -88,9 +88,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-ids/setup.py b/packages/google-cloud-ids/setup.py
index 83d09ccc178f..aeaa641dfbed 100644
--- a/packages/google-cloud-ids/setup.py
+++ b/packages/google-cloud-ids/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/ids/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-ids"
diff --git a/packages/google-cloud-ids/testing/constraints-3.10.txt b/packages/google-cloud-ids/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-ids/testing/constraints-3.10.txt
+++ b/packages/google-cloud-ids/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-ids/testing/constraints-3.13.txt b/packages/google-cloud-ids/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-ids/testing/constraints-3.13.txt
+++ b/packages/google-cloud-ids/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-ids/testing/constraints-3.14.txt b/packages/google-cloud-ids/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-ids/testing/constraints-3.14.txt
+++ b/packages/google-cloud-ids/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-kms-inventory/google/cloud/kms_inventory_v1/__init__.py b/packages/google-cloud-kms-inventory/google/cloud/kms_inventory_v1/__init__.py
index 36256352e82c..a2b9d1840e6c 100644
--- a/packages/google-cloud-kms-inventory/google/cloud/kms_inventory_v1/__init__.py
+++ b/packages/google-cloud-kms-inventory/google/cloud/kms_inventory_v1/__init__.py
@@ -67,7 +67,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -96,9 +96,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-kms-inventory/setup.py b/packages/google-cloud-kms-inventory/setup.py
index 8ee40e58be3d..af10201eddf1 100644
--- a/packages/google-cloud-kms-inventory/setup.py
+++ b/packages/google-cloud-kms-inventory/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/kms_inventory/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "google-cloud-kms >= 2.13.0, <4.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "google-cloud-kms >= 3.4.1, <4.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-kms-inventory"
diff --git a/packages/google-cloud-kms-inventory/testing/constraints-3.10.txt b/packages/google-cloud-kms-inventory/testing/constraints-3.10.txt
index c7005b0b2be5..2793afc2cd1c 100644
--- a/packages/google-cloud-kms-inventory/testing/constraints-3.10.txt
+++ b/packages/google-cloud-kms-inventory/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-google-cloud-kms==2.13.0
+proto-plus==1.26.1
+protobuf==6.33.5
+google-cloud-kms==3.4.1
diff --git a/packages/google-cloud-kms-inventory/testing/constraints-3.13.txt b/packages/google-cloud-kms-inventory/testing/constraints-3.13.txt
index d5a2c60c2972..8573f096b0fa 100644
--- a/packages/google-cloud-kms-inventory/testing/constraints-3.13.txt
+++ b/packages/google-cloud-kms-inventory/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-cloud-kms>=3
diff --git a/packages/google-cloud-kms-inventory/testing/constraints-3.14.txt b/packages/google-cloud-kms-inventory/testing/constraints-3.14.txt
index d5a2c60c2972..8573f096b0fa 100644
--- a/packages/google-cloud-kms-inventory/testing/constraints-3.14.txt
+++ b/packages/google-cloud-kms-inventory/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-cloud-kms>=3
diff --git a/packages/google-cloud-kms/google/cloud/kms_v1/__init__.py b/packages/google-cloud-kms/google/cloud/kms_v1/__init__.py
index d56fee18f02b..13dc1bc42ae5 100644
--- a/packages/google-cloud-kms/google/cloud/kms_v1/__init__.py
+++ b/packages/google-cloud-kms/google/cloud/kms_v1/__init__.py
@@ -177,7 +177,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -206,9 +206,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-kms/setup.py b/packages/google-cloud-kms/setup.py
index 91013ea6d3b3..27d191e70382 100644
--- a/packages/google-cloud-kms/setup.py
+++ b/packages/google-cloud-kms/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/kms/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-kms"
diff --git a/packages/google-cloud-kms/testing/constraints-3.10.txt b/packages/google-cloud-kms/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-kms/testing/constraints-3.10.txt
+++ b/packages/google-cloud-kms/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-kms/testing/constraints-3.13.txt b/packages/google-cloud-kms/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-kms/testing/constraints-3.13.txt
+++ b/packages/google-cloud-kms/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-kms/testing/constraints-3.14.txt b/packages/google-cloud-kms/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-kms/testing/constraints-3.14.txt
+++ b/packages/google-cloud-kms/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-language/google/cloud/language_v1/__init__.py b/packages/google-cloud-language/google/cloud/language_v1/__init__.py
index 697de8232046..d8cacd6bbcfd 100644
--- a/packages/google-cloud-language/google/cloud/language_v1/__init__.py
+++ b/packages/google-cloud-language/google/cloud/language_v1/__init__.py
@@ -78,7 +78,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -107,9 +107,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-language/google/cloud/language_v1beta2/__init__.py b/packages/google-cloud-language/google/cloud/language_v1beta2/__init__.py
index a2523883aaf2..a2246a7f2db3 100644
--- a/packages/google-cloud-language/google/cloud/language_v1beta2/__init__.py
+++ b/packages/google-cloud-language/google/cloud/language_v1beta2/__init__.py
@@ -78,7 +78,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -107,9 +107,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-language/google/cloud/language_v2/__init__.py b/packages/google-cloud-language/google/cloud/language_v2/__init__.py
index 12680d0d3483..538ae8f15044 100644
--- a/packages/google-cloud-language/google/cloud/language_v2/__init__.py
+++ b/packages/google-cloud-language/google/cloud/language_v2/__init__.py
@@ -70,7 +70,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -99,9 +99,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-language/setup.py b/packages/google-cloud-language/setup.py
index 422879cbb6fa..fcb9cefd238e 100644
--- a/packages/google-cloud-language/setup.py
+++ b/packages/google-cloud-language/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/language/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-language"
diff --git a/packages/google-cloud-language/testing/constraints-3.10.txt b/packages/google-cloud-language/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-language/testing/constraints-3.10.txt
+++ b/packages/google-cloud-language/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-language/testing/constraints-3.13.txt b/packages/google-cloud-language/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-language/testing/constraints-3.13.txt
+++ b/packages/google-cloud-language/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-language/testing/constraints-3.14.txt b/packages/google-cloud-language/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-language/testing/constraints-3.14.txt
+++ b/packages/google-cloud-language/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-licensemanager/google/cloud/licensemanager_v1/__init__.py b/packages/google-cloud-licensemanager/google/cloud/licensemanager_v1/__init__.py
index ef8e5a477c03..b1fcba013d0d 100644
--- a/packages/google-cloud-licensemanager/google/cloud/licensemanager_v1/__init__.py
+++ b/packages/google-cloud-licensemanager/google/cloud/licensemanager_v1/__init__.py
@@ -82,7 +82,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -111,9 +111,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-licensemanager/setup.py b/packages/google-cloud-licensemanager/setup.py
index e6ae92e3cc25..344bc7e965f1 100644
--- a/packages/google-cloud-licensemanager/setup.py
+++ b/packages/google-cloud-licensemanager/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/licensemanager/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-licensemanager"
diff --git a/packages/google-cloud-licensemanager/testing/constraints-3.10.txt b/packages/google-cloud-licensemanager/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-licensemanager/testing/constraints-3.10.txt
+++ b/packages/google-cloud-licensemanager/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-licensemanager/testing/constraints-3.13.txt b/packages/google-cloud-licensemanager/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-licensemanager/testing/constraints-3.13.txt
+++ b/packages/google-cloud-licensemanager/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-licensemanager/testing/constraints-3.14.txt b/packages/google-cloud-licensemanager/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-licensemanager/testing/constraints-3.14.txt
+++ b/packages/google-cloud-licensemanager/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-life-sciences/google/cloud/lifesciences_v2beta/__init__.py b/packages/google-cloud-life-sciences/google/cloud/lifesciences_v2beta/__init__.py
index cc2e76ddeafb..624a50735ea2 100644
--- a/packages/google-cloud-life-sciences/google/cloud/lifesciences_v2beta/__init__.py
+++ b/packages/google-cloud-life-sciences/google/cloud/lifesciences_v2beta/__init__.py
@@ -83,7 +83,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -112,9 +112,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-life-sciences/setup.py b/packages/google-cloud-life-sciences/setup.py
index c8809c0aaaed..31b60e1195cf 100644
--- a/packages/google-cloud-life-sciences/setup.py
+++ b/packages/google-cloud-life-sciences/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/lifesciences/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-life-sciences"
diff --git a/packages/google-cloud-life-sciences/testing/constraints-3.10.txt b/packages/google-cloud-life-sciences/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-life-sciences/testing/constraints-3.10.txt
+++ b/packages/google-cloud-life-sciences/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-life-sciences/testing/constraints-3.13.txt b/packages/google-cloud-life-sciences/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-life-sciences/testing/constraints-3.13.txt
+++ b/packages/google-cloud-life-sciences/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-life-sciences/testing/constraints-3.14.txt b/packages/google-cloud-life-sciences/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-life-sciences/testing/constraints-3.14.txt
+++ b/packages/google-cloud-life-sciences/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-locationfinder/google/cloud/locationfinder_v1/__init__.py b/packages/google-cloud-locationfinder/google/cloud/locationfinder_v1/__init__.py
index 2fdff819e6d6..ce76365ea1c2 100644
--- a/packages/google-cloud-locationfinder/google/cloud/locationfinder_v1/__init__.py
+++ b/packages/google-cloud-locationfinder/google/cloud/locationfinder_v1/__init__.py
@@ -61,7 +61,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -90,9 +90,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-locationfinder/setup.py b/packages/google-cloud-locationfinder/setup.py
index db61f4b9fc5b..fa31eb157ebe 100644
--- a/packages/google-cloud-locationfinder/setup.py
+++ b/packages/google-cloud-locationfinder/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/locationfinder/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-locationfinder"
diff --git a/packages/google-cloud-locationfinder/testing/constraints-3.10.txt b/packages/google-cloud-locationfinder/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-locationfinder/testing/constraints-3.10.txt
+++ b/packages/google-cloud-locationfinder/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-locationfinder/testing/constraints-3.13.txt b/packages/google-cloud-locationfinder/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-locationfinder/testing/constraints-3.13.txt
+++ b/packages/google-cloud-locationfinder/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-locationfinder/testing/constraints-3.14.txt b/packages/google-cloud-locationfinder/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-locationfinder/testing/constraints-3.14.txt
+++ b/packages/google-cloud-locationfinder/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-logging/setup.py b/packages/google-cloud-logging/setup.py
index 97568c52429b..7514bb1cd51a 100644
--- a/packages/google-cloud-logging/setup.py
+++ b/packages/google-cloud-logging/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/logging/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,7 +42,7 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
@@ -50,9 +53,8 @@
     "opentelemetry-api >= 1.16.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-logging"
diff --git a/packages/google-cloud-logging/testing/constraints-3.10.txt b/packages/google-cloud-logging/testing/constraints-3.10.txt
index 3ff5c516b82a..05c86a6b123f 100644
--- a/packages/google-cloud-logging/testing/constraints-3.10.txt
+++ b/packages/google-cloud-logging/testing/constraints-3.10.txt
@@ -4,7 +4,7 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 google-cloud-appengine-logging==0.1.3
 google-cloud-audit-log==0.3.1
@@ -12,5 +12,5 @@ google-cloud-core==2.0.0
 grpc-google-iam-v1==0.12.4
 opentelemetry-api==1.16.0
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-logging/testing/constraints-3.13.txt b/packages/google-cloud-logging/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-logging/testing/constraints-3.13.txt
+++ b/packages/google-cloud-logging/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-logging/testing/constraints-3.14.txt b/packages/google-cloud-logging/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-logging/testing/constraints-3.14.txt
+++ b/packages/google-cloud-logging/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-lustre/google/cloud/lustre_v1/__init__.py b/packages/google-cloud-lustre/google/cloud/lustre_v1/__init__.py
index 4067f922809a..ff29229acbe0 100644
--- a/packages/google-cloud-lustre/google/cloud/lustre_v1/__init__.py
+++ b/packages/google-cloud-lustre/google/cloud/lustre_v1/__init__.py
@@ -75,7 +75,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -104,9 +104,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-lustre/setup.py b/packages/google-cloud-lustre/setup.py
index 79ffe101e41f..7bfcba2bfa1b 100644
--- a/packages/google-cloud-lustre/setup.py
+++ b/packages/google-cloud-lustre/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/lustre/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-lustre"
diff --git a/packages/google-cloud-lustre/testing/constraints-3.10.txt b/packages/google-cloud-lustre/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-lustre/testing/constraints-3.10.txt
+++ b/packages/google-cloud-lustre/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-lustre/testing/constraints-3.13.txt b/packages/google-cloud-lustre/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-lustre/testing/constraints-3.13.txt
+++ b/packages/google-cloud-lustre/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-lustre/testing/constraints-3.14.txt b/packages/google-cloud-lustre/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-lustre/testing/constraints-3.14.txt
+++ b/packages/google-cloud-lustre/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-maintenance-api/google/cloud/maintenance_api_v1/__init__.py b/packages/google-cloud-maintenance-api/google/cloud/maintenance_api_v1/__init__.py
index fa6863381d74..967f784e0519 100644
--- a/packages/google-cloud-maintenance-api/google/cloud/maintenance_api_v1/__init__.py
+++ b/packages/google-cloud-maintenance-api/google/cloud/maintenance_api_v1/__init__.py
@@ -61,7 +61,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -90,9 +90,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-maintenance-api/google/cloud/maintenance_api_v1beta/__init__.py b/packages/google-cloud-maintenance-api/google/cloud/maintenance_api_v1beta/__init__.py
index f0a652bc6a57..9663c2f55e52 100644
--- a/packages/google-cloud-maintenance-api/google/cloud/maintenance_api_v1beta/__init__.py
+++ b/packages/google-cloud-maintenance-api/google/cloud/maintenance_api_v1beta/__init__.py
@@ -61,7 +61,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -90,9 +90,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-maintenance-api/setup.py b/packages/google-cloud-maintenance-api/setup.py
index b6c5444d0ce4..703795455eff 100644
--- a/packages/google-cloud-maintenance-api/setup.py
+++ b/packages/google-cloud-maintenance-api/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/maintenance_api/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-maintenance-api"
diff --git a/packages/google-cloud-maintenance-api/testing/constraints-3.10.txt b/packages/google-cloud-maintenance-api/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-maintenance-api/testing/constraints-3.10.txt
+++ b/packages/google-cloud-maintenance-api/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-maintenance-api/testing/constraints-3.13.txt b/packages/google-cloud-maintenance-api/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-maintenance-api/testing/constraints-3.13.txt
+++ b/packages/google-cloud-maintenance-api/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-maintenance-api/testing/constraints-3.14.txt b/packages/google-cloud-maintenance-api/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-maintenance-api/testing/constraints-3.14.txt
+++ b/packages/google-cloud-maintenance-api/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-managed-identities/google/cloud/managedidentities_v1/__init__.py b/packages/google-cloud-managed-identities/google/cloud/managedidentities_v1/__init__.py
index 325bde76d519..8d09f98f9358 100644
--- a/packages/google-cloud-managed-identities/google/cloud/managedidentities_v1/__init__.py
+++ b/packages/google-cloud-managed-identities/google/cloud/managedidentities_v1/__init__.py
@@ -69,7 +69,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -98,9 +98,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-managed-identities/setup.py b/packages/google-cloud-managed-identities/setup.py
index 6b43890953d3..c5071c973582 100644
--- a/packages/google-cloud-managed-identities/setup.py
+++ b/packages/google-cloud-managed-identities/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/managedidentities/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-managed-identities"
diff --git a/packages/google-cloud-managed-identities/testing/constraints-3.10.txt b/packages/google-cloud-managed-identities/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-managed-identities/testing/constraints-3.10.txt
+++ b/packages/google-cloud-managed-identities/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-managed-identities/testing/constraints-3.13.txt b/packages/google-cloud-managed-identities/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-managed-identities/testing/constraints-3.13.txt
+++ b/packages/google-cloud-managed-identities/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-managed-identities/testing/constraints-3.14.txt b/packages/google-cloud-managed-identities/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-managed-identities/testing/constraints-3.14.txt
+++ b/packages/google-cloud-managed-identities/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-managedkafka-schemaregistry/google/cloud/managedkafka_schemaregistry_v1/__init__.py b/packages/google-cloud-managedkafka-schemaregistry/google/cloud/managedkafka_schemaregistry_v1/__init__.py
index e0f3ef69420a..95421fa41155 100644
--- a/packages/google-cloud-managedkafka-schemaregistry/google/cloud/managedkafka_schemaregistry_v1/__init__.py
+++ b/packages/google-cloud-managedkafka-schemaregistry/google/cloud/managedkafka_schemaregistry_v1/__init__.py
@@ -92,7 +92,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -121,9 +121,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-managedkafka-schemaregistry/setup.py b/packages/google-cloud-managedkafka-schemaregistry/setup.py
index 9416c56d5a36..fe7ec9207344 100644
--- a/packages/google-cloud-managedkafka-schemaregistry/setup.py
+++ b/packages/google-cloud-managedkafka-schemaregistry/setup.py
@@ -33,7 +33,10 @@
         package_root, "google/cloud/managedkafka_schemaregistry/gapic_version.py"
     )
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -43,15 +46,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-managedkafka-schemaregistry"
diff --git a/packages/google-cloud-managedkafka-schemaregistry/testing/constraints-3.10.txt b/packages/google-cloud-managedkafka-schemaregistry/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-managedkafka-schemaregistry/testing/constraints-3.10.txt
+++ b/packages/google-cloud-managedkafka-schemaregistry/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-managedkafka-schemaregistry/testing/constraints-3.13.txt b/packages/google-cloud-managedkafka-schemaregistry/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-managedkafka-schemaregistry/testing/constraints-3.13.txt
+++ b/packages/google-cloud-managedkafka-schemaregistry/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-managedkafka-schemaregistry/testing/constraints-3.14.txt b/packages/google-cloud-managedkafka-schemaregistry/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-managedkafka-schemaregistry/testing/constraints-3.14.txt
+++ b/packages/google-cloud-managedkafka-schemaregistry/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-managedkafka/google/cloud/managedkafka_v1/__init__.py b/packages/google-cloud-managedkafka/google/cloud/managedkafka_v1/__init__.py
index 972633cef999..782f8c772354 100644
--- a/packages/google-cloud-managedkafka/google/cloud/managedkafka_v1/__init__.py
+++ b/packages/google-cloud-managedkafka/google/cloud/managedkafka_v1/__init__.py
@@ -128,7 +128,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -157,9 +157,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-managedkafka/setup.py b/packages/google-cloud-managedkafka/setup.py
index d9ea063674ea..09e86f8d94da 100644
--- a/packages/google-cloud-managedkafka/setup.py
+++ b/packages/google-cloud-managedkafka/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/managedkafka/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-managedkafka"
diff --git a/packages/google-cloud-managedkafka/testing/constraints-3.10.txt b/packages/google-cloud-managedkafka/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-managedkafka/testing/constraints-3.10.txt
+++ b/packages/google-cloud-managedkafka/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-managedkafka/testing/constraints-3.13.txt b/packages/google-cloud-managedkafka/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-managedkafka/testing/constraints-3.13.txt
+++ b/packages/google-cloud-managedkafka/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-managedkafka/testing/constraints-3.14.txt b/packages/google-cloud-managedkafka/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-managedkafka/testing/constraints-3.14.txt
+++ b/packages/google-cloud-managedkafka/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-media-translation/google/cloud/mediatranslation_v1beta1/__init__.py b/packages/google-cloud-media-translation/google/cloud/mediatranslation_v1beta1/__init__.py
index 7a72cefff50e..e4eae055056a 100644
--- a/packages/google-cloud-media-translation/google/cloud/mediatranslation_v1beta1/__init__.py
+++ b/packages/google-cloud-media-translation/google/cloud/mediatranslation_v1beta1/__init__.py
@@ -60,7 +60,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -89,9 +89,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-media-translation/setup.py b/packages/google-cloud-media-translation/setup.py
index 44edff2adc76..6180f605c0c7 100644
--- a/packages/google-cloud-media-translation/setup.py
+++ b/packages/google-cloud-media-translation/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/mediatranslation/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-media-translation"
diff --git a/packages/google-cloud-media-translation/testing/constraints-3.10.txt b/packages/google-cloud-media-translation/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-media-translation/testing/constraints-3.10.txt
+++ b/packages/google-cloud-media-translation/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-media-translation/testing/constraints-3.13.txt b/packages/google-cloud-media-translation/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-media-translation/testing/constraints-3.13.txt
+++ b/packages/google-cloud-media-translation/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-media-translation/testing/constraints-3.14.txt b/packages/google-cloud-media-translation/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-media-translation/testing/constraints-3.14.txt
+++ b/packages/google-cloud-media-translation/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-memcache/google/cloud/memcache_v1/__init__.py b/packages/google-cloud-memcache/google/cloud/memcache_v1/__init__.py
index 10d3f88e69f5..4cbab1dd69bc 100644
--- a/packages/google-cloud-memcache/google/cloud/memcache_v1/__init__.py
+++ b/packages/google-cloud-memcache/google/cloud/memcache_v1/__init__.py
@@ -70,7 +70,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -99,9 +99,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-memcache/google/cloud/memcache_v1beta2/__init__.py b/packages/google-cloud-memcache/google/cloud/memcache_v1beta2/__init__.py
index b568dee8aedf..39a008463637 100644
--- a/packages/google-cloud-memcache/google/cloud/memcache_v1beta2/__init__.py
+++ b/packages/google-cloud-memcache/google/cloud/memcache_v1beta2/__init__.py
@@ -71,7 +71,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -100,9 +100,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-memcache/setup.py b/packages/google-cloud-memcache/setup.py
index 79d8a055aabe..541bb28df4d1 100644
--- a/packages/google-cloud-memcache/setup.py
+++ b/packages/google-cloud-memcache/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/memcache/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-memcache"
diff --git a/packages/google-cloud-memcache/testing/constraints-3.10.txt b/packages/google-cloud-memcache/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-memcache/testing/constraints-3.10.txt
+++ b/packages/google-cloud-memcache/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-memcache/testing/constraints-3.13.txt b/packages/google-cloud-memcache/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-memcache/testing/constraints-3.13.txt
+++ b/packages/google-cloud-memcache/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-memcache/testing/constraints-3.14.txt b/packages/google-cloud-memcache/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-memcache/testing/constraints-3.14.txt
+++ b/packages/google-cloud-memcache/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-memorystore/google/cloud/memorystore_v1/__init__.py b/packages/google-cloud-memorystore/google/cloud/memorystore_v1/__init__.py
index 826ae3aa5fa4..fd0f4561b3f1 100644
--- a/packages/google-cloud-memorystore/google/cloud/memorystore_v1/__init__.py
+++ b/packages/google-cloud-memorystore/google/cloud/memorystore_v1/__init__.py
@@ -92,7 +92,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -121,9 +121,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-memorystore/google/cloud/memorystore_v1beta/__init__.py b/packages/google-cloud-memorystore/google/cloud/memorystore_v1beta/__init__.py
index 36cf30060c9d..b299b61b2bcb 100644
--- a/packages/google-cloud-memorystore/google/cloud/memorystore_v1beta/__init__.py
+++ b/packages/google-cloud-memorystore/google/cloud/memorystore_v1beta/__init__.py
@@ -72,7 +72,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -101,9 +101,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-memorystore/setup.py b/packages/google-cloud-memorystore/setup.py
index 208691caab56..bad2fb388ea9 100644
--- a/packages/google-cloud-memorystore/setup.py
+++ b/packages/google-cloud-memorystore/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/memorystore/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-memorystore"
diff --git a/packages/google-cloud-memorystore/testing/constraints-3.10.txt b/packages/google-cloud-memorystore/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-memorystore/testing/constraints-3.10.txt
+++ b/packages/google-cloud-memorystore/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-memorystore/testing/constraints-3.13.txt b/packages/google-cloud-memorystore/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-memorystore/testing/constraints-3.13.txt
+++ b/packages/google-cloud-memorystore/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-memorystore/testing/constraints-3.14.txt b/packages/google-cloud-memorystore/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-memorystore/testing/constraints-3.14.txt
+++ b/packages/google-cloud-memorystore/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-migrationcenter/google/cloud/migrationcenter_v1/__init__.py b/packages/google-cloud-migrationcenter/google/cloud/migrationcenter_v1/__init__.py
index 1890ed202e21..c88508f2a229 100644
--- a/packages/google-cloud-migrationcenter/google/cloud/migrationcenter_v1/__init__.py
+++ b/packages/google-cloud-migrationcenter/google/cloud/migrationcenter_v1/__init__.py
@@ -210,7 +210,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -239,9 +239,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-migrationcenter/setup.py b/packages/google-cloud-migrationcenter/setup.py
index e86879e9c131..7b5139ef8f60 100644
--- a/packages/google-cloud-migrationcenter/setup.py
+++ b/packages/google-cloud-migrationcenter/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/migrationcenter/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-migrationcenter"
diff --git a/packages/google-cloud-migrationcenter/testing/constraints-3.10.txt b/packages/google-cloud-migrationcenter/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-migrationcenter/testing/constraints-3.10.txt
+++ b/packages/google-cloud-migrationcenter/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-migrationcenter/testing/constraints-3.13.txt b/packages/google-cloud-migrationcenter/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-migrationcenter/testing/constraints-3.13.txt
+++ b/packages/google-cloud-migrationcenter/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-migrationcenter/testing/constraints-3.14.txt b/packages/google-cloud-migrationcenter/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-migrationcenter/testing/constraints-3.14.txt
+++ b/packages/google-cloud-migrationcenter/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-modelarmor/google/cloud/modelarmor_v1/__init__.py b/packages/google-cloud-modelarmor/google/cloud/modelarmor_v1/__init__.py
index c93c523b3f4a..89d2dcbb660f 100644
--- a/packages/google-cloud-modelarmor/google/cloud/modelarmor_v1/__init__.py
+++ b/packages/google-cloud-modelarmor/google/cloud/modelarmor_v1/__init__.py
@@ -98,7 +98,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -127,9 +127,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-modelarmor/google/cloud/modelarmor_v1beta/__init__.py b/packages/google-cloud-modelarmor/google/cloud/modelarmor_v1beta/__init__.py
index 98c3d030ab6d..6d9803207727 100644
--- a/packages/google-cloud-modelarmor/google/cloud/modelarmor_v1beta/__init__.py
+++ b/packages/google-cloud-modelarmor/google/cloud/modelarmor_v1beta/__init__.py
@@ -99,7 +99,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -128,9 +128,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-modelarmor/setup.py b/packages/google-cloud-modelarmor/setup.py
index 8506f9fb203b..cb1761764ec2 100644
--- a/packages/google-cloud-modelarmor/setup.py
+++ b/packages/google-cloud-modelarmor/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/modelarmor/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-modelarmor"
diff --git a/packages/google-cloud-modelarmor/testing/constraints-3.10.txt b/packages/google-cloud-modelarmor/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-modelarmor/testing/constraints-3.10.txt
+++ b/packages/google-cloud-modelarmor/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-modelarmor/testing/constraints-3.13.txt b/packages/google-cloud-modelarmor/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-modelarmor/testing/constraints-3.13.txt
+++ b/packages/google-cloud-modelarmor/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-modelarmor/testing/constraints-3.14.txt b/packages/google-cloud-modelarmor/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-modelarmor/testing/constraints-3.14.txt
+++ b/packages/google-cloud-modelarmor/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-monitoring-dashboards/google/cloud/monitoring_dashboard_v1/__init__.py b/packages/google-cloud-monitoring-dashboards/google/cloud/monitoring_dashboard_v1/__init__.py
index 84f96411042b..879516cbe56d 100644
--- a/packages/google-cloud-monitoring-dashboards/google/cloud/monitoring_dashboard_v1/__init__.py
+++ b/packages/google-cloud-monitoring-dashboards/google/cloud/monitoring_dashboard_v1/__init__.py
@@ -86,7 +86,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -115,9 +115,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-monitoring-dashboards/setup.py b/packages/google-cloud-monitoring-dashboards/setup.py
index 95971113f4db..d4e6dd1a5eaf 100644
--- a/packages/google-cloud-monitoring-dashboards/setup.py
+++ b/packages/google-cloud-monitoring-dashboards/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/monitoring_dashboard/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-monitoring-dashboards"
diff --git a/packages/google-cloud-monitoring-dashboards/testing/constraints-3.10.txt b/packages/google-cloud-monitoring-dashboards/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-monitoring-dashboards/testing/constraints-3.10.txt
+++ b/packages/google-cloud-monitoring-dashboards/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-monitoring-dashboards/testing/constraints-3.13.txt b/packages/google-cloud-monitoring-dashboards/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-monitoring-dashboards/testing/constraints-3.13.txt
+++ b/packages/google-cloud-monitoring-dashboards/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-monitoring-dashboards/testing/constraints-3.14.txt b/packages/google-cloud-monitoring-dashboards/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-monitoring-dashboards/testing/constraints-3.14.txt
+++ b/packages/google-cloud-monitoring-dashboards/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-monitoring-metrics-scopes/google/cloud/monitoring_metrics_scope_v1/__init__.py b/packages/google-cloud-monitoring-metrics-scopes/google/cloud/monitoring_metrics_scope_v1/__init__.py
index 1e13c92aea6d..e520b377c8b4 100644
--- a/packages/google-cloud-monitoring-metrics-scopes/google/cloud/monitoring_metrics_scope_v1/__init__.py
+++ b/packages/google-cloud-monitoring-metrics-scopes/google/cloud/monitoring_metrics_scope_v1/__init__.py
@@ -59,7 +59,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -88,9 +88,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-monitoring-metrics-scopes/setup.py b/packages/google-cloud-monitoring-metrics-scopes/setup.py
index 00bd7975c4cb..9445363dc558 100644
--- a/packages/google-cloud-monitoring-metrics-scopes/setup.py
+++ b/packages/google-cloud-monitoring-metrics-scopes/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/monitoring_metrics_scope/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-monitoring-metrics-scopes"
diff --git a/packages/google-cloud-monitoring-metrics-scopes/testing/constraints-3.10.txt b/packages/google-cloud-monitoring-metrics-scopes/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-monitoring-metrics-scopes/testing/constraints-3.10.txt
+++ b/packages/google-cloud-monitoring-metrics-scopes/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-monitoring-metrics-scopes/testing/constraints-3.13.txt b/packages/google-cloud-monitoring-metrics-scopes/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-monitoring-metrics-scopes/testing/constraints-3.13.txt
+++ b/packages/google-cloud-monitoring-metrics-scopes/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-monitoring-metrics-scopes/testing/constraints-3.14.txt b/packages/google-cloud-monitoring-metrics-scopes/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-monitoring-metrics-scopes/testing/constraints-3.14.txt
+++ b/packages/google-cloud-monitoring-metrics-scopes/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-monitoring/google/cloud/monitoring_v3/__init__.py b/packages/google-cloud-monitoring/google/cloud/monitoring_v3/__init__.py
index 0d3318ec2d4b..344bd1ab6b6b 100644
--- a/packages/google-cloud-monitoring/google/cloud/monitoring_v3/__init__.py
+++ b/packages/google-cloud-monitoring/google/cloud/monitoring_v3/__init__.py
@@ -193,7 +193,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -222,9 +222,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-monitoring/setup.py b/packages/google-cloud-monitoring/setup.py
index e549aed6fc15..2eb2a37ed01b 100644
--- a/packages/google-cloud-monitoring/setup.py
+++ b/packages/google-cloud-monitoring/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/monitoring/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {"pandas": "pandas >= 1.3.4"}
 
diff --git a/packages/google-cloud-monitoring/testing/constraints-3.10.txt b/packages/google-cloud-monitoring/testing/constraints-3.10.txt
index d335f6419cf8..53e51cd75bb0 100644
--- a/packages/google-cloud-monitoring/testing/constraints-3.10.txt
+++ b/packages/google-cloud-monitoring/testing/constraints-3.10.txt
@@ -4,10 +4,10 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 pandas==1.3.4
 numpy==1.21.3
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-monitoring/testing/constraints-3.13.txt b/packages/google-cloud-monitoring/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-monitoring/testing/constraints-3.13.txt
+++ b/packages/google-cloud-monitoring/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-monitoring/testing/constraints-3.14.txt b/packages/google-cloud-monitoring/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-monitoring/testing/constraints-3.14.txt
+++ b/packages/google-cloud-monitoring/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-netapp/google/cloud/netapp_v1/__init__.py b/packages/google-cloud-netapp/google/cloud/netapp_v1/__init__.py
index f0716178a060..3944cb800dcd 100644
--- a/packages/google-cloud-netapp/google/cloud/netapp_v1/__init__.py
+++ b/packages/google-cloud-netapp/google/cloud/netapp_v1/__init__.py
@@ -213,7 +213,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -242,9 +242,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-netapp/setup.py b/packages/google-cloud-netapp/setup.py
index f7360b1daeb6..b421fbec29d5 100644
--- a/packages/google-cloud-netapp/setup.py
+++ b/packages/google-cloud-netapp/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/netapp/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-netapp"
diff --git a/packages/google-cloud-netapp/testing/constraints-3.10.txt b/packages/google-cloud-netapp/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-netapp/testing/constraints-3.10.txt
+++ b/packages/google-cloud-netapp/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-netapp/testing/constraints-3.13.txt b/packages/google-cloud-netapp/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-netapp/testing/constraints-3.13.txt
+++ b/packages/google-cloud-netapp/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-netapp/testing/constraints-3.14.txt b/packages/google-cloud-netapp/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-netapp/testing/constraints-3.14.txt
+++ b/packages/google-cloud-netapp/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-network-connectivity/google/cloud/networkconnectivity_v1/__init__.py b/packages/google-cloud-network-connectivity/google/cloud/networkconnectivity_v1/__init__.py
index 981e0ecc117f..721e5394aa69 100644
--- a/packages/google-cloud-network-connectivity/google/cloud/networkconnectivity_v1/__init__.py
+++ b/packages/google-cloud-network-connectivity/google/cloud/networkconnectivity_v1/__init__.py
@@ -200,7 +200,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -229,9 +229,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-network-connectivity/google/cloud/networkconnectivity_v1alpha1/__init__.py b/packages/google-cloud-network-connectivity/google/cloud/networkconnectivity_v1alpha1/__init__.py
index e57ea4a58693..a69b4193269d 100644
--- a/packages/google-cloud-network-connectivity/google/cloud/networkconnectivity_v1alpha1/__init__.py
+++ b/packages/google-cloud-network-connectivity/google/cloud/networkconnectivity_v1alpha1/__init__.py
@@ -69,7 +69,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -98,9 +98,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-network-connectivity/google/cloud/networkconnectivity_v1beta/__init__.py b/packages/google-cloud-network-connectivity/google/cloud/networkconnectivity_v1beta/__init__.py
index 92ac5dcf3760..01f50021c944 100644
--- a/packages/google-cloud-network-connectivity/google/cloud/networkconnectivity_v1beta/__init__.py
+++ b/packages/google-cloud-network-connectivity/google/cloud/networkconnectivity_v1beta/__init__.py
@@ -180,7 +180,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -209,9 +209,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-network-connectivity/setup.py b/packages/google-cloud-network-connectivity/setup.py
index de8d11e404f4..775af2c3ba2b 100644
--- a/packages/google-cloud-network-connectivity/setup.py
+++ b/packages/google-cloud-network-connectivity/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/networkconnectivity/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-network-connectivity"
diff --git a/packages/google-cloud-network-connectivity/testing/constraints-3.10.txt b/packages/google-cloud-network-connectivity/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-network-connectivity/testing/constraints-3.10.txt
+++ b/packages/google-cloud-network-connectivity/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-network-connectivity/testing/constraints-3.13.txt b/packages/google-cloud-network-connectivity/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-network-connectivity/testing/constraints-3.13.txt
+++ b/packages/google-cloud-network-connectivity/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-network-connectivity/testing/constraints-3.14.txt b/packages/google-cloud-network-connectivity/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-network-connectivity/testing/constraints-3.14.txt
+++ b/packages/google-cloud-network-connectivity/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-network-management/google/cloud/network_management_v1/__init__.py b/packages/google-cloud-network-management/google/cloud/network_management_v1/__init__.py
index cb7447d8e3b3..eecf50e9cdd5 100644
--- a/packages/google-cloud-network-management/google/cloud/network_management_v1/__init__.py
+++ b/packages/google-cloud-network-management/google/cloud/network_management_v1/__init__.py
@@ -134,7 +134,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -163,9 +163,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-network-management/setup.py b/packages/google-cloud-network-management/setup.py
index 8af6d1192eee..992aefaafe8b 100644
--- a/packages/google-cloud-network-management/setup.py
+++ b/packages/google-cloud-network-management/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/network_management/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-network-management"
diff --git a/packages/google-cloud-network-management/testing/constraints-3.10.txt b/packages/google-cloud-network-management/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-network-management/testing/constraints-3.10.txt
+++ b/packages/google-cloud-network-management/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-network-management/testing/constraints-3.13.txt b/packages/google-cloud-network-management/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-network-management/testing/constraints-3.13.txt
+++ b/packages/google-cloud-network-management/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-network-management/testing/constraints-3.14.txt b/packages/google-cloud-network-management/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-network-management/testing/constraints-3.14.txt
+++ b/packages/google-cloud-network-management/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-network-security/google/cloud/network_security_v1/__init__.py b/packages/google-cloud-network-security/google/cloud/network_security_v1/__init__.py
index 962e4da8b6ad..0e6d79c26858 100644
--- a/packages/google-cloud-network-security/google/cloud/network_security_v1/__init__.py
+++ b/packages/google-cloud-network-security/google/cloud/network_security_v1/__init__.py
@@ -311,7 +311,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -340,9 +340,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-network-security/google/cloud/network_security_v1alpha1/__init__.py b/packages/google-cloud-network-security/google/cloud/network_security_v1alpha1/__init__.py
index e7dc75a22db1..0157cdac082b 100644
--- a/packages/google-cloud-network-security/google/cloud/network_security_v1alpha1/__init__.py
+++ b/packages/google-cloud-network-security/google/cloud/network_security_v1alpha1/__init__.py
@@ -308,7 +308,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -337,9 +337,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-network-security/google/cloud/network_security_v1beta1/__init__.py b/packages/google-cloud-network-security/google/cloud/network_security_v1beta1/__init__.py
index 4969f11a1ee9..e97b8c25195a 100644
--- a/packages/google-cloud-network-security/google/cloud/network_security_v1beta1/__init__.py
+++ b/packages/google-cloud-network-security/google/cloud/network_security_v1beta1/__init__.py
@@ -97,7 +97,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -126,9 +126,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-network-security/setup.py b/packages/google-cloud-network-security/setup.py
index 0c5a80731f77..a7e51d60dfdb 100644
--- a/packages/google-cloud-network-security/setup.py
+++ b/packages/google-cloud-network-security/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/network_security/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-network-security"
diff --git a/packages/google-cloud-network-security/testing/constraints-3.10.txt b/packages/google-cloud-network-security/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-network-security/testing/constraints-3.10.txt
+++ b/packages/google-cloud-network-security/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-network-security/testing/constraints-3.13.txt b/packages/google-cloud-network-security/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-network-security/testing/constraints-3.13.txt
+++ b/packages/google-cloud-network-security/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-network-security/testing/constraints-3.14.txt b/packages/google-cloud-network-security/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-network-security/testing/constraints-3.14.txt
+++ b/packages/google-cloud-network-security/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-network-services/google/cloud/network_services_v1/__init__.py b/packages/google-cloud-network-services/google/cloud/network_services_v1/__init__.py
index ae423bbb90b7..1a36dfb8920e 100644
--- a/packages/google-cloud-network-services/google/cloud/network_services_v1/__init__.py
+++ b/packages/google-cloud-network-services/google/cloud/network_services_v1/__init__.py
@@ -208,7 +208,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -237,9 +237,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-network-services/setup.py b/packages/google-cloud-network-services/setup.py
index 8a72208f46e3..6823cf82dba1 100644
--- a/packages/google-cloud-network-services/setup.py
+++ b/packages/google-cloud-network-services/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/network_services/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-network-services"
diff --git a/packages/google-cloud-network-services/testing/constraints-3.10.txt b/packages/google-cloud-network-services/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-network-services/testing/constraints-3.10.txt
+++ b/packages/google-cloud-network-services/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-network-services/testing/constraints-3.13.txt b/packages/google-cloud-network-services/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-network-services/testing/constraints-3.13.txt
+++ b/packages/google-cloud-network-services/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-network-services/testing/constraints-3.14.txt b/packages/google-cloud-network-services/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-network-services/testing/constraints-3.14.txt
+++ b/packages/google-cloud-network-services/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-notebooks/google/cloud/notebooks_v1/__init__.py b/packages/google-cloud-notebooks/google/cloud/notebooks_v1/__init__.py
index f0a864e3a305..e7f13c9c2ba9 100644
--- a/packages/google-cloud-notebooks/google/cloud/notebooks_v1/__init__.py
+++ b/packages/google-cloud-notebooks/google/cloud/notebooks_v1/__init__.py
@@ -136,7 +136,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -165,9 +165,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-notebooks/google/cloud/notebooks_v1beta1/__init__.py b/packages/google-cloud-notebooks/google/cloud/notebooks_v1beta1/__init__.py
index e2dd11997cba..15da11447402 100644
--- a/packages/google-cloud-notebooks/google/cloud/notebooks_v1beta1/__init__.py
+++ b/packages/google-cloud-notebooks/google/cloud/notebooks_v1beta1/__init__.py
@@ -77,7 +77,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -106,9 +106,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-notebooks/google/cloud/notebooks_v2/__init__.py b/packages/google-cloud-notebooks/google/cloud/notebooks_v2/__init__.py
index 963fa2bd93cc..32134fac90b9 100644
--- a/packages/google-cloud-notebooks/google/cloud/notebooks_v2/__init__.py
+++ b/packages/google-cloud-notebooks/google/cloud/notebooks_v2/__init__.py
@@ -84,7 +84,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -113,9 +113,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-notebooks/setup.py b/packages/google-cloud-notebooks/setup.py
index 1d4d559b4a37..cd13f812512b 100644
--- a/packages/google-cloud-notebooks/setup.py
+++ b/packages/google-cloud-notebooks/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/notebooks/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-notebooks"
diff --git a/packages/google-cloud-notebooks/testing/constraints-3.10.txt b/packages/google-cloud-notebooks/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-notebooks/testing/constraints-3.10.txt
+++ b/packages/google-cloud-notebooks/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-notebooks/testing/constraints-3.13.txt b/packages/google-cloud-notebooks/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-notebooks/testing/constraints-3.13.txt
+++ b/packages/google-cloud-notebooks/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-notebooks/testing/constraints-3.14.txt b/packages/google-cloud-notebooks/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-notebooks/testing/constraints-3.14.txt
+++ b/packages/google-cloud-notebooks/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-optimization/google/cloud/optimization_v1/__init__.py b/packages/google-cloud-optimization/google/cloud/optimization_v1/__init__.py
index 3af18a4c0156..fa7ded4432c7 100644
--- a/packages/google-cloud-optimization/google/cloud/optimization_v1/__init__.py
+++ b/packages/google-cloud-optimization/google/cloud/optimization_v1/__init__.py
@@ -83,7 +83,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -112,9 +112,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-optimization/setup.py b/packages/google-cloud-optimization/setup.py
index c29d9b8b6cd2..4d97583945bb 100644
--- a/packages/google-cloud-optimization/setup.py
+++ b/packages/google-cloud-optimization/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/optimization/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-optimization"
diff --git a/packages/google-cloud-optimization/testing/constraints-3.10.txt b/packages/google-cloud-optimization/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-optimization/testing/constraints-3.10.txt
+++ b/packages/google-cloud-optimization/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-optimization/testing/constraints-3.13.txt b/packages/google-cloud-optimization/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-optimization/testing/constraints-3.13.txt
+++ b/packages/google-cloud-optimization/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-optimization/testing/constraints-3.14.txt b/packages/google-cloud-optimization/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-optimization/testing/constraints-3.14.txt
+++ b/packages/google-cloud-optimization/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-oracledatabase/google/cloud/oracledatabase_v1/__init__.py b/packages/google-cloud-oracledatabase/google/cloud/oracledatabase_v1/__init__.py
index 9ba5e09b5c0f..cc926ee58385 100644
--- a/packages/google-cloud-oracledatabase/google/cloud/oracledatabase_v1/__init__.py
+++ b/packages/google-cloud-oracledatabase/google/cloud/oracledatabase_v1/__init__.py
@@ -336,7 +336,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -365,9 +365,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-oracledatabase/setup.py b/packages/google-cloud-oracledatabase/setup.py
index 46d329fbff77..01f7265aa733 100644
--- a/packages/google-cloud-oracledatabase/setup.py
+++ b/packages/google-cloud-oracledatabase/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/oracledatabase/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-oracledatabase"
diff --git a/packages/google-cloud-oracledatabase/testing/constraints-3.10.txt b/packages/google-cloud-oracledatabase/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-oracledatabase/testing/constraints-3.10.txt
+++ b/packages/google-cloud-oracledatabase/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-oracledatabase/testing/constraints-3.13.txt b/packages/google-cloud-oracledatabase/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-oracledatabase/testing/constraints-3.13.txt
+++ b/packages/google-cloud-oracledatabase/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-oracledatabase/testing/constraints-3.14.txt b/packages/google-cloud-oracledatabase/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-oracledatabase/testing/constraints-3.14.txt
+++ b/packages/google-cloud-oracledatabase/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-orchestration-airflow/google/cloud/orchestration/airflow/service_v1/__init__.py b/packages/google-cloud-orchestration-airflow/google/cloud/orchestration/airflow/service_v1/__init__.py
index 3ab93ea509a1..ce2f826871d3 100644
--- a/packages/google-cloud-orchestration-airflow/google/cloud/orchestration/airflow/service_v1/__init__.py
+++ b/packages/google-cloud-orchestration-airflow/google/cloud/orchestration/airflow/service_v1/__init__.py
@@ -121,7 +121,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -150,9 +150,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-orchestration-airflow/google/cloud/orchestration/airflow/service_v1beta1/__init__.py b/packages/google-cloud-orchestration-airflow/google/cloud/orchestration/airflow/service_v1beta1/__init__.py
index c9c12c473dc2..09190ab22bd3 100644
--- a/packages/google-cloud-orchestration-airflow/google/cloud/orchestration/airflow/service_v1beta1/__init__.py
+++ b/packages/google-cloud-orchestration-airflow/google/cloud/orchestration/airflow/service_v1beta1/__init__.py
@@ -124,7 +124,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -153,9 +153,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-orchestration-airflow/setup.py b/packages/google-cloud-orchestration-airflow/setup.py
index d695956c7ffe..1948b7c3af0a 100644
--- a/packages/google-cloud-orchestration-airflow/setup.py
+++ b/packages/google-cloud-orchestration-airflow/setup.py
@@ -33,7 +33,10 @@
         package_root, "google/cloud/orchestration/airflow/service/gapic_version.py"
     )
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -43,15 +46,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-orchestration-airflow"
diff --git a/packages/google-cloud-orchestration-airflow/testing/constraints-3.10.txt b/packages/google-cloud-orchestration-airflow/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-orchestration-airflow/testing/constraints-3.10.txt
+++ b/packages/google-cloud-orchestration-airflow/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-orchestration-airflow/testing/constraints-3.13.txt b/packages/google-cloud-orchestration-airflow/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-orchestration-airflow/testing/constraints-3.13.txt
+++ b/packages/google-cloud-orchestration-airflow/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-orchestration-airflow/testing/constraints-3.14.txt b/packages/google-cloud-orchestration-airflow/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-orchestration-airflow/testing/constraints-3.14.txt
+++ b/packages/google-cloud-orchestration-airflow/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-org-policy/google/cloud/orgpolicy_v2/__init__.py b/packages/google-cloud-org-policy/google/cloud/orgpolicy_v2/__init__.py
index ee3ed8b4ed24..abb179a2e16e 100644
--- a/packages/google-cloud-org-policy/google/cloud/orgpolicy_v2/__init__.py
+++ b/packages/google-cloud-org-policy/google/cloud/orgpolicy_v2/__init__.py
@@ -71,7 +71,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -100,9 +100,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-org-policy/setup.py b/packages/google-cloud-org-policy/setup.py
index eeeb8c23b623..cce90859b4a7 100644
--- a/packages/google-cloud-org-policy/setup.py
+++ b/packages/google-cloud-org-policy/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/orgpolicy/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-org-policy"
diff --git a/packages/google-cloud-org-policy/testing/constraints-3.10.txt b/packages/google-cloud-org-policy/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-org-policy/testing/constraints-3.10.txt
+++ b/packages/google-cloud-org-policy/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-org-policy/testing/constraints-3.13.txt b/packages/google-cloud-org-policy/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-org-policy/testing/constraints-3.13.txt
+++ b/packages/google-cloud-org-policy/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-org-policy/testing/constraints-3.14.txt b/packages/google-cloud-org-policy/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-org-policy/testing/constraints-3.14.txt
+++ b/packages/google-cloud-org-policy/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-os-config/google/cloud/osconfig_v1/__init__.py b/packages/google-cloud-os-config/google/cloud/osconfig_v1/__init__.py
index f424f56097a1..16589199972e 100644
--- a/packages/google-cloud-os-config/google/cloud/osconfig_v1/__init__.py
+++ b/packages/google-cloud-os-config/google/cloud/osconfig_v1/__init__.py
@@ -130,7 +130,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -159,9 +159,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-os-config/google/cloud/osconfig_v1alpha/__init__.py b/packages/google-cloud-os-config/google/cloud/osconfig_v1alpha/__init__.py
index a3fb0b49b4a6..c3e71dbb6f58 100644
--- a/packages/google-cloud-os-config/google/cloud/osconfig_v1alpha/__init__.py
+++ b/packages/google-cloud-os-config/google/cloud/osconfig_v1alpha/__init__.py
@@ -98,7 +98,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -127,9 +127,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-os-config/setup.py b/packages/google-cloud-os-config/setup.py
index 8e3a7eabbf6e..e9dc57fa548c 100644
--- a/packages/google-cloud-os-config/setup.py
+++ b/packages/google-cloud-os-config/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/osconfig/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-os-config"
diff --git a/packages/google-cloud-os-config/testing/constraints-3.10.txt b/packages/google-cloud-os-config/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-os-config/testing/constraints-3.10.txt
+++ b/packages/google-cloud-os-config/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-os-config/testing/constraints-3.13.txt b/packages/google-cloud-os-config/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-os-config/testing/constraints-3.13.txt
+++ b/packages/google-cloud-os-config/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-os-config/testing/constraints-3.14.txt b/packages/google-cloud-os-config/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-os-config/testing/constraints-3.14.txt
+++ b/packages/google-cloud-os-config/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-os-login/google/cloud/oslogin_v1/__init__.py b/packages/google-cloud-os-login/google/cloud/oslogin_v1/__init__.py
index 5d0a9a28e8a3..de46c4aa1787 100644
--- a/packages/google-cloud-os-login/google/cloud/oslogin_v1/__init__.py
+++ b/packages/google-cloud-os-login/google/cloud/oslogin_v1/__init__.py
@@ -61,7 +61,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -90,9 +90,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-os-login/setup.py b/packages/google-cloud-os-login/setup.py
index fc9fcd2ffe66..1f4dc68bd225 100644
--- a/packages/google-cloud-os-login/setup.py
+++ b/packages/google-cloud-os-login/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/oslogin/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-os-login"
diff --git a/packages/google-cloud-os-login/testing/constraints-3.10.txt b/packages/google-cloud-os-login/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-os-login/testing/constraints-3.10.txt
+++ b/packages/google-cloud-os-login/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-os-login/testing/constraints-3.13.txt b/packages/google-cloud-os-login/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-os-login/testing/constraints-3.13.txt
+++ b/packages/google-cloud-os-login/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-os-login/testing/constraints-3.14.txt b/packages/google-cloud-os-login/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-os-login/testing/constraints-3.14.txt
+++ b/packages/google-cloud-os-login/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-parallelstore/google/cloud/parallelstore_v1/__init__.py b/packages/google-cloud-parallelstore/google/cloud/parallelstore_v1/__init__.py
index 48484f52d23a..d4ae70c5e1ec 100644
--- a/packages/google-cloud-parallelstore/google/cloud/parallelstore_v1/__init__.py
+++ b/packages/google-cloud-parallelstore/google/cloud/parallelstore_v1/__init__.py
@@ -79,7 +79,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -108,9 +108,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-parallelstore/google/cloud/parallelstore_v1beta/__init__.py b/packages/google-cloud-parallelstore/google/cloud/parallelstore_v1beta/__init__.py
index b3ecc0ef887e..28d74e1809fe 100644
--- a/packages/google-cloud-parallelstore/google/cloud/parallelstore_v1beta/__init__.py
+++ b/packages/google-cloud-parallelstore/google/cloud/parallelstore_v1beta/__init__.py
@@ -79,7 +79,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -108,9 +108,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-parallelstore/setup.py b/packages/google-cloud-parallelstore/setup.py
index 6ef4df5c52ac..a944c6a662e6 100644
--- a/packages/google-cloud-parallelstore/setup.py
+++ b/packages/google-cloud-parallelstore/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/parallelstore/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-parallelstore"
diff --git a/packages/google-cloud-parallelstore/testing/constraints-3.10.txt b/packages/google-cloud-parallelstore/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-parallelstore/testing/constraints-3.10.txt
+++ b/packages/google-cloud-parallelstore/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-parallelstore/testing/constraints-3.13.txt b/packages/google-cloud-parallelstore/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-parallelstore/testing/constraints-3.13.txt
+++ b/packages/google-cloud-parallelstore/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-parallelstore/testing/constraints-3.14.txt b/packages/google-cloud-parallelstore/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-parallelstore/testing/constraints-3.14.txt
+++ b/packages/google-cloud-parallelstore/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-parametermanager/google/cloud/parametermanager_v1/__init__.py b/packages/google-cloud-parametermanager/google/cloud/parametermanager_v1/__init__.py
index 0b52a17d3b34..6fed83bdb57c 100644
--- a/packages/google-cloud-parametermanager/google/cloud/parametermanager_v1/__init__.py
+++ b/packages/google-cloud-parametermanager/google/cloud/parametermanager_v1/__init__.py
@@ -74,7 +74,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -103,9 +103,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-parametermanager/setup.py b/packages/google-cloud-parametermanager/setup.py
index 96a75cc8f4ca..6bf84a9e0129 100644
--- a/packages/google-cloud-parametermanager/setup.py
+++ b/packages/google-cloud-parametermanager/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/parametermanager/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-parametermanager"
diff --git a/packages/google-cloud-parametermanager/testing/constraints-3.10.txt b/packages/google-cloud-parametermanager/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-parametermanager/testing/constraints-3.10.txt
+++ b/packages/google-cloud-parametermanager/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-parametermanager/testing/constraints-3.13.txt b/packages/google-cloud-parametermanager/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-parametermanager/testing/constraints-3.13.txt
+++ b/packages/google-cloud-parametermanager/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-parametermanager/testing/constraints-3.14.txt b/packages/google-cloud-parametermanager/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-parametermanager/testing/constraints-3.14.txt
+++ b/packages/google-cloud-parametermanager/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-phishing-protection/google/cloud/phishingprotection_v1beta1/__init__.py b/packages/google-cloud-phishing-protection/google/cloud/phishingprotection_v1beta1/__init__.py
index 1a57f91a69b1..2e871b0961ae 100644
--- a/packages/google-cloud-phishing-protection/google/cloud/phishingprotection_v1beta1/__init__.py
+++ b/packages/google-cloud-phishing-protection/google/cloud/phishingprotection_v1beta1/__init__.py
@@ -54,7 +54,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -83,9 +83,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-phishing-protection/setup.py b/packages/google-cloud-phishing-protection/setup.py
index 5f84e31c66e3..af18d8b4c6ae 100644
--- a/packages/google-cloud-phishing-protection/setup.py
+++ b/packages/google-cloud-phishing-protection/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/phishingprotection/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-phishing-protection"
diff --git a/packages/google-cloud-phishing-protection/testing/constraints-3.10.txt b/packages/google-cloud-phishing-protection/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-phishing-protection/testing/constraints-3.10.txt
+++ b/packages/google-cloud-phishing-protection/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-phishing-protection/testing/constraints-3.13.txt b/packages/google-cloud-phishing-protection/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-phishing-protection/testing/constraints-3.13.txt
+++ b/packages/google-cloud-phishing-protection/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-phishing-protection/testing/constraints-3.14.txt b/packages/google-cloud-phishing-protection/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-phishing-protection/testing/constraints-3.14.txt
+++ b/packages/google-cloud-phishing-protection/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-policy-troubleshooter/google/cloud/policytroubleshooter_v1/__init__.py b/packages/google-cloud-policy-troubleshooter/google/cloud/policytroubleshooter_v1/__init__.py
index 3470b5141817..19686075b803 100644
--- a/packages/google-cloud-policy-troubleshooter/google/cloud/policytroubleshooter_v1/__init__.py
+++ b/packages/google-cloud-policy-troubleshooter/google/cloud/policytroubleshooter_v1/__init__.py
@@ -58,7 +58,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -87,9 +87,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-policy-troubleshooter/setup.py b/packages/google-cloud-policy-troubleshooter/setup.py
index 4b0add742904..c821e7ea1b09 100644
--- a/packages/google-cloud-policy-troubleshooter/setup.py
+++ b/packages/google-cloud-policy-troubleshooter/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/policytroubleshooter/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-policy-troubleshooter"
diff --git a/packages/google-cloud-policy-troubleshooter/testing/constraints-3.10.txt b/packages/google-cloud-policy-troubleshooter/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-policy-troubleshooter/testing/constraints-3.10.txt
+++ b/packages/google-cloud-policy-troubleshooter/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-policy-troubleshooter/testing/constraints-3.13.txt b/packages/google-cloud-policy-troubleshooter/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-policy-troubleshooter/testing/constraints-3.13.txt
+++ b/packages/google-cloud-policy-troubleshooter/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-policy-troubleshooter/testing/constraints-3.14.txt b/packages/google-cloud-policy-troubleshooter/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-policy-troubleshooter/testing/constraints-3.14.txt
+++ b/packages/google-cloud-policy-troubleshooter/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-policysimulator/google/cloud/policysimulator_v1/__init__.py b/packages/google-cloud-policysimulator/google/cloud/policysimulator_v1/__init__.py
index ecd207b296a7..00ff3e27fc2d 100644
--- a/packages/google-cloud-policysimulator/google/cloud/policysimulator_v1/__init__.py
+++ b/packages/google-cloud-policysimulator/google/cloud/policysimulator_v1/__init__.py
@@ -88,7 +88,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -117,9 +117,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-policysimulator/setup.py b/packages/google-cloud-policysimulator/setup.py
index 2fcef358e8bc..1b6ba8c636b2 100644
--- a/packages/google-cloud-policysimulator/setup.py
+++ b/packages/google-cloud-policysimulator/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/policysimulator/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,17 +44,16 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "google-cloud-org-policy >= 1.11.1, <2.0.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-policysimulator"
diff --git a/packages/google-cloud-policysimulator/testing/constraints-3.10.txt b/packages/google-cloud-policysimulator/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-policysimulator/testing/constraints-3.10.txt
+++ b/packages/google-cloud-policysimulator/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-policysimulator/testing/constraints-3.13.txt b/packages/google-cloud-policysimulator/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-policysimulator/testing/constraints-3.13.txt
+++ b/packages/google-cloud-policysimulator/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-policysimulator/testing/constraints-3.14.txt b/packages/google-cloud-policysimulator/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-policysimulator/testing/constraints-3.14.txt
+++ b/packages/google-cloud-policysimulator/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-policytroubleshooter-iam/google/cloud/policytroubleshooter_iam_v3/__init__.py b/packages/google-cloud-policytroubleshooter-iam/google/cloud/policytroubleshooter_iam_v3/__init__.py
index 0fe6b843e149..7f13b2532597 100644
--- a/packages/google-cloud-policytroubleshooter-iam/google/cloud/policytroubleshooter_iam_v3/__init__.py
+++ b/packages/google-cloud-policytroubleshooter-iam/google/cloud/policytroubleshooter_iam_v3/__init__.py
@@ -73,7 +73,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -102,9 +102,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-policytroubleshooter-iam/setup.py b/packages/google-cloud-policytroubleshooter-iam/setup.py
index 304049104b14..4e55b87b9009 100644
--- a/packages/google-cloud-policytroubleshooter-iam/setup.py
+++ b/packages/google-cloud-policytroubleshooter-iam/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/policytroubleshooter_iam/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,17 +44,16 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
-    "google-cloud-iam >= 2.12.2, <3.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
+    "google-cloud-iam >= 2.18.2, <3.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-policytroubleshooter-iam"
diff --git a/packages/google-cloud-policytroubleshooter-iam/testing/constraints-3.10.txt b/packages/google-cloud-policytroubleshooter-iam/testing/constraints-3.10.txt
index 674a39705cb1..bbd3b5241b82 100644
--- a/packages/google-cloud-policytroubleshooter-iam/testing/constraints-3.10.txt
+++ b/packages/google-cloud-policytroubleshooter-iam/testing/constraints-3.10.txt
@@ -4,10 +4,10 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
-google-cloud-iam==2.12.2
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
+google-cloud-iam==2.18.2
diff --git a/packages/google-cloud-policytroubleshooter-iam/testing/constraints-3.13.txt b/packages/google-cloud-policytroubleshooter-iam/testing/constraints-3.13.txt
index 1eb835cabc37..d72c71aba784 100644
--- a/packages/google-cloud-policytroubleshooter-iam/testing/constraints-3.13.txt
+++ b/packages/google-cloud-policytroubleshooter-iam/testing/constraints-3.13.txt
@@ -9,6 +9,6 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
 google-cloud-iam>=2
diff --git a/packages/google-cloud-policytroubleshooter-iam/testing/constraints-3.14.txt b/packages/google-cloud-policytroubleshooter-iam/testing/constraints-3.14.txt
index 1eb835cabc37..d72c71aba784 100644
--- a/packages/google-cloud-policytroubleshooter-iam/testing/constraints-3.14.txt
+++ b/packages/google-cloud-policytroubleshooter-iam/testing/constraints-3.14.txt
@@ -9,6 +9,6 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
 google-cloud-iam>=2
diff --git a/packages/google-cloud-private-ca/google/cloud/security/privateca_v1/__init__.py b/packages/google-cloud-private-ca/google/cloud/security/privateca_v1/__init__.py
index 16edba16d777..466fd02d220d 100644
--- a/packages/google-cloud-private-ca/google/cloud/security/privateca_v1/__init__.py
+++ b/packages/google-cloud-private-ca/google/cloud/security/privateca_v1/__init__.py
@@ -117,7 +117,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -146,9 +146,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-private-ca/google/cloud/security/privateca_v1beta1/__init__.py b/packages/google-cloud-private-ca/google/cloud/security/privateca_v1beta1/__init__.py
index daf7edfa9e4f..577d072ca6fd 100644
--- a/packages/google-cloud-private-ca/google/cloud/security/privateca_v1beta1/__init__.py
+++ b/packages/google-cloud-private-ca/google/cloud/security/privateca_v1beta1/__init__.py
@@ -99,7 +99,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -128,9 +128,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-private-ca/setup.py b/packages/google-cloud-private-ca/setup.py
index c11f2d1df881..7571cbd46c83 100644
--- a/packages/google-cloud-private-ca/setup.py
+++ b/packages/google-cloud-private-ca/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/security/privateca/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-private-ca"
diff --git a/packages/google-cloud-private-ca/testing/constraints-3.10.txt b/packages/google-cloud-private-ca/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-private-ca/testing/constraints-3.10.txt
+++ b/packages/google-cloud-private-ca/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-private-ca/testing/constraints-3.13.txt b/packages/google-cloud-private-ca/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-private-ca/testing/constraints-3.13.txt
+++ b/packages/google-cloud-private-ca/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-private-ca/testing/constraints-3.14.txt b/packages/google-cloud-private-ca/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-private-ca/testing/constraints-3.14.txt
+++ b/packages/google-cloud-private-ca/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-private-catalog/google/cloud/privatecatalog_v1beta1/__init__.py b/packages/google-cloud-private-catalog/google/cloud/privatecatalog_v1beta1/__init__.py
index 4b7dfeb6b305..2378ebb5c3c5 100644
--- a/packages/google-cloud-private-catalog/google/cloud/privatecatalog_v1beta1/__init__.py
+++ b/packages/google-cloud-private-catalog/google/cloud/privatecatalog_v1beta1/__init__.py
@@ -65,7 +65,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -94,9 +94,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-private-catalog/setup.py b/packages/google-cloud-private-catalog/setup.py
index 37ec2442c612..0be5fa792fa6 100644
--- a/packages/google-cloud-private-catalog/setup.py
+++ b/packages/google-cloud-private-catalog/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/privatecatalog/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-private-catalog"
diff --git a/packages/google-cloud-private-catalog/testing/constraints-3.10.txt b/packages/google-cloud-private-catalog/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-private-catalog/testing/constraints-3.10.txt
+++ b/packages/google-cloud-private-catalog/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-private-catalog/testing/constraints-3.13.txt b/packages/google-cloud-private-catalog/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-private-catalog/testing/constraints-3.13.txt
+++ b/packages/google-cloud-private-catalog/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-private-catalog/testing/constraints-3.14.txt b/packages/google-cloud-private-catalog/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-private-catalog/testing/constraints-3.14.txt
+++ b/packages/google-cloud-private-catalog/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-privilegedaccessmanager/google/cloud/privilegedaccessmanager_v1/__init__.py b/packages/google-cloud-privilegedaccessmanager/google/cloud/privilegedaccessmanager_v1/__init__.py
index d276cb37b00b..0cf880476781 100644
--- a/packages/google-cloud-privilegedaccessmanager/google/cloud/privilegedaccessmanager_v1/__init__.py
+++ b/packages/google-cloud-privilegedaccessmanager/google/cloud/privilegedaccessmanager_v1/__init__.py
@@ -82,7 +82,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -111,9 +111,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-privilegedaccessmanager/setup.py b/packages/google-cloud-privilegedaccessmanager/setup.py
index e2bbe8c24c01..5bf5a8122e8d 100644
--- a/packages/google-cloud-privilegedaccessmanager/setup.py
+++ b/packages/google-cloud-privilegedaccessmanager/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/privilegedaccessmanager/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-privilegedaccessmanager"
diff --git a/packages/google-cloud-privilegedaccessmanager/testing/constraints-3.10.txt b/packages/google-cloud-privilegedaccessmanager/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-privilegedaccessmanager/testing/constraints-3.10.txt
+++ b/packages/google-cloud-privilegedaccessmanager/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-privilegedaccessmanager/testing/constraints-3.13.txt b/packages/google-cloud-privilegedaccessmanager/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-privilegedaccessmanager/testing/constraints-3.13.txt
+++ b/packages/google-cloud-privilegedaccessmanager/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-privilegedaccessmanager/testing/constraints-3.14.txt b/packages/google-cloud-privilegedaccessmanager/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-privilegedaccessmanager/testing/constraints-3.14.txt
+++ b/packages/google-cloud-privilegedaccessmanager/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-pubsub/google/pubsub_v1/__init__.py b/packages/google-cloud-pubsub/google/pubsub_v1/__init__.py
index b766bd04eff7..9393ffac76e6 100644
--- a/packages/google-cloud-pubsub/google/pubsub_v1/__init__.py
+++ b/packages/google-cloud-pubsub/google/pubsub_v1/__init__.py
@@ -126,7 +126,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -155,9 +155,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-pubsub/setup.py b/packages/google-cloud-pubsub/setup.py
index 96a086c5c694..66c9606ffc26 100644
--- a/packages/google-cloud-pubsub/setup.py
+++ b/packages/google-cloud-pubsub/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/pubsub/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.51.3, < 2.0.0; python_version < '3.14'",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
     "grpcio-status >= 1.51.3",
     "opentelemetry-api >= 1.27.0",
     "opentelemetry-sdk >= 1.27.0",
diff --git a/packages/google-cloud-pubsub/testing/constraints-3.10.txt b/packages/google-cloud-pubsub/testing/constraints-3.10.txt
index aa2a4f1e90a4..00a8388e941c 100644
--- a/packages/google-cloud-pubsub/testing/constraints-3.10.txt
+++ b/packages/google-cloud-pubsub/testing/constraints-3.10.txt
@@ -4,12 +4,12 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.51.3
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
 grpcio-status==1.51.3
 opentelemetry-api==1.27.0
 opentelemetry-sdk==1.27.0
\ No newline at end of file
diff --git a/packages/google-cloud-pubsub/testing/constraints-3.13.txt b/packages/google-cloud-pubsub/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-pubsub/testing/constraints-3.13.txt
+++ b/packages/google-cloud-pubsub/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-pubsub/testing/constraints-3.14.txt b/packages/google-cloud-pubsub/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-pubsub/testing/constraints-3.14.txt
+++ b/packages/google-cloud-pubsub/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-quotas/google/cloud/cloudquotas_v1/__init__.py b/packages/google-cloud-quotas/google/cloud/cloudquotas_v1/__init__.py
index 1e3583052da8..e345603d7297 100644
--- a/packages/google-cloud-quotas/google/cloud/cloudquotas_v1/__init__.py
+++ b/packages/google-cloud-quotas/google/cloud/cloudquotas_v1/__init__.py
@@ -70,7 +70,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -99,9 +99,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-quotas/google/cloud/cloudquotas_v1beta/__init__.py b/packages/google-cloud-quotas/google/cloud/cloudquotas_v1beta/__init__.py
index 437e33d5dbd5..ad81101c823e 100644
--- a/packages/google-cloud-quotas/google/cloud/cloudquotas_v1beta/__init__.py
+++ b/packages/google-cloud-quotas/google/cloud/cloudquotas_v1beta/__init__.py
@@ -79,7 +79,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -108,9 +108,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-quotas/setup.py b/packages/google-cloud-quotas/setup.py
index 511993a5d9e8..d9112924a284 100644
--- a/packages/google-cloud-quotas/setup.py
+++ b/packages/google-cloud-quotas/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/cloudquotas/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-quotas"
diff --git a/packages/google-cloud-quotas/testing/constraints-3.10.txt b/packages/google-cloud-quotas/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-quotas/testing/constraints-3.10.txt
+++ b/packages/google-cloud-quotas/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-quotas/testing/constraints-3.13.txt b/packages/google-cloud-quotas/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-quotas/testing/constraints-3.13.txt
+++ b/packages/google-cloud-quotas/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-quotas/testing/constraints-3.14.txt b/packages/google-cloud-quotas/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-quotas/testing/constraints-3.14.txt
+++ b/packages/google-cloud-quotas/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-rapidmigrationassessment/google/cloud/rapidmigrationassessment_v1/__init__.py b/packages/google-cloud-rapidmigrationassessment/google/cloud/rapidmigrationassessment_v1/__init__.py
index 8f8092abba4d..a94b6c386ecb 100644
--- a/packages/google-cloud-rapidmigrationassessment/google/cloud/rapidmigrationassessment_v1/__init__.py
+++ b/packages/google-cloud-rapidmigrationassessment/google/cloud/rapidmigrationassessment_v1/__init__.py
@@ -68,7 +68,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -97,9 +97,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-rapidmigrationassessment/setup.py b/packages/google-cloud-rapidmigrationassessment/setup.py
index eaac50568810..4fe64eb850fc 100644
--- a/packages/google-cloud-rapidmigrationassessment/setup.py
+++ b/packages/google-cloud-rapidmigrationassessment/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/rapidmigrationassessment/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-rapidmigrationassessment"
diff --git a/packages/google-cloud-rapidmigrationassessment/testing/constraints-3.10.txt b/packages/google-cloud-rapidmigrationassessment/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-rapidmigrationassessment/testing/constraints-3.10.txt
+++ b/packages/google-cloud-rapidmigrationassessment/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-rapidmigrationassessment/testing/constraints-3.13.txt b/packages/google-cloud-rapidmigrationassessment/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-rapidmigrationassessment/testing/constraints-3.13.txt
+++ b/packages/google-cloud-rapidmigrationassessment/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-rapidmigrationassessment/testing/constraints-3.14.txt b/packages/google-cloud-rapidmigrationassessment/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-rapidmigrationassessment/testing/constraints-3.14.txt
+++ b/packages/google-cloud-rapidmigrationassessment/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-recaptcha-enterprise/google/cloud/recaptchaenterprise_v1/__init__.py b/packages/google-cloud-recaptcha-enterprise/google/cloud/recaptchaenterprise_v1/__init__.py
index 1aeb6a567ca1..a2fe88ed6d13 100644
--- a/packages/google-cloud-recaptcha-enterprise/google/cloud/recaptchaenterprise_v1/__init__.py
+++ b/packages/google-cloud-recaptcha-enterprise/google/cloud/recaptchaenterprise_v1/__init__.py
@@ -125,7 +125,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -154,9 +154,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-recaptcha-enterprise/setup.py b/packages/google-cloud-recaptcha-enterprise/setup.py
index 8c7c85c164f7..543d463a08a8 100644
--- a/packages/google-cloud-recaptcha-enterprise/setup.py
+++ b/packages/google-cloud-recaptcha-enterprise/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/recaptchaenterprise/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-recaptcha-enterprise"
diff --git a/packages/google-cloud-recaptcha-enterprise/testing/constraints-3.10.txt b/packages/google-cloud-recaptcha-enterprise/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-recaptcha-enterprise/testing/constraints-3.10.txt
+++ b/packages/google-cloud-recaptcha-enterprise/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-recaptcha-enterprise/testing/constraints-3.13.txt b/packages/google-cloud-recaptcha-enterprise/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-recaptcha-enterprise/testing/constraints-3.13.txt
+++ b/packages/google-cloud-recaptcha-enterprise/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-recaptcha-enterprise/testing/constraints-3.14.txt b/packages/google-cloud-recaptcha-enterprise/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-recaptcha-enterprise/testing/constraints-3.14.txt
+++ b/packages/google-cloud-recaptcha-enterprise/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-recommendations-ai/google/cloud/recommendationengine_v1beta1/__init__.py b/packages/google-cloud-recommendations-ai/google/cloud/recommendationengine_v1beta1/__init__.py
index d71aa9f4180c..ae967c987aff 100644
--- a/packages/google-cloud-recommendations-ai/google/cloud/recommendationengine_v1beta1/__init__.py
+++ b/packages/google-cloud-recommendations-ai/google/cloud/recommendationengine_v1beta1/__init__.py
@@ -110,7 +110,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -139,9 +139,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-recommendations-ai/setup.py b/packages/google-cloud-recommendations-ai/setup.py
index 6a3d2c00be48..8593f40466cf 100644
--- a/packages/google-cloud-recommendations-ai/setup.py
+++ b/packages/google-cloud-recommendations-ai/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/recommendationengine/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-recommendations-ai"
diff --git a/packages/google-cloud-recommendations-ai/testing/constraints-3.10.txt b/packages/google-cloud-recommendations-ai/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-recommendations-ai/testing/constraints-3.10.txt
+++ b/packages/google-cloud-recommendations-ai/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-recommendations-ai/testing/constraints-3.13.txt b/packages/google-cloud-recommendations-ai/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-recommendations-ai/testing/constraints-3.13.txt
+++ b/packages/google-cloud-recommendations-ai/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-recommendations-ai/testing/constraints-3.14.txt b/packages/google-cloud-recommendations-ai/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-recommendations-ai/testing/constraints-3.14.txt
+++ b/packages/google-cloud-recommendations-ai/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-recommender/google/cloud/recommender_v1/__init__.py b/packages/google-cloud-recommender/google/cloud/recommender_v1/__init__.py
index 944d0e34daba..756ce83af459 100644
--- a/packages/google-cloud-recommender/google/cloud/recommender_v1/__init__.py
+++ b/packages/google-cloud-recommender/google/cloud/recommender_v1/__init__.py
@@ -83,7 +83,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -112,9 +112,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-recommender/google/cloud/recommender_v1beta1/__init__.py b/packages/google-cloud-recommender/google/cloud/recommender_v1beta1/__init__.py
index 2b8c92a4c1e5..713fd5826372 100644
--- a/packages/google-cloud-recommender/google/cloud/recommender_v1beta1/__init__.py
+++ b/packages/google-cloud-recommender/google/cloud/recommender_v1beta1/__init__.py
@@ -86,7 +86,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -115,9 +115,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-recommender/setup.py b/packages/google-cloud-recommender/setup.py
index 54e16ef9de61..8bf364d2e206 100644
--- a/packages/google-cloud-recommender/setup.py
+++ b/packages/google-cloud-recommender/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/recommender/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-recommender"
diff --git a/packages/google-cloud-recommender/testing/constraints-3.10.txt b/packages/google-cloud-recommender/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-recommender/testing/constraints-3.10.txt
+++ b/packages/google-cloud-recommender/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-recommender/testing/constraints-3.13.txt b/packages/google-cloud-recommender/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-recommender/testing/constraints-3.13.txt
+++ b/packages/google-cloud-recommender/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-recommender/testing/constraints-3.14.txt b/packages/google-cloud-recommender/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-recommender/testing/constraints-3.14.txt
+++ b/packages/google-cloud-recommender/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-redis-cluster/google/cloud/redis_cluster_v1/__init__.py b/packages/google-cloud-redis-cluster/google/cloud/redis_cluster_v1/__init__.py
index a466f04b66df..180568fddcaf 100644
--- a/packages/google-cloud-redis-cluster/google/cloud/redis_cluster_v1/__init__.py
+++ b/packages/google-cloud-redis-cluster/google/cloud/redis_cluster_v1/__init__.py
@@ -101,7 +101,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -130,9 +130,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-redis-cluster/google/cloud/redis_cluster_v1beta1/__init__.py b/packages/google-cloud-redis-cluster/google/cloud/redis_cluster_v1beta1/__init__.py
index 5f39b56f7410..5c1181837ba2 100644
--- a/packages/google-cloud-redis-cluster/google/cloud/redis_cluster_v1beta1/__init__.py
+++ b/packages/google-cloud-redis-cluster/google/cloud/redis_cluster_v1beta1/__init__.py
@@ -101,7 +101,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -130,9 +130,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-redis-cluster/setup.py b/packages/google-cloud-redis-cluster/setup.py
index 9c6a891cd9fb..932a4d9c1485 100644
--- a/packages/google-cloud-redis-cluster/setup.py
+++ b/packages/google-cloud-redis-cluster/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/redis_cluster/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-redis-cluster"
diff --git a/packages/google-cloud-redis-cluster/testing/constraints-3.10.txt b/packages/google-cloud-redis-cluster/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-redis-cluster/testing/constraints-3.10.txt
+++ b/packages/google-cloud-redis-cluster/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-redis-cluster/testing/constraints-3.13.txt b/packages/google-cloud-redis-cluster/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-redis-cluster/testing/constraints-3.13.txt
+++ b/packages/google-cloud-redis-cluster/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-redis-cluster/testing/constraints-3.14.txt b/packages/google-cloud-redis-cluster/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-redis-cluster/testing/constraints-3.14.txt
+++ b/packages/google-cloud-redis-cluster/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-redis/google/cloud/redis_v1/__init__.py b/packages/google-cloud-redis/google/cloud/redis_v1/__init__.py
index dc3033429796..7f67c87bda33 100644
--- a/packages/google-cloud-redis/google/cloud/redis_v1/__init__.py
+++ b/packages/google-cloud-redis/google/cloud/redis_v1/__init__.py
@@ -79,7 +79,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -108,9 +108,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-redis/google/cloud/redis_v1beta1/__init__.py b/packages/google-cloud-redis/google/cloud/redis_v1beta1/__init__.py
index f35f33fda484..889192b5eb99 100644
--- a/packages/google-cloud-redis/google/cloud/redis_v1beta1/__init__.py
+++ b/packages/google-cloud-redis/google/cloud/redis_v1beta1/__init__.py
@@ -78,7 +78,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -107,9 +107,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-redis/setup.py b/packages/google-cloud-redis/setup.py
index 85c6bfd22bd7..cbdddc70227f 100644
--- a/packages/google-cloud-redis/setup.py
+++ b/packages/google-cloud-redis/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/redis/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-redis"
diff --git a/packages/google-cloud-redis/testing/constraints-3.10.txt b/packages/google-cloud-redis/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-redis/testing/constraints-3.10.txt
+++ b/packages/google-cloud-redis/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-redis/testing/constraints-3.13.txt b/packages/google-cloud-redis/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-redis/testing/constraints-3.13.txt
+++ b/packages/google-cloud-redis/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-redis/testing/constraints-3.14.txt b/packages/google-cloud-redis/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-redis/testing/constraints-3.14.txt
+++ b/packages/google-cloud-redis/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-resource-manager/google/cloud/resourcemanager_v3/__init__.py b/packages/google-cloud-resource-manager/google/cloud/resourcemanager_v3/__init__.py
index 4fdd145f90f8..5f146121796c 100644
--- a/packages/google-cloud-resource-manager/google/cloud/resourcemanager_v3/__init__.py
+++ b/packages/google-cloud-resource-manager/google/cloud/resourcemanager_v3/__init__.py
@@ -148,7 +148,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -177,9 +177,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-resource-manager/setup.py b/packages/google-cloud-resource-manager/setup.py
index 7e406112d4c0..1815015501be 100644
--- a/packages/google-cloud-resource-manager/setup.py
+++ b/packages/google-cloud-resource-manager/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/resourcemanager/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-resource-manager"
diff --git a/packages/google-cloud-resource-manager/testing/constraints-3.10.txt b/packages/google-cloud-resource-manager/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-resource-manager/testing/constraints-3.10.txt
+++ b/packages/google-cloud-resource-manager/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-resource-manager/testing/constraints-3.13.txt b/packages/google-cloud-resource-manager/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-resource-manager/testing/constraints-3.13.txt
+++ b/packages/google-cloud-resource-manager/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-resource-manager/testing/constraints-3.14.txt b/packages/google-cloud-resource-manager/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-resource-manager/testing/constraints-3.14.txt
+++ b/packages/google-cloud-resource-manager/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-retail/google/cloud/retail_v2/__init__.py b/packages/google-cloud-retail/google/cloud/retail_v2/__init__.py
index 963a4610b622..125136f55792 100644
--- a/packages/google-cloud-retail/google/cloud/retail_v2/__init__.py
+++ b/packages/google-cloud-retail/google/cloud/retail_v2/__init__.py
@@ -262,7 +262,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -291,9 +291,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-retail/google/cloud/retail_v2alpha/__init__.py b/packages/google-cloud-retail/google/cloud/retail_v2alpha/__init__.py
index e3981c3e52bb..784ae53a93a6 100644
--- a/packages/google-cloud-retail/google/cloud/retail_v2alpha/__init__.py
+++ b/packages/google-cloud-retail/google/cloud/retail_v2alpha/__init__.py
@@ -308,7 +308,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -337,9 +337,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-retail/google/cloud/retail_v2beta/__init__.py b/packages/google-cloud-retail/google/cloud/retail_v2beta/__init__.py
index 40b56c721de0..2b39193f0ec4 100644
--- a/packages/google-cloud-retail/google/cloud/retail_v2beta/__init__.py
+++ b/packages/google-cloud-retail/google/cloud/retail_v2beta/__init__.py
@@ -274,7 +274,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -303,9 +303,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-retail/setup.py b/packages/google-cloud-retail/setup.py
index d630659866d7..ebb74b63e02d 100644
--- a/packages/google-cloud-retail/setup.py
+++ b/packages/google-cloud-retail/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/retail/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-retail"
diff --git a/packages/google-cloud-retail/testing/constraints-3.10.txt b/packages/google-cloud-retail/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-retail/testing/constraints-3.10.txt
+++ b/packages/google-cloud-retail/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-retail/testing/constraints-3.13.txt b/packages/google-cloud-retail/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-retail/testing/constraints-3.13.txt
+++ b/packages/google-cloud-retail/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-retail/testing/constraints-3.14.txt b/packages/google-cloud-retail/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-retail/testing/constraints-3.14.txt
+++ b/packages/google-cloud-retail/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-run/google/cloud/run_v2/__init__.py b/packages/google-cloud-run/google/cloud/run_v2/__init__.py
index 243d5084cf9a..df742f00336a 100644
--- a/packages/google-cloud-run/google/cloud/run_v2/__init__.py
+++ b/packages/google-cloud-run/google/cloud/run_v2/__init__.py
@@ -172,7 +172,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -201,9 +201,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-run/setup.py b/packages/google-cloud-run/setup.py
index ff8b20df8c5d..0620a6b2ed39 100644
--- a/packages/google-cloud-run/setup.py
+++ b/packages/google-cloud-run/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/run/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-run"
diff --git a/packages/google-cloud-run/testing/constraints-3.10.txt b/packages/google-cloud-run/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-run/testing/constraints-3.10.txt
+++ b/packages/google-cloud-run/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-run/testing/constraints-3.13.txt b/packages/google-cloud-run/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-run/testing/constraints-3.13.txt
+++ b/packages/google-cloud-run/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-run/testing/constraints-3.14.txt b/packages/google-cloud-run/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-run/testing/constraints-3.14.txt
+++ b/packages/google-cloud-run/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-saasplatform-saasservicemgmt/google/cloud/saasplatform_saasservicemgmt_v1beta1/__init__.py b/packages/google-cloud-saasplatform-saasservicemgmt/google/cloud/saasplatform_saasservicemgmt_v1beta1/__init__.py
index 8eaafcd4bde3..983862c7c71e 100644
--- a/packages/google-cloud-saasplatform-saasservicemgmt/google/cloud/saasplatform_saasservicemgmt_v1beta1/__init__.py
+++ b/packages/google-cloud-saasplatform-saasservicemgmt/google/cloud/saasplatform_saasservicemgmt_v1beta1/__init__.py
@@ -145,7 +145,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -174,9 +174,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-saasplatform-saasservicemgmt/setup.py b/packages/google-cloud-saasplatform-saasservicemgmt/setup.py
index a5201c621115..1ec1808f63c9 100644
--- a/packages/google-cloud-saasplatform-saasservicemgmt/setup.py
+++ b/packages/google-cloud-saasplatform-saasservicemgmt/setup.py
@@ -33,7 +33,10 @@
         package_root, "google/cloud/saasplatform_saasservicemgmt/gapic_version.py"
     )
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -43,15 +46,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-saasplatform-saasservicemgmt"
diff --git a/packages/google-cloud-saasplatform-saasservicemgmt/testing/constraints-3.10.txt b/packages/google-cloud-saasplatform-saasservicemgmt/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-saasplatform-saasservicemgmt/testing/constraints-3.10.txt
+++ b/packages/google-cloud-saasplatform-saasservicemgmt/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-saasplatform-saasservicemgmt/testing/constraints-3.13.txt b/packages/google-cloud-saasplatform-saasservicemgmt/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-saasplatform-saasservicemgmt/testing/constraints-3.13.txt
+++ b/packages/google-cloud-saasplatform-saasservicemgmt/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-saasplatform-saasservicemgmt/testing/constraints-3.14.txt b/packages/google-cloud-saasplatform-saasservicemgmt/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-saasplatform-saasservicemgmt/testing/constraints-3.14.txt
+++ b/packages/google-cloud-saasplatform-saasservicemgmt/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-scheduler/google/cloud/scheduler_v1/__init__.py b/packages/google-cloud-scheduler/google/cloud/scheduler_v1/__init__.py
index 028e06eda7c8..e4ea86b0647e 100644
--- a/packages/google-cloud-scheduler/google/cloud/scheduler_v1/__init__.py
+++ b/packages/google-cloud-scheduler/google/cloud/scheduler_v1/__init__.py
@@ -71,7 +71,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -100,9 +100,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-scheduler/google/cloud/scheduler_v1beta1/__init__.py b/packages/google-cloud-scheduler/google/cloud/scheduler_v1beta1/__init__.py
index d4b0d0c35e50..233e33cc9568 100644
--- a/packages/google-cloud-scheduler/google/cloud/scheduler_v1beta1/__init__.py
+++ b/packages/google-cloud-scheduler/google/cloud/scheduler_v1beta1/__init__.py
@@ -71,7 +71,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -100,9 +100,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-scheduler/setup.py b/packages/google-cloud-scheduler/setup.py
index 7209982c00b6..dee4047082b4 100644
--- a/packages/google-cloud-scheduler/setup.py
+++ b/packages/google-cloud-scheduler/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/scheduler/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-scheduler"
diff --git a/packages/google-cloud-scheduler/testing/constraints-3.10.txt b/packages/google-cloud-scheduler/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-scheduler/testing/constraints-3.10.txt
+++ b/packages/google-cloud-scheduler/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-scheduler/testing/constraints-3.13.txt b/packages/google-cloud-scheduler/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-scheduler/testing/constraints-3.13.txt
+++ b/packages/google-cloud-scheduler/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-scheduler/testing/constraints-3.14.txt b/packages/google-cloud-scheduler/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-scheduler/testing/constraints-3.14.txt
+++ b/packages/google-cloud-scheduler/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-secret-manager/google/cloud/secretmanager_v1/__init__.py b/packages/google-cloud-secret-manager/google/cloud/secretmanager_v1/__init__.py
index a47740a66d05..5370bcfc99d2 100644
--- a/packages/google-cloud-secret-manager/google/cloud/secretmanager_v1/__init__.py
+++ b/packages/google-cloud-secret-manager/google/cloud/secretmanager_v1/__init__.py
@@ -81,7 +81,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -110,9 +110,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-secret-manager/google/cloud/secretmanager_v1beta1/__init__.py b/packages/google-cloud-secret-manager/google/cloud/secretmanager_v1beta1/__init__.py
index e03614eebc26..aeba7b920f51 100644
--- a/packages/google-cloud-secret-manager/google/cloud/secretmanager_v1beta1/__init__.py
+++ b/packages/google-cloud-secret-manager/google/cloud/secretmanager_v1beta1/__init__.py
@@ -71,7 +71,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -100,9 +100,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-secret-manager/google/cloud/secretmanager_v1beta2/__init__.py b/packages/google-cloud-secret-manager/google/cloud/secretmanager_v1beta2/__init__.py
index a95c6472a078..505e054be690 100644
--- a/packages/google-cloud-secret-manager/google/cloud/secretmanager_v1beta2/__init__.py
+++ b/packages/google-cloud-secret-manager/google/cloud/secretmanager_v1beta2/__init__.py
@@ -81,7 +81,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -110,9 +110,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-secret-manager/setup.py b/packages/google-cloud-secret-manager/setup.py
index fe1c04e8b58d..f6cd66555e9c 100644
--- a/packages/google-cloud-secret-manager/setup.py
+++ b/packages/google-cloud-secret-manager/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/secretmanager/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-secret-manager"
diff --git a/packages/google-cloud-secret-manager/testing/constraints-3.10.txt b/packages/google-cloud-secret-manager/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-secret-manager/testing/constraints-3.10.txt
+++ b/packages/google-cloud-secret-manager/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-secret-manager/testing/constraints-3.13.txt b/packages/google-cloud-secret-manager/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-secret-manager/testing/constraints-3.13.txt
+++ b/packages/google-cloud-secret-manager/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-secret-manager/testing/constraints-3.14.txt b/packages/google-cloud-secret-manager/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-secret-manager/testing/constraints-3.14.txt
+++ b/packages/google-cloud-secret-manager/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-securesourcemanager/google/cloud/securesourcemanager_v1/__init__.py b/packages/google-cloud-securesourcemanager/google/cloud/securesourcemanager_v1/__init__.py
index 1e6831f3aadf..cc27b9f9eb5f 100644
--- a/packages/google-cloud-securesourcemanager/google/cloud/securesourcemanager_v1/__init__.py
+++ b/packages/google-cloud-securesourcemanager/google/cloud/securesourcemanager_v1/__init__.py
@@ -129,7 +129,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -158,9 +158,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-securesourcemanager/setup.py b/packages/google-cloud-securesourcemanager/setup.py
index 8531b16d46ab..a915aca135dc 100644
--- a/packages/google-cloud-securesourcemanager/setup.py
+++ b/packages/google-cloud-securesourcemanager/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/securesourcemanager/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-securesourcemanager"
diff --git a/packages/google-cloud-securesourcemanager/testing/constraints-3.10.txt b/packages/google-cloud-securesourcemanager/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-securesourcemanager/testing/constraints-3.10.txt
+++ b/packages/google-cloud-securesourcemanager/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-securesourcemanager/testing/constraints-3.13.txt b/packages/google-cloud-securesourcemanager/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-securesourcemanager/testing/constraints-3.13.txt
+++ b/packages/google-cloud-securesourcemanager/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-securesourcemanager/testing/constraints-3.14.txt b/packages/google-cloud-securesourcemanager/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-securesourcemanager/testing/constraints-3.14.txt
+++ b/packages/google-cloud-securesourcemanager/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-security-publicca/google/cloud/security/publicca_v1/__init__.py b/packages/google-cloud-security-publicca/google/cloud/security/publicca_v1/__init__.py
index 8bc792bef3e5..d88cb949c0f0 100644
--- a/packages/google-cloud-security-publicca/google/cloud/security/publicca_v1/__init__.py
+++ b/packages/google-cloud-security-publicca/google/cloud/security/publicca_v1/__init__.py
@@ -55,7 +55,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -84,9 +84,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-security-publicca/google/cloud/security/publicca_v1beta1/__init__.py b/packages/google-cloud-security-publicca/google/cloud/security/publicca_v1beta1/__init__.py
index 58fc718f2bce..cd62bbbd8bc0 100644
--- a/packages/google-cloud-security-publicca/google/cloud/security/publicca_v1beta1/__init__.py
+++ b/packages/google-cloud-security-publicca/google/cloud/security/publicca_v1beta1/__init__.py
@@ -55,7 +55,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -84,9 +84,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-security-publicca/setup.py b/packages/google-cloud-security-publicca/setup.py
index 432b05c125f6..05e59d0b1807 100644
--- a/packages/google-cloud-security-publicca/setup.py
+++ b/packages/google-cloud-security-publicca/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/security/publicca/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-security-publicca"
diff --git a/packages/google-cloud-security-publicca/testing/constraints-3.10.txt b/packages/google-cloud-security-publicca/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-security-publicca/testing/constraints-3.10.txt
+++ b/packages/google-cloud-security-publicca/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-security-publicca/testing/constraints-3.13.txt b/packages/google-cloud-security-publicca/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-security-publicca/testing/constraints-3.13.txt
+++ b/packages/google-cloud-security-publicca/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-security-publicca/testing/constraints-3.14.txt b/packages/google-cloud-security-publicca/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-security-publicca/testing/constraints-3.14.txt
+++ b/packages/google-cloud-security-publicca/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-securitycenter/google/cloud/securitycenter_v1/__init__.py b/packages/google-cloud-securitycenter/google/cloud/securitycenter_v1/__init__.py
index 0fde9ea125d7..7e6f19b8c06b 100644
--- a/packages/google-cloud-securitycenter/google/cloud/securitycenter_v1/__init__.py
+++ b/packages/google-cloud-securitycenter/google/cloud/securitycenter_v1/__init__.py
@@ -222,7 +222,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -251,9 +251,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-securitycenter/google/cloud/securitycenter_v1beta1/__init__.py b/packages/google-cloud-securitycenter/google/cloud/securitycenter_v1beta1/__init__.py
index 8994a8f4c737..0c0a02fc6e85 100644
--- a/packages/google-cloud-securitycenter/google/cloud/securitycenter_v1beta1/__init__.py
+++ b/packages/google-cloud-securitycenter/google/cloud/securitycenter_v1beta1/__init__.py
@@ -79,7 +79,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -108,9 +108,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-securitycenter/google/cloud/securitycenter_v1p1beta1/__init__.py b/packages/google-cloud-securitycenter/google/cloud/securitycenter_v1p1beta1/__init__.py
index e645271bf148..e93cc808c238 100644
--- a/packages/google-cloud-securitycenter/google/cloud/securitycenter_v1p1beta1/__init__.py
+++ b/packages/google-cloud-securitycenter/google/cloud/securitycenter_v1p1beta1/__init__.py
@@ -89,7 +89,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -118,9 +118,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-securitycenter/google/cloud/securitycenter_v2/__init__.py b/packages/google-cloud-securitycenter/google/cloud/securitycenter_v2/__init__.py
index 10586934426e..20f87f2e97b3 100644
--- a/packages/google-cloud-securitycenter/google/cloud/securitycenter_v2/__init__.py
+++ b/packages/google-cloud-securitycenter/google/cloud/securitycenter_v2/__init__.py
@@ -180,7 +180,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -209,9 +209,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-securitycenter/setup.py b/packages/google-cloud-securitycenter/setup.py
index 8bf26ebefc2a..fc4777070a7c 100644
--- a/packages/google-cloud-securitycenter/setup.py
+++ b/packages/google-cloud-securitycenter/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/securitycenter/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-securitycenter"
diff --git a/packages/google-cloud-securitycenter/testing/constraints-3.10.txt b/packages/google-cloud-securitycenter/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-securitycenter/testing/constraints-3.10.txt
+++ b/packages/google-cloud-securitycenter/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-securitycenter/testing/constraints-3.13.txt b/packages/google-cloud-securitycenter/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-securitycenter/testing/constraints-3.13.txt
+++ b/packages/google-cloud-securitycenter/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-securitycenter/testing/constraints-3.14.txt b/packages/google-cloud-securitycenter/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-securitycenter/testing/constraints-3.14.txt
+++ b/packages/google-cloud-securitycenter/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-securitycentermanagement/google/cloud/securitycentermanagement_v1/__init__.py b/packages/google-cloud-securitycentermanagement/google/cloud/securitycentermanagement_v1/__init__.py
index 7489e577f8e2..6fbda4426174 100644
--- a/packages/google-cloud-securitycentermanagement/google/cloud/securitycentermanagement_v1/__init__.py
+++ b/packages/google-cloud-securitycentermanagement/google/cloud/securitycentermanagement_v1/__init__.py
@@ -92,7 +92,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -121,9 +121,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-securitycentermanagement/setup.py b/packages/google-cloud-securitycentermanagement/setup.py
index 84e2f6c02601..b80b2fd16450 100644
--- a/packages/google-cloud-securitycentermanagement/setup.py
+++ b/packages/google-cloud-securitycentermanagement/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/securitycentermanagement/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-securitycentermanagement"
diff --git a/packages/google-cloud-securitycentermanagement/testing/constraints-3.10.txt b/packages/google-cloud-securitycentermanagement/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-securitycentermanagement/testing/constraints-3.10.txt
+++ b/packages/google-cloud-securitycentermanagement/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-securitycentermanagement/testing/constraints-3.13.txt b/packages/google-cloud-securitycentermanagement/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-securitycentermanagement/testing/constraints-3.13.txt
+++ b/packages/google-cloud-securitycentermanagement/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-securitycentermanagement/testing/constraints-3.14.txt b/packages/google-cloud-securitycentermanagement/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-securitycentermanagement/testing/constraints-3.14.txt
+++ b/packages/google-cloud-securitycentermanagement/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-service-control/google/cloud/servicecontrol_v1/__init__.py b/packages/google-cloud-service-control/google/cloud/servicecontrol_v1/__init__.py
index dfc7ca5ea5d4..415681b343c3 100644
--- a/packages/google-cloud-service-control/google/cloud/servicecontrol_v1/__init__.py
+++ b/packages/google-cloud-service-control/google/cloud/servicecontrol_v1/__init__.py
@@ -72,7 +72,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -101,9 +101,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-service-control/google/cloud/servicecontrol_v2/__init__.py b/packages/google-cloud-service-control/google/cloud/servicecontrol_v2/__init__.py
index 0db18863cdd3..0e067f14eff7 100644
--- a/packages/google-cloud-service-control/google/cloud/servicecontrol_v2/__init__.py
+++ b/packages/google-cloud-service-control/google/cloud/servicecontrol_v2/__init__.py
@@ -61,7 +61,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -90,9 +90,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-service-control/setup.py b/packages/google-cloud-service-control/setup.py
index 805a88f437ca..de8e556f8f74 100644
--- a/packages/google-cloud-service-control/setup.py
+++ b/packages/google-cloud-service-control/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/servicecontrol/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-service-control"
diff --git a/packages/google-cloud-service-control/testing/constraints-3.10.txt b/packages/google-cloud-service-control/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-service-control/testing/constraints-3.10.txt
+++ b/packages/google-cloud-service-control/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-service-control/testing/constraints-3.13.txt b/packages/google-cloud-service-control/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-service-control/testing/constraints-3.13.txt
+++ b/packages/google-cloud-service-control/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-service-control/testing/constraints-3.14.txt b/packages/google-cloud-service-control/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-service-control/testing/constraints-3.14.txt
+++ b/packages/google-cloud-service-control/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-service-directory/google/cloud/servicedirectory_v1/__init__.py b/packages/google-cloud-service-directory/google/cloud/servicedirectory_v1/__init__.py
index 996ff19fd8e6..63d8a0699faa 100644
--- a/packages/google-cloud-service-directory/google/cloud/servicedirectory_v1/__init__.py
+++ b/packages/google-cloud-service-directory/google/cloud/servicedirectory_v1/__init__.py
@@ -78,7 +78,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -107,9 +107,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-service-directory/google/cloud/servicedirectory_v1beta1/__init__.py b/packages/google-cloud-service-directory/google/cloud/servicedirectory_v1beta1/__init__.py
index 8cae386c0582..1d69856679c4 100644
--- a/packages/google-cloud-service-directory/google/cloud/servicedirectory_v1beta1/__init__.py
+++ b/packages/google-cloud-service-directory/google/cloud/servicedirectory_v1beta1/__init__.py
@@ -78,7 +78,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -107,9 +107,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-service-directory/setup.py b/packages/google-cloud-service-directory/setup.py
index a77b67882b1a..bd10ddf46ea9 100644
--- a/packages/google-cloud-service-directory/setup.py
+++ b/packages/google-cloud-service-directory/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/servicedirectory/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-service-directory"
diff --git a/packages/google-cloud-service-directory/testing/constraints-3.10.txt b/packages/google-cloud-service-directory/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-service-directory/testing/constraints-3.10.txt
+++ b/packages/google-cloud-service-directory/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-service-directory/testing/constraints-3.13.txt b/packages/google-cloud-service-directory/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-service-directory/testing/constraints-3.13.txt
+++ b/packages/google-cloud-service-directory/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-service-directory/testing/constraints-3.14.txt b/packages/google-cloud-service-directory/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-service-directory/testing/constraints-3.14.txt
+++ b/packages/google-cloud-service-directory/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-service-management/google/cloud/servicemanagement_v1/__init__.py b/packages/google-cloud-service-management/google/cloud/servicemanagement_v1/__init__.py
index 4f8e943f2fee..b038ac3bed4f 100644
--- a/packages/google-cloud-service-management/google/cloud/servicemanagement_v1/__init__.py
+++ b/packages/google-cloud-service-management/google/cloud/servicemanagement_v1/__init__.py
@@ -82,7 +82,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -111,9 +111,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-service-management/setup.py b/packages/google-cloud-service-management/setup.py
index 779085f98aa9..f13f9a998e1a 100644
--- a/packages/google-cloud-service-management/setup.py
+++ b/packages/google-cloud-service-management/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/servicemanagement/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-service-management"
diff --git a/packages/google-cloud-service-management/testing/constraints-3.10.txt b/packages/google-cloud-service-management/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-service-management/testing/constraints-3.10.txt
+++ b/packages/google-cloud-service-management/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-service-management/testing/constraints-3.13.txt b/packages/google-cloud-service-management/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-service-management/testing/constraints-3.13.txt
+++ b/packages/google-cloud-service-management/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-service-management/testing/constraints-3.14.txt b/packages/google-cloud-service-management/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-service-management/testing/constraints-3.14.txt
+++ b/packages/google-cloud-service-management/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-service-usage/google/cloud/service_usage_v1/__init__.py b/packages/google-cloud-service-usage/google/cloud/service_usage_v1/__init__.py
index dfcdd744118a..f434353a0ba6 100644
--- a/packages/google-cloud-service-usage/google/cloud/service_usage_v1/__init__.py
+++ b/packages/google-cloud-service-usage/google/cloud/service_usage_v1/__init__.py
@@ -64,7 +64,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -93,9 +93,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-service-usage/setup.py b/packages/google-cloud-service-usage/setup.py
index 81e525f5379e..a60b2167cc88 100644
--- a/packages/google-cloud-service-usage/setup.py
+++ b/packages/google-cloud-service-usage/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/service_usage/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-service-usage"
diff --git a/packages/google-cloud-service-usage/testing/constraints-3.10.txt b/packages/google-cloud-service-usage/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-service-usage/testing/constraints-3.10.txt
+++ b/packages/google-cloud-service-usage/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-service-usage/testing/constraints-3.13.txt b/packages/google-cloud-service-usage/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-service-usage/testing/constraints-3.13.txt
+++ b/packages/google-cloud-service-usage/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-service-usage/testing/constraints-3.14.txt b/packages/google-cloud-service-usage/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-service-usage/testing/constraints-3.14.txt
+++ b/packages/google-cloud-service-usage/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-servicehealth/google/cloud/servicehealth_v1/__init__.py b/packages/google-cloud-servicehealth/google/cloud/servicehealth_v1/__init__.py
index 116f632bee7d..ab979bfceb78 100644
--- a/packages/google-cloud-servicehealth/google/cloud/servicehealth_v1/__init__.py
+++ b/packages/google-cloud-servicehealth/google/cloud/servicehealth_v1/__init__.py
@@ -71,7 +71,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -100,9 +100,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-servicehealth/setup.py b/packages/google-cloud-servicehealth/setup.py
index 48fb14123db0..83300905b6a5 100644
--- a/packages/google-cloud-servicehealth/setup.py
+++ b/packages/google-cloud-servicehealth/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/servicehealth/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-servicehealth"
diff --git a/packages/google-cloud-servicehealth/testing/constraints-3.10.txt b/packages/google-cloud-servicehealth/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-servicehealth/testing/constraints-3.10.txt
+++ b/packages/google-cloud-servicehealth/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-servicehealth/testing/constraints-3.13.txt b/packages/google-cloud-servicehealth/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-servicehealth/testing/constraints-3.13.txt
+++ b/packages/google-cloud-servicehealth/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-servicehealth/testing/constraints-3.14.txt b/packages/google-cloud-servicehealth/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-servicehealth/testing/constraints-3.14.txt
+++ b/packages/google-cloud-servicehealth/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-shell/google/cloud/shell_v1/__init__.py b/packages/google-cloud-shell/google/cloud/shell_v1/__init__.py
index 39be64494a5c..649097214d1b 100644
--- a/packages/google-cloud-shell/google/cloud/shell_v1/__init__.py
+++ b/packages/google-cloud-shell/google/cloud/shell_v1/__init__.py
@@ -72,7 +72,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -101,9 +101,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-shell/setup.py b/packages/google-cloud-shell/setup.py
index 268f5e47af1f..35c3015f17dc 100644
--- a/packages/google-cloud-shell/setup.py
+++ b/packages/google-cloud-shell/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/shell/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-shell"
diff --git a/packages/google-cloud-shell/testing/constraints-3.10.txt b/packages/google-cloud-shell/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-shell/testing/constraints-3.10.txt
+++ b/packages/google-cloud-shell/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-shell/testing/constraints-3.13.txt b/packages/google-cloud-shell/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-shell/testing/constraints-3.13.txt
+++ b/packages/google-cloud-shell/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-shell/testing/constraints-3.14.txt b/packages/google-cloud-shell/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-shell/testing/constraints-3.14.txt
+++ b/packages/google-cloud-shell/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-source-context/google/cloud/source_context_v1/__init__.py b/packages/google-cloud-source-context/google/cloud/source_context_v1/__init__.py
index 0c47b446db02..b685c50e6c43 100644
--- a/packages/google-cloud-source-context/google/cloud/source_context_v1/__init__.py
+++ b/packages/google-cloud-source-context/google/cloud/source_context_v1/__init__.py
@@ -61,7 +61,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -90,9 +90,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-source-context/setup.py b/packages/google-cloud-source-context/setup.py
index dac66291ccbe..2fb7c986b6f5 100644
--- a/packages/google-cloud-source-context/setup.py
+++ b/packages/google-cloud-source-context/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/source_context/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-source-context"
diff --git a/packages/google-cloud-source-context/testing/constraints-3.10.txt b/packages/google-cloud-source-context/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-source-context/testing/constraints-3.10.txt
+++ b/packages/google-cloud-source-context/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-source-context/testing/constraints-3.13.txt b/packages/google-cloud-source-context/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-source-context/testing/constraints-3.13.txt
+++ b/packages/google-cloud-source-context/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-source-context/testing/constraints-3.14.txt b/packages/google-cloud-source-context/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-source-context/testing/constraints-3.14.txt
+++ b/packages/google-cloud-source-context/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-spanner/google/cloud/spanner_admin_database_v1/__init__.py b/packages/google-cloud-spanner/google/cloud/spanner_admin_database_v1/__init__.py
index 470cf062a455..7e9ebcceba0a 100644
--- a/packages/google-cloud-spanner/google/cloud/spanner_admin_database_v1/__init__.py
+++ b/packages/google-cloud-spanner/google/cloud/spanner_admin_database_v1/__init__.py
@@ -119,7 +119,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -148,9 +148,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-spanner/google/cloud/spanner_admin_instance_v1/__init__.py b/packages/google-cloud-spanner/google/cloud/spanner_admin_instance_v1/__init__.py
index 09d1033f7db1..e0b4f577353e 100644
--- a/packages/google-cloud-spanner/google/cloud/spanner_admin_instance_v1/__init__.py
+++ b/packages/google-cloud-spanner/google/cloud/spanner_admin_instance_v1/__init__.py
@@ -91,7 +91,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -120,9 +120,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-spanner/setup.py b/packages/google-cloud-spanner/setup.py
index e7dce1a06904..927d60a871ce 100644
--- a/packages/google-cloud-spanner/setup.py
+++ b/packages/google-cloud-spanner/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/spanner/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,7 +42,7 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
diff --git a/packages/google-cloud-spanner/testing/constraints-3.10.txt b/packages/google-cloud-spanner/testing/constraints-3.10.txt
index 77670a5b9fc6..a366fdf7fd97 100644
--- a/packages/google-cloud-spanner/testing/constraints-3.10.txt
+++ b/packages/google-cloud-spanner/testing/constraints-3.10.txt
@@ -4,12 +4,12 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.49.1
 grpcio-status==1.49.1
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
 google-cloud-core==2.0.0
 grpc-google-iam-v1==0.12.4
 sqlparse==0.4.4
diff --git a/packages/google-cloud-spanner/testing/constraints-3.13.txt b/packages/google-cloud-spanner/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-spanner/testing/constraints-3.13.txt
+++ b/packages/google-cloud-spanner/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-spanner/testing/constraints-3.14.txt b/packages/google-cloud-spanner/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-spanner/testing/constraints-3.14.txt
+++ b/packages/google-cloud-spanner/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-speech/google/cloud/speech_v1/__init__.py b/packages/google-cloud-speech/google/cloud/speech_v1/__init__.py
index e73b4e5104f0..130b6ccaa930 100644
--- a/packages/google-cloud-speech/google/cloud/speech_v1/__init__.py
+++ b/packages/google-cloud-speech/google/cloud/speech_v1/__init__.py
@@ -92,7 +92,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -121,9 +121,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-speech/google/cloud/speech_v1p1beta1/__init__.py b/packages/google-cloud-speech/google/cloud/speech_v1p1beta1/__init__.py
index 34836f8aeab2..d7e51e833f15 100644
--- a/packages/google-cloud-speech/google/cloud/speech_v1p1beta1/__init__.py
+++ b/packages/google-cloud-speech/google/cloud/speech_v1p1beta1/__init__.py
@@ -92,7 +92,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -121,9 +121,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-speech/google/cloud/speech_v2/__init__.py b/packages/google-cloud-speech/google/cloud/speech_v2/__init__.py
index 0423a3f26fb1..eb13ed51e30c 100644
--- a/packages/google-cloud-speech/google/cloud/speech_v2/__init__.py
+++ b/packages/google-cloud-speech/google/cloud/speech_v2/__init__.py
@@ -125,7 +125,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -154,9 +154,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-speech/setup.py b/packages/google-cloud-speech/setup.py
index 46a8b8bc8298..772736540ae7 100644
--- a/packages/google-cloud-speech/setup.py
+++ b/packages/google-cloud-speech/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/speech/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-speech"
diff --git a/packages/google-cloud-speech/testing/constraints-3.10.txt b/packages/google-cloud-speech/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-speech/testing/constraints-3.10.txt
+++ b/packages/google-cloud-speech/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-speech/testing/constraints-3.13.txt b/packages/google-cloud-speech/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-speech/testing/constraints-3.13.txt
+++ b/packages/google-cloud-speech/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-speech/testing/constraints-3.14.txt b/packages/google-cloud-speech/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-speech/testing/constraints-3.14.txt
+++ b/packages/google-cloud-speech/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-storage-control/google/cloud/storage_control_v2/__init__.py b/packages/google-cloud-storage-control/google/cloud/storage_control_v2/__init__.py
index 3b297eafced5..c6bffc6da1da 100644
--- a/packages/google-cloud-storage-control/google/cloud/storage_control_v2/__init__.py
+++ b/packages/google-cloud-storage-control/google/cloud/storage_control_v2/__init__.py
@@ -104,7 +104,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -133,9 +133,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-storage-control/setup.py b/packages/google-cloud-storage-control/setup.py
index 462cddfbec14..ac5d24ba2cff 100644
--- a/packages/google-cloud-storage-control/setup.py
+++ b/packages/google-cloud-storage-control/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/storage_control/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-storage-control"
diff --git a/packages/google-cloud-storage-control/testing/constraints-3.10.txt b/packages/google-cloud-storage-control/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-storage-control/testing/constraints-3.10.txt
+++ b/packages/google-cloud-storage-control/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-storage-control/testing/constraints-3.13.txt b/packages/google-cloud-storage-control/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-storage-control/testing/constraints-3.13.txt
+++ b/packages/google-cloud-storage-control/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-storage-control/testing/constraints-3.14.txt b/packages/google-cloud-storage-control/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-storage-control/testing/constraints-3.14.txt
+++ b/packages/google-cloud-storage-control/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-storage-transfer/google/cloud/storage_transfer_v1/__init__.py b/packages/google-cloud-storage-transfer/google/cloud/storage_transfer_v1/__init__.py
index e8a4639ea8e3..7dfeb7645faf 100644
--- a/packages/google-cloud-storage-transfer/google/cloud/storage_transfer_v1/__init__.py
+++ b/packages/google-cloud-storage-transfer/google/cloud/storage_transfer_v1/__init__.py
@@ -100,7 +100,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -129,9 +129,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-storage-transfer/setup.py b/packages/google-cloud-storage-transfer/setup.py
index 36982fbbe3df..dbafea2eca36 100644
--- a/packages/google-cloud-storage-transfer/setup.py
+++ b/packages/google-cloud-storage-transfer/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/storage_transfer/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-storage-transfer"
diff --git a/packages/google-cloud-storage-transfer/testing/constraints-3.10.txt b/packages/google-cloud-storage-transfer/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-storage-transfer/testing/constraints-3.10.txt
+++ b/packages/google-cloud-storage-transfer/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-storage-transfer/testing/constraints-3.13.txt b/packages/google-cloud-storage-transfer/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-storage-transfer/testing/constraints-3.13.txt
+++ b/packages/google-cloud-storage-transfer/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-storage-transfer/testing/constraints-3.14.txt b/packages/google-cloud-storage-transfer/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-storage-transfer/testing/constraints-3.14.txt
+++ b/packages/google-cloud-storage-transfer/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-storage/google/cloud/_storage_v2/__init__.py b/packages/google-cloud-storage/google/cloud/_storage_v2/__init__.py
index cc6a108f30b2..44f646ecdf5a 100644
--- a/packages/google-cloud-storage/google/cloud/_storage_v2/__init__.py
+++ b/packages/google-cloud-storage/google/cloud/_storage_v2/__init__.py
@@ -108,7 +108,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -137,9 +137,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-storage/setup.py b/packages/google-cloud-storage/setup.py
index 0f339a119486..b872eff7dbd8 100644
--- a/packages/google-cloud-storage/setup.py
+++ b/packages/google-cloud-storage/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/_storage/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
diff --git a/packages/google-cloud-storagebatchoperations/google/cloud/storagebatchoperations_v1/__init__.py b/packages/google-cloud-storagebatchoperations/google/cloud/storagebatchoperations_v1/__init__.py
index 282008b8c8bc..1cbeffeea172 100644
--- a/packages/google-cloud-storagebatchoperations/google/cloud/storagebatchoperations_v1/__init__.py
+++ b/packages/google-cloud-storagebatchoperations/google/cloud/storagebatchoperations_v1/__init__.py
@@ -85,7 +85,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -114,9 +114,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-storagebatchoperations/setup.py b/packages/google-cloud-storagebatchoperations/setup.py
index a56b82d620e2..f053549ad73e 100644
--- a/packages/google-cloud-storagebatchoperations/setup.py
+++ b/packages/google-cloud-storagebatchoperations/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/storagebatchoperations/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-storagebatchoperations"
diff --git a/packages/google-cloud-storagebatchoperations/testing/constraints-3.10.txt b/packages/google-cloud-storagebatchoperations/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-storagebatchoperations/testing/constraints-3.10.txt
+++ b/packages/google-cloud-storagebatchoperations/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-storagebatchoperations/testing/constraints-3.13.txt b/packages/google-cloud-storagebatchoperations/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-storagebatchoperations/testing/constraints-3.13.txt
+++ b/packages/google-cloud-storagebatchoperations/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-storagebatchoperations/testing/constraints-3.14.txt b/packages/google-cloud-storagebatchoperations/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-storagebatchoperations/testing/constraints-3.14.txt
+++ b/packages/google-cloud-storagebatchoperations/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-storageinsights/google/cloud/storageinsights_v1/__init__.py b/packages/google-cloud-storageinsights/google/cloud/storageinsights_v1/__init__.py
index d9c422e41f25..5edeb233767b 100644
--- a/packages/google-cloud-storageinsights/google/cloud/storageinsights_v1/__init__.py
+++ b/packages/google-cloud-storageinsights/google/cloud/storageinsights_v1/__init__.py
@@ -82,7 +82,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -111,9 +111,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-storageinsights/setup.py b/packages/google-cloud-storageinsights/setup.py
index 875651f634a5..df724f39c7ae 100644
--- a/packages/google-cloud-storageinsights/setup.py
+++ b/packages/google-cloud-storageinsights/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/storageinsights/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-storageinsights"
diff --git a/packages/google-cloud-storageinsights/testing/constraints-3.10.txt b/packages/google-cloud-storageinsights/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-storageinsights/testing/constraints-3.10.txt
+++ b/packages/google-cloud-storageinsights/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-storageinsights/testing/constraints-3.13.txt b/packages/google-cloud-storageinsights/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-storageinsights/testing/constraints-3.13.txt
+++ b/packages/google-cloud-storageinsights/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-storageinsights/testing/constraints-3.14.txt b/packages/google-cloud-storageinsights/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-storageinsights/testing/constraints-3.14.txt
+++ b/packages/google-cloud-storageinsights/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-support/google/cloud/support_v2/__init__.py b/packages/google-cloud-support/google/cloud/support_v2/__init__.py
index 9649728d5e9c..5c1776102997 100644
--- a/packages/google-cloud-support/google/cloud/support_v2/__init__.py
+++ b/packages/google-cloud-support/google/cloud/support_v2/__init__.py
@@ -84,7 +84,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -113,9 +113,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-support/google/cloud/support_v2beta/__init__.py b/packages/google-cloud-support/google/cloud/support_v2beta/__init__.py
index b21dd23db19c..23e7f9d851f1 100644
--- a/packages/google-cloud-support/google/cloud/support_v2beta/__init__.py
+++ b/packages/google-cloud-support/google/cloud/support_v2beta/__init__.py
@@ -89,7 +89,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -118,9 +118,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-support/setup.py b/packages/google-cloud-support/setup.py
index 85dacdc67f2b..1cd2cf3222cc 100644
--- a/packages/google-cloud-support/setup.py
+++ b/packages/google-cloud-support/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/support/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-support"
diff --git a/packages/google-cloud-support/testing/constraints-3.10.txt b/packages/google-cloud-support/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-support/testing/constraints-3.10.txt
+++ b/packages/google-cloud-support/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-support/testing/constraints-3.13.txt b/packages/google-cloud-support/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-support/testing/constraints-3.13.txt
+++ b/packages/google-cloud-support/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-support/testing/constraints-3.14.txt b/packages/google-cloud-support/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-support/testing/constraints-3.14.txt
+++ b/packages/google-cloud-support/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-talent/google/cloud/talent_v4/__init__.py b/packages/google-cloud-talent/google/cloud/talent_v4/__init__.py
index 0f2b7ee0a32b..63bc3f5def6f 100644
--- a/packages/google-cloud-talent/google/cloud/talent_v4/__init__.py
+++ b/packages/google-cloud-talent/google/cloud/talent_v4/__init__.py
@@ -117,7 +117,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -146,9 +146,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-talent/google/cloud/talent_v4beta1/__init__.py b/packages/google-cloud-talent/google/cloud/talent_v4beta1/__init__.py
index 34cf5dd14249..189251e36f11 100644
--- a/packages/google-cloud-talent/google/cloud/talent_v4beta1/__init__.py
+++ b/packages/google-cloud-talent/google/cloud/talent_v4beta1/__init__.py
@@ -114,7 +114,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -143,9 +143,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-talent/setup.py b/packages/google-cloud-talent/setup.py
index 82577fd8b8b8..f59aced32002 100644
--- a/packages/google-cloud-talent/setup.py
+++ b/packages/google-cloud-talent/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/talent/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-talent"
diff --git a/packages/google-cloud-talent/testing/constraints-3.10.txt b/packages/google-cloud-talent/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-talent/testing/constraints-3.10.txt
+++ b/packages/google-cloud-talent/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-talent/testing/constraints-3.13.txt b/packages/google-cloud-talent/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-talent/testing/constraints-3.13.txt
+++ b/packages/google-cloud-talent/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-talent/testing/constraints-3.14.txt b/packages/google-cloud-talent/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-talent/testing/constraints-3.14.txt
+++ b/packages/google-cloud-talent/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-tasks/google/cloud/tasks_v2/__init__.py b/packages/google-cloud-tasks/google/cloud/tasks_v2/__init__.py
index e2e6c2d5b104..4d5431a036c5 100644
--- a/packages/google-cloud-tasks/google/cloud/tasks_v2/__init__.py
+++ b/packages/google-cloud-tasks/google/cloud/tasks_v2/__init__.py
@@ -77,7 +77,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -106,9 +106,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-tasks/google/cloud/tasks_v2beta2/__init__.py b/packages/google-cloud-tasks/google/cloud/tasks_v2beta2/__init__.py
index 8212d629baf4..da9fe6287eac 100644
--- a/packages/google-cloud-tasks/google/cloud/tasks_v2beta2/__init__.py
+++ b/packages/google-cloud-tasks/google/cloud/tasks_v2beta2/__init__.py
@@ -90,7 +90,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -119,9 +119,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-tasks/google/cloud/tasks_v2beta3/__init__.py b/packages/google-cloud-tasks/google/cloud/tasks_v2beta3/__init__.py
index 69f0155ffa89..e7900a1d6b5e 100644
--- a/packages/google-cloud-tasks/google/cloud/tasks_v2beta3/__init__.py
+++ b/packages/google-cloud-tasks/google/cloud/tasks_v2beta3/__init__.py
@@ -89,7 +89,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -118,9 +118,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-tasks/setup.py b/packages/google-cloud-tasks/setup.py
index 36fb9a623d04..23480d4779df 100644
--- a/packages/google-cloud-tasks/setup.py
+++ b/packages/google-cloud-tasks/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/tasks/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-tasks"
diff --git a/packages/google-cloud-tasks/testing/constraints-3.10.txt b/packages/google-cloud-tasks/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-tasks/testing/constraints-3.10.txt
+++ b/packages/google-cloud-tasks/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-tasks/testing/constraints-3.13.txt b/packages/google-cloud-tasks/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-tasks/testing/constraints-3.13.txt
+++ b/packages/google-cloud-tasks/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-tasks/testing/constraints-3.14.txt b/packages/google-cloud-tasks/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-tasks/testing/constraints-3.14.txt
+++ b/packages/google-cloud-tasks/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-telcoautomation/google/cloud/telcoautomation_v1/__init__.py b/packages/google-cloud-telcoautomation/google/cloud/telcoautomation_v1/__init__.py
index b3563c10f192..6d31533986a3 100644
--- a/packages/google-cloud-telcoautomation/google/cloud/telcoautomation_v1/__init__.py
+++ b/packages/google-cloud-telcoautomation/google/cloud/telcoautomation_v1/__init__.py
@@ -124,7 +124,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -153,9 +153,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-telcoautomation/google/cloud/telcoautomation_v1alpha1/__init__.py b/packages/google-cloud-telcoautomation/google/cloud/telcoautomation_v1alpha1/__init__.py
index 91ee97c852b9..bd41994daae6 100644
--- a/packages/google-cloud-telcoautomation/google/cloud/telcoautomation_v1alpha1/__init__.py
+++ b/packages/google-cloud-telcoautomation/google/cloud/telcoautomation_v1alpha1/__init__.py
@@ -124,7 +124,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -153,9 +153,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-telcoautomation/setup.py b/packages/google-cloud-telcoautomation/setup.py
index c92bf913c9e8..3b03f181a224 100644
--- a/packages/google-cloud-telcoautomation/setup.py
+++ b/packages/google-cloud-telcoautomation/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/telcoautomation/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-telcoautomation"
diff --git a/packages/google-cloud-telcoautomation/testing/constraints-3.10.txt b/packages/google-cloud-telcoautomation/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-telcoautomation/testing/constraints-3.10.txt
+++ b/packages/google-cloud-telcoautomation/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-telcoautomation/testing/constraints-3.13.txt b/packages/google-cloud-telcoautomation/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-telcoautomation/testing/constraints-3.13.txt
+++ b/packages/google-cloud-telcoautomation/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-telcoautomation/testing/constraints-3.14.txt b/packages/google-cloud-telcoautomation/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-telcoautomation/testing/constraints-3.14.txt
+++ b/packages/google-cloud-telcoautomation/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-texttospeech/google/cloud/texttospeech_v1/__init__.py b/packages/google-cloud-texttospeech/google/cloud/texttospeech_v1/__init__.py
index 93755da86ee2..2583f8c94a57 100644
--- a/packages/google-cloud-texttospeech/google/cloud/texttospeech_v1/__init__.py
+++ b/packages/google-cloud-texttospeech/google/cloud/texttospeech_v1/__init__.py
@@ -84,7 +84,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -113,9 +113,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-texttospeech/google/cloud/texttospeech_v1beta1/__init__.py b/packages/google-cloud-texttospeech/google/cloud/texttospeech_v1beta1/__init__.py
index 0ac7c07db17e..777a5830fcd0 100644
--- a/packages/google-cloud-texttospeech/google/cloud/texttospeech_v1beta1/__init__.py
+++ b/packages/google-cloud-texttospeech/google/cloud/texttospeech_v1beta1/__init__.py
@@ -85,7 +85,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -114,9 +114,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-texttospeech/setup.py b/packages/google-cloud-texttospeech/setup.py
index 6787142e1078..7bbe6fbed848 100644
--- a/packages/google-cloud-texttospeech/setup.py
+++ b/packages/google-cloud-texttospeech/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/texttospeech/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-texttospeech"
diff --git a/packages/google-cloud-texttospeech/testing/constraints-3.10.txt b/packages/google-cloud-texttospeech/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-texttospeech/testing/constraints-3.10.txt
+++ b/packages/google-cloud-texttospeech/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-texttospeech/testing/constraints-3.13.txt b/packages/google-cloud-texttospeech/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-texttospeech/testing/constraints-3.13.txt
+++ b/packages/google-cloud-texttospeech/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-texttospeech/testing/constraints-3.14.txt b/packages/google-cloud-texttospeech/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-texttospeech/testing/constraints-3.14.txt
+++ b/packages/google-cloud-texttospeech/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-tpu/google/cloud/tpu_v1/__init__.py b/packages/google-cloud-tpu/google/cloud/tpu_v1/__init__.py
index 2a61f42cd6be..7ca9bcb83552 100644
--- a/packages/google-cloud-tpu/google/cloud/tpu_v1/__init__.py
+++ b/packages/google-cloud-tpu/google/cloud/tpu_v1/__init__.py
@@ -73,7 +73,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -102,9 +102,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-tpu/google/cloud/tpu_v2/__init__.py b/packages/google-cloud-tpu/google/cloud/tpu_v2/__init__.py
index c69b2ad5605d..3e907805e968 100644
--- a/packages/google-cloud-tpu/google/cloud/tpu_v2/__init__.py
+++ b/packages/google-cloud-tpu/google/cloud/tpu_v2/__init__.py
@@ -95,7 +95,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -124,9 +124,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-tpu/google/cloud/tpu_v2alpha1/__init__.py b/packages/google-cloud-tpu/google/cloud/tpu_v2alpha1/__init__.py
index cd780ec23b07..a67c0bf953ca 100644
--- a/packages/google-cloud-tpu/google/cloud/tpu_v2alpha1/__init__.py
+++ b/packages/google-cloud-tpu/google/cloud/tpu_v2alpha1/__init__.py
@@ -104,7 +104,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -133,9 +133,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-tpu/setup.py b/packages/google-cloud-tpu/setup.py
index ebf078b4b589..91c1e16a3b39 100644
--- a/packages/google-cloud-tpu/setup.py
+++ b/packages/google-cloud-tpu/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/tpu/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-tpu"
diff --git a/packages/google-cloud-tpu/testing/constraints-3.10.txt b/packages/google-cloud-tpu/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-tpu/testing/constraints-3.10.txt
+++ b/packages/google-cloud-tpu/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-tpu/testing/constraints-3.13.txt b/packages/google-cloud-tpu/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-tpu/testing/constraints-3.13.txt
+++ b/packages/google-cloud-tpu/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-tpu/testing/constraints-3.14.txt b/packages/google-cloud-tpu/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-tpu/testing/constraints-3.14.txt
+++ b/packages/google-cloud-tpu/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-trace/google/cloud/trace_v1/__init__.py b/packages/google-cloud-trace/google/cloud/trace_v1/__init__.py
index 61679a3445c2..44351fa12de9 100644
--- a/packages/google-cloud-trace/google/cloud/trace_v1/__init__.py
+++ b/packages/google-cloud-trace/google/cloud/trace_v1/__init__.py
@@ -59,7 +59,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -88,9 +88,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-trace/google/cloud/trace_v2/__init__.py b/packages/google-cloud-trace/google/cloud/trace_v2/__init__.py
index 4b3f460d1ac4..6dae62900491 100644
--- a/packages/google-cloud-trace/google/cloud/trace_v2/__init__.py
+++ b/packages/google-cloud-trace/google/cloud/trace_v2/__init__.py
@@ -52,7 +52,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -81,9 +81,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-trace/setup.py b/packages/google-cloud-trace/setup.py
index 4b8ded729adf..550f4d30d4c0 100644
--- a/packages/google-cloud-trace/setup.py
+++ b/packages/google-cloud-trace/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/trace/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-trace"
diff --git a/packages/google-cloud-trace/testing/constraints-3.10.txt b/packages/google-cloud-trace/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-trace/testing/constraints-3.10.txt
+++ b/packages/google-cloud-trace/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-trace/testing/constraints-3.13.txt b/packages/google-cloud-trace/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-trace/testing/constraints-3.13.txt
+++ b/packages/google-cloud-trace/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-trace/testing/constraints-3.14.txt b/packages/google-cloud-trace/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-trace/testing/constraints-3.14.txt
+++ b/packages/google-cloud-trace/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-translate/google/cloud/translate_v3/__init__.py b/packages/google-cloud-translate/google/cloud/translate_v3/__init__.py
index 5d37c2dd5d73..06fdb44d9e8f 100644
--- a/packages/google-cloud-translate/google/cloud/translate_v3/__init__.py
+++ b/packages/google-cloud-translate/google/cloud/translate_v3/__init__.py
@@ -161,7 +161,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -190,9 +190,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-translate/google/cloud/translate_v3beta1/__init__.py b/packages/google-cloud-translate/google/cloud/translate_v3beta1/__init__.py
index 1983fb0586dc..10492b805c39 100644
--- a/packages/google-cloud-translate/google/cloud/translate_v3beta1/__init__.py
+++ b/packages/google-cloud-translate/google/cloud/translate_v3beta1/__init__.py
@@ -95,7 +95,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -124,9 +124,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-translate/setup.py b/packages/google-cloud-translate/setup.py
index c79b32162195..b32c7f6572ea 100644
--- a/packages/google-cloud-translate/setup.py
+++ b/packages/google-cloud-translate/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/translate/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,17 +42,16 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "google-cloud-core >= 2.0.0, <3.0.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-translate"
diff --git a/packages/google-cloud-translate/testing/constraints-3.10.txt b/packages/google-cloud-translate/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-translate/testing/constraints-3.10.txt
+++ b/packages/google-cloud-translate/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-translate/testing/constraints-3.13.txt b/packages/google-cloud-translate/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-translate/testing/constraints-3.13.txt
+++ b/packages/google-cloud-translate/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-translate/testing/constraints-3.14.txt b/packages/google-cloud-translate/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-translate/testing/constraints-3.14.txt
+++ b/packages/google-cloud-translate/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-vectorsearch/google/cloud/vectorsearch_v1/__init__.py b/packages/google-cloud-vectorsearch/google/cloud/vectorsearch_v1/__init__.py
index 5e1efa6bdf92..6113a04a7798 100644
--- a/packages/google-cloud-vectorsearch/google/cloud/vectorsearch_v1/__init__.py
+++ b/packages/google-cloud-vectorsearch/google/cloud/vectorsearch_v1/__init__.py
@@ -124,7 +124,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -153,9 +153,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-vectorsearch/google/cloud/vectorsearch_v1beta/__init__.py b/packages/google-cloud-vectorsearch/google/cloud/vectorsearch_v1beta/__init__.py
index 7ccbf95e312d..1710753bcc45 100644
--- a/packages/google-cloud-vectorsearch/google/cloud/vectorsearch_v1beta/__init__.py
+++ b/packages/google-cloud-vectorsearch/google/cloud/vectorsearch_v1beta/__init__.py
@@ -126,7 +126,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -155,9 +155,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-vectorsearch/setup.py b/packages/google-cloud-vectorsearch/setup.py
index d1b95b1755fa..0da7fb2df079 100644
--- a/packages/google-cloud-vectorsearch/setup.py
+++ b/packages/google-cloud-vectorsearch/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/vectorsearch/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-vectorsearch"
diff --git a/packages/google-cloud-vectorsearch/testing/constraints-3.10.txt b/packages/google-cloud-vectorsearch/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-vectorsearch/testing/constraints-3.10.txt
+++ b/packages/google-cloud-vectorsearch/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-vectorsearch/testing/constraints-3.13.txt b/packages/google-cloud-vectorsearch/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-vectorsearch/testing/constraints-3.13.txt
+++ b/packages/google-cloud-vectorsearch/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-vectorsearch/testing/constraints-3.14.txt b/packages/google-cloud-vectorsearch/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-vectorsearch/testing/constraints-3.14.txt
+++ b/packages/google-cloud-vectorsearch/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-video-live-stream/google/cloud/video/live_stream_v1/__init__.py b/packages/google-cloud-video-live-stream/google/cloud/video/live_stream_v1/__init__.py
index 2f13f62540b1..9047532fff1f 100644
--- a/packages/google-cloud-video-live-stream/google/cloud/video/live_stream_v1/__init__.py
+++ b/packages/google-cloud-video-live-stream/google/cloud/video/live_stream_v1/__init__.py
@@ -139,7 +139,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -168,9 +168,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-video-live-stream/setup.py b/packages/google-cloud-video-live-stream/setup.py
index 7377ca4fc650..05f2a253529a 100644
--- a/packages/google-cloud-video-live-stream/setup.py
+++ b/packages/google-cloud-video-live-stream/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/video/live_stream/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-video-live-stream"
diff --git a/packages/google-cloud-video-live-stream/testing/constraints-3.10.txt b/packages/google-cloud-video-live-stream/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-video-live-stream/testing/constraints-3.10.txt
+++ b/packages/google-cloud-video-live-stream/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-video-live-stream/testing/constraints-3.13.txt b/packages/google-cloud-video-live-stream/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-video-live-stream/testing/constraints-3.13.txt
+++ b/packages/google-cloud-video-live-stream/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-video-live-stream/testing/constraints-3.14.txt b/packages/google-cloud-video-live-stream/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-video-live-stream/testing/constraints-3.14.txt
+++ b/packages/google-cloud-video-live-stream/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-video-stitcher/google/cloud/video/stitcher_v1/__init__.py b/packages/google-cloud-video-stitcher/google/cloud/video/stitcher_v1/__init__.py
index 9a643521e403..fada95aa2269 100644
--- a/packages/google-cloud-video-stitcher/google/cloud/video/stitcher_v1/__init__.py
+++ b/packages/google-cloud-video-stitcher/google/cloud/video/stitcher_v1/__init__.py
@@ -124,7 +124,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -153,9 +153,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-video-stitcher/setup.py b/packages/google-cloud-video-stitcher/setup.py
index 57fcc6a1b62d..f65ee6ba9e2c 100644
--- a/packages/google-cloud-video-stitcher/setup.py
+++ b/packages/google-cloud-video-stitcher/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/video/stitcher/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-video-stitcher"
diff --git a/packages/google-cloud-video-stitcher/testing/constraints-3.10.txt b/packages/google-cloud-video-stitcher/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-video-stitcher/testing/constraints-3.10.txt
+++ b/packages/google-cloud-video-stitcher/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-video-stitcher/testing/constraints-3.13.txt b/packages/google-cloud-video-stitcher/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-video-stitcher/testing/constraints-3.13.txt
+++ b/packages/google-cloud-video-stitcher/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-video-stitcher/testing/constraints-3.14.txt b/packages/google-cloud-video-stitcher/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-video-stitcher/testing/constraints-3.14.txt
+++ b/packages/google-cloud-video-stitcher/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-video-transcoder/google/cloud/video/transcoder_v1/__init__.py b/packages/google-cloud-video-transcoder/google/cloud/video/transcoder_v1/__init__.py
index 010bea2804c5..24393a0fc125 100644
--- a/packages/google-cloud-video-transcoder/google/cloud/video/transcoder_v1/__init__.py
+++ b/packages/google-cloud-video-transcoder/google/cloud/video/transcoder_v1/__init__.py
@@ -88,7 +88,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -117,9 +117,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-video-transcoder/setup.py b/packages/google-cloud-video-transcoder/setup.py
index add5a553a150..cfd187ced81b 100644
--- a/packages/google-cloud-video-transcoder/setup.py
+++ b/packages/google-cloud-video-transcoder/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/video/transcoder/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-video-transcoder"
diff --git a/packages/google-cloud-video-transcoder/testing/constraints-3.10.txt b/packages/google-cloud-video-transcoder/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-video-transcoder/testing/constraints-3.10.txt
+++ b/packages/google-cloud-video-transcoder/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-video-transcoder/testing/constraints-3.13.txt b/packages/google-cloud-video-transcoder/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-video-transcoder/testing/constraints-3.13.txt
+++ b/packages/google-cloud-video-transcoder/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-video-transcoder/testing/constraints-3.14.txt b/packages/google-cloud-video-transcoder/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-video-transcoder/testing/constraints-3.14.txt
+++ b/packages/google-cloud-video-transcoder/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1/__init__.py b/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1/__init__.py
index e9e9ee740f5f..9690037e2693 100644
--- a/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1/__init__.py
+++ b/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1/__init__.py
@@ -101,7 +101,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -130,9 +130,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1beta2/__init__.py b/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1beta2/__init__.py
index 1d37f3041354..88f8c2be2d08 100644
--- a/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1beta2/__init__.py
+++ b/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1beta2/__init__.py
@@ -79,7 +79,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -108,9 +108,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1p1beta1/__init__.py b/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1p1beta1/__init__.py
index e26b9cdf6a01..7bf3f10906be 100644
--- a/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1p1beta1/__init__.py
+++ b/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1p1beta1/__init__.py
@@ -79,7 +79,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -108,9 +108,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1p2beta1/__init__.py b/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1p2beta1/__init__.py
index 20a3ba3c4724..c01580d89eed 100644
--- a/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1p2beta1/__init__.py
+++ b/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1p2beta1/__init__.py
@@ -83,7 +83,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -112,9 +112,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1p3beta1/__init__.py b/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1p3beta1/__init__.py
index 77686a4543a0..2d0d035a3b64 100644
--- a/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1p3beta1/__init__.py
+++ b/packages/google-cloud-videointelligence/google/cloud/videointelligence_v1p3beta1/__init__.py
@@ -118,7 +118,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -147,9 +147,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-videointelligence/setup.py b/packages/google-cloud-videointelligence/setup.py
index 3573c98f7480..f026a3b3c878 100644
--- a/packages/google-cloud-videointelligence/setup.py
+++ b/packages/google-cloud-videointelligence/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/videointelligence/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-videointelligence"
diff --git a/packages/google-cloud-videointelligence/testing/constraints-3.10.txt b/packages/google-cloud-videointelligence/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-videointelligence/testing/constraints-3.10.txt
+++ b/packages/google-cloud-videointelligence/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-videointelligence/testing/constraints-3.13.txt b/packages/google-cloud-videointelligence/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-videointelligence/testing/constraints-3.13.txt
+++ b/packages/google-cloud-videointelligence/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-videointelligence/testing/constraints-3.14.txt b/packages/google-cloud-videointelligence/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-videointelligence/testing/constraints-3.14.txt
+++ b/packages/google-cloud-videointelligence/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-vision/google/cloud/vision_v1/__init__.py b/packages/google-cloud-vision/google/cloud/vision_v1/__init__.py
index ad4531c6cea7..e37a4e8188c0 100644
--- a/packages/google-cloud-vision/google/cloud/vision_v1/__init__.py
+++ b/packages/google-cloud-vision/google/cloud/vision_v1/__init__.py
@@ -134,7 +134,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -163,9 +163,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-vision/google/cloud/vision_v1p1beta1/__init__.py b/packages/google-cloud-vision/google/cloud/vision_v1p1beta1/__init__.py
index 63385ec4b144..32fddf6282cd 100644
--- a/packages/google-cloud-vision/google/cloud/vision_v1p1beta1/__init__.py
+++ b/packages/google-cloud-vision/google/cloud/vision_v1p1beta1/__init__.py
@@ -82,7 +82,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -111,9 +111,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-vision/google/cloud/vision_v1p2beta1/__init__.py b/packages/google-cloud-vision/google/cloud/vision_v1p2beta1/__init__.py
index 6c9a922ae9be..156cfcbfdaf3 100644
--- a/packages/google-cloud-vision/google/cloud/vision_v1p2beta1/__init__.py
+++ b/packages/google-cloud-vision/google/cloud/vision_v1p2beta1/__init__.py
@@ -93,7 +93,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -122,9 +122,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-vision/google/cloud/vision_v1p3beta1/__init__.py b/packages/google-cloud-vision/google/cloud/vision_v1p3beta1/__init__.py
index 5f68e4357fe4..c3a0ca19dfeb 100644
--- a/packages/google-cloud-vision/google/cloud/vision_v1p3beta1/__init__.py
+++ b/packages/google-cloud-vision/google/cloud/vision_v1p3beta1/__init__.py
@@ -127,7 +127,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -156,9 +156,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-vision/google/cloud/vision_v1p4beta1/__init__.py b/packages/google-cloud-vision/google/cloud/vision_v1p4beta1/__init__.py
index 415eedaa8838..99039b68dcfa 100644
--- a/packages/google-cloud-vision/google/cloud/vision_v1p4beta1/__init__.py
+++ b/packages/google-cloud-vision/google/cloud/vision_v1p4beta1/__init__.py
@@ -135,7 +135,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -164,9 +164,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-vision/setup.py b/packages/google-cloud-vision/setup.py
index c3b44abecd05..1d9adf89627c 100644
--- a/packages/google-cloud-vision/setup.py
+++ b/packages/google-cloud-vision/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/vision/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-vision"
diff --git a/packages/google-cloud-vision/testing/constraints-3.10.txt b/packages/google-cloud-vision/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-vision/testing/constraints-3.10.txt
+++ b/packages/google-cloud-vision/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-vision/testing/constraints-3.13.txt b/packages/google-cloud-vision/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-vision/testing/constraints-3.13.txt
+++ b/packages/google-cloud-vision/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-vision/testing/constraints-3.14.txt b/packages/google-cloud-vision/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-vision/testing/constraints-3.14.txt
+++ b/packages/google-cloud-vision/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-visionai/google/cloud/visionai_v1/__init__.py b/packages/google-cloud-visionai/google/cloud/visionai_v1/__init__.py
index be5b2569f01d..14462be39420 100644
--- a/packages/google-cloud-visionai/google/cloud/visionai_v1/__init__.py
+++ b/packages/google-cloud-visionai/google/cloud/visionai_v1/__init__.py
@@ -421,7 +421,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -450,9 +450,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-visionai/google/cloud/visionai_v1alpha1/__init__.py b/packages/google-cloud-visionai/google/cloud/visionai_v1alpha1/__init__.py
index 911275f59ea5..fe1456cef925 100644
--- a/packages/google-cloud-visionai/google/cloud/visionai_v1alpha1/__init__.py
+++ b/packages/google-cloud-visionai/google/cloud/visionai_v1alpha1/__init__.py
@@ -296,7 +296,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -325,9 +325,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-visionai/setup.py b/packages/google-cloud-visionai/setup.py
index b3c81042e3e9..368bc1872711 100644
--- a/packages/google-cloud-visionai/setup.py
+++ b/packages/google-cloud-visionai/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/visionai/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-visionai"
diff --git a/packages/google-cloud-visionai/testing/constraints-3.10.txt b/packages/google-cloud-visionai/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-visionai/testing/constraints-3.10.txt
+++ b/packages/google-cloud-visionai/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-visionai/testing/constraints-3.13.txt b/packages/google-cloud-visionai/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-visionai/testing/constraints-3.13.txt
+++ b/packages/google-cloud-visionai/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-visionai/testing/constraints-3.14.txt b/packages/google-cloud-visionai/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-visionai/testing/constraints-3.14.txt
+++ b/packages/google-cloud-visionai/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-vm-migration/google/cloud/vmmigration_v1/__init__.py b/packages/google-cloud-vm-migration/google/cloud/vmmigration_v1/__init__.py
index 2c93ea92ac72..841e632a4408 100644
--- a/packages/google-cloud-vm-migration/google/cloud/vmmigration_v1/__init__.py
+++ b/packages/google-cloud-vm-migration/google/cloud/vmmigration_v1/__init__.py
@@ -235,7 +235,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -264,9 +264,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-vm-migration/setup.py b/packages/google-cloud-vm-migration/setup.py
index d3acee99be47..dc2266d98558 100644
--- a/packages/google-cloud-vm-migration/setup.py
+++ b/packages/google-cloud-vm-migration/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/vmmigration/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-vm-migration"
diff --git a/packages/google-cloud-vm-migration/testing/constraints-3.10.txt b/packages/google-cloud-vm-migration/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-vm-migration/testing/constraints-3.10.txt
+++ b/packages/google-cloud-vm-migration/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-vm-migration/testing/constraints-3.13.txt b/packages/google-cloud-vm-migration/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-vm-migration/testing/constraints-3.13.txt
+++ b/packages/google-cloud-vm-migration/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-vm-migration/testing/constraints-3.14.txt b/packages/google-cloud-vm-migration/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-vm-migration/testing/constraints-3.14.txt
+++ b/packages/google-cloud-vm-migration/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-vmwareengine/google/cloud/vmwareengine_v1/__init__.py b/packages/google-cloud-vmwareengine/google/cloud/vmwareengine_v1/__init__.py
index 72640fb1d286..34f4ec5d5c30 100644
--- a/packages/google-cloud-vmwareengine/google/cloud/vmwareengine_v1/__init__.py
+++ b/packages/google-cloud-vmwareengine/google/cloud/vmwareengine_v1/__init__.py
@@ -173,7 +173,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -202,9 +202,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-vmwareengine/setup.py b/packages/google-cloud-vmwareengine/setup.py
index 53d0bd968b92..79b66e1bc1d8 100644
--- a/packages/google-cloud-vmwareengine/setup.py
+++ b/packages/google-cloud-vmwareengine/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/vmwareengine/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-vmwareengine"
diff --git a/packages/google-cloud-vmwareengine/testing/constraints-3.10.txt b/packages/google-cloud-vmwareengine/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-vmwareengine/testing/constraints-3.10.txt
+++ b/packages/google-cloud-vmwareengine/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-vmwareengine/testing/constraints-3.13.txt b/packages/google-cloud-vmwareengine/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-vmwareengine/testing/constraints-3.13.txt
+++ b/packages/google-cloud-vmwareengine/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-vmwareengine/testing/constraints-3.14.txt b/packages/google-cloud-vmwareengine/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-vmwareengine/testing/constraints-3.14.txt
+++ b/packages/google-cloud-vmwareengine/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-vpc-access/google/cloud/vpcaccess_v1/__init__.py b/packages/google-cloud-vpc-access/google/cloud/vpcaccess_v1/__init__.py
index e85a2c101470..bc21f07c112a 100644
--- a/packages/google-cloud-vpc-access/google/cloud/vpcaccess_v1/__init__.py
+++ b/packages/google-cloud-vpc-access/google/cloud/vpcaccess_v1/__init__.py
@@ -62,7 +62,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -91,9 +91,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-vpc-access/setup.py b/packages/google-cloud-vpc-access/setup.py
index d8665c6bd1c4..674ed837bbf8 100644
--- a/packages/google-cloud-vpc-access/setup.py
+++ b/packages/google-cloud-vpc-access/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/vpcaccess/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-vpc-access"
diff --git a/packages/google-cloud-vpc-access/testing/constraints-3.10.txt b/packages/google-cloud-vpc-access/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-vpc-access/testing/constraints-3.10.txt
+++ b/packages/google-cloud-vpc-access/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-vpc-access/testing/constraints-3.13.txt b/packages/google-cloud-vpc-access/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-vpc-access/testing/constraints-3.13.txt
+++ b/packages/google-cloud-vpc-access/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-vpc-access/testing/constraints-3.14.txt b/packages/google-cloud-vpc-access/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-vpc-access/testing/constraints-3.14.txt
+++ b/packages/google-cloud-vpc-access/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-webrisk/google/cloud/webrisk_v1/__init__.py b/packages/google-cloud-webrisk/google/cloud/webrisk_v1/__init__.py
index 389b932e51ca..2d29bdb83e89 100644
--- a/packages/google-cloud-webrisk/google/cloud/webrisk_v1/__init__.py
+++ b/packages/google-cloud-webrisk/google/cloud/webrisk_v1/__init__.py
@@ -71,7 +71,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -100,9 +100,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-webrisk/google/cloud/webrisk_v1beta1/__init__.py b/packages/google-cloud-webrisk/google/cloud/webrisk_v1beta1/__init__.py
index 2f2e2656a942..52af7aac3686 100644
--- a/packages/google-cloud-webrisk/google/cloud/webrisk_v1beta1/__init__.py
+++ b/packages/google-cloud-webrisk/google/cloud/webrisk_v1beta1/__init__.py
@@ -68,7 +68,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -97,9 +97,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-webrisk/setup.py b/packages/google-cloud-webrisk/setup.py
index 993bdd3378ba..f7ecf8ce0623 100644
--- a/packages/google-cloud-webrisk/setup.py
+++ b/packages/google-cloud-webrisk/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/webrisk/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-webrisk"
diff --git a/packages/google-cloud-webrisk/testing/constraints-3.10.txt b/packages/google-cloud-webrisk/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-webrisk/testing/constraints-3.10.txt
+++ b/packages/google-cloud-webrisk/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-webrisk/testing/constraints-3.13.txt b/packages/google-cloud-webrisk/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-webrisk/testing/constraints-3.13.txt
+++ b/packages/google-cloud-webrisk/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-webrisk/testing/constraints-3.14.txt b/packages/google-cloud-webrisk/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-webrisk/testing/constraints-3.14.txt
+++ b/packages/google-cloud-webrisk/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-websecurityscanner/google/cloud/websecurityscanner_v1/__init__.py b/packages/google-cloud-websecurityscanner/google/cloud/websecurityscanner_v1/__init__.py
index 3f09af7f9c4b..3f51dc4ec113 100644
--- a/packages/google-cloud-websecurityscanner/google/cloud/websecurityscanner_v1/__init__.py
+++ b/packages/google-cloud-websecurityscanner/google/cloud/websecurityscanner_v1/__init__.py
@@ -91,7 +91,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -120,9 +120,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-websecurityscanner/google/cloud/websecurityscanner_v1alpha/__init__.py b/packages/google-cloud-websecurityscanner/google/cloud/websecurityscanner_v1alpha/__init__.py
index cbbd5ed1895a..c3d50586fb61 100644
--- a/packages/google-cloud-websecurityscanner/google/cloud/websecurityscanner_v1alpha/__init__.py
+++ b/packages/google-cloud-websecurityscanner/google/cloud/websecurityscanner_v1alpha/__init__.py
@@ -85,7 +85,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -114,9 +114,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-websecurityscanner/google/cloud/websecurityscanner_v1beta/__init__.py b/packages/google-cloud-websecurityscanner/google/cloud/websecurityscanner_v1beta/__init__.py
index a205a1727d67..b0a6ed45e031 100644
--- a/packages/google-cloud-websecurityscanner/google/cloud/websecurityscanner_v1beta/__init__.py
+++ b/packages/google-cloud-websecurityscanner/google/cloud/websecurityscanner_v1beta/__init__.py
@@ -89,7 +89,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -118,9 +118,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-websecurityscanner/setup.py b/packages/google-cloud-websecurityscanner/setup.py
index 57f3e54bd80d..eba5f3bc1840 100644
--- a/packages/google-cloud-websecurityscanner/setup.py
+++ b/packages/google-cloud-websecurityscanner/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/websecurityscanner/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-websecurityscanner"
diff --git a/packages/google-cloud-websecurityscanner/testing/constraints-3.10.txt b/packages/google-cloud-websecurityscanner/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-websecurityscanner/testing/constraints-3.10.txt
+++ b/packages/google-cloud-websecurityscanner/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-websecurityscanner/testing/constraints-3.13.txt b/packages/google-cloud-websecurityscanner/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-websecurityscanner/testing/constraints-3.13.txt
+++ b/packages/google-cloud-websecurityscanner/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-websecurityscanner/testing/constraints-3.14.txt b/packages/google-cloud-websecurityscanner/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-websecurityscanner/testing/constraints-3.14.txt
+++ b/packages/google-cloud-websecurityscanner/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-workflows/google/cloud/workflows/executions_v1/__init__.py b/packages/google-cloud-workflows/google/cloud/workflows/executions_v1/__init__.py
index 378371c379a0..42bdf27d9121 100644
--- a/packages/google-cloud-workflows/google/cloud/workflows/executions_v1/__init__.py
+++ b/packages/google-cloud-workflows/google/cloud/workflows/executions_v1/__init__.py
@@ -59,7 +59,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -88,9 +88,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-workflows/google/cloud/workflows/executions_v1beta/__init__.py b/packages/google-cloud-workflows/google/cloud/workflows/executions_v1beta/__init__.py
index 33352d0d3b15..0edd35c8aef6 100644
--- a/packages/google-cloud-workflows/google/cloud/workflows/executions_v1beta/__init__.py
+++ b/packages/google-cloud-workflows/google/cloud/workflows/executions_v1beta/__init__.py
@@ -59,7 +59,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -88,9 +88,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-workflows/google/cloud/workflows_v1/__init__.py b/packages/google-cloud-workflows/google/cloud/workflows_v1/__init__.py
index 76f0ccfb42b4..854f1d40757e 100644
--- a/packages/google-cloud-workflows/google/cloud/workflows_v1/__init__.py
+++ b/packages/google-cloud-workflows/google/cloud/workflows_v1/__init__.py
@@ -63,7 +63,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -92,9 +92,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-workflows/google/cloud/workflows_v1beta/__init__.py b/packages/google-cloud-workflows/google/cloud/workflows_v1beta/__init__.py
index b9da95f8c9fa..10e355bde3b4 100644
--- a/packages/google-cloud-workflows/google/cloud/workflows_v1beta/__init__.py
+++ b/packages/google-cloud-workflows/google/cloud/workflows_v1beta/__init__.py
@@ -60,7 +60,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -89,9 +89,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-workflows/setup.py b/packages/google-cloud-workflows/setup.py
index fddb078de9fb..5e02c2029645 100644
--- a/packages/google-cloud-workflows/setup.py
+++ b/packages/google-cloud-workflows/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/cloud/workflows/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-workflows"
diff --git a/packages/google-cloud-workflows/testing/constraints-3.10.txt b/packages/google-cloud-workflows/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-workflows/testing/constraints-3.10.txt
+++ b/packages/google-cloud-workflows/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-workflows/testing/constraints-3.13.txt b/packages/google-cloud-workflows/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-workflows/testing/constraints-3.13.txt
+++ b/packages/google-cloud-workflows/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-workflows/testing/constraints-3.14.txt b/packages/google-cloud-workflows/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-workflows/testing/constraints-3.14.txt
+++ b/packages/google-cloud-workflows/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-workloadmanager/google/cloud/workloadmanager_v1/__init__.py b/packages/google-cloud-workloadmanager/google/cloud/workloadmanager_v1/__init__.py
index 5a8e6ed77d10..0cca8a0318d4 100644
--- a/packages/google-cloud-workloadmanager/google/cloud/workloadmanager_v1/__init__.py
+++ b/packages/google-cloud-workloadmanager/google/cloud/workloadmanager_v1/__init__.py
@@ -86,7 +86,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -115,9 +115,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-workloadmanager/setup.py b/packages/google-cloud-workloadmanager/setup.py
index 4746534cd2e1..f5bd88b3b67f 100644
--- a/packages/google-cloud-workloadmanager/setup.py
+++ b/packages/google-cloud-workloadmanager/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/workloadmanager/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-workloadmanager"
diff --git a/packages/google-cloud-workloadmanager/testing/constraints-3.10.txt b/packages/google-cloud-workloadmanager/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-cloud-workloadmanager/testing/constraints-3.10.txt
+++ b/packages/google-cloud-workloadmanager/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-cloud-workloadmanager/testing/constraints-3.13.txt b/packages/google-cloud-workloadmanager/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-workloadmanager/testing/constraints-3.13.txt
+++ b/packages/google-cloud-workloadmanager/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-workloadmanager/testing/constraints-3.14.txt b/packages/google-cloud-workloadmanager/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-cloud-workloadmanager/testing/constraints-3.14.txt
+++ b/packages/google-cloud-workloadmanager/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-cloud-workstations/google/cloud/workstations_v1/__init__.py b/packages/google-cloud-workstations/google/cloud/workstations_v1/__init__.py
index 324dff0b595b..d0e618414dca 100644
--- a/packages/google-cloud-workstations/google/cloud/workstations_v1/__init__.py
+++ b/packages/google-cloud-workstations/google/cloud/workstations_v1/__init__.py
@@ -82,7 +82,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -111,9 +111,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-workstations/google/cloud/workstations_v1beta/__init__.py b/packages/google-cloud-workstations/google/cloud/workstations_v1beta/__init__.py
index 1a0ed5c51123..2d41ff26af33 100644
--- a/packages/google-cloud-workstations/google/cloud/workstations_v1beta/__init__.py
+++ b/packages/google-cloud-workstations/google/cloud/workstations_v1beta/__init__.py
@@ -84,7 +84,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -113,9 +113,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-cloud-workstations/setup.py b/packages/google-cloud-workstations/setup.py
index 2f2874b979a1..312cf8146d5c 100644
--- a/packages/google-cloud-workstations/setup.py
+++ b/packages/google-cloud-workstations/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/cloud/workstations/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "grpc-google-iam-v1 >= 0.14.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "grpc-google-iam-v1 >= 0.14.2, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-cloud-workstations"
diff --git a/packages/google-cloud-workstations/testing/constraints-3.10.txt b/packages/google-cloud-workstations/testing/constraints-3.10.txt
index b39cd54634f9..3a84666fb90e 100644
--- a/packages/google-cloud-workstations/testing/constraints-3.10.txt
+++ b/packages/google-cloud-workstations/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-grpc-google-iam-v1==0.14.0
+proto-plus==1.26.1
+protobuf==6.33.5
+grpc-google-iam-v1==0.14.2
diff --git a/packages/google-cloud-workstations/testing/constraints-3.13.txt b/packages/google-cloud-workstations/testing/constraints-3.13.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-workstations/testing/constraints-3.13.txt
+++ b/packages/google-cloud-workstations/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-cloud-workstations/testing/constraints-3.14.txt b/packages/google-cloud-workstations/testing/constraints-3.14.txt
index 2ae5a677e852..f85022a2fb62 100644
--- a/packages/google-cloud-workstations/testing/constraints-3.14.txt
+++ b/packages/google-cloud-workstations/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 grpc-google-iam-v1>=0
diff --git a/packages/google-developer-knowledge/google/developer_knowledge_v1/__init__.py b/packages/google-developer-knowledge/google/developer_knowledge_v1/__init__.py
index 7ea2fc16961e..075278bba7e4 100644
--- a/packages/google-developer-knowledge/google/developer_knowledge_v1/__init__.py
+++ b/packages/google-developer-knowledge/google/developer_knowledge_v1/__init__.py
@@ -63,7 +63,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -92,9 +92,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-developer-knowledge/setup.py b/packages/google-developer-knowledge/setup.py
index 7feece0e9cd6..c3942c02af48 100644
--- a/packages/google-developer-knowledge/setup.py
+++ b/packages/google-developer-knowledge/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/developer_knowledge/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-developer-knowledge"
diff --git a/packages/google-developer-knowledge/testing/constraints-3.10.txt b/packages/google-developer-knowledge/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-developer-knowledge/testing/constraints-3.10.txt
+++ b/packages/google-developer-knowledge/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-developer-knowledge/testing/constraints-3.13.txt b/packages/google-developer-knowledge/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-developer-knowledge/testing/constraints-3.13.txt
+++ b/packages/google-developer-knowledge/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-developer-knowledge/testing/constraints-3.14.txt b/packages/google-developer-knowledge/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-developer-knowledge/testing/constraints-3.14.txt
+++ b/packages/google-developer-knowledge/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-devicesandservices-health/google/devicesandservices/health_v4/__init__.py b/packages/google-devicesandservices-health/google/devicesandservices/health_v4/__init__.py
index c6014be40728..3929447111d5 100644
--- a/packages/google-devicesandservices-health/google/devicesandservices/health_v4/__init__.py
+++ b/packages/google-devicesandservices-health/google/devicesandservices/health_v4/__init__.py
@@ -209,7 +209,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -238,9 +238,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-devicesandservices-health/setup.py b/packages/google-devicesandservices-health/setup.py
index b87889d68543..5c592f85c234 100644
--- a/packages/google-devicesandservices-health/setup.py
+++ b/packages/google-devicesandservices-health/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/devicesandservices/health/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-devicesandservices-health"
diff --git a/packages/google-devicesandservices-health/testing/constraints-3.10.txt b/packages/google-devicesandservices-health/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-devicesandservices-health/testing/constraints-3.10.txt
+++ b/packages/google-devicesandservices-health/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-devicesandservices-health/testing/constraints-3.13.txt b/packages/google-devicesandservices-health/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-devicesandservices-health/testing/constraints-3.13.txt
+++ b/packages/google-devicesandservices-health/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-devicesandservices-health/testing/constraints-3.14.txt b/packages/google-devicesandservices-health/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-devicesandservices-health/testing/constraints-3.14.txt
+++ b/packages/google-devicesandservices-health/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-geo-type/google/geo/type/__init__.py b/packages/google-geo-type/google/geo/type/__init__.py
index e69ed30b7b6d..e88eaba90537 100644
--- a/packages/google-geo-type/google/geo/type/__init__.py
+++ b/packages/google-geo-type/google/geo/type/__init__.py
@@ -50,7 +50,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -79,9 +79,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-geo-type/setup.py b/packages/google-geo-type/setup.py
index ead51acc329a..1deaa98f0943 100644
--- a/packages/google-geo-type/setup.py
+++ b/packages/google-geo-type/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/geo/type/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-geo-type"
diff --git a/packages/google-geo-type/testing/constraints-3.10.txt b/packages/google-geo-type/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-geo-type/testing/constraints-3.10.txt
+++ b/packages/google-geo-type/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-geo-type/testing/constraints-3.13.txt b/packages/google-geo-type/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-geo-type/testing/constraints-3.13.txt
+++ b/packages/google-geo-type/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-geo-type/testing/constraints-3.14.txt b/packages/google-geo-type/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-geo-type/testing/constraints-3.14.txt
+++ b/packages/google-geo-type/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-maps-addressvalidation/google/maps/addressvalidation_v1/__init__.py b/packages/google-maps-addressvalidation/google/maps/addressvalidation_v1/__init__.py
index fe473316a703..2e2577e17a3f 100644
--- a/packages/google-maps-addressvalidation/google/maps/addressvalidation_v1/__init__.py
+++ b/packages/google-maps-addressvalidation/google/maps/addressvalidation_v1/__init__.py
@@ -65,7 +65,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -94,9 +94,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-maps-addressvalidation/setup.py b/packages/google-maps-addressvalidation/setup.py
index bd661bcc6605..f941d7de681e 100644
--- a/packages/google-maps-addressvalidation/setup.py
+++ b/packages/google-maps-addressvalidation/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/maps/addressvalidation/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "google-geo-type >= 0.1.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "google-geo-type >= 0.3.12, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-maps-addressvalidation"
diff --git a/packages/google-maps-addressvalidation/testing/constraints-3.10.txt b/packages/google-maps-addressvalidation/testing/constraints-3.10.txt
index ea5951376612..ee60d295a792 100644
--- a/packages/google-maps-addressvalidation/testing/constraints-3.10.txt
+++ b/packages/google-maps-addressvalidation/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-google-geo-type==0.1.0
+proto-plus==1.26.1
+protobuf==6.33.5
+google-geo-type==0.3.12
diff --git a/packages/google-maps-addressvalidation/testing/constraints-3.13.txt b/packages/google-maps-addressvalidation/testing/constraints-3.13.txt
index c6b6ca67e783..5c8b50a29836 100644
--- a/packages/google-maps-addressvalidation/testing/constraints-3.13.txt
+++ b/packages/google-maps-addressvalidation/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-geo-type>=0
diff --git a/packages/google-maps-addressvalidation/testing/constraints-3.14.txt b/packages/google-maps-addressvalidation/testing/constraints-3.14.txt
index c6b6ca67e783..5c8b50a29836 100644
--- a/packages/google-maps-addressvalidation/testing/constraints-3.14.txt
+++ b/packages/google-maps-addressvalidation/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-geo-type>=0
diff --git a/packages/google-maps-areainsights/google/maps/areainsights_v1/__init__.py b/packages/google-maps-areainsights/google/maps/areainsights_v1/__init__.py
index e790d5492c98..7eb80ddb96c4 100644
--- a/packages/google-maps-areainsights/google/maps/areainsights_v1/__init__.py
+++ b/packages/google-maps-areainsights/google/maps/areainsights_v1/__init__.py
@@ -62,7 +62,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -91,9 +91,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-maps-areainsights/setup.py b/packages/google-maps-areainsights/setup.py
index 9f670777e6fe..86bfa4c4e78d 100644
--- a/packages/google-maps-areainsights/setup.py
+++ b/packages/google-maps-areainsights/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/maps/areainsights/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-maps-areainsights"
diff --git a/packages/google-maps-areainsights/testing/constraints-3.10.txt b/packages/google-maps-areainsights/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-maps-areainsights/testing/constraints-3.10.txt
+++ b/packages/google-maps-areainsights/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-maps-areainsights/testing/constraints-3.13.txt b/packages/google-maps-areainsights/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-maps-areainsights/testing/constraints-3.13.txt
+++ b/packages/google-maps-areainsights/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-maps-areainsights/testing/constraints-3.14.txt b/packages/google-maps-areainsights/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-maps-areainsights/testing/constraints-3.14.txt
+++ b/packages/google-maps-areainsights/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-maps-fleetengine-delivery/google/maps/fleetengine_delivery_v1/__init__.py b/packages/google-maps-fleetengine-delivery/google/maps/fleetengine_delivery_v1/__init__.py
index 9318f00aee7e..07a9e17aefee 100644
--- a/packages/google-maps-fleetengine-delivery/google/maps/fleetengine_delivery_v1/__init__.py
+++ b/packages/google-maps-fleetengine-delivery/google/maps/fleetengine_delivery_v1/__init__.py
@@ -84,7 +84,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -113,9 +113,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-maps-fleetengine-delivery/setup.py b/packages/google-maps-fleetengine-delivery/setup.py
index 8b10fafb1c3d..a7135a9da67a 100644
--- a/packages/google-maps-fleetengine-delivery/setup.py
+++ b/packages/google-maps-fleetengine-delivery/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/maps/fleetengine_delivery/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,16 +44,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "google-geo-type >= 0.1.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "google-geo-type >= 0.3.12, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-maps-fleetengine-delivery"
diff --git a/packages/google-maps-fleetengine-delivery/testing/constraints-3.10.txt b/packages/google-maps-fleetengine-delivery/testing/constraints-3.10.txt
index ea5951376612..ee60d295a792 100644
--- a/packages/google-maps-fleetengine-delivery/testing/constraints-3.10.txt
+++ b/packages/google-maps-fleetengine-delivery/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-google-geo-type==0.1.0
+proto-plus==1.26.1
+protobuf==6.33.5
+google-geo-type==0.3.12
diff --git a/packages/google-maps-fleetengine-delivery/testing/constraints-3.13.txt b/packages/google-maps-fleetengine-delivery/testing/constraints-3.13.txt
index c6b6ca67e783..5c8b50a29836 100644
--- a/packages/google-maps-fleetengine-delivery/testing/constraints-3.13.txt
+++ b/packages/google-maps-fleetengine-delivery/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-geo-type>=0
diff --git a/packages/google-maps-fleetengine-delivery/testing/constraints-3.14.txt b/packages/google-maps-fleetengine-delivery/testing/constraints-3.14.txt
index c6b6ca67e783..5c8b50a29836 100644
--- a/packages/google-maps-fleetengine-delivery/testing/constraints-3.14.txt
+++ b/packages/google-maps-fleetengine-delivery/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-geo-type>=0
diff --git a/packages/google-maps-fleetengine/google/maps/fleetengine_v1/__init__.py b/packages/google-maps-fleetengine/google/maps/fleetengine_v1/__init__.py
index 0e88fc3d2140..7d78781219e4 100644
--- a/packages/google-maps-fleetengine/google/maps/fleetengine_v1/__init__.py
+++ b/packages/google-maps-fleetengine/google/maps/fleetengine_v1/__init__.py
@@ -109,7 +109,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -138,9 +138,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-maps-fleetengine/setup.py b/packages/google-maps-fleetengine/setup.py
index a19334f38827..3a600cdfa4f8 100644
--- a/packages/google-maps-fleetengine/setup.py
+++ b/packages/google-maps-fleetengine/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/maps/fleetengine/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "google-geo-type >= 0.1.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "google-geo-type >= 0.3.12, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-maps-fleetengine"
diff --git a/packages/google-maps-fleetengine/testing/constraints-3.10.txt b/packages/google-maps-fleetengine/testing/constraints-3.10.txt
index ea5951376612..ee60d295a792 100644
--- a/packages/google-maps-fleetengine/testing/constraints-3.10.txt
+++ b/packages/google-maps-fleetengine/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-google-geo-type==0.1.0
+proto-plus==1.26.1
+protobuf==6.33.5
+google-geo-type==0.3.12
diff --git a/packages/google-maps-fleetengine/testing/constraints-3.13.txt b/packages/google-maps-fleetengine/testing/constraints-3.13.txt
index c6b6ca67e783..5c8b50a29836 100644
--- a/packages/google-maps-fleetengine/testing/constraints-3.13.txt
+++ b/packages/google-maps-fleetengine/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-geo-type>=0
diff --git a/packages/google-maps-fleetengine/testing/constraints-3.14.txt b/packages/google-maps-fleetengine/testing/constraints-3.14.txt
index c6b6ca67e783..5c8b50a29836 100644
--- a/packages/google-maps-fleetengine/testing/constraints-3.14.txt
+++ b/packages/google-maps-fleetengine/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-geo-type>=0
diff --git a/packages/google-maps-geocode/google/maps/geocode_v4/__init__.py b/packages/google-maps-geocode/google/maps/geocode_v4/__init__.py
index 5ea4476eba29..4c5f8360118a 100644
--- a/packages/google-maps-geocode/google/maps/geocode_v4/__init__.py
+++ b/packages/google-maps-geocode/google/maps/geocode_v4/__init__.py
@@ -72,7 +72,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -101,9 +101,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-maps-geocode/setup.py b/packages/google-maps-geocode/setup.py
index e6e2810f399d..c5f5a0e20cb0 100644
--- a/packages/google-maps-geocode/setup.py
+++ b/packages/google-maps-geocode/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/maps/geocode/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "google-geo-type >= 0.1.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "google-geo-type >= 0.3.12, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-maps-geocode"
diff --git a/packages/google-maps-geocode/testing/constraints-3.10.txt b/packages/google-maps-geocode/testing/constraints-3.10.txt
index ea5951376612..ee60d295a792 100644
--- a/packages/google-maps-geocode/testing/constraints-3.10.txt
+++ b/packages/google-maps-geocode/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-google-geo-type==0.1.0
+proto-plus==1.26.1
+protobuf==6.33.5
+google-geo-type==0.3.12
diff --git a/packages/google-maps-geocode/testing/constraints-3.13.txt b/packages/google-maps-geocode/testing/constraints-3.13.txt
index c6b6ca67e783..5c8b50a29836 100644
--- a/packages/google-maps-geocode/testing/constraints-3.13.txt
+++ b/packages/google-maps-geocode/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-geo-type>=0
diff --git a/packages/google-maps-geocode/testing/constraints-3.14.txt b/packages/google-maps-geocode/testing/constraints-3.14.txt
index c6b6ca67e783..5c8b50a29836 100644
--- a/packages/google-maps-geocode/testing/constraints-3.14.txt
+++ b/packages/google-maps-geocode/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-geo-type>=0
diff --git a/packages/google-maps-mapmanagement/google/maps/mapmanagement_v2beta/__init__.py b/packages/google-maps-mapmanagement/google/maps/mapmanagement_v2beta/__init__.py
index 6f5b09169301..517fd5374323 100644
--- a/packages/google-maps-mapmanagement/google/maps/mapmanagement_v2beta/__init__.py
+++ b/packages/google-maps-mapmanagement/google/maps/mapmanagement_v2beta/__init__.py
@@ -76,7 +76,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -105,9 +105,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-maps-mapmanagement/setup.py b/packages/google-maps-mapmanagement/setup.py
index 17039bfee030..001c091ff153 100644
--- a/packages/google-maps-mapmanagement/setup.py
+++ b/packages/google-maps-mapmanagement/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/maps/mapmanagement/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-maps-mapmanagement"
diff --git a/packages/google-maps-mapmanagement/testing/constraints-3.10.txt b/packages/google-maps-mapmanagement/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-maps-mapmanagement/testing/constraints-3.10.txt
+++ b/packages/google-maps-mapmanagement/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-maps-mapmanagement/testing/constraints-3.13.txt b/packages/google-maps-mapmanagement/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-maps-mapmanagement/testing/constraints-3.13.txt
+++ b/packages/google-maps-mapmanagement/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-maps-mapmanagement/testing/constraints-3.14.txt b/packages/google-maps-mapmanagement/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-maps-mapmanagement/testing/constraints-3.14.txt
+++ b/packages/google-maps-mapmanagement/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-maps-mapsplatformdatasets/google/maps/mapsplatformdatasets_v1/__init__.py b/packages/google-maps-mapsplatformdatasets/google/maps/mapsplatformdatasets_v1/__init__.py
index 4cb327465e1b..a3e24597be2b 100644
--- a/packages/google-maps-mapsplatformdatasets/google/maps/mapsplatformdatasets_v1/__init__.py
+++ b/packages/google-maps-mapsplatformdatasets/google/maps/mapsplatformdatasets_v1/__init__.py
@@ -65,7 +65,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -94,9 +94,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-maps-mapsplatformdatasets/setup.py b/packages/google-maps-mapsplatformdatasets/setup.py
index 31f32789eaee..6acadb1485cd 100644
--- a/packages/google-maps-mapsplatformdatasets/setup.py
+++ b/packages/google-maps-mapsplatformdatasets/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/maps/mapsplatformdatasets/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-maps-mapsplatformdatasets"
diff --git a/packages/google-maps-mapsplatformdatasets/testing/constraints-3.10.txt b/packages/google-maps-mapsplatformdatasets/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-maps-mapsplatformdatasets/testing/constraints-3.10.txt
+++ b/packages/google-maps-mapsplatformdatasets/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-maps-mapsplatformdatasets/testing/constraints-3.13.txt b/packages/google-maps-mapsplatformdatasets/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-maps-mapsplatformdatasets/testing/constraints-3.13.txt
+++ b/packages/google-maps-mapsplatformdatasets/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-maps-mapsplatformdatasets/testing/constraints-3.14.txt b/packages/google-maps-mapsplatformdatasets/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-maps-mapsplatformdatasets/testing/constraints-3.14.txt
+++ b/packages/google-maps-mapsplatformdatasets/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-maps-navconnect/google/maps/navconnect_v1/__init__.py b/packages/google-maps-navconnect/google/maps/navconnect_v1/__init__.py
index ae649f3cb2bf..f3993622e2aa 100644
--- a/packages/google-maps-navconnect/google/maps/navconnect_v1/__init__.py
+++ b/packages/google-maps-navconnect/google/maps/navconnect_v1/__init__.py
@@ -63,7 +63,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -92,9 +92,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-maps-navconnect/setup.py b/packages/google-maps-navconnect/setup.py
index c4634db58cad..b6f9e9bcc32b 100644
--- a/packages/google-maps-navconnect/setup.py
+++ b/packages/google-maps-navconnect/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/maps/navconnect/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-maps-navconnect"
diff --git a/packages/google-maps-navconnect/testing/constraints-3.10.txt b/packages/google-maps-navconnect/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-maps-navconnect/testing/constraints-3.10.txt
+++ b/packages/google-maps-navconnect/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-maps-navconnect/testing/constraints-3.13.txt b/packages/google-maps-navconnect/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-maps-navconnect/testing/constraints-3.13.txt
+++ b/packages/google-maps-navconnect/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-maps-navconnect/testing/constraints-3.14.txt b/packages/google-maps-navconnect/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-maps-navconnect/testing/constraints-3.14.txt
+++ b/packages/google-maps-navconnect/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-maps-places/google/maps/places_v1/__init__.py b/packages/google-maps-places/google/maps/places_v1/__init__.py
index 21cb42522c09..64b3b4ccdf62 100644
--- a/packages/google-maps-places/google/maps/places_v1/__init__.py
+++ b/packages/google-maps-places/google/maps/places_v1/__init__.py
@@ -86,7 +86,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -115,9 +115,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-maps-places/setup.py b/packages/google-maps-places/setup.py
index a625b8be55dd..072ad51a8604 100644
--- a/packages/google-maps-places/setup.py
+++ b/packages/google-maps-places/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/maps/places/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "google-geo-type >= 0.1.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "google-geo-type >= 0.3.12, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-maps-places"
diff --git a/packages/google-maps-places/testing/constraints-3.10.txt b/packages/google-maps-places/testing/constraints-3.10.txt
index ea5951376612..ee60d295a792 100644
--- a/packages/google-maps-places/testing/constraints-3.10.txt
+++ b/packages/google-maps-places/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-google-geo-type==0.1.0
+proto-plus==1.26.1
+protobuf==6.33.5
+google-geo-type==0.3.12
diff --git a/packages/google-maps-places/testing/constraints-3.13.txt b/packages/google-maps-places/testing/constraints-3.13.txt
index c6b6ca67e783..5c8b50a29836 100644
--- a/packages/google-maps-places/testing/constraints-3.13.txt
+++ b/packages/google-maps-places/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-geo-type>=0
diff --git a/packages/google-maps-places/testing/constraints-3.14.txt b/packages/google-maps-places/testing/constraints-3.14.txt
index c6b6ca67e783..5c8b50a29836 100644
--- a/packages/google-maps-places/testing/constraints-3.14.txt
+++ b/packages/google-maps-places/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-geo-type>=0
diff --git a/packages/google-maps-routeoptimization/google/maps/routeoptimization_v1/__init__.py b/packages/google-maps-routeoptimization/google/maps/routeoptimization_v1/__init__.py
index 9ca378fec5d9..c626d4eb195e 100644
--- a/packages/google-maps-routeoptimization/google/maps/routeoptimization_v1/__init__.py
+++ b/packages/google-maps-routeoptimization/google/maps/routeoptimization_v1/__init__.py
@@ -88,7 +88,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -117,9 +117,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-maps-routeoptimization/setup.py b/packages/google-maps-routeoptimization/setup.py
index e8c88c8a570a..834a721a442d 100644
--- a/packages/google-maps-routeoptimization/setup.py
+++ b/packages/google-maps-routeoptimization/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/maps/routeoptimization/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-maps-routeoptimization"
diff --git a/packages/google-maps-routeoptimization/testing/constraints-3.10.txt b/packages/google-maps-routeoptimization/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-maps-routeoptimization/testing/constraints-3.10.txt
+++ b/packages/google-maps-routeoptimization/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-maps-routeoptimization/testing/constraints-3.13.txt b/packages/google-maps-routeoptimization/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-maps-routeoptimization/testing/constraints-3.13.txt
+++ b/packages/google-maps-routeoptimization/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-maps-routeoptimization/testing/constraints-3.14.txt b/packages/google-maps-routeoptimization/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-maps-routeoptimization/testing/constraints-3.14.txt
+++ b/packages/google-maps-routeoptimization/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-maps-routing/google/maps/routing_v2/__init__.py b/packages/google-maps-routing/google/maps/routing_v2/__init__.py
index af21c2e4599a..f6e540e3c3bf 100644
--- a/packages/google-maps-routing/google/maps/routing_v2/__init__.py
+++ b/packages/google-maps-routing/google/maps/routing_v2/__init__.py
@@ -90,7 +90,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -119,9 +119,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-maps-routing/setup.py b/packages/google-maps-routing/setup.py
index 72db4db4484d..8cecb1bd365d 100644
--- a/packages/google-maps-routing/setup.py
+++ b/packages/google-maps-routing/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/maps/routing/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,16 +42,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
-    "google-geo-type >= 0.1.0, <1.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
+    "google-geo-type >= 0.3.12, <1.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-maps-routing"
diff --git a/packages/google-maps-routing/testing/constraints-3.10.txt b/packages/google-maps-routing/testing/constraints-3.10.txt
index ea5951376612..ee60d295a792 100644
--- a/packages/google-maps-routing/testing/constraints-3.10.txt
+++ b/packages/google-maps-routing/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
-google-geo-type==0.1.0
+proto-plus==1.26.1
+protobuf==6.33.5
+google-geo-type==0.3.12
diff --git a/packages/google-maps-routing/testing/constraints-3.13.txt b/packages/google-maps-routing/testing/constraints-3.13.txt
index c6b6ca67e783..5c8b50a29836 100644
--- a/packages/google-maps-routing/testing/constraints-3.13.txt
+++ b/packages/google-maps-routing/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-geo-type>=0
diff --git a/packages/google-maps-routing/testing/constraints-3.14.txt b/packages/google-maps-routing/testing/constraints-3.14.txt
index c6b6ca67e783..5c8b50a29836 100644
--- a/packages/google-maps-routing/testing/constraints-3.14.txt
+++ b/packages/google-maps-routing/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-geo-type>=0
diff --git a/packages/google-maps-solar/google/maps/solar_v1/__init__.py b/packages/google-maps-solar/google/maps/solar_v1/__init__.py
index 56b2e45ca05f..cde0a0d4519c 100644
--- a/packages/google-maps-solar/google/maps/solar_v1/__init__.py
+++ b/packages/google-maps-solar/google/maps/solar_v1/__init__.py
@@ -74,7 +74,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -103,9 +103,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-maps-solar/setup.py b/packages/google-maps-solar/setup.py
index f435db555b02..e5cfaaa5fe98 100644
--- a/packages/google-maps-solar/setup.py
+++ b/packages/google-maps-solar/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/maps/solar/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-maps-solar"
diff --git a/packages/google-maps-solar/testing/constraints-3.10.txt b/packages/google-maps-solar/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-maps-solar/testing/constraints-3.10.txt
+++ b/packages/google-maps-solar/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-maps-solar/testing/constraints-3.13.txt b/packages/google-maps-solar/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-maps-solar/testing/constraints-3.13.txt
+++ b/packages/google-maps-solar/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-maps-solar/testing/constraints-3.14.txt b/packages/google-maps-solar/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-maps-solar/testing/constraints-3.14.txt
+++ b/packages/google-maps-solar/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-shopping-css/google/shopping/css_v1/__init__.py b/packages/google-shopping-css/google/shopping/css_v1/__init__.py
index bc342edcdfb3..172094bc5973 100644
--- a/packages/google-shopping-css/google/shopping/css_v1/__init__.py
+++ b/packages/google-shopping-css/google/shopping/css_v1/__init__.py
@@ -107,7 +107,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -136,9 +136,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-css/setup.py b/packages/google-shopping-css/setup.py
index 42a8a1c8dea4..36d97fc87922 100644
--- a/packages/google-shopping-css/setup.py
+++ b/packages/google-shopping-css/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/shopping/css/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
     "google-shopping-type >= 1.0.0, <2.0.0",
 ]
 extras = {}
diff --git a/packages/google-shopping-css/testing/constraints-3.10.txt b/packages/google-shopping-css/testing/constraints-3.10.txt
index b408428a99a2..250670a79385 100644
--- a/packages/google-shopping-css/testing/constraints-3.10.txt
+++ b/packages/google-shopping-css/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
 google-shopping-type==1.0.0
diff --git a/packages/google-shopping-css/testing/constraints-3.13.txt b/packages/google-shopping-css/testing/constraints-3.13.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-css/testing/constraints-3.13.txt
+++ b/packages/google-shopping-css/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-css/testing/constraints-3.14.txt b/packages/google-shopping-css/testing/constraints-3.14.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-css/testing/constraints-3.14.txt
+++ b/packages/google-shopping-css/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-accounts/google/shopping/merchant_accounts_v1/__init__.py b/packages/google-shopping-merchant-accounts/google/shopping/merchant_accounts_v1/__init__.py
index c7feb410a5db..9a88e23c0974 100644
--- a/packages/google-shopping-merchant-accounts/google/shopping/merchant_accounts_v1/__init__.py
+++ b/packages/google-shopping-merchant-accounts/google/shopping/merchant_accounts_v1/__init__.py
@@ -325,7 +325,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -354,9 +354,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-accounts/google/shopping/merchant_accounts_v1beta/__init__.py b/packages/google-shopping-merchant-accounts/google/shopping/merchant_accounts_v1beta/__init__.py
index 0fcb5989577c..ffbeb99b523f 100644
--- a/packages/google-shopping-merchant-accounts/google/shopping/merchant_accounts_v1beta/__init__.py
+++ b/packages/google-shopping-merchant-accounts/google/shopping/merchant_accounts_v1beta/__init__.py
@@ -289,7 +289,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -318,9 +318,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-accounts/setup.py b/packages/google-shopping-merchant-accounts/setup.py
index 3f5197604129..82427c44f8e5 100644
--- a/packages/google-shopping-merchant-accounts/setup.py
+++ b/packages/google-shopping-merchant-accounts/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/shopping/merchant_accounts/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
     "google-shopping-type >= 1.0.0, <2.0.0",
 ]
 extras = {}
diff --git a/packages/google-shopping-merchant-accounts/testing/constraints-3.10.txt b/packages/google-shopping-merchant-accounts/testing/constraints-3.10.txt
index b408428a99a2..250670a79385 100644
--- a/packages/google-shopping-merchant-accounts/testing/constraints-3.10.txt
+++ b/packages/google-shopping-merchant-accounts/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
 google-shopping-type==1.0.0
diff --git a/packages/google-shopping-merchant-accounts/testing/constraints-3.13.txt b/packages/google-shopping-merchant-accounts/testing/constraints-3.13.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-accounts/testing/constraints-3.13.txt
+++ b/packages/google-shopping-merchant-accounts/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-accounts/testing/constraints-3.14.txt b/packages/google-shopping-merchant-accounts/testing/constraints-3.14.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-accounts/testing/constraints-3.14.txt
+++ b/packages/google-shopping-merchant-accounts/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-conversions/google/shopping/merchant_conversions_v1/__init__.py b/packages/google-shopping-merchant-conversions/google/shopping/merchant_conversions_v1/__init__.py
index 962b1086f963..16954200b036 100644
--- a/packages/google-shopping-merchant-conversions/google/shopping/merchant_conversions_v1/__init__.py
+++ b/packages/google-shopping-merchant-conversions/google/shopping/merchant_conversions_v1/__init__.py
@@ -66,7 +66,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -95,9 +95,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-conversions/google/shopping/merchant_conversions_v1beta/__init__.py b/packages/google-shopping-merchant-conversions/google/shopping/merchant_conversions_v1beta/__init__.py
index 85edf806e2fb..86471764ff6a 100644
--- a/packages/google-shopping-merchant-conversions/google/shopping/merchant_conversions_v1beta/__init__.py
+++ b/packages/google-shopping-merchant-conversions/google/shopping/merchant_conversions_v1beta/__init__.py
@@ -66,7 +66,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -95,9 +95,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-conversions/setup.py b/packages/google-shopping-merchant-conversions/setup.py
index b9738abb789e..17cb6dce825a 100644
--- a/packages/google-shopping-merchant-conversions/setup.py
+++ b/packages/google-shopping-merchant-conversions/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/shopping/merchant_conversions/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-shopping-merchant-conversions"
diff --git a/packages/google-shopping-merchant-conversions/testing/constraints-3.10.txt b/packages/google-shopping-merchant-conversions/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-shopping-merchant-conversions/testing/constraints-3.10.txt
+++ b/packages/google-shopping-merchant-conversions/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-shopping-merchant-conversions/testing/constraints-3.13.txt b/packages/google-shopping-merchant-conversions/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-shopping-merchant-conversions/testing/constraints-3.13.txt
+++ b/packages/google-shopping-merchant-conversions/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-shopping-merchant-conversions/testing/constraints-3.14.txt b/packages/google-shopping-merchant-conversions/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-shopping-merchant-conversions/testing/constraints-3.14.txt
+++ b/packages/google-shopping-merchant-conversions/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-shopping-merchant-datasources/google/shopping/merchant_datasources_v1/__init__.py b/packages/google-shopping-merchant-datasources/google/shopping/merchant_datasources_v1/__init__.py
index 3c92be291518..5b6466d6e240 100644
--- a/packages/google-shopping-merchant-datasources/google/shopping/merchant_datasources_v1/__init__.py
+++ b/packages/google-shopping-merchant-datasources/google/shopping/merchant_datasources_v1/__init__.py
@@ -79,7 +79,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -108,9 +108,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-datasources/google/shopping/merchant_datasources_v1beta/__init__.py b/packages/google-shopping-merchant-datasources/google/shopping/merchant_datasources_v1beta/__init__.py
index 0869dbcde175..ffaef646d739 100644
--- a/packages/google-shopping-merchant-datasources/google/shopping/merchant_datasources_v1beta/__init__.py
+++ b/packages/google-shopping-merchant-datasources/google/shopping/merchant_datasources_v1beta/__init__.py
@@ -79,7 +79,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -108,9 +108,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-datasources/setup.py b/packages/google-shopping-merchant-datasources/setup.py
index 326a0b6fe7f3..25bac4046235 100644
--- a/packages/google-shopping-merchant-datasources/setup.py
+++ b/packages/google-shopping-merchant-datasources/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/shopping/merchant_datasources/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
     "google-shopping-type >= 1.0.0, <2.0.0",
 ]
 extras = {}
diff --git a/packages/google-shopping-merchant-datasources/testing/constraints-3.10.txt b/packages/google-shopping-merchant-datasources/testing/constraints-3.10.txt
index b408428a99a2..250670a79385 100644
--- a/packages/google-shopping-merchant-datasources/testing/constraints-3.10.txt
+++ b/packages/google-shopping-merchant-datasources/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
 google-shopping-type==1.0.0
diff --git a/packages/google-shopping-merchant-datasources/testing/constraints-3.13.txt b/packages/google-shopping-merchant-datasources/testing/constraints-3.13.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-datasources/testing/constraints-3.13.txt
+++ b/packages/google-shopping-merchant-datasources/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-datasources/testing/constraints-3.14.txt b/packages/google-shopping-merchant-datasources/testing/constraints-3.14.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-datasources/testing/constraints-3.14.txt
+++ b/packages/google-shopping-merchant-datasources/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-inventories/google/shopping/merchant_inventories_v1/__init__.py b/packages/google-shopping-merchant-inventories/google/shopping/merchant_inventories_v1/__init__.py
index 195445ad187f..5bb720f1f344 100644
--- a/packages/google-shopping-merchant-inventories/google/shopping/merchant_inventories_v1/__init__.py
+++ b/packages/google-shopping-merchant-inventories/google/shopping/merchant_inventories_v1/__init__.py
@@ -76,7 +76,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -105,9 +105,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-inventories/google/shopping/merchant_inventories_v1beta/__init__.py b/packages/google-shopping-merchant-inventories/google/shopping/merchant_inventories_v1beta/__init__.py
index 43a87ad51963..ccecae9f0d54 100644
--- a/packages/google-shopping-merchant-inventories/google/shopping/merchant_inventories_v1beta/__init__.py
+++ b/packages/google-shopping-merchant-inventories/google/shopping/merchant_inventories_v1beta/__init__.py
@@ -71,7 +71,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -100,9 +100,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-inventories/setup.py b/packages/google-shopping-merchant-inventories/setup.py
index 275ba33e8c0c..b84ec4335dfe 100644
--- a/packages/google-shopping-merchant-inventories/setup.py
+++ b/packages/google-shopping-merchant-inventories/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/shopping/merchant_inventories/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
     "google-shopping-type >= 1.0.0, <2.0.0",
 ]
 extras = {}
diff --git a/packages/google-shopping-merchant-inventories/testing/constraints-3.10.txt b/packages/google-shopping-merchant-inventories/testing/constraints-3.10.txt
index b408428a99a2..250670a79385 100644
--- a/packages/google-shopping-merchant-inventories/testing/constraints-3.10.txt
+++ b/packages/google-shopping-merchant-inventories/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
 google-shopping-type==1.0.0
diff --git a/packages/google-shopping-merchant-inventories/testing/constraints-3.13.txt b/packages/google-shopping-merchant-inventories/testing/constraints-3.13.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-inventories/testing/constraints-3.13.txt
+++ b/packages/google-shopping-merchant-inventories/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-inventories/testing/constraints-3.14.txt b/packages/google-shopping-merchant-inventories/testing/constraints-3.14.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-inventories/testing/constraints-3.14.txt
+++ b/packages/google-shopping-merchant-inventories/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-issueresolution/google/shopping/merchant_issueresolution_v1/__init__.py b/packages/google-shopping-merchant-issueresolution/google/shopping/merchant_issueresolution_v1/__init__.py
index 3727846e1bea..38921d274e71 100644
--- a/packages/google-shopping-merchant-issueresolution/google/shopping/merchant_issueresolution_v1/__init__.py
+++ b/packages/google-shopping-merchant-issueresolution/google/shopping/merchant_issueresolution_v1/__init__.py
@@ -88,7 +88,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -117,9 +117,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-issueresolution/google/shopping/merchant_issueresolution_v1beta/__init__.py b/packages/google-shopping-merchant-issueresolution/google/shopping/merchant_issueresolution_v1beta/__init__.py
index e92747550669..92862bf2f966 100644
--- a/packages/google-shopping-merchant-issueresolution/google/shopping/merchant_issueresolution_v1beta/__init__.py
+++ b/packages/google-shopping-merchant-issueresolution/google/shopping/merchant_issueresolution_v1beta/__init__.py
@@ -92,7 +92,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -121,9 +121,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-issueresolution/setup.py b/packages/google-shopping-merchant-issueresolution/setup.py
index ab2d9ffc5a01..1e6c065eedfb 100644
--- a/packages/google-shopping-merchant-issueresolution/setup.py
+++ b/packages/google-shopping-merchant-issueresolution/setup.py
@@ -33,7 +33,10 @@
         package_root, "google/shopping/merchant_issueresolution/gapic_version.py"
     )
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -43,15 +46,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
     "google-shopping-type >= 1.0.0, <2.0.0",
 ]
 extras = {}
diff --git a/packages/google-shopping-merchant-issueresolution/testing/constraints-3.10.txt b/packages/google-shopping-merchant-issueresolution/testing/constraints-3.10.txt
index b408428a99a2..250670a79385 100644
--- a/packages/google-shopping-merchant-issueresolution/testing/constraints-3.10.txt
+++ b/packages/google-shopping-merchant-issueresolution/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
 google-shopping-type==1.0.0
diff --git a/packages/google-shopping-merchant-issueresolution/testing/constraints-3.13.txt b/packages/google-shopping-merchant-issueresolution/testing/constraints-3.13.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-issueresolution/testing/constraints-3.13.txt
+++ b/packages/google-shopping-merchant-issueresolution/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-issueresolution/testing/constraints-3.14.txt b/packages/google-shopping-merchant-issueresolution/testing/constraints-3.14.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-issueresolution/testing/constraints-3.14.txt
+++ b/packages/google-shopping-merchant-issueresolution/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-lfp/google/shopping/merchant_lfp_v1/__init__.py b/packages/google-shopping-merchant-lfp/google/shopping/merchant_lfp_v1/__init__.py
index 5d4b6f8c7aec..62b4a3d38f51 100644
--- a/packages/google-shopping-merchant-lfp/google/shopping/merchant_lfp_v1/__init__.py
+++ b/packages/google-shopping-merchant-lfp/google/shopping/merchant_lfp_v1/__init__.py
@@ -73,7 +73,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -102,9 +102,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-lfp/google/shopping/merchant_lfp_v1beta/__init__.py b/packages/google-shopping-merchant-lfp/google/shopping/merchant_lfp_v1beta/__init__.py
index da94e4483bb0..b502a464f20f 100644
--- a/packages/google-shopping-merchant-lfp/google/shopping/merchant_lfp_v1beta/__init__.py
+++ b/packages/google-shopping-merchant-lfp/google/shopping/merchant_lfp_v1beta/__init__.py
@@ -73,7 +73,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -102,9 +102,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-lfp/setup.py b/packages/google-shopping-merchant-lfp/setup.py
index e8228bbd3130..3de53ddb5a6f 100644
--- a/packages/google-shopping-merchant-lfp/setup.py
+++ b/packages/google-shopping-merchant-lfp/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/shopping/merchant_lfp/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
     "google-shopping-type >= 1.0.0, <2.0.0",
 ]
 extras = {}
diff --git a/packages/google-shopping-merchant-lfp/testing/constraints-3.10.txt b/packages/google-shopping-merchant-lfp/testing/constraints-3.10.txt
index b408428a99a2..250670a79385 100644
--- a/packages/google-shopping-merchant-lfp/testing/constraints-3.10.txt
+++ b/packages/google-shopping-merchant-lfp/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
 google-shopping-type==1.0.0
diff --git a/packages/google-shopping-merchant-lfp/testing/constraints-3.13.txt b/packages/google-shopping-merchant-lfp/testing/constraints-3.13.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-lfp/testing/constraints-3.13.txt
+++ b/packages/google-shopping-merchant-lfp/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-lfp/testing/constraints-3.14.txt b/packages/google-shopping-merchant-lfp/testing/constraints-3.14.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-lfp/testing/constraints-3.14.txt
+++ b/packages/google-shopping-merchant-lfp/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-notifications/google/shopping/merchant_notifications_v1/__init__.py b/packages/google-shopping-merchant-notifications/google/shopping/merchant_notifications_v1/__init__.py
index 9075296a39c7..663d47edf843 100644
--- a/packages/google-shopping-merchant-notifications/google/shopping/merchant_notifications_v1/__init__.py
+++ b/packages/google-shopping-merchant-notifications/google/shopping/merchant_notifications_v1/__init__.py
@@ -64,7 +64,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -93,9 +93,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-notifications/google/shopping/merchant_notifications_v1beta/__init__.py b/packages/google-shopping-merchant-notifications/google/shopping/merchant_notifications_v1beta/__init__.py
index 6d9228e02862..91596a101bb6 100644
--- a/packages/google-shopping-merchant-notifications/google/shopping/merchant_notifications_v1beta/__init__.py
+++ b/packages/google-shopping-merchant-notifications/google/shopping/merchant_notifications_v1beta/__init__.py
@@ -68,7 +68,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -97,9 +97,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-notifications/setup.py b/packages/google-shopping-merchant-notifications/setup.py
index 77399923b484..f94604f15d22 100644
--- a/packages/google-shopping-merchant-notifications/setup.py
+++ b/packages/google-shopping-merchant-notifications/setup.py
@@ -33,7 +33,10 @@
         package_root, "google/shopping/merchant_notifications/gapic_version.py"
     )
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -43,16 +46,15 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "google-shopping-type >= 1.0.0, <2.0.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-shopping-merchant-notifications"
diff --git a/packages/google-shopping-merchant-notifications/testing/constraints-3.10.txt b/packages/google-shopping-merchant-notifications/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-shopping-merchant-notifications/testing/constraints-3.10.txt
+++ b/packages/google-shopping-merchant-notifications/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-shopping-merchant-notifications/testing/constraints-3.13.txt b/packages/google-shopping-merchant-notifications/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-shopping-merchant-notifications/testing/constraints-3.13.txt
+++ b/packages/google-shopping-merchant-notifications/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-shopping-merchant-notifications/testing/constraints-3.14.txt b/packages/google-shopping-merchant-notifications/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-shopping-merchant-notifications/testing/constraints-3.14.txt
+++ b/packages/google-shopping-merchant-notifications/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-shopping-merchant-ordertracking/google/shopping/merchant_ordertracking_v1/__init__.py b/packages/google-shopping-merchant-ordertracking/google/shopping/merchant_ordertracking_v1/__init__.py
index 22c2b5383959..374230334be2 100644
--- a/packages/google-shopping-merchant-ordertracking/google/shopping/merchant_ordertracking_v1/__init__.py
+++ b/packages/google-shopping-merchant-ordertracking/google/shopping/merchant_ordertracking_v1/__init__.py
@@ -57,7 +57,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -86,9 +86,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-ordertracking/google/shopping/merchant_ordertracking_v1beta/__init__.py b/packages/google-shopping-merchant-ordertracking/google/shopping/merchant_ordertracking_v1beta/__init__.py
index 089330b7af8c..c77d1dc6d2f3 100644
--- a/packages/google-shopping-merchant-ordertracking/google/shopping/merchant_ordertracking_v1beta/__init__.py
+++ b/packages/google-shopping-merchant-ordertracking/google/shopping/merchant_ordertracking_v1beta/__init__.py
@@ -59,7 +59,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -88,9 +88,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-ordertracking/setup.py b/packages/google-shopping-merchant-ordertracking/setup.py
index 2ea862f833bf..e70f7a811aa7 100644
--- a/packages/google-shopping-merchant-ordertracking/setup.py
+++ b/packages/google-shopping-merchant-ordertracking/setup.py
@@ -33,7 +33,10 @@
         package_root, "google/shopping/merchant_ordertracking/gapic_version.py"
     )
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -43,15 +46,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
     "google-shopping-type >= 1.0.0, <2.0.0",
 ]
 extras = {}
diff --git a/packages/google-shopping-merchant-ordertracking/testing/constraints-3.10.txt b/packages/google-shopping-merchant-ordertracking/testing/constraints-3.10.txt
index b408428a99a2..250670a79385 100644
--- a/packages/google-shopping-merchant-ordertracking/testing/constraints-3.10.txt
+++ b/packages/google-shopping-merchant-ordertracking/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
 google-shopping-type==1.0.0
diff --git a/packages/google-shopping-merchant-ordertracking/testing/constraints-3.13.txt b/packages/google-shopping-merchant-ordertracking/testing/constraints-3.13.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-ordertracking/testing/constraints-3.13.txt
+++ b/packages/google-shopping-merchant-ordertracking/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-ordertracking/testing/constraints-3.14.txt b/packages/google-shopping-merchant-ordertracking/testing/constraints-3.14.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-ordertracking/testing/constraints-3.14.txt
+++ b/packages/google-shopping-merchant-ordertracking/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-products/google/shopping/merchant_products_v1/__init__.py b/packages/google-shopping-merchant-products/google/shopping/merchant_products_v1/__init__.py
index a37adcba5d38..f853e9116a2d 100644
--- a/packages/google-shopping-merchant-products/google/shopping/merchant_products_v1/__init__.py
+++ b/packages/google-shopping-merchant-products/google/shopping/merchant_products_v1/__init__.py
@@ -106,7 +106,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -135,9 +135,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-products/google/shopping/merchant_products_v1beta/__init__.py b/packages/google-shopping-merchant-products/google/shopping/merchant_products_v1beta/__init__.py
index 82686a6930f2..50cbfd949ef1 100644
--- a/packages/google-shopping-merchant-products/google/shopping/merchant_products_v1beta/__init__.py
+++ b/packages/google-shopping-merchant-products/google/shopping/merchant_products_v1beta/__init__.py
@@ -91,7 +91,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -120,9 +120,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-products/setup.py b/packages/google-shopping-merchant-products/setup.py
index 03638308dec1..bb370a8911ce 100644
--- a/packages/google-shopping-merchant-products/setup.py
+++ b/packages/google-shopping-merchant-products/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/shopping/merchant_products/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
     "google-shopping-type >= 1.0.0, <2.0.0",
 ]
 extras = {}
diff --git a/packages/google-shopping-merchant-products/testing/constraints-3.10.txt b/packages/google-shopping-merchant-products/testing/constraints-3.10.txt
index b408428a99a2..250670a79385 100644
--- a/packages/google-shopping-merchant-products/testing/constraints-3.10.txt
+++ b/packages/google-shopping-merchant-products/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
 google-shopping-type==1.0.0
diff --git a/packages/google-shopping-merchant-products/testing/constraints-3.13.txt b/packages/google-shopping-merchant-products/testing/constraints-3.13.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-products/testing/constraints-3.13.txt
+++ b/packages/google-shopping-merchant-products/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-products/testing/constraints-3.14.txt b/packages/google-shopping-merchant-products/testing/constraints-3.14.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-products/testing/constraints-3.14.txt
+++ b/packages/google-shopping-merchant-products/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-productstudio/google/shopping/merchant_productstudio_v1alpha/__init__.py b/packages/google-shopping-merchant-productstudio/google/shopping/merchant_productstudio_v1alpha/__init__.py
index f40f3fbf5062..a22b918fc048 100644
--- a/packages/google-shopping-merchant-productstudio/google/shopping/merchant_productstudio_v1alpha/__init__.py
+++ b/packages/google-shopping-merchant-productstudio/google/shopping/merchant_productstudio_v1alpha/__init__.py
@@ -80,7 +80,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -109,9 +109,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-productstudio/setup.py b/packages/google-shopping-merchant-productstudio/setup.py
index 20e11ca62385..e38d58e0eea9 100644
--- a/packages/google-shopping-merchant-productstudio/setup.py
+++ b/packages/google-shopping-merchant-productstudio/setup.py
@@ -33,7 +33,10 @@
         package_root, "google/shopping/merchant_productstudio/gapic_version.py"
     )
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -43,15 +46,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-shopping-merchant-productstudio"
diff --git a/packages/google-shopping-merchant-productstudio/testing/constraints-3.10.txt b/packages/google-shopping-merchant-productstudio/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-shopping-merchant-productstudio/testing/constraints-3.10.txt
+++ b/packages/google-shopping-merchant-productstudio/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-shopping-merchant-productstudio/testing/constraints-3.13.txt b/packages/google-shopping-merchant-productstudio/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-shopping-merchant-productstudio/testing/constraints-3.13.txt
+++ b/packages/google-shopping-merchant-productstudio/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-shopping-merchant-productstudio/testing/constraints-3.14.txt b/packages/google-shopping-merchant-productstudio/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-shopping-merchant-productstudio/testing/constraints-3.14.txt
+++ b/packages/google-shopping-merchant-productstudio/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-shopping-merchant-promotions/google/shopping/merchant_promotions_v1/__init__.py b/packages/google-shopping-merchant-promotions/google/shopping/merchant_promotions_v1/__init__.py
index 85ef7209ede0..5bc481062af2 100644
--- a/packages/google-shopping-merchant-promotions/google/shopping/merchant_promotions_v1/__init__.py
+++ b/packages/google-shopping-merchant-promotions/google/shopping/merchant_promotions_v1/__init__.py
@@ -69,7 +69,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -98,9 +98,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-promotions/google/shopping/merchant_promotions_v1beta/__init__.py b/packages/google-shopping-merchant-promotions/google/shopping/merchant_promotions_v1beta/__init__.py
index a7322b6f3381..43a34ec35edb 100644
--- a/packages/google-shopping-merchant-promotions/google/shopping/merchant_promotions_v1beta/__init__.py
+++ b/packages/google-shopping-merchant-promotions/google/shopping/merchant_promotions_v1beta/__init__.py
@@ -69,7 +69,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -98,9 +98,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-promotions/setup.py b/packages/google-shopping-merchant-promotions/setup.py
index 69f37d950a6e..5bc3db2108ae 100644
--- a/packages/google-shopping-merchant-promotions/setup.py
+++ b/packages/google-shopping-merchant-promotions/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/shopping/merchant_promotions/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
     "google-shopping-type >= 1.0.0, <2.0.0",
 ]
 extras = {}
diff --git a/packages/google-shopping-merchant-promotions/testing/constraints-3.10.txt b/packages/google-shopping-merchant-promotions/testing/constraints-3.10.txt
index b408428a99a2..250670a79385 100644
--- a/packages/google-shopping-merchant-promotions/testing/constraints-3.10.txt
+++ b/packages/google-shopping-merchant-promotions/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
 google-shopping-type==1.0.0
diff --git a/packages/google-shopping-merchant-promotions/testing/constraints-3.13.txt b/packages/google-shopping-merchant-promotions/testing/constraints-3.13.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-promotions/testing/constraints-3.13.txt
+++ b/packages/google-shopping-merchant-promotions/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-promotions/testing/constraints-3.14.txt b/packages/google-shopping-merchant-promotions/testing/constraints-3.14.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-promotions/testing/constraints-3.14.txt
+++ b/packages/google-shopping-merchant-promotions/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-quota/google/shopping/merchant_quota_v1/__init__.py b/packages/google-shopping-merchant-quota/google/shopping/merchant_quota_v1/__init__.py
index 27eaa7673d11..1f71f5b3dbab 100644
--- a/packages/google-shopping-merchant-quota/google/shopping/merchant_quota_v1/__init__.py
+++ b/packages/google-shopping-merchant-quota/google/shopping/merchant_quota_v1/__init__.py
@@ -67,7 +67,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -96,9 +96,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-quota/google/shopping/merchant_quota_v1beta/__init__.py b/packages/google-shopping-merchant-quota/google/shopping/merchant_quota_v1beta/__init__.py
index 9c67d36d6091..445ccce5d33a 100644
--- a/packages/google-shopping-merchant-quota/google/shopping/merchant_quota_v1beta/__init__.py
+++ b/packages/google-shopping-merchant-quota/google/shopping/merchant_quota_v1beta/__init__.py
@@ -56,7 +56,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -85,9 +85,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-quota/setup.py b/packages/google-shopping-merchant-quota/setup.py
index 382890aaea9e..ce7f014db2b2 100644
--- a/packages/google-shopping-merchant-quota/setup.py
+++ b/packages/google-shopping-merchant-quota/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/shopping/merchant_quota/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-shopping-merchant-quota"
diff --git a/packages/google-shopping-merchant-quota/testing/constraints-3.10.txt b/packages/google-shopping-merchant-quota/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-shopping-merchant-quota/testing/constraints-3.10.txt
+++ b/packages/google-shopping-merchant-quota/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-shopping-merchant-quota/testing/constraints-3.13.txt b/packages/google-shopping-merchant-quota/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-shopping-merchant-quota/testing/constraints-3.13.txt
+++ b/packages/google-shopping-merchant-quota/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-shopping-merchant-quota/testing/constraints-3.14.txt b/packages/google-shopping-merchant-quota/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-shopping-merchant-quota/testing/constraints-3.14.txt
+++ b/packages/google-shopping-merchant-quota/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-shopping-merchant-reports/google/shopping/merchant_reports_v1/__init__.py b/packages/google-shopping-merchant-reports/google/shopping/merchant_reports_v1/__init__.py
index 4d5677c5ce78..4a1f4a2dcc91 100644
--- a/packages/google-shopping-merchant-reports/google/shopping/merchant_reports_v1/__init__.py
+++ b/packages/google-shopping-merchant-reports/google/shopping/merchant_reports_v1/__init__.py
@@ -71,7 +71,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -100,9 +100,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-reports/google/shopping/merchant_reports_v1alpha/__init__.py b/packages/google-shopping-merchant-reports/google/shopping/merchant_reports_v1alpha/__init__.py
index d6e7cb1cc7c8..f73a3fc23c8a 100644
--- a/packages/google-shopping-merchant-reports/google/shopping/merchant_reports_v1alpha/__init__.py
+++ b/packages/google-shopping-merchant-reports/google/shopping/merchant_reports_v1alpha/__init__.py
@@ -73,7 +73,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -102,9 +102,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-reports/google/shopping/merchant_reports_v1beta/__init__.py b/packages/google-shopping-merchant-reports/google/shopping/merchant_reports_v1beta/__init__.py
index 543e0f0a68e2..286c425e7b12 100644
--- a/packages/google-shopping-merchant-reports/google/shopping/merchant_reports_v1beta/__init__.py
+++ b/packages/google-shopping-merchant-reports/google/shopping/merchant_reports_v1beta/__init__.py
@@ -70,7 +70,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -99,9 +99,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-reports/setup.py b/packages/google-shopping-merchant-reports/setup.py
index 52bc61fba399..0b271803015a 100644
--- a/packages/google-shopping-merchant-reports/setup.py
+++ b/packages/google-shopping-merchant-reports/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/shopping/merchant_reports/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
     "google-shopping-type >= 1.0.0, <2.0.0",
 ]
 extras = {}
diff --git a/packages/google-shopping-merchant-reports/testing/constraints-3.10.txt b/packages/google-shopping-merchant-reports/testing/constraints-3.10.txt
index b408428a99a2..250670a79385 100644
--- a/packages/google-shopping-merchant-reports/testing/constraints-3.10.txt
+++ b/packages/google-shopping-merchant-reports/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
 google-shopping-type==1.0.0
diff --git a/packages/google-shopping-merchant-reports/testing/constraints-3.13.txt b/packages/google-shopping-merchant-reports/testing/constraints-3.13.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-reports/testing/constraints-3.13.txt
+++ b/packages/google-shopping-merchant-reports/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-reports/testing/constraints-3.14.txt b/packages/google-shopping-merchant-reports/testing/constraints-3.14.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-reports/testing/constraints-3.14.txt
+++ b/packages/google-shopping-merchant-reports/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-reviews/google/shopping/merchant_reviews_v1beta/__init__.py b/packages/google-shopping-merchant-reviews/google/shopping/merchant_reviews_v1beta/__init__.py
index ed24b9773df9..9799b4b88335 100644
--- a/packages/google-shopping-merchant-reviews/google/shopping/merchant_reviews_v1beta/__init__.py
+++ b/packages/google-shopping-merchant-reviews/google/shopping/merchant_reviews_v1beta/__init__.py
@@ -75,7 +75,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -104,9 +104,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-merchant-reviews/setup.py b/packages/google-shopping-merchant-reviews/setup.py
index e93978164816..17a6a4f6a260 100644
--- a/packages/google-shopping-merchant-reviews/setup.py
+++ b/packages/google-shopping-merchant-reviews/setup.py
@@ -31,7 +31,10 @@
 with open(
     os.path.join(package_root, "google/shopping/merchant_reviews/gapic_version.py")
 ) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -41,15 +44,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
     "google-shopping-type >= 1.0.0, <2.0.0",
 ]
 extras = {}
diff --git a/packages/google-shopping-merchant-reviews/testing/constraints-3.10.txt b/packages/google-shopping-merchant-reviews/testing/constraints-3.10.txt
index b408428a99a2..250670a79385 100644
--- a/packages/google-shopping-merchant-reviews/testing/constraints-3.10.txt
+++ b/packages/google-shopping-merchant-reviews/testing/constraints-3.10.txt
@@ -4,9 +4,9 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
 google-shopping-type==1.0.0
diff --git a/packages/google-shopping-merchant-reviews/testing/constraints-3.13.txt b/packages/google-shopping-merchant-reviews/testing/constraints-3.13.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-reviews/testing/constraints-3.13.txt
+++ b/packages/google-shopping-merchant-reviews/testing/constraints-3.13.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-merchant-reviews/testing/constraints-3.14.txt b/packages/google-shopping-merchant-reviews/testing/constraints-3.14.txt
index d17e4ad50309..72a0563100f5 100644
--- a/packages/google-shopping-merchant-reviews/testing/constraints-3.14.txt
+++ b/packages/google-shopping-merchant-reviews/testing/constraints-3.14.txt
@@ -9,5 +9,5 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
 google-shopping-type>=1
diff --git a/packages/google-shopping-type/google/shopping/type/__init__.py b/packages/google-shopping-type/google/shopping/type/__init__.py
index 71dfc5ab3857..c71475aec70a 100644
--- a/packages/google-shopping-type/google/shopping/type/__init__.py
+++ b/packages/google-shopping-type/google/shopping/type/__init__.py
@@ -57,7 +57,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -86,9 +86,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/google-shopping-type/setup.py b/packages/google-shopping-type/setup.py
index fdd70a0e1433..f22eed3eb758 100644
--- a/packages/google-shopping-type/setup.py
+++ b/packages/google-shopping-type/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "google/shopping/type/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/google-shopping-type"
diff --git a/packages/google-shopping-type/testing/constraints-3.10.txt b/packages/google-shopping-type/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/google-shopping-type/testing/constraints-3.10.txt
+++ b/packages/google-shopping-type/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/google-shopping-type/testing/constraints-3.13.txt b/packages/google-shopping-type/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-shopping-type/testing/constraints-3.13.txt
+++ b/packages/google-shopping-type/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/google-shopping-type/testing/constraints-3.14.txt b/packages/google-shopping-type/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/google-shopping-type/testing/constraints-3.14.txt
+++ b/packages/google-shopping-type/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/grafeas/grafeas/grafeas_v1/__init__.py b/packages/grafeas/grafeas/grafeas_v1/__init__.py
index 76db9067f15e..4277fcf561bb 100644
--- a/packages/grafeas/grafeas/grafeas_v1/__init__.py
+++ b/packages/grafeas/grafeas/grafeas_v1/__init__.py
@@ -158,7 +158,7 @@
 
         def parse_version_to_tuple(version_string: str):
             """Safely converts a semantic version string to a comparable tuple of integers.
-            Example: "4.25.8" -> (4, 25, 8)
+            Example: "6.33.5" -> (6, 33, 5)
             Ignores non-numeric parts and handles common version formats.
             Args:
                 version_string: Version string in the format "x.y.z" or "x.y.z<suffix>"
@@ -187,9 +187,9 @@ def _get_version(dependency_name):
                 return (None, "--")
 
         _dependency_package = "google.protobuf"
-        _next_supported_version = "4.25.8"
-        _next_supported_version_tuple = (4, 25, 8)
-        _recommendation = " (we recommend 6.x)"
+        _next_supported_version = "6.33.5"
+        _next_supported_version_tuple = (6, 33, 5)
+        _recommendation = " (we recommend 7.x)"
         (_version_used, _version_used_string) = _get_version(_dependency_package)
         if _version_used and _version_used < _next_supported_version_tuple:
             warnings.warn(
diff --git a/packages/grafeas/setup.py b/packages/grafeas/setup.py
index 42618c18ebff..5a2fa1fb7d4b 100644
--- a/packages/grafeas/setup.py
+++ b/packages/grafeas/setup.py
@@ -29,7 +29,10 @@
 version = None
 
 with open(os.path.join(package_root, "grafeas/grafeas/gapic_version.py")) as fp:
-    version_candidates = re.findall(r"(?<=\")\d+.\d+.\d+(?=\")", fp.read())
+    version_candidates = re.findall(
+        r"(?<=\")\d+\.\d+\.\d+[^\"\s]*(?=\")",
+        fp.read(),
+    )
     assert len(version_candidates) == 1
     version = version_candidates[0]
 
@@ -39,15 +42,14 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "google-api-core[grpc] >= 2.17.1, <3.0.0",
+    "google-api-core[grpc] >= 2.24.2, <3.0.0",
     # Exclude incompatible versions of `google-auth`
     # See https://github.com/googleapis/google-cloud-python/issues/12364
     "google-auth >= 2.14.1, <3.0.0,!=2.24.0,!=2.25.0",
     "grpcio >= 1.59.0, < 2.0.0",
     "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
-    "proto-plus >= 1.22.3, <2.0.0",
-    "proto-plus >= 1.25.0, <2.0.0; python_version >= '3.13'",
-    "protobuf >= 4.25.8, < 8.0.0",
+    "proto-plus >= 1.26.1, <2.0.0",
+    "protobuf >= 6.33.5, < 8.0.0",
 ]
 extras = {}
 url = "https://github.com/googleapis/google-cloud-python/tree/main/packages/grafeas"
diff --git a/packages/grafeas/testing/constraints-3.10.txt b/packages/grafeas/testing/constraints-3.10.txt
index 7be9c36933fc..81605a716d32 100644
--- a/packages/grafeas/testing/constraints-3.10.txt
+++ b/packages/grafeas/testing/constraints-3.10.txt
@@ -4,8 +4,8 @@
 # pinning their versions to their lower bounds.
 # For example, if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0",
 # then this file should have google-cloud-foo==1.14.0
-google-api-core==2.17.1
+google-api-core==2.24.2
 google-auth==2.14.1
 grpcio==1.59.0
-proto-plus==1.22.3
-protobuf==4.25.8
+proto-plus==1.26.1
+protobuf==6.33.5
diff --git a/packages/grafeas/testing/constraints-3.13.txt b/packages/grafeas/testing/constraints-3.13.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/grafeas/testing/constraints-3.13.txt
+++ b/packages/grafeas/testing/constraints-3.13.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7
diff --git a/packages/grafeas/testing/constraints-3.14.txt b/packages/grafeas/testing/constraints-3.14.txt
index 1e93c60e50aa..6bd7e1f5b03d 100644
--- a/packages/grafeas/testing/constraints-3.14.txt
+++ b/packages/grafeas/testing/constraints-3.14.txt
@@ -9,4 +9,4 @@ google-api-core>=2
 google-auth>=2
 grpcio>=1
 proto-plus>=1
-protobuf>=6
+protobuf>=7